ZIF-8-Modified multifunctional bone-adhesive hydrogels promoting angiogenesis and osteogenesis for bone regeneration
Abstract
Designing bone adhesives with adhesiveness, antideformation, biocompatibility, and biofunctional effects has great practical significance for bone defect reconstructive treatment, especially for bone graft repair surgery. Here, we designed zeolitic imidazolate framework-8 nanoparticle (ZIF-8 NP)-modified catechol-chitosan (CA-CS) multifunctional hydrogels (CA-CS/Z) to stabilize the bone graft environment, ensure blood supply, promote osteogenic differentiation, and accelerate bone reconstruction. Characterizations confirmed the successful synthesis of CA-CS/Z hydrogels. Hydrogels exhibited advanced rheological properties, reliable mechanical strength, and excellent adhesion for clinical applications. Based on excellent biocompatibility, it could enhance paracrine of the vascular endothelial growth factor (VEGF) in rat bone marrow mesenchymal stem cells (rBMSCs) to ensure blood supply reconstruction in bone defect areas. Furthermore, the ZIF-8 NPs released from the hydrogels could also up-regulate the production and secretion of alkaline phosphatase, collagen 1, and osteocalcin, promoting the osteogenic differentiation of rBMSCs. In addition, the antibacterial properties of CA-CS/Z could also be observed. In vivo experiments further provided a powerful proof that CA-CS/Z promoted vascularized osteogenesis in wound areas by stabilizing bone graft materials and greatly accelerated the speed and healing of bone reconstruction. These results indicate the promising potential of CA-CS/Z hydrogels with promoting implantation stability, angiogenesis, and osteogenesis for bone regeneration applications.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
MOF scaffolds are promising strategies for bone tissue regeneration.
“Although metal-organic framework (MOF) scaffolds are promising strategies for bone tissue regeneration, their potential use for exosome loading remains unexplored.”
MOF incorporated scaffolds are a promising strategy for bone tissue regeneration.
“The application of MOF incorporated scaffolds is a promising strategy for bone tissue regeneration, e.g., ZIF-8-modified multifunctional bone-adhesive hydrogels promoted angiogenesis and osteogenesis during bone regeneration [21].”
Zn2+ serves as an essential trace element in human physiology, participating in osteoblast differentiation and bone matrix mineralization.
“The incorporated Zn2+ serves as an essential trace element in human physiology, participating in osteoblast differentiation and bone matrix mineralization [43].”
From Hydrogel scaffold encapsulating MSC-Exos and ZIF-8 promotes bone regeneration via coordinating osteogenesis and immunomodulation (2025) · cites this paper as [43]
Cites
Highly stretchable and tough hydrogels
Sun, J., Zhao, X., Illeperuma, W. R. K., Chaudhuri, O., Oh, K. H., Mooney, D. J., Vlassak, J. J., & Suo, Z. (2012) · Nature · doi:10.1038/nature11409 · Cited by 5,499 · see citing works
Metal–Organic Frameworks in Biomedicine
Horcajada, P., Gref, R., Baâti, T., Allan, P. K., Maurin, G., Couvreur, P., Férey, G., Morris, R. E., & Serre, C. (2011) · Chemical Reviews · doi:10.1021/cr200256v · Cited by 4,175 · see citing works
Kern, S., Eichler, H., Stoeve, J., Klüter, H., & Bieback, K. (2006) · STEM CELLS · doi:10.1634/stemcells.2005-0342 · Cited by 3,370 · see citing works
The biochemical basis of zinc physiology
Vallée, B. L., & Falchuk, K. H. (1993) · Physiological Reviews · doi:10.1152/physrev.1993.73.1.79 · Cited by 3,005 · see citing works
Advances in engineering hydrogels
Zhang, Y. S., & Khademhosseini, A. (2017) · Science · doi:10.1126/science.aaf3627 · Cited by 2,908 · see citing works
The control of human mesenchymal cell differentiation using nanoscale symmetry and disorder
Dalby, M. J., Gadegaard, N., Tare, R. S., Andar, A. U., Riehle, M. O., Herzyk, P., Wilkinson, C. D. W., & Oreffo, R. O. C. (2007) · Nature Materials · doi:10.1038/nmat2013 · Cited by 2,420 · see citing works
Polyionic hydrocolloids for the intestinal delivery of protein drugs: alginate and chitosan—a review
George, M., & Abraham, T. E. (2006) · Journal of Controlled Release · doi:10.1016/j.jconrel.2006.04.017 · Cited by 2,012 · see citing works
Chitosan: A versatile biopolymer for orthopaedic tissue-engineering
Martino, A. C. D., Sittinger, M., & Risbud, M. V. (2005) · Biomaterials · doi:10.1016/j.biomaterials.2005.03.016 · Cited by 1,638 · see citing works
Zheng, H., Zhang, Y., Liu, L., Wan, W., Guo, P., Nyström, A. M., & Zou, X. (2015) · Journal of the American Chemical Society · doi:10.1021/jacs.5b11720 · Cited by 1,386 · see citing works
Inflammation, fracture and bone repair
Loi, F., Córdova, L. A., Pajarinen, J., Lin, T., Yao, Z., & Goodman, S. B. (2016) · Bone · doi:10.1016/j.bone.2016.02.020 · Cited by 1,306 · see citing works
Nitric oxide synthase modulates angiogenesis in response to tissue ischemia.
Murohara, T., Asahara, T., Silver, M., Bauters, C., Masuda, H., Kalka, C., Kearney, M., Chen, D., Symes, J. F., Fishman, M. C., et al. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1560 · Cited by 1,201 · see citing works
Skin-inspired hydrogel–elastomer hybrids with robust interfaces and functional microstructures
Yuk, H., Zhang, T., Parada, G. A., Liu, X., & Zhao, X. (2016) · Nature Communications · doi:10.1038/ncomms12028 · Cited by 1,035 · see citing works
Forlino, A., & Marini, J. C. (2015) · The Lancet · doi:10.1016/s0140-6736(15)00728-x · Cited by 972 · see citing works
Natural‐Based Nanocomposites for Bone Tissue Engineering and Regenerative Medicine: A Review
Pina, S., Oliveira, J. M., & Reis, R. L. (2015) · Advanced Materials · doi:10.1002/adma.201403354 · Cited by 945 · see citing works
Harris, P. N. A., Tambyah, P. A., Lye, D. C., Mo, Y., Lee, T. H., Yılmaz, M., Alenazi, T. H., Arabi, Y. M., Falcone, M., Bassetti, M., et al. (2018) · JAMA · doi:10.1001/jama.2018.12163 · Cited by 789 · see citing works
Biomaterial strategies for engineering implants for enhanced osseointegration and bone repair
Agarwal, R., & Garcı́a, A. J. (2015) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.03.013 · Cited by 785 · see citing works
The biological inorganic chemistry of zinc ions
Krężel, A., & Maret, W. (2016) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2016.04.010 · Cited by 768 · see citing works
Zinc oxide nanoparticles: Synthesis, antiseptic activity and toxicity mechanism
Król, A., Pomastowski, P., Rafińska, K., Railean‐Plugaru, V., & Buszewski, B. (2017) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2017.07.033 · Cited by 739 · see citing works
Growth and transplantation of a custom vascularised bone graft in a man
Warnke, P. H., Springer, I. N. G., Wiltfang, J., Açil, Y., Eufinger, H., Wehmöller, M., Russo, P., Bolte, H., Sherry, E., Behrens, E., et al. (2004) · The Lancet · doi:10.1016/s0140-6736(04)16935-3 · Cited by 713 · see citing works
Catechol-functionalized chitosan/pluronic hydrogels for tissue adhesives and hemostatic materials
Ryu, J. H., Lee, Y., Kong, W. H., Kim, T. G., Park, T. G., & Lee, H. (2011) · Biomacromolecules · doi:10.1021/bm200464x · Cited by 677 · see citing works
Evaluation of bone regeneration using the rat critical size calvarial defect
Spicer, P. P., Kretlow, J. D., Young, S. W., Jansen, J. A., Kasper, F. K., & Mikos, A. G. (2012) · Nature Protocols · doi:10.1038/nprot.2012.113 · Cited by 666 · see citing works
Iron-chelation properties of phenolic acids bearing catechol and galloyl groups
Andjelković, M., VanCamp, J., Demeulenaer, B., Depaemelaere, G., Socaciu, C., Verloo, M. G., & Verhé, R. (2005) · Food Chemistry · doi:10.1016/j.foodchem.2005.05.044 · Cited by 665 · see citing works
New insights into the biology of osteocalcin
Zoch, M. L., Clemens, T. L., & Riddle, R. C. (2015) · Bone · doi:10.1016/j.bone.2015.05.046 · Cited by 612 · see citing works
The role of vasculature in bone development, regeneration and proper systemic functioning
Filipowska, J., Tomaszewski, K. A., Niedźwiedzki, Ł., Walocha, J. A., & Niedźwiedzki, T. (2017) · Angiogenesis · doi:10.1007/s10456-017-9541-1 · Cited by 564 · see citing works
de Lageneste, O. D., Julien, A., Abou-Khalil, R., Frangi, G., Carvalho, C., Cagnard, N., Cordier, C., Conway, S. J., & Colnot, C. (2018) · Nature Communications · doi:10.1038/s41467-018-03124-z · Cited by 559 · see citing works
Novel Mussel‐Inspired Injectable Self‐Healing Hydrogel with Anti‐Biofouling Property
Li, L., Yan, B., Yang, J., Chen, L., & Zeng, H. (2015) · Advanced Materials · doi:10.1002/adma.201405166 · Cited by 553 · see citing works
Biphasic calcium phosphate ceramics for bone reconstruction: A review of biological response
Bouler, J., Pilet, P., Gauthier, O., & Verron, É. (2017) · Acta Biomaterialia · doi:10.1016/j.actbio.2017.01.076 · Cited by 499 · see citing works
Vascularized 3D printed scaffolds for promoting bone regeneration
Yan, Y., Chen, H., Zhang, H., Guo, C., Yang, K., Chen, K., Cheng, R., Qian, N., Sandler, N., Zhang, Y. S., et al. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2018.10.033 · Cited by 475 · see citing works
Mussel protein adhesion depends on interprotein thiol-mediated redox modulation
Yu, J., Wei, W., Danner, E., Ashley, R. K., Israelachvili, J. N., & Waite, J. H. (2011) · Nature Chemical Biology · doi:10.1038/nchembio.630 · Cited by 463 · see citing works
Li, W., Liu, Y., Zhang, P., Tang, Y., Zhou, M., Jiang, W., Zhang, X., Wu, G., & Zhou, Y. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b17620 · Cited by 459 · see citing works
Self-citationComparison of the mucoadhesive properties of various polymers
Grabovac, V., Guggi, D., & Bernkop‐Schnürch, A. (2005) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2005.07.006 · Cited by 451 · see citing works
A new class of synthetic retinoid antibiotics effective against bacterial persisters
Kim, W., Zhu, W., Hendricks, G. L., Tyne, D. V., Steele, A. D., Keohane, C. E., Fricke, N., Conery, A. L., Shen, S., Pan, W., et al. (2018) · Nature · doi:10.1038/nature26157 · Cited by 412 · see citing works
Millward, D. J. (2017) · Nutrition Research Reviews · doi:10.1017/s0954422416000238 · Cited by 368 · see citing works
Zhao, D., Huang, S., Lu, F., Wang, B., Yang, L., Qin, L., Yang, K., Li, Y., Li, W., Wang, W., et al. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.11.038 · Cited by 350 · see citing works
Self-citationWang, J., Wang, Y., Zhang, Y., Uliana, A., Zhu, J., Liu, J., & der Bruggen, B. V. (2016) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b06992 · Cited by 338 · see citing works
Self-citationGao, F., Xu, Z., Liang, Q., Liu, B., Li, H., Wu, Y., Zhang, Y., Lin, Z., Wu, M., Ruan, C., et al. (2018) · Advanced Functional Materials · doi:10.1002/adfm.201706644 · Cited by 330 · see citing works
Pobloth, A., Checa, S., Razi, H., Petersen, A., Weaver, J. C., Schmidt‐Bleek, K., Windolf, M., Tatai, A. Á., Roth, C. P., Schaser, K., et al. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aam8828 · Cited by 315 · see citing works
Cheng, H., Yue, K., Kazemzadeh‐Narbat, M., Liu, Y., Khalilpour, A., Li, B., Zhang, Y. S., Annabi, N., & Khademhosseini, A. (2017) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b16779 · Cited by 263 · see citing works
Self-citationMultifunctional Antimicrobial Biometallohydrogels Based on Amino Acid Coordinated Self‐Assembly
Song, J., Yuan, C., Jiao, T., et al. (2020) · Small · doi:10.1002/smll.201907309 · Cited by 259 · see citing works
Lai, Y., Cao, H., Wang, X., Chen, S., Zhang, M., Wang, N., Yao, Z., Dai, Y., Xie, X., Zhang, P., et al. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.10.025 · Cited by 252 · see citing works
Yu, P., Bao, R., Shi, X.-J., Yang, W. M., & Yang, M. (2016) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2016.09.001 · Cited by 248 · see citing works
Regulation of Adult Bone Mass by the Zinc Finger Adapter Protein Schnurri-3
Jones, D. C., Wein, M. N., Oukka, M., Hofstaetter, J. G., Glimcher, M. J., & Glimcher, L. H. (2006) · Science · doi:10.1126/science.1126313 · Cited by 246 · see citing works
A Multifunctional Polymeric Periodontal Membrane with Osteogenic and Antibacterial Characteristics
Nasajpour, A., Ansari, S., Rinoldi, C., Rad, A. S., Aghaloo, T. L., Shin, S. R., Mishra, Y. K., Adelung, R., Święszkowski, W., Annabi, N., et al. (2017) · Advanced Functional Materials · doi:10.1002/adfm.201703437 · Cited by 242 · see citing works
Zhu, D., Su, Y., Young, M. L., Ma, J., Zheng, Y., & Tang, L. (2017) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b06654 · Cited by 227 · see citing works
Wu, J., Zheng, K., Huang, X., Liu, J., Liu, H., Boccaccini, A. R., Wan, Y., Guo, X., & Shao, Z. (2019) · Acta Biomaterialia · doi:10.1016/j.actbio.2019.04.023 · Cited by 201 · see citing works
Kim, K., Ryu, J. H., Lee, D. Y., & Lee, H. (2013) · Biomaterials Science · doi:10.1039/c3bm00004d · Cited by 200 · see citing works
Protection against zinc toxicity by metallothionein and zinc transporter 1
Palmiter, R. D. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401022101 · Cited by 197 · see citing works
Neto, A. I., Cibrão, A., Correia, C. R., Carvalho, R. R., Luz, G. M., Ferrer, G. G., Botelho, G., Picart, C., Alves, N. M., & Mano, J. F. (2014) · Small · doi:10.1002/smll.201303568 · Cited by 191 · see citing works
Xu, H., Nishida, J., Ma, W., Wu, H., Kobayashi, M., Otsuka, H., & Takahara, A. (2012) · ACS Macro Letters · doi:10.1021/mz200217d · Cited by 187 · see citing works
An Autolytic High Strength Instant Adhesive Hydrogel for Emergency Self‐Rescue
Cui, C., Wu, T., Gao, F., Fan, C., Xu, Z., Wang, H., Liu, B., & Liu, W. (2018) · Advanced Functional Materials · doi:10.1002/adfm.201804925 · Cited by 174 · see citing works
Cui, H., Zhu, W., Holmes, B. B., & Zhang, L. G. (2016) · Advanced Science · doi:10.1002/advs.201600058 · Cited by 155 · see citing works
A strontium-incorporated nanoporous titanium implant surface for rapid osseointegration
Zhang, W., Cao, H., Zhang, X., Li, G., Chang, Q. H., Zhao, J., Qiao, Y., Ding, X., Yang, G., Liu, X., et al. (2016) · Nanoscale · doi:10.1039/c5nr08580b · Cited by 151 · see citing works
Self-citationFilippi, M., Dasen, B., Guerrero, J., Garello, F., Isu, G., Born, G., Ehrbar, M., Martín, I., & Scherberich, A. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.119468 · Cited by 146 · see citing works
Salt‐Assisted Toughening of Protein Hydrogel with Controlled Degradation for Bone Regeneration
Jiang, L., Su, D., Ding, S., Zhang, Q., Li, Z., Chen, F., Ding, W., Zhang, S., & Dong, J. (2019) · Advanced Functional Materials · doi:10.1002/adfm.201901314 · Cited by 139 · see citing works
Su, C., Li, W., Tsao, L.-C., Wang, L.-C., Hsu, Y.-P., Wang, W., Liao, M.-C., Lee, C.-L., & Yeh, C. (2019) · ACS Nano · doi:10.1021/acsnano.8b09417 · Cited by 124 · see citing works
Kuang, L., Ma, X., Ma, Y., et al. (2019) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.9b03173 · Cited by 111 · see citing works
Luo, Z., Zhang, S., Pan, J., Shi, R., Liu, H., Lyu, Y., Han, X. Y., Li, Y., Yang, Y., Xu, Z., et al. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.02.025 · Cited by 96 · see citing works
Enhanced Osseointegration of Porous Titanium Modified with Zeolitic Imidazolate Framework-8
Zhang, X., Chen, J., Pei, X., Wang, J., Wan, Q., Jiang, S., Huang, C., & Pei, X. (2017) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b07800 · Cited by 94 · see citing works
Self-citationGao, L., An, Y., Lei, M., et al. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.09.017 · Cited by 91 · see citing works
Zhang, T., Cheng, Q., Ye, D., & Chang, C. (2017) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2017.04.007 · Cited by 86 · see citing works
Zhu, Z., Jiang, S., Liu, Y., et al. (2020) · Nano Research · doi:10.1007/s12274-020-2642-y · Cited by 86 · see citing works
Self-citationZhu, Z., Liu, Y., Xue, Y., Cheng, X., Zhao, W., Wang, J., He, R., Wan, Q., & Pei, X. (2019) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.9b13271 · Cited by 82 · see citing works
Self-citationBone regeneration induced by a 3D architectured hydrogel in a rat critical-size calvarial defect
Lohmann, P., Willuweit, A., Neffe, A. T., et al. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.10.039 · Cited by 78 · see citing works
Kihara, T., Hirose, M., Oshima, A., et al. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.01.059 · Cited by 76 · see citing works
Multifunctional Polymer Nanocomposites Reinforced by 3D Continuous Ceramic Nanofillers
Ahn, C., Kim, S., Jung, J., et al. (2018) · ACS Nano · doi:10.1021/acsnano.8b03264 · Cited by 67 · see citing works
Zinc bioglasses regulate mineralization in human dental pulp stem cells
Huang, M., Hill, R. G., & Rawlinson, S. C. F. (2017) · Dental Materials · doi:10.1016/j.dental.2017.03.011 · Cited by 56 · see citing works
Yu, P., Xie, J., Chen, Y., Liu, J., Liu, Y., Bi, B., Luo, J., Li, S., Jiang, X., & Li, J. (2019) · Journal of Materials Chemistry B · doi:10.1039/c9tb02049g · Cited by 51 · see citing works
Self-citationChandel, A. K. S., Kannan, D., Nutan, B., Singh, S., & Jewrajka, S. K. (2017) · Journal of Materials Chemistry B · doi:10.1039/c7tb00848a · Cited by 49 · see citing works
Effects of Zinc Transporter on Differentiation of Bone Marrow Mesenchymal Stem Cells to Osteoblasts
Liu, Y., Yan, F., Yang, W.-L., Lu, X., & Wang, W. (2013) · Biological Trace Element Research · doi:10.1007/s12011-013-9683-y · Cited by 28 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Kang, Y., Xu, C., Meng, L., Dong, X., Qi, M., & Jiang, D. (2022) · Bioactive materials · doi:10.1016/j.bioactmat.2022.02.012 · Cited by 253 · see citing works
Wu, M., Liu, H., Zhu, Y., Wu, P., Chen, Y., Deng, Z., Zhu, X., & Cai, L. (2024) · Theranostics · doi:10.7150/thno.97335 · Cited by 189 · see citing works
Current status and prospects of metal-organic frameworks for bone therapy and bone repair
Li, M., Yin, S., Lin, M., Chen, X., Pan, Y., Peng, Y., Sun, J., Kumar, A., & Liu, J. (2022) · Journal of Materials Chemistry B · doi:10.1039/d2tb00742h · Cited by 156 · see citing works
Nanoscale zeolitic imidazolate framework-8 activator of canonical MAPK signaling for bone repair
Gao, X., Xue, Y., Zhu, Z., Chen, J., Liu, Y., Cheng, X., Zhang, X., Wang, J., Pei, X., & Wan, Q. (2021) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.0c15945 · Cited by 127 · see citing works
MOFs and bone: application of MOFs in bone tissue engineering and bone diseases
Li, X., Shu, X., Shi, Y., Li, H., & Pei, X. (2023) · Chinese Chemical Letters · doi:10.1016/j.cclet.2022.107986 · Cited by 65 · see citing works
Self-citationMetal-organic framework (MOF)-based biomaterials in bone tissue engineering
Liu, C., Xu, X., Cui, W., & Zhang, H. (2021) · Engineered Regeneration · doi:10.1016/j.engreg.2021.09.001 · Cited by 59 · see citing works
Wu, M., Chen, F., Liu, H., Wu, P., Yang, Z., Zhang, Z., Su, J., Cai, L., & Zhang, Y. (2022) · Materials Today Bio · doi:10.1016/j.mtbio.2022.100458 · Cited by 55 · see citing works
Advances in immunomodulatory MOFs for biomedical applications
Zhang, B., Chen, J., Zhu, Z., Zhang, X., & Wang, J. (2024) · Small · doi:10.1002/smll.202307299 · Cited by 31 · see citing works
Self-citationWan, L., Liu, F., Wang, A., He, Y., Pan, J., Liu, Y., Xu, J., Xu, C., Wu, F., & Ye, Q. (2025) · Biomaterials Advances · doi:10.1016/j.bioadv.2024.214064 · Cited by 25 · see citing works
Self-citationSi, Y., Li, X., Dong, S., Gao, X., Zhu, Y., Mo, L., Wang, Z., Wang, S., & Zhang, C. (2025) · Bioactive Materials · doi:10.1016/j.bioactmat.2025.08.026 · Cited by 17 · see citing works
“The incorporated Zn 2 + serves as an essential trace element in human physiology, participating in osteoblast differentiation and bone matrix mineralization [43].”
Self-citation
- Authors
- Liu, Y., Zhu, Z., Pei, X., Zhang, X., Cheng, X., Hu, S., Gao, X., Wang, J., Chen, J., & Wan, Q.
- Affiliations
- Sichuan University (CN)
- Corresponding author
- Chen, Junyu
- Wan, Qianbing
- ORCID
- Venue
- ACS Applied Materials & Interfaces
- Publisher
- American Chemical Society (ACS)
- Published
- 2020-07-29
- Volume
- 12
- Issue
- 33
- Pages
- 36978-36995
- ISSN
- 1944-8244 (ISSN-L)
- 1944-8252
- OpenAlex
- W3045513448
- Cited by
- 259
- References
- 69
- Citations by year
- 2026: 23 · 2025: 55 · 2024: 63 · 2023: 57 · 2022: 45 · 2021: 12 · 2020: 4
- FWCI
- 9.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- ACS Applied Materials & Interfaces (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Department of Science and Technology of Sichuan Province (2018SZ0037, 2019YFS0142)
- National Natural Science Foundation of China (81601613, 81771122, 81901060, 81970984, 81970985)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Health Sciences › Medicine › Rheumatology › Bone Tumor Diagnosis and Treatments
- Keywords
- ZIF-8 nanoparticles, bone regeneration, angiogenesis, osteogenic differentiation, bone marrow mesenchymal stem cells, vascular endothelial growth factor, alkaline phosphatase, osteocalcin, type I collagen, antibacterial activity, bone grafting, vascularized bone tissue engineering
- MeSH terms
- Adhesives, Alkaline Phosphatase, Anti-Bacterial Agents, Biocompatible Materials, Bone and Bones, Bone Regeneration, Catechols, Cell Differentiation, Cells, Cultured, Collagen, Escherichia coli, Gene Expression Regulation, Humans, Osteogenesis, Rheology, Staphylococcus aureus, Surface Properties, Wound Healing, Osteocalcin, Zeolites, Hydrogels, Tissue Engineering, Vascular Endothelial Growth Factor A, Chitosan, Nanoparticles, Tissue Scaffolds, Mesenchymal Stem Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
