The DOI matches its Crossref record; 77 of the 77 references it cites were found in a registry or an index.
C-terminal calcium binding of α-synuclein modulates synaptic vesicle interaction
Open accessAbstract
Alpha-synuclein is known to bind to small unilamellar vesicles (SUVs) via its N terminus, which forms an amphipathic alpha-helix upon membrane interaction. Here we show that calcium binds to the C terminus of alpha-synuclein, therewith increasing its lipid-binding capacity. Using CEST-NMR, we reveal that alpha-synuclein interacts with isolated synaptic vesicles with two regions, the N terminus, already known from studies on SUVs, and additionally via its C terminus, which is regulated by the binding of calcium. Indeed, dSTORM on synaptosomes shows that calcium mediates the localization of alpha-synuclein at the pre-synaptic terminal, and an imbalance in calcium or alpha-synuclein can cause synaptic vesicle clustering, as seen ex vivo and in vitro. This study provides a new view on the binding of alpha-synuclein to synaptic vesicles, which might also affect our understanding of synucleinopathies.
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1 retracted
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Nguyen, P. H., Ramamoorthy, A., Sahoo, B. R., Zheng, J., Faller, P., Straub, J. E., Dominguez, L., Shea, J.-E., Dokholyan, N. V., De Simone, A., et al. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.0c01122 · Cited by 678
Self-citationPhase separation and neurodegenerative diseases: a disturbance in the force
Zbinden, A., Pérez-Berlanga, M., De Rossi, P., & Polymenidou, M. (2020) · Developmental Cell · doi:10.1016/j.devcel.2020.09.014 · Cited by 500
α-Synuclein misfolding and aggregation: Implications in Parkinson’s disease pathogenesis
Mehra, S., Sahay, S., & Maji, S. K. (2019) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2019.03.001 · Cited by 499
Determinants of dopaminergic neuron loss in Parkinson's disease
Surmeier, D. J. (2018) · The FEBS Journal · doi:10.1111/febs.14607 · Cited by 444
Metadata
- Authors
- Lautenschläger, J., Stephens, A. D., Fusco, G., Ströhl, F., Curry, N., Zacharopoulou, M., Michel, C. H., Laine, R., Nespovitaya, N., Fantham, M., Pinotsi, D., Zago, W., Fraser, P., Tandon, A., St George-Hyslop, P., Rees, E., Phillips, J. J., De Simone, A., Kaminski, C. F., & Schierle, G. S. K.
- Venue
- Nature Communications
- Published
- 2018-02-19
- Volume
- 9
- Issue
- 1
- Pages
- 712-712
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2788764523
- Cited by
- 334
- References
- 77
- FWCI
- 19.12
- Type
- journal article
- Language
- en
- Open access
- gold
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- Lautenschläger, J., Stephens, A. D., Fusco, G., Ströhl, F., Curry, N., Zacharopoulou, M., Michel, C. H., Laine, R., Nespovitaya, N., Fantham, M., Pinotsi, D., Zago, W., Fraser, P., Tandon, A., St George-Hyslop, P., Rees, E., Phillips, J. J., De Simone, A., Kaminski, C. F., & Schierle, G. S. K. (2018). C-terminal calcium binding of α-synuclein modulates synaptic vesicle interaction. Nature Communications. https://doi.org/10.1038/s41467-018-03111-4
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
