The DOI matches its Crossref record; 82 of the 82 references it cites were found in a registry or an index.
Pan-cancer analysis of transcriptional metabolic dysregulation using The Cancer Genome Atlas
Open accessAbstract
Understanding metabolic dysregulation in different disease settings is vital for the safe and effective incorporation of metabolism-targeted therapeutics in the clinic. Here, using transcriptomic data for 10,704 tumor and normal samples from The Cancer Genome Atlas, across 26 disease sites, we present a novel bioinformatics pipeline that distinguishes tumor from normal tissues, based on differential gene expression for 114 metabolic pathways. We confirm pathway dysregulation in separate patient populations, demonstrating the robustness of our approach. Bootstrapping simulations were then applied to assess the biological significance of these alterations. We provide distinct examples of the types of analysis that can be accomplished with this tool to understand cancer specific metabolic dysregulation, highlighting novel pathways of interest, and patterns of metabolic flux, in both common and rare disease sites. Further, we show that Master Metabolic Transcriptional Regulators explain why metabolic differences exist, can segregate patient populations, and predict responders to different metabolism-targeted therapeutics.
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Cites
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Cited by
Li, Y., Ge, X., Peng, F., Li, W., & Li, J. J. (2022) · Genome Biology · doi:10.1186/s13059-022-02648-4 · Cited by 303
Translational genomics and recent advances in oral squamous cell carcinoma
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Functional Proteomic Profiling Analysis in Four Major Types of Gastrointestinal Cancers
Wang, Y., Gao, X., & Wang, J. (2023) · Biomolecules · doi:10.3390/biom13040701 · Cited by 9
Metadata
- Authors
- Rosario, S. R., Long, M. D., Affronti, H. C., Rowsam, A. M., Eng, K. H., & Smiraglia, D. J.
- Venue
- Nature Communications
- Published
- 2018-12-14
- Volume
- 9
- Issue
- 1
- Pages
- 5330-5330
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2952752961
- Cited by
- 266
- References
- 82
- FWCI
- 5.96
- Type
- journal article
- Language
- en
- Open access
- gold
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- Rosario, S. R., Long, M. D., Affronti, H. C., Rowsam, A. M., Eng, K. H., & Smiraglia, D. J. (2018). Pan-cancer analysis of transcriptional metabolic dysregulation using The Cancer Genome Atlas. Nature Communications. https://doi.org/10.1038/s41467-018-07232-8
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
