The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Metal-organic frameworks for precise inclusion of single-stranded DNA and transfection in immune cells
Open accessAbstract
Effective transfection of genetic molecules such as DNA usually relies on vectors that can reversibly uptake and release these molecules, and protect them from digestion by nuclease. Non-viral vectors meeting these requirements are rare due to the lack of specific interactions with DNA. Here, we design a series of four isoreticular metal-organic frameworks (Ni-IRMOF-74-II to -V) with progressively tuned pore size from 2.2 to 4.2 nm to precisely include single-stranded DNA (ssDNA, 11–53 nt), and to achieve reversible interaction between MOFs and ssDNA. The entire nucleic acid chain is completely confined inside the pores providing excellent protection, and the geometric distribution of the confined ssDNA is visualized by X-ray diffraction. Two MOFs in this series exhibit excellent transfection efficiency in mammalian immune cells, 92% in the primary mouse immune cells (CD4+ T cell) and 30% in human immune cells (THP-1 cell), unrivaled by the commercialized agents (Lipo and Neofect).
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Non-viral vectors for gene-based therapy
Yin, H., Kanasty, R. L., Eltoukhy, A. A., Vegas, A. J., Dorkin, J. R., & Anderson, D. G. (2014) · Nature Reviews Genetics · doi:10.1038/nrg3763 · Cited by 3,123
Salicylic acid, a multifaceted hormone to combat disease
Vlot, A. C., Dempsey, D. A., & Klessig, D. F. (2009) · Annual Review of Phytopathology · doi:10.1146/annurev.phyto.050908.135202 · Cited by 2,568
In vitro and ex vivo strategies for intracellular delivery
Stewart, M. P., Sharei, A., Ding, X., Sahay, G., Langer, R., & Jensen, K. F. (2016) · Nature · doi:10.1038/nature19764 · Cited by 885
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Delivery technologies for genome editing
Yin, H., Kauffman, K. J., & Anderson, D. G. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.280 · Cited by 597
CRISPR-Cas Encoding of a Digital Movie into the Genomes of a Population of Living Bacteria
Shipman, S. L., Nivala, J., Macklis, J. D., & Church, G. M. (2017) · Nature · doi:10.1038/nature23017 · Cited by 361
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Wang, H., Chen, Y., Wang, H., Liu, X., Zhou, X., & Wang, F. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201902714 · Cited by 417
Self-citationZhou, Z., Vázquez-González, M., & Willner, I. (2021) · Chemical Society Reviews · doi:10.1039/d0cs01030h · Cited by 308
Nanoscale covalent organic frameworks: from controlled synthesis to cancer therapy
He, X., Jiang, Z., Akakuru, O. U., Li, J., & Wu, A. (2021) · Chemical Communications · doi:10.1039/d1cc04846e · Cited by 303
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Metadata
- Authors
- Peng, S., Bie, B., Sun, Y., Liu, M., Cong, H., Zhou, W., Xia, Y., Tang, H., Deng, H., & Zhou, X.
- Venue
- Nature Communications
- Published
- 2018-04-03
- Volume
- 9
- Issue
- 1
- Pages
- 1293-1293
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2796351974
- Cited by
- 261
- References
- 6
- FWCI
- 9.28
- Type
- journal article
- Language
- en
- Open access
- gold
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- Peng, S., Bie, B., Sun, Y., Liu, M., Cong, H., Zhou, W., Xia, Y., Tang, H., Deng, H., & Zhou, X. (2018). Metal-organic frameworks for precise inclusion of single-stranded DNA and transfection in immune cells. Nature Communications. https://doi.org/10.1038/s41467-018-03650-w
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