Paclitaxel-Loaded PEG-PE–Based Micellar Nanopreparations Targeted with Tumor-Specific Landscape Phage Fusion Protein Enhance Apoptosis and Efficiently Reduce Tumors

Tumor delivery of macromolecular drugs based on the EPR effect

Torchilin, V. P. (2010) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2010.03.011 · Cited by 2,032 · see citing works

Assessment of Ki67 in Breast Cancer: Recommendations from the International Ki67 in Breast Cancer Working Group

Dowsett, M., Nielsen, T. O., A’Hern, R., Bartlett, J., Coombes, R. C., Cuzick, J. M., Ellis, M., Henry, N. L., Hugh, J. C., Lively, T., et al. (2011) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djr393 · Cited by 1,985 · see citing works

Micellar Nanocarriers: Pharmaceutical Perspectives

Torchilin, V. P. (2006) · Pharmaceutical Research · doi:10.1007/s11095-006-9132-0 · Cited by 1,910 · see citing works

Paclitaxel and its formulations

Singla, A. K., Garg, A. B., & Aggarwal, D. (2002) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(01)00986-3 · Cited by 1,100 · see citing works

Phase I and pharmacokinetic study of Genexol-PM, a cremophor-free, polymeric micelle-formulated paclitaxel, in patients with advanced malignancies

Kim, T.-Y., Kim, D.-W., Chung, J.-Y., Shin, S. G., Kim, S.-C., Heo, D. S., Kim, N. K., & Bang, Y.-J. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-03-0655 · Cited by 821 · see citing works

Targeted pharmaceutical nanocarriers for cancer therapy and imaging

Torchilin, V. P. (2007) · The AAPS Journal · doi:10.1208/aapsj0902015 · Cited by 758 · see citing works

Phase I clinical trial and pharmacokinetic evaluation of NK911, a micelle-encapsulated doxorubicin

Matsumura, Y., Hamaguchi, T., Ura, T., Muro, K., Yamada, Y., Shimada, Y., Shirao, K., Okusaka, T., Ueno, H., Ikeda, M., et al. (2004) · British Journal of Cancer · doi:10.1038/sj.bjc.6602204 · Cited by 623 · see citing works

Functionalized micellar systems for cancer targeted drug delivery

Sutton, D., Nasongkla, N., Blanco, E., & Gao, J. (2007) · Pharmaceutical Research · doi:10.1007/s11095-006-9223-y · Cited by 557 · see citing works

Tumour-targeted nanomedicines: principles and practice

Lammers, T., Hennink, W. E., & Storm, G. (2008) · British Journal of Cancer · doi:10.1038/sj.bjc.6604483 · Cited by 542 · see citing works

Immunomicelles: Targeted pharmaceutical carriers for poorly soluble drugs

Torchilin, V. P., Lukyanov, A. N., Gao, Z., & Papahadjopoulos‐Sternberg, B. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0931428100 · Cited by 538 · see citing works

Phase I dose escalation and pharmacokinetic study of pluronic polymer-bound doxorubicin (SP1049C) in patients with advanced cancer

Danson, S., Ferry, D., Alakhov, V, Margison, J., Kerr, D., Jowle, D., Brampton, M., Halbert, G., & Ranson, M. (2004) · British Journal of Cancer · doi:10.1038/sj.bjc.6601856 · Cited by 382 · see citing works

Enhanced anticancer activity of nanopreparation containing an MMP2-sensitive PEG-drug conjugate and cell-penetrating moiety

Zhu, L., Wang, T., Perche, F., Taigind, A., & Torchilin, V. P. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1304987110 · Cited by 360 · see citing works

Novel formulations of taxanes: a review. Old wine in a new bottle?

Hennenfent, K. L., & Govindan, R. (2005) · Annals of Oncology · doi:10.1093/annonc/mdj100 · Cited by 347 · see citing works

Relationship of Mitotic Arrest and Apoptosis to Antitumor Effect of Paclitaxel

Milross, C., Mason, K. A., Hunter, N. R., Chung, W.-K., Peters, L. J., & Milas, L. (1996) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/88.18.1308 · Cited by 286 · see citing works

Matrix metalloproteinase 2-sensitive multifunctional polymeric micelles for tumor-specific co-delivery of siRNA and hydrophobic drugs

Zhu, L., Perche, F., Wang, T., & Torchilin, V. P. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.01.060 · Cited by 220 · see citing works

Paclitaxel-induced apoptosis and mitotic arrest assessed by serial fine-needle aspiration: implications for early prediction of breast cancer response to neoadjuvant treatment.

Symmans, W. F., Volm, M. D., Shapiro, R. L., Perkins, A., Kim, A. Y., Demaria, S., Yee, H. T., McMullen, H., Oratz, R., Klein, P., et al. (2000) · PubMed · Cited by 149 · see citing works

Apoptosis: implications of basic research for clinical oncology

Tamm, I., Schriever, F., & Dörken, B. (2001) · The Lancet Oncology · doi:10.1016/s1470-2045(00)00193-5 · Cited by 145 · see citing works

Novel RGD lipopeptides for the targeting of liposomes to integrin-expressing endothelial and melanoma cells

Hölig, P., Bach, M., Völkel, T., Nahde, T., Hoffmann, S., Müller, R., & Kontermann, R. E. (2004) · Protein Engineering Design and Selection · doi:10.1093/protein/gzh055 · Cited by 128 · see citing works

Paclitaxel-induced apoptosis in MCF-7 breast-cancer cells

Saunders, D. E., Lawrence, W. D., CHRISTENSEN, C. W., Wappler, N. L., Ruan, H., & Deppe, G. (1997) · International Journal of Cancer · doi:10.1002/(sici)1097-0215(19970117)70:2 · Cited by 121 · see citing works

Evolution of phage display: from bioactive peptides to bioselective nanomaterials

Petrenko, V. A. (2008) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.5.8.825 · Cited by 103 · see citing works

Paclitaxel-Loaded Polymeric Micelles Modified with MCF-7 Cell-Specific Phage Protein: Enhanced Binding to Target Cancer Cells and Increased Cytotoxicity

Wang, T., Petrenko, V. A., & Torchilin, V. P. (2010) · Molecular Pharmaceutics · doi:10.1021/mp1001125 · Cited by 100 · see citing works

A Colorimetric Assay for Estimation of Polyethylene Glycol and Polyethylene Glycolated Protein Using Ammonium Ferrothiocyanate

Nag, A., Mitra, G., & Ghosh, P. C. (1996) · Analytical Biochemistry · doi:10.1006/abio.1996.0233 · Cited by 100 · see citing works

Early changes in apoptosis and proliferation following primary chemotherapy for breast cancer

Archer, C. D., Parton, M., Smith, I. E., Ellis, P., Salter, J., Ashley, S. E., Gui, G. P. H., Sacks, N., Ebbs, S. R., Allum, W., et al. (2003) · British Journal of Cancer · doi:10.1038/sj.bjc.6601173 · Cited by 90 · see citing works

Enhanced Binding and Killing of Target Tumor Cells by Drug-Loaded Liposomes Modified with Tumor-Specific Phage Fusion Coat Protein

Wang, T., D’Souza, G. G. M., Bedi, D., Fagbohun, O. A., Potturi, L. P., Papahadjopoulos‐Sternberg, B., Petrenko, V. A., & Torchilin, V. P. (2010) · Nanomedicine · doi:10.2217/nnm.10.30 · Cited by 89 · see citing works

The Use of Phage-Displayed Peptide Libraries to Develop Tumor-Targeting Drugs

Krumpe, L. R. H., & Mori, T. (2006) · International Journal of Peptide Research and Therapeutics · doi:10.1007/s10989-005-9002-3 · Cited by 87 · see citing works

The biology of neoadjuvant chemotherapy for breast cancer.

Cleator, S. J., Parton, M., & Dowsett, M. (2002) · Endocrine Related Cancer · doi:10.1677/erc.0.0090183 · Cited by 79 · see citing works

Diversity and censoring of landscape phage libraries

Kuzmicheva, G. A., Jayanna, P. K., Sorokulova, I. B., & Petrenko, V. A. (2008) · Protein Engineering Design and Selection · doi:10.1093/protein/gzn060 · Cited by 72 · see citing works

Cytoplasmic Delivery of Liposomes into MCF-7 Breast Cancer Cells Mediated by Cell-Specific Phage Fusion Coat Protein

Wang, T., Yang, S., Petrenko, V. A., & Torchilin, V. P. (2010) · Molecular Pharmaceutics · doi:10.1021/mp1000229 · Cited by 69 · see citing works

Enhanced tumor delivery and antitumor activity in vivo of liposomal doxorubicin modified with MCF-7-specific phage fusion protein

Wang, T., Hartner, W. C., Gillespie, J. W., Kulkarni, P. P., Yang, S., Mei, L. A., Petrenko, V. A., & Torchilin, V. P. (2013) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2013.08.009 · Cited by 62 · see citing works

Idoxifene antagonizes estradiol-dependent MCF-7 breast cancer xenograft growth through sustained induction of apoptosis.

Johnston, S. R. D., Boeddinghaus, I., Riddler, S., Haynes, B. P., Hardcastle, I. R., Rowlands, M. G., Grimshaw, R., Jarman, M., & Dowsett, M. (1999) · PubMed · Cited by 58 · see citing works

Landscape phage fusion protein-mediated targeting of nanomedicines enhances their prostate tumor cell association and cytotoxic efficiency

Jayanna, P. K., Bedi, D., Gillespie, J. W., DeInnocentes, P., Wang, T., Torchilin, V. P., Bird, R. C., & Petrenko, V. A. (2010) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2010.01.005 · Cited by 41 · see citing works

Molecular mechanisms in the antiproliferative action of taxol and tiazofurin.

Oláh, E., Csókay, B., Prajda, N., Kote‐Jarai, Z., Yeh, Y. A., & Weber, G. (1996) · PubMed · Cited by 33 · see citing works

In vitrooptimization of liposomal nanocarriers prepared from breast tumor cell specific phage fusion protein

Wang, T., Kulkarni, N., Bedi, D., D’Souza, G. G. M., Papahadjopoulos‐Sternberg, B., Petrenko, V. A., & Torchilin, V. P. (2011) · Journal of drug targeting · doi:10.3109/1061186x.2010.550920 · Cited by 22 · see citing works

On the Mechanism of Targeting of Phage Fusion Protein-Modified Nanocarriers: Only the Binding Peptide Sequence Matters

Wang, T., Kulkarni, N., D’Souza, G. G. M., Petrenko, V. A., & Torchilin, V. P. (2011) · Molecular Pharmaceutics · doi:10.1021/mp200080h · Cited by 15 · see citing works

Phase I study of paclitaxel administered by ten-day continuous infusion

Shade, R. J., Pisters, K. M. W., Huber, M. H., Fossella, F. V., Perez-Soler, R., Shin, D. M., Kurie, J. M., Glisson, B. S., Lippman, S. M., & Lee, J. S. (1998) · Investigational New Drugs · doi:10.1023/a:1006157226693 · Cited by 13 · see citing works

Optimization of Landscape Phage Fusion Protein-Modified Polymeric Peg-Pe Micelles for Improved Breast Cancer Cell Targeting

Petrenko, V. A. (2011) · Journal of Nanomedicine & Nanotechnology · doi:10.4172/2157-7439.s4-008 · Cited by 13 · see citing works

Nanoparticle-Mediated Combination Therapy: Two-in-One Approach for Cancer

Gurunathan, S., Kang, M.-H., Qasim, M., & Kim, J.-H. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19103264 · Cited by 367 · see citing works

PEGylation: a promising strategy to overcome challenges to cancer-targeted nanomedicines: a review of challenges to clinical transition and promising resolution

Hussain, Z., Khan, S., Imran, M., Sohail, M. F., Shah, S. W. A., & de Matas, M. (2019) · Drug Delivery and Translational Research · doi:10.1007/s13346-019-00631-4 · Cited by 225 · see citing works

Recent Advances in Nanomicelles Delivery Systems.

Tawfik, S. M., Azizov, S., Elmasry, M. R., Sharipov, M., & Lee, Y.-I. (2020) · Nanomaterials · doi:10.3390/nano11010070 · Cited by 156 · see citing works

Doxorubicin and siRNA Codelivery via Chitosan-Coated pH-Responsive Mixed Micellar Polyplexes for Enhanced Cancer Therapy in Multidrug-Resistant Tumors

Butt, A. M., Amin, M. C. I. M., Katas, H., Murad, N. A. A., Jamal, R. A., & Kesharwani, P. (2016) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.6b00776 · Cited by 115 · see citing works

Beyond phage display: non-traditional applications of the filamentous bacteriophage as a vaccine carrier, therapeutic biologic, and bioconjugation scaffold

Henry, K. A., Arbabi‐Ghahroudi, M., & Scott, J. K. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.00755 · Cited by 105 · see citing works

The Therapeutic Efficacy of Dendrimer and Micelle Formulations for Breast Cancer Treatment

Alven, S., & Aderibigbe, B. A. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12121212 · Cited by 86 · see citing works

Multifunctional polymeric micellar nanomedicine in the diagnosis and treatment of cancer

Raval, N., Maheshwari, R., Shukla, H., Kalia, K., Torchilin, V. P., & Tekade, R. K. (2021) · Materials Science and Engineering C · doi:10.1016/j.msec.2021.112186 · Cited by 64 · see citing works

Anti-EGFR lipid micellar nanoparticles co-encapsulating quantum dots and paclitaxel for tumor-targeted theranosis

Kang, S. J., Jeong, H. Y., Kim, M. W., Jeong, I. H., Choi, M. J., You, Y. M., Im, C. S., Song, I. H., Lee, T. S., & Park, Y. S. (2018) · Nanoscale · doi:10.1039/c8nr05099f · Cited by 60 · see citing works

Synthesis, characterization and radiolabeling of polymeric nano-micelles as a platform for tumor delivering

Oda, C. M. R., Fernandes, R. S., Lopes, S. C. D. A., Oliveira, M. C., Cardoso, V. N., dos Santos, D. M., Pimenta, A. M. C., Malachias, Â., Paniago, R. M., Townsend, D. M., et al. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.01.144 · Cited by 52 · see citing works

Landscape Phage: Evolution from Phage Display to Nanobiotechnology

Petrenko, V. A. (2018) · Viruses · doi:10.3390/v10060311 · Cited by 51 · see citing works

PEGylation rate influences peptide-based nanoparticles mediated siRNA delivery in vitro and in vivo

Aldrian, G., Vaissière, A., Konate, K., Seisel, Q., Vivès, É., Fernandez, F., Viguier, V., Genevois, C., Couillaud, F., Déméné, H., et al. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.04.012 · Cited by 50 · see citing works

Salidroside prevents skin carcinogenesis induced by DMBA/TPA in a mouse model through suppression of inflammation and promotion of apoptosis

Kong, Y., & Xu, S. (2018) · Oncology Reports · doi:10.3892/or.2018.6381 · Cited by 50 · see citing works

Biomimetic bacterial and viral-based nanovesicles for drug delivery, theranostics, and vaccine applications

Loo, Y. S., Bose, R. J., McCarthy, J. R., Azmi, I. D. M., & Madheswaran, T. (2020) · Drug Discovery Today · doi:10.1016/j.drudis.2020.12.017 · Cited by 42 · see citing works

Co-delivery of peptide-modified cisplatin and doxorubicin via mucoadhesive nanocapsules for potential synergistic intravesical chemotherapy of non-muscle-invasive bladder cancer

Lu, S., Xu, L., Kang, E. T., Mahendran, R., Chiong, E., & Neoh, K. G. (2016) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2016.01.013 · Cited by 40 · see citing works

Nanomicelles in Diagnosis and Drug Delivery∗

Trinh, H. M., Joseph, M. A., Cholkar, K., Mitra, R., & Mitra, A. K. (2017) · Elsevier eBooks · doi:10.1016/b978-0-323-42978-8.00003-6 · Cited by 33 · see citing works

Synthesis and Antitumor Activity of Doxycycline Polymeric Nanoparticles: Effect on Tumor Apoptosis in Solid Ehrlich Carcinoma

Gardouh, A. R., Attia, M. A., Enan, E. T., Elbahaie, A. M., Fouad, R. A., El‐Shafey, M., Youssef, A. M., Alomar, S. Y., Ali, Z. A.-E., Zaitone, S. A., et al. (2020) · Molecules · doi:10.3390/molecules25143230 · Cited by 28 · see citing works

Unraveling the potential of M13 phages in biomedicine: Advancing drug nanodelivery and gene therapy

Fadaie, M., Dianat‐Moghadam, H., Ghafouri, E., Naderi, S., Darvishali, M. H., Ghovvati, M., Khanahmad, H., Boshtam, M., & Makvandi, P. (2023) · Environmental Research · doi:10.1016/j.envres.2023.117132 · Cited by 24 · see citing works

Polymeric nanocarriers in drug delivery, bioimaging, and biosensing: advances and perspectives on nanomicelles, nanogels, and dendrimers

Rajabi, M., & Feyzbakhsh, H. (2025) · RSC Advances · doi:10.1039/d5ra05399d · Cited by 30 · see citing works

Study on release of naproxen and metformin encapsulated in biopolymer-inorganic mesoporous matrices as controlled drug-delivery systems

Ghazaie, M., Ghiaci, P., & Ghiaci, M. (2016) · Microporous and Mesoporous Materials · doi:10.1016/j.micromeso.2016.11.004 · Cited by 15 · see citing works

Autonomous self-navigating drug-delivery vehicles: From Science Fiction to Reality

Petrenko, V. A. (2017) · Therapeutic Delivery · doi:10.4155/tde-2017-0086 · Cited by 13 · see citing works

Utilização de Nanopartículas no Tratamento do Câncer: Aspectos Gerais, Mecanismos de Ação Antineoplásicos e Aplicabilidades Tumorais

Lopes, J. C., & Torres, M. L. P. (2020) · Revista Brasileira de Cancerologia · doi:10.32635/2176-9745.rbc.2019v65n4.400 · Cited by 12 · see citing works

Selection of Lung Cancer-Specific Landscape Phage for Targeted Drug Delivery

Gillespie, J. W., Wei, L., & Petrenko, V. A. (2016) · Combinatorial Chemistry & High Throughput Screening · doi:10.2174/1386207319666160420141024 · Cited by 12 · see citing works

Specifically Targeted Transport of Plasma Membrane Transporters: From Potential Mechanisms for Regulating Cell Health or Disease to Applications

He, Y., He, G., & He, T. (2021) · Membranes · doi:10.3390/membranes11100736 · Cited by 11 · see citing works

Phage-derived protein-mediated targeted chemotherapy of pancreatic cancer

Wang, T., Narayanaswamy, R., Ren, H., Gillespie, J. W., Petrenko, V. A., & Torchilin, V. P. (2017) · Journal of drug targeting · doi:10.1080/1061186x.2017.1405424 · Cited by 11 · see citing works

Tissue Distribution and Systemic Toxicity Evaluation of Raloxifene Targeted Polymeric Micelles of Poly (Styrene-Maleic Acid)-Poly (Amide- Ether-Ester-Imide)-Poly (Ethylene Glycol) Loaded With Docetaxel in Breast Cancer Bearing Mice

Varshosaz, J., Hassanzadeh, F., Hashemibeni, B., Minaiyan, M., & Enteshari, S. (2019) · Recent Patents on Anti-Cancer Drug Discovery · doi:10.2174/1574892814666190919163731 · Cited by 7 · see citing works

Nanocarrier based precise approaches for anticancer agents in treatment of breast cancer.

Kandekar, U., & Pujari, R. (2021) · Hacettepe University Journal of the Faculty of Pharmacy · doi:10.52794/hujpharm.891355 · Cited by 3 · see citing works

Polymeric Nanomicelles for Cancer Nanomedicine—Review

Kujundziski, A. P., & Chamovska, D. (2025) · doi:10.3390/engproc2025099012 · Cited by 2 · see citing works

Smart Nanocarrier-Based Cancer Therapeutics

Awan, U. A., Naeem, M., Saeed, R. F., Mumtaz, S., & Akhtar, N. (2023) · Cancer treatment and research · doi:10.1007/978-3-031-27156-4_11 · Cited by 2 · see citing works

Programmable self-replicating JEV nanotherapeutics redefine RNA delivery in ALS

Loo, Y. S., Yusoh, N. A., Yap, K., & Ng, C. S. (2025) · Communications Biology · doi:10.1038/s42003-025-08579-7 · Cited by 1 · see citing works

Targeted nanopreparations for cancer therapy

Narayanaswamy, R. (2020) · doi:10.17760/d20382012

Nanotherapeutics: Tumor delivery of drugs and genes using nanoparticles for synergistic therapeutic effects in the modern pharmaceutical world for welfare of human

Vimala, K., Asaikkutti, A., & Kannan, S. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-821013-0.00008-8

Correction: Paclitaxel-Loaded PEG-PE–Based Micellar Nanopreparations Targeted with Tumor-Specific Landscape Phage Fusion Protein Enhance Apoptosis and Efficiently Reduce Tumors

(2015) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-15-0179

Nanocarriers For Breast Cancer: Advanced Perspective

Kandekar, U., & Pujari, R. (2021) · DergiPark (Istanbul University)

Nanomicelles-based drug delivery systems as for targeted therapy of colon cancer

Paul, A., Ali, A., Prabhakar, P. K., & Upadhyay, T. K. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-40443-6.00018-0

Paclitaxel-Loaded Polymeric Micelles Modified with MCF-7 Cell-Specific Phage Protein: Enhanced Binding to Target Cancer Cells and Increased Cytotoxicity

Wang, T., Petrenko, V. A., & Torchilin, V. P. (2010) · Molecular Pharmaceutics · doi:10.1021/mp1001125 · Cited by 100 · see citing works

Targeted nanopreparations for cancer therapy

Narayanaswamy, R. (2020) · doi:10.17760/d20382012

Phage-derived protein-mediated targeted chemotherapy of pancreatic cancer

Wang, T., Narayanaswamy, R., Ren, H., Gillespie, J. W., Petrenko, V. A., & Torchilin, V. P. (2017) · Journal of drug targeting · doi:10.1080/1061186x.2017.1405424 · Cited by 11 · see citing works

Tumor-targeting peptide functionalized PEG-PLA micelles for efficient drug delivery

Cai, Y., Xu, Z., Shuai, Q., Zhu, F., Xu, J. H., Gao, X., & Sun, X. (2020) · Biomaterials Science · doi:10.1039/c9bm02036e · Cited by 69 · see citing works

Targeted delivery of paclitaxel in phospholipid micelles for improved chemotherapy of breast cancer.

Krishnadas, A. (2025) · Figshare