The DOI matches its Crossref record; 110 of the 110 references it cites were found in a registry or an index.
Disease-associated gut microbiome and metabolome changes in patients with chronic obstructive pulmonary disease
Open accessAbstract
Chronic obstructive pulmonary disease (COPD) is the third commonest cause of death globally, and manifests as a progressive inflammatory lung disease with no curative treatment. The lung microbiome contributes to COPD progression, but the function of the gut microbiome remains unclear. Here we examine the faecal microbiome and metabolome of COPD patients and healthy controls, finding 146 bacterial species differing between the two groups. Several species, including Streptococcus sp000187445,Streptococcus vestibularis and multiple members of the family Lachnospiraceae, also correlate with reduced lung function. Untargeted metabolomics identifies a COPD signature comprising 46% lipid, 20% xenobiotic and 20% amino acid related metabolites. Furthermore, we describe a disease-associated network connecting Streptococcus parasanguinis_B with COPD-associated metabolites, including N-acetylglutamate and its analogue N-carbamoylglutamate. While correlative, our results suggest that the faecal microbiome and metabolome of COPD patients are distinct from those of healthy individuals, and may thus aid in the search for biomarkers for COPD.
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Metadata
- Authors
- Bowerman, K. L., Rehman, S. F., Vaughan, A., Lachner, N., Budden, K. F., Kim, R. Y., Wood, D. L. A., Gellatly, S. L., Shukla, S. D., Wood, L. G., Yang, I. A., Wark, P. A., Hugenholtz, P., & Hansbro, P. M.
- Venue
- Nature Communications
- Published
- 2020-11-18
- Volume
- 11
- Issue
- 1
- Pages
- 5886-5886
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W3102506821
- Cited by
- 425
- References
- 110
- FWCI
- 12.86
- Type
- journal article
- Language
- en
- Open access
- gold
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- Bowerman, K. L., Rehman, S. F., Vaughan, A., Lachner, N., Budden, K. F., Kim, R. Y., Wood, D. L. A., Gellatly, S. L., Shukla, S. D., Wood, L. G., Yang, I. A., Wark, P. A., Hugenholtz, P., & Hansbro, P. M. (2020). Disease-associated gut microbiome and metabolome changes in patients with chronic obstructive pulmonary disease. Nature Communications. https://doi.org/10.1038/s41467-020-19701-0
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
