The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Genome-wide gene-based analyses of weight loss interventions identify a potential role for NKX6.3 in metabolism
Open accessAbstract
Hundreds of genetic variants have been associated with Body Mass Index (BMI) through genome-wide association studies (GWAS) using observational cohorts. However, the genetic contribution to efficient weight loss in response to dietary intervention remains unknown. We perform a GWAS in two large low-caloric diet intervention cohorts of obese participants. Two loci close to NKX6.3/MIR486 and RBSG4 are identified in the Canadian discovery cohort (n = 1166) and replicated in the DiOGenes cohort (n = 789). Modulation of HGTX(NKX6.3 ortholog) levels in Drosophila melanogaster leads to significantly altered triglyceride levels. Additional tissue-specific experiments demonstrate an action through the oenocytes, fly hepatocyte-like cells that regulate lipid metabolism. Our results identify genetic variants associated with the efficacy of weight loss in obese subjects and identify a role for NKX6.3 in lipid metabolism, and thereby possibly weight control.
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Metadata
- Authors
- Valsesia, A., Wang, Q.-P., Gheldof, N., Carayol, J., Ruffieux, H., Clark, T., Shenton, V., Oyston, L. J., Lefebvre, G., Metairon, S., Chabert, C., Walter, O., Mironova, P., Lau, P., Descombes, P., Viguerie, N., Langin, D., Harper, M.-E., Astrup, A., Saris, W. H., Dent, R., Neely, G. G., & Hager, J.
- Venue
- Nature Communications
- Published
- 2019-02-01
- Volume
- 10
- Issue
- 1
- Pages
- 540-540
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2912664120
- Cited by
- 1,073
- References
- 17
- FWCI
- 142.75
- Type
- journal article
- Language
- en
- Open access
- gold
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- Valsesia, A., Wang, Q.-P., Gheldof, N., Carayol, J., Ruffieux, H., Clark, T., Shenton, V., Oyston, L. J., Lefebvre, G., Metairon, S., Chabert, C., Walter, O., Mironova, P., Lau, P., Descombes, P., Viguerie, N., Langin, D., Harper, M.-E., Astrup, A., . . . Hager, J. (2019). Genome-wide gene-based analyses of weight loss interventions identify a potential role for NKX6.3 in metabolism. Nature Communications. https://doi.org/10.1038/s41467-019-08492-8
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