The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Macrophages directly contribute collagen to scar formation during zebrafish heart regeneration and mouse heart repair
Open accessAbstract
Canonical roles for macrophages in mediating the fibrotic response after a heart attack include extracellular matrix turnover and activation of cardiac fibroblasts to initiate collagen deposition. Here we reveal that macrophages directly contribute collagen to the forming post-injury scar. Unbiased transcriptomics shows an upregulation of collagens in both zebrafish and mouse macrophages following heart injury. Adoptive transfer of macrophages, from either collagen-tagged zebrafish or adult mouse GFP tpz -collagen donors, enhances scar formation via cell autonomous production of collagen. In zebrafish, the majority of tagged collagen localises proximal to the injury, within the overlying epicardial region, suggesting a possible distinction between macrophage-deposited collagen and that predominantly laid-down by myofibroblasts. Macrophage-specific targeting of col4a3bpa and cognate col4a1 in zebrafish significantly reduces scarring in cryoinjured hosts. Our findings contrast with the current model of scarring, whereby collagen deposition is exclusively attributed to myofibroblasts, and implicate macrophages as direct contributors to fibrosis during heart repair.
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The extracellular matrix and the immune system: A mutually dependent relationship
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Role of Cardiac Macrophages on Cardiac Inflammation, Fibrosis and Tissue Repair
Lafuse, W. P., Wozniak, D. J., & Rajaram, M. V. S. (2020) · Cells · doi:10.3390/cells10010051 · Cited by 401
Macrophage phenotypes and functions: resolving inflammation and restoring homeostasis
Rodríguez-Morales, P., & Franklin, R. A. (2023) · Trends in Immunology · doi:10.1016/j.it.2023.10.004 · Cited by 304
TGF‐β as a driver of fibrosis: physiological roles and therapeutic opportunities
Budi, E. H., Schaub, J. R., Decaris, M., Turner, S., & Derynck, R. (2021) · The Journal of Pathology · doi:10.1002/path.5680 · Cited by 292
Xiong, J., Xiao, R., Zhao, J., Zhao, Q., Luo, M., Li, F., Zhang, W., & Wu, M. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-023-04810-3 · Cited by 79
Metadata
- Authors
- Simões, F. C., Cahill, T. J., Kenyon, A., Gavriouchkina, D., Vieira, J. M., Sun, X., Pezzolla, D., Ravaud, C., Masmanian, E., Weinberger, M., Mayes, S., Lemieux, M. E., Barnette, D. N., Gunadasa-Rohling, M., Williams, R. M., Greaves, D. R., Trinh, L. A., Fraser, S. E., Dallas, S. L., Choudhury, R. P., Sauka-Spengler, T., & Riley, P. R.
- Venue
- Nature Communications
- Published
- 2020-01-30
- Volume
- 11
- Issue
- 1
- Pages
- 600-600
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2997366069
- Cited by
- 390
- References
- 13
- FWCI
- 14.87
- Type
- journal article
- Language
- en
- Open access
- gold
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- Simões, F. C., Cahill, T. J., Kenyon, A., Gavriouchkina, D., Vieira, J. M., Sun, X., Pezzolla, D., Ravaud, C., Masmanian, E., Weinberger, M., Mayes, S., Lemieux, M. E., Barnette, D. N., Gunadasa-Rohling, M., Williams, R. M., Greaves, D. R., Trinh, L. A., Fraser, S. E., Dallas, S. L., . . . Riley, P. R. (2020). Macrophages directly contribute collagen to scar formation during zebrafish heart regeneration and mouse heart repair. Nature Communications. https://doi.org/10.1038/s41467-019-14263-2
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
