The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Microbiota-derived short-chain fatty acids promote Th1 cell IL-10 production to maintain intestinal homeostasis
Open accessAbstract
T-cells are crucial in maintanence of intestinal homeostasis, however, it is still unclear how microbiota metabolites regulate T-effector cells. Here we show gut microbiota-derived short-chain fatty acids (SCFAs) promote microbiota antigen-specific Th1 cell IL-10 production, mediated by G-protein coupled receptors 43 (GPR43). Microbiota antigen-specific Gpr43−/− CBir1 transgenic (Tg) Th1 cells, specific for microbiota antigen CBir1 flagellin, induce more severe colitis compared with wide type (WT) CBir1 Tg Th1 cells in Rag−/− recipient mice. Treatment with SCFAs limits colitis induction by promoting IL-10 production, and administration of anti-IL-10R antibody promotes colitis development. Mechanistically, SCFAs activate Th1 cell STAT3 and mTOR, and consequently upregulate transcription factor B lymphocyte-induced maturation protein 1 (Blimp-1), which mediates SCFA-induction of IL-10. SCFA-treated Blimp1−/− Th1 cells produce less IL-10 and induce more severe colitis compared to SCFA-treated WT Th1 cells. Our studies, thus, provide insight into how microbiota metabolites regulate Th1 cell functions to maintain intestinal homeostasis.
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Cites
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“In addition, SCFAs upregulated the expression of Blimp-1, which was associated with IL-10 production in Th1 cells and T cell function maintenance (Figure 2) (55).”
BackgroundPossible role of gut microbes and host's immune response in gut-lung homeostasis
Rastogi, S., Mohanty, S., Sharma, S., & Tripathi, P. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.954339 · Cited by 94
Li, L., He, S., Liao, B., Wang, M., Lin, H., Hu, B., Lan, X., Shu, Z., Zhang, C., Yu, M., et al. (2024) · Research · doi:10.34133/research.0364 · Cited by 79
From taxonomy to metabolic output: what factors define gut microbiome health?
Wilmanski, T., Rappaport, N., Diener, C., Gibbons, S. M., & Price, N. D. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1907270 · Cited by 73
Novel Nutraceutical Compounds in Alzheimer Prevention
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Maternal microbiome in preeclampsia pathophysiology and implications on offspring health
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Metadata
- Authors
- Sun, M., Wu, W., Chen, L., Yang, W., Huang, X., Ma, C., Chen, F., Xiao, Y., Zhao, Y., Ma, C., Yao, S., Carpio, V. H., Dann, S. M., Zhao, Q., Liu, Z., & Cong, Y.
- Venue
- Nature Communications
- Published
- 2018-09-03
- Volume
- 9
- Issue
- 1
- Pages
- 3555-3555
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2889133269
- Cited by
- 658
- References
- 8
- FWCI
- 14.05
- Type
- journal article
- Language
- en
- Open access
- gold
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