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Cited by 319Cellular Mechanics and InteractionsCancer Cells and MetastasisHippo pathway signaling and YAP/TAZ

Mechanotransduction in tumor progression: The dark side of the force

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Broders-Bondon, Florence, Nguyen Ho-Bouldoires, Thanh Huong, Fernandez-Sanchez, Maria-Elena, Farge, Emmanuel·2018·Journal of Cell Biology
DOI 10.1083/jcb.201701039PMC PMC5940296
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Abstract

Cancer has been characterized as a genetic disease, associated with mutations that cause pathological alterations of the cell cycle, adhesion, or invasive motility. Recently, the importance of the anomalous mechanical properties of tumor tissues, which activate tumorigenic biochemical pathways, has become apparent. This mechanical induction in tumors appears to consist of the destabilization of adult tissue homeostasis as a result of the reactivation of embryonic developmental mechanosensitive pathways in response to pathological mechanical strains. These strains occur in many forms, for example, hypervascularization in late tumors leads to high static hydrodynamic pressure that can promote malignant progression through hypoxia or anomalous interstitial liquid and blood flow. The high stiffness of tumors directly induces the mechanical activation of biochemical pathways enhancing the cell cycle, epithelial–mesenchymal transition, and cell motility. Furthermore, increases in solid-stress pressure associated with cell hyperproliferation activate tumorigenic pathways in the healthy epithelial cells compressed by the neighboring tumor. The underlying molecular mechanisms of the translation of a mechanical signal into a tumor inducing biochemical signal are based on mechanically induced protein conformational changes that activate classical tumorigenic signaling pathways. Understanding these mechanisms will be important for the development of innovative treatments to target such mechanical anomalies in cancer.

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  • A growing literature on mechanotransduction suggests that normal or shear strain may be a major determinant of cellular responses.

    “Indeed, a growing literature on mechanotransduction, mostly in the cancer field, suggests that normal or shear strain may be a major determinant of cellular responses [27].”

    From Fascia Mobility, Proprioception, and Myofascial Pain. (2021) · cites this paper as [27]

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Authors
Broders-Bondon, F., Nguyen Ho-Bouldoires, T. H., Fernandez-Sanchez, M.-E., & Farge, E.
Affiliations
  • Mechanics and Genetics of Embryonic and Tumor Development Group, Institut Curie, PSL Research University, Centre National de la Recherche Scientifique, UMR168, Inserm, Sorbonne Universities, Paris, France
  • Centre National de la Recherche Scientifique (FR)
Corresponding author
Farge, Emmanuel
ORCID
Venue
Journal of Cell Biology
Publisher
Rockefeller University Press
Published
2018-02-21
Volume
217
Issue
5
Pages
1571-1587
ISSN
  • 0021-9525 (ISSN-L)
  • 1540-8140
DOI
10.1083/jcb.201701039
PMC
PMC5940296
OpenAlex
W2789065958
Cited by
319
References
188
Citations by year
2026: 21 · 2025: 28 · 2024: 41 · 2023: 37 · 2022: 52 · 2021: 52 · 2020: 43 · 2019: 32 · 2018: 13
FWCI
3.93
Type
journal article
Language
en
Open access
Licence
Locations
  • The Journal of Cell Biology (publishedVersion, cc-by-nc-sa)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-sa)
  • PubMed Central (publishedVersion, cc-by-nc-sa)
  • PubMed (publishedVersion)
  • HAL (submittedVersion)
Funders
  • Institut National du Cancer (PLBIO13-172)
  • Foundation pour la Recherche Médicale (DEQ20150331702)
  • Agence Nationale de la Recherche (16CE14002801)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
  • Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hippo pathway signaling and YAP/TAZ
Keywords
mechanotransduction, tumor progression, tumor stiffness, tumor hypervascularization, hydrodynamic pressure, solid stress, epithelial-mesenchymal transition, cell motility, cell cycle, protein conformational change, tumor microenvironment
MeSH terms
Animals, Extracellular Matrix, Humans, Models, Biological, Neoplasms, Disease Progression, Mechanotransduction, Cellular, Carcinogenesis

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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