The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Interplay of protein corona and immune cells controls blood residency of liposomes
Open accessAbstract
In vivo liposomes, like other types of nanoparticles, acquire a totally new ‘biological identity’ due to the formation of a biomolecular coating known as the protein corona that depends on and modifies the liposomes’ synthetic identity. The liposome–protein corona is a dynamic interface that regulates the interaction of liposomes with the physiological environment. Here we show that the biological identity of liposomes is clearly linked to their sequestration from peripheral blood mononuclear cells (PBMCs) of healthy donors that ultimately leads to removal from the bloodstream. Pre-coating liposomes with an artificial corona made of human plasma proteins drastically reduces capture by circulating leukocytes in whole blood and may be an effective strategy to enable prolonged circulation in vivo. We conclude with a critical assessment of the key concepts of liposome technology that need to be reviewed for its definitive clinical translation.
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Cites
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Non-viral vectors for gene-based therapy
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Self-citationStealth Effect of Biomolecular Corona on Nanoparticle Uptake by Immune Cells
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Cited by
Liposomes: Structure, composition, types, and clinical applications
Nsairat, H., Khater, D., Sayed, U., Odeh, F., Al Bawab, A., & Alshaer, W. (2022) · Heliyon · doi:10.1016/j.heliyon.2022.e09394 · Cited by 1,561
Formation of a protein corona on the surface of extracellular vesicles in blood plasma
Tóth, E. Á., Turiák, L., Visnovitz, T., Cserép, C., Mázló, A., Sódar, B. W., Försönits, A. I., Petővári, G., Sebestyén, A., Komlósi, Z., et al. (2021) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12140 · Cited by 522
Nanotechnology-Based Strategies to Overcome Current Barriers in Gene Delivery
Mirón-Barroso, S., Domènech, E. B., & Trigueros, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22168537 · Cited by 91
Metadata
- Authors
- Giulimondi, F., Digiacomo, L., Pozzi, D., Palchetti, S., Vulpis, E., Capriotti, A. L., Chiozzi, R. Z., Laganà, A., Amenitsch, H., Masuelli, L., Peruzzi, G., Mahmoudi, M., Screpanti, I., Zingoni, A., & Caracciolo, G.
- Venue
- Nature Communications
- Published
- 2019-08-15
- Volume
- 10
- Issue
- 1
- Pages
- 3686-3686
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2969017294
- Cited by
- 264
- References
- 9
- FWCI
- 8.09
- Type
- journal article
- Language
- en
- Open access
- gold
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- Giulimondi, F., Digiacomo, L., Pozzi, D., Palchetti, S., Vulpis, E., Capriotti, A. L., Chiozzi, R. Z., Laganà, A., Amenitsch, H., Masuelli, L., Peruzzi, G., Mahmoudi, M., Screpanti, I., Zingoni, A., & Caracciolo, G. (2019). Interplay of protein corona and immune cells controls blood residency of liposomes. Nature Communications. https://doi.org/10.1038/s41467-019-11642-7
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