The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Microbiota-derived short-chain fatty acids promote Th1 cell IL-10 production to maintain intestinal homeostasis
Open accessAbstract
T-cells are crucial in maintanence of intestinal homeostasis, however, it is still unclear how microbiota metabolites regulate T-effector cells. Here we show gut microbiota-derived short-chain fatty acids (SCFAs) promote microbiota antigen-specific Th1 cell IL-10 production, mediated by G-protein coupled receptors 43 (GPR43). Microbiota antigen-specific Gpr43−/− CBir1 transgenic (Tg) Th1 cells, specific for microbiota antigen CBir1 flagellin, induce more severe colitis compared with wide type (WT) CBir1 Tg Th1 cells in Rag−/− recipient mice. Treatment with SCFAs limits colitis induction by promoting IL-10 production, and administration of anti-IL-10R antibody promotes colitis development. Mechanistically, SCFAs activate Th1 cell STAT3 and mTOR, and consequently upregulate transcription factor B lymphocyte-induced maturation protein 1 (Blimp-1), which mediates SCFA-induction of IL-10. SCFA-treated Blimp1−/− Th1 cells produce less IL-10 and induce more severe colitis compared to SCFA-treated WT Th1 cells. Our studies, thus, provide insight into how microbiota metabolites regulate Th1 cell functions to maintain intestinal homeostasis.
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Cites
Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells
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Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation
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Cited by
Short-chain fatty acids: Linking diet, the microbiome and immunity
Mann, E. R., Lam, Y. K., & Uhlig, H. H. (2024) · Nature reviews. Immunology · doi:10.1038/s41577-024-01014-8 · Cited by 1,595
Kim, C. H. (2023) · Cellular & Molecular Immunology · doi:10.1038/s41423-023-00987-1 · Cited by 420
The Immunomodulatory Functions of Butyrate
Siddiqui, M. T., & Cresci, G. A. (2021) · Journal of Inflammation Research · doi:10.2147/jir.s300989 · Cited by 381
Precision medicine in the era of artificial intelligence: implications in chronic disease management
Subramanian, M., Wojtusciszyn, A., Favre, L., Boughorbel, S., Shan, J., Letaief, K. B., Pitteloud, N., & Chouchane, L. (2020) · Journal of Translational Medicine · doi:10.1186/s12967-020-02658-5 · Cited by 362
Han, K., Nam, J., Xu, J., Sun, X., Huang, X., Animasahun, O., Achreja, A., Jeon, J. H., Pursley, B., Kamada, N., et al. (2021) · Nature Biomedical Engineering · doi:10.1038/s41551-021-00749-2 · Cited by 287
Self-citation
Metadata
- Authors
- Sun, M., Wu, W., Chen, L., Yang, W., Huang, X., Ma, C., Chen, F., Xiao, Y., Zhao, Y., Ma, C., Yao, S., Carpio, V. H., Dann, S. M., Zhao, Q., Liu, Z., & Cong, Y.
- Venue
- Nature Communications
- Published
- 2018-09-03
- Volume
- 9
- Issue
- 1
- Pages
- 3555-3555
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2889133269
- Cited by
- 658
- References
- 8
- FWCI
- 14.05
- Type
- journal article
- Language
- en
- Open access
- gold
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