Control over the emerging chirality in supramolecular gels and solutions by chiral microvortices in milliseconds
Open accessAbstract
The origin of homochirality in life is a fundamental mystery. Symmetry breaking and subsequent amplification of chiral bias are regarded as one of the underlying mechanisms. However, the selection and control of initial chiral bias in a spontaneous mirror symmetry breaking process remains a great challenge. Here we show experimental evidences that laminar chiral microvortices generated within asymmetric microchambers can lead to a hydrodynamic selection of initial chiral bias of supramolecular systems composed of exclusively achiral molecules within milliseconds. The self-assembled nuclei with the chirality sign affected by the shear force of enantiomorphic microvortices are subsequently amplified into almost absolutely chirality-controlled supramolecular gels or nanotubes. In contrast, turbulent vortices in stirring cuvettes fail to select the chirality of supramolecular gels. This study reveals that a laminar chiral microflow can induce enantioselection far from equilibrium, and provides an insight on the origin of natural homochirality.
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Vortices, being induced by stirring, microfluidics or temperature gradients, are capable of controlling the handedness of supramolecular helical assemblies.
“It has been indeed found that vortices, being induced by stirring, microfluidics or temperature gradients, are capable of controlling the handedness of supramolecular helical assemblies.60,[145][146][147][148][149][150][151][152][153][154][155][156][157][158][159]”
From Possible chemical and physical scenarios towards biological homochirality (2022) · cites this paper as [60]
The Introduction and Discussion report that microfluidically generated laminar chiral microvortices control the handedness of supramolecular gels and nanotubes. The Introduction also describes stirring-dependent handedness in solution aggregates, but the Results find that turbulent stirring vortices do not control gel chirality. No passage establishes control by vortices induced by temperature gradients. (LLM, conf=0.88)
Experimental — accuracy not yet measuredLaminar vortices have been recently employed as the single chiral discriminating source for the emergence of homochiral supramolecular gels in milliseconds.
“Laminar vortices have been recently employed as the single chiral discriminating source for the emergence of homochiral supramolecular gels in milliseconds.60”
From Possible chemical and physical scenarios towards biological homochirality (2022) · cites this paper as [60]
The Results section (no page number available) says laminar chiral microvortices select the initial chiral bias within tens of milliseconds, and the Discussion reports 96% control over BTAC gel chirality after amplification. The paper supports rapid chiral selection in an achiral-molecule system, but it does not say that fully formed, perfectly homochiral gels emerge within milliseconds. (LLM, conf=0.86)
Experimental — accuracy not yet measuredHydrothermal vents in primeval oceans are reaction domains often evoked for prebiotic chemistry and may include potential sources of asymmetry such as high-speed microvortices.
“Alternatively, hydrothermal vents in primeval oceans constitute an example of reaction domains often evoked for prebiotic chemistry which may also include potential sources of asymmetry such as high-speed microvortices.60”
From Possible chemical and physical scenarios towards biological homochirality (2022) · cites this paper as [60]
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Induction of Chirality in a Metal–Organic Framework Built from Achiral Precursors
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Self-citationWhat can molecular assembly learn from catalysed assembly in living organisms?
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Self-citationPhotoresponsive chiral molecular crystal for light-directing nanostructures
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Self-citationEffects of the Mixing Protocol on the Self-Assembling Process of Water Soluble Porphyrins
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Self-citationInstrument-free enrichment and detection of phosphopeptides using paper-based Phos-PAD
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Versatile hydrogels prepared by microfluidics technology for bone tissue engineering applications
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Self-citationPrecise control of chirality transfer by adjusting the alkyl substituents of guests
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Chiroptical Signal Inversion of Peptido‐Coassemblies in Confined Parallel‐Laminar Microfluidics
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Self-citationAbsolute Asymmetric Catalysis, from Concept to Experiment: A Narrative
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- Authors
- Sun, J., Li, Y., Yan, F., Liu, C., Sang, Y., Tian, F., Feng, Q., Duan, P., Zhang, L., Shi, X., Ding, B., & Liu, M.
- Affiliations
- National Center for Nanoscience and Technology (CN)
- Chinese Academy of Sciences (CN)
- Corresponding author
- Sun, Jiashu
- Ding, Baoquan
- Liu, Minghua
- ORCID
- Venue
- Nature Communications
- Published
- 2018-07-03
- Volume
- 9
- Issue
- 1
- Pages
- 2599-2599
- ISSN
- 2041-1723 (ISSN-L)
- PMC
- PMC6030102
- OpenAlex
- W2811351535
- Cited by
- 134
- References
- 62
- Citations by year
- 2026: 8 · 2025: 18 · 2024: 18 · 2023: 17 · 2022: 20 · 2021: 16 · 2020: 13 · 2019: 17 · 2018: 7
- FWCI
- 7.10
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Nature Communications (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Chinese Academy of Sciences (2016035)
- National Natural Science Foundation of China (21622503, 21475028, 91427302)
- Topics
- Physical Sciences › Physics and Astronomy › Astronomy and Astrophysics › Origins and Evolution of Life
- Physical Sciences › Materials Science › Biomaterials › Supramolecular Self-Assembly in Materials
- Physical Sciences › Chemistry › Organic Chemistry › Supramolecular Chemistry and Complexes
- Keywords
- homochirality, origin of homochirality, enantioselectivity, supramolecular gels, supramolecular nanotubes, symmetry breaking, shear force, chiral bias, self-assembly
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