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Cited by 196

The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.

Self-selection of dissipative assemblies driven by primitive chemical reaction networks

Open access
Tena-Solsona, Marta, Wanzke, Caren, Riess, Benedikt, Bausch, Andreas R., Boekhoven, Job·2018·Nature Communications
DOI 10.1038/s41467-018-04488-y
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Abstract

Life is a dissipative nonequilibrium structure that requires constant consumption of energy to sustain itself. How such an unstable state could have selected from an abiotic pool of molecules remains a mystery. Here we show that liquid phase-separation offers a mechanism for the selection of dissipative products from a library of reacting molecules. We bring a set of primitive carboxylic acids out-of-equilibrium by addition of high-energy condensing agents. The resulting anhydrides are transiently present before deactivation via hydrolysis. We find the anhydrides that phase-separate into droplets to protect themselves from hydrolysis and to be more persistent than non-assembling ones. Thus, after several starvation-refueling cycles, the library self-selects the phase-separating anhydrides. We observe that the self-selection mechanism is more effective when the library is brought out-of-equilibrium by periodic addition of batches as opposed to feeding it continuously. Our results suggest that phase-separation offers a selection mechanism for energy dissipating assemblies.

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Cited by

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Metadata

Authors
Tena-Solsona, M., Wanzke, C., Riess, B., Bausch, A. R., & Boekhoven, J.
Venue
Nature Communications
Publisher
Springer Science and Business Media LLC
Published
2018-05-23
Volume
9
Issue
1
Pages
2044-2044
ISSN
2041-1723 (ISSN-L)
DOI
10.1038/s41467-018-04488-y
OpenAlex
W2803795590
Cited by
196
References
6
FWCI
13.80
Type
journal article
Language
en
Open access
gold
Licence

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CoChat. (2026). Citation check: Self-selection of dissipative assemblies driven by primitive chemical reaction networks. https://app.cochat.ai/papers/10.1038/s41467-018-04488-y
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Tena-Solsona, M., Wanzke, C., Riess, B., Bausch, A. R., & Boekhoven, J. (2018). Self-selection of dissipative assemblies driven by primitive chemical reaction networks. Nature Communications. https://doi.org/10.1038/s41467-018-04488-y

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