The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Distinct epigenetic landscapes underlie the pathobiology of pancreatic cancer subtypes
Open accessAbstract
Recent studies have offered ample insight into genome-wide expression patterns to define pancreatic ductal adenocarcinoma (PDAC) subtypes, although there remains a lack of knowledge regarding the underlying epigenomics of PDAC. Here we perform multi-parametric integrative analyses of chromatin immunoprecipitation-sequencing (ChIP-seq) on multiple histone modifications, RNA-sequencing (RNA-seq), and DNA methylation to define epigenomic landscapes for PDAC subtypes, which can predict their relative aggressiveness and survival. Moreover, we describe the state of promoters, enhancers, super-enhancers, euchromatic, and heterochromatic regions for each subtype. Further analyses indicate that the distinct epigenomic landscapes are regulated by different membrane-to-nucleus pathways. Inactivation of a basal-specific super-enhancer associated pathway reveals the existence of plasticity between subtypes. Thus, our study provides new insight into the epigenetic landscapes associated with the heterogeneity of PDAC, thereby increasing our mechanistic understanding of this disease, as well as offering potential new markers and therapeutic targets.
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Ordered and deterministic cancer genome evolution after p53 loss
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Metadata
- Authors
- Lomberk, G., Blum, Y., Nicolle, R., Nair, A., Gaonkar, K. S., Marisa, L., Mathison, A., Sun, Z., Yan, H., Elarouci, N., Armenoult, L., Ayadi, M., Ordog, T., Lee, J.-H., Oliver, G., Klee, E., Moutardier, V., Gayet, O., Bian, B., Duconseil, P., Gilabert, M., Bigonnet, M., Garcia, S., Turrini, O., Delpero, J.-R., Giovannini, M., Grandval, P., Gasmi, M., Secq, V., De Reyniès, A., Dusetti, N., Iovanna, J., & Urrutia, R.
- Venue
- Nature Communications
- Published
- 2018-05-17
- Volume
- 9
- Issue
- 1
- Pages
- 1978-1978
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2803273701
- Cited by
- 261
- References
- 12
- FWCI
- 11.21
- Type
- journal article
- Language
- en
- Open access
- gold
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- Lomberk, G., Blum, Y., Nicolle, R., Nair, A., Gaonkar, K. S., Marisa, L., Mathison, A., Sun, Z., Yan, H., Elarouci, N., Armenoult, L., Ayadi, M., Ordog, T., Lee, J.-H., Oliver, G., Klee, E., Moutardier, V., Gayet, O., Bian, B., . . . Urrutia, R. (2018). Distinct epigenetic landscapes underlie the pathobiology of pancreatic cancer subtypes. Nature Communications. https://doi.org/10.1038/s41467-018-04383-6
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
