The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
A water-soluble nucleolin aptamer-paclitaxel conjugate for tumor-specific targeting in ovarian cancer
Open accessAbstract
Paclitaxel (PTX) is among the most commonly used first-line drugs for cancer chemotherapy. However, its poor water solubility and indiscriminate distribution in normal tissues remain clinical challenges. Here we design and synthesize a highly water-soluble nucleolin aptamer-paclitaxel conjugate (NucA-PTX) that selectively delivers PTX to the tumor site. By connecting a tumor-targeting nucleolin aptamer (NucA) to the active hydroxyl group at 2′ position of PTX via a cathepsin B sensitive dipeptide bond, NucA-PTX remains stable and inactive in the circulation. NucA facilitates the uptake of the conjugated PTX specifically in tumor cells. Once inside cells, the dipeptide bond linker of NucA-PTX is cleaved by cathepsin B and then the conjugated PTX is released for action. The NucA modification assists the selective accumulation of the conjugated PTX in ovarian tumor tissue rather than normal tissues, and subsequently resulting in notably improved antitumor activity and reduced toxicity.
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The Gut Microbiota Plays a Protective Role in the Host Defence Against Pneumococcal Pneumonia
Schuijt, T. J., Lankelma, J. M., Scicluna, B. P., de Sousa e Melo, F., Roelofs, J. J. T. H., de Boer, J. D., Hoogendijk, A. J., de Beer, R., de Vos, A., Belzer, C., et al. (2016) · Gut · doi:10.1136/gutjnl-2015-309728 · Cited by 832
Nucleolin Targeting AS1411 Modified Protein Nanoparticle for Antitumor Drugs Delivery
Wu, J., Song, C., Jiang, C., Shen, X., Qiao, Q., & Hu, Y. (2013) · Molecular Pharmaceutics · doi:10.1021/mp300686g · Cited by 125
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Supramolecular cancer nanotheranostics
Zhou, J., Rao, L., Yu, G., Cook, T. R., Chen, X., & Huang, F. (2021) · Chemical Society Reviews · doi:10.1039/d0cs00011f · Cited by 411
Aptamer‐PROTAC Conjugates (APCs) for Tumor‐Specific Targeting in Breast Cancer
He, S., Gao, F., Ma, J., Ma, H., Dong, G., & Sheng, C. (2021) · Angewandte Chemie International Edition · doi:10.1002/anie.202107347 · Cited by 299
He, J., Peng, T., Peng, Y., Ai, L., Deng, Z., Wang, X.-Q., & Tan, W. (2020) · Journal of the American Chemical Society · doi:10.1021/jacs.9b10510 · Cited by 160
Cathepsin-sensitive nanoscale drug delivery systems for cancer therapy and other diseases
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Metadata
- Authors
- Li, F., Lu, J., Liu, J., Liang, C., Wang, M., Wang, L., Li, D., Yao, H., Zhang, Q., Wen, J., Zhang, Z.-K., Li, J., Lv, Q., He, X., Guo, B., Guan, D., Yu, Y., Dang, L., Wu, X., Li, Y., Chen, G., Jiang, F., Sun, S., Zhang, B.-T., Lu, A., & Zhang, G.
- Venue
- Nature Communications
- Published
- 2017-11-09
- Volume
- 8
- Issue
- 1
- Pages
- 1390-1390
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2765418773
- Cited by
- 281
- References
- 5
- FWCI
- 6.19
- Type
- journal article
- Language
- en
- Status
- Retracted
- Open access
- gold
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- Li, F., Lu, J., Liu, J., Liang, C., Wang, M., Wang, L., Li, D., Yao, H., Zhang, Q., Wen, J., Zhang, Z.-K., Li, J., Lv, Q., He, X., Guo, B., Guan, D., Yu, Y., Dang, L., Wu, X., . . . Zhang, G. (2017). A water-soluble nucleolin aptamer-paclitaxel conjugate for tumor-specific targeting in ovarian cancer. Nature Communications. https://doi.org/10.1038/s41467-017-01565-6
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
