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Cell differentiation modifies the p53 transcriptional program through a combination of gene silencing and constitutive transactivation

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The Influence of Modifiable Factors on Breast and Prostate Cancer Risk and Disease Progression

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Culture of Cancer Cells at Physiological Oxygen Levels Affects Gene Expression in a Cell-Type Specific Manner

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Single-cell multi-omics analysis reveals candidate therapeutic drugs and key transcription factor specifically for the mesenchymal subtype of glioblastoma

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Empowering hypoxia to convert cold tumors into hot tumors for breast cancer immunotherapy

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Application of Hypoxia-Activated Prodrugs in Tumor Therapy: Design Strategies and Perspectives

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Short-term hypoxia triggers ROS and SAFB mediated nuclear matrix and mRNA splicing remodeling

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Harnessing p53 for targeted cancer therapy: new advances and future directions

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Hypoxia-inducible transcription factors: architects of tumorigenesis and targets for anticancer drug discovery

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Hypoxia as a regulator of tumor stroma and metastasis

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Hypoxia signaling pathway: A central mediator in endocrine tumors

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RNF20 links the DNA damage response and metabolic rewiring in lung cancer through HIF1α

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Unveiling the impact of CDK8 on tumor progression: mechanisms and therapeutic strategies

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BTG2 as a tumor target for the treatment of luminal A breast cancer

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Transcriptional elongation control of hypoxic response

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TGFβ2 is a Prognostic Biomarker for Gastric Cancer and is Associated With Methylation and Immunotherapy Responses

Han, B., Fang, T., Wang, Y., Zhang, Y., & Xue, Y. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.808041 · Cited by 12 · see citing works

Hypoxia-induced circSTT3A enhances serine synthesis and promotes H3K4me3 modification to facilitate breast cancer stem cell formation.

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Active Iron‐Drug Nanocomplexes Improve Photodynamic and Photothermal Cancer Therapy by Mitigating Tumor Hypoxia and Counteracting Tumor Heat Resistance

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Phytochemical profiling and anticancer potential of pistachio wastes against MCF-7 breast cancer cells: a metabolic and apoptotic pathway analysis

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Uncovering Oncogenic Mechanisms of Tumor Suppressor Genes in Breast Cancer Multi-Omics Data

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Systems approaches to understand oxygen sensing: how multi-omics has driven advances in understanding oxygen-based signalling

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Mediator kinase inhibition suppresses hyperactive interferon signaling in Down syndrome

Cozzolino, K., Sanford, L., Hunter, S., Molison, K., Erickson, B., Courvan, M. C., Jones, T., Ajit, D., Galbraith, M. D., Espinosa, J. M., et al. (2025) · eLife · doi:10.7554/elife.100197.3 · Cited by 7 · see citing works

Harnessing transcriptional regulation of alternative end-joining to predict cancer treatment

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Multi-omics investigation reveals functional specialization of transcriptional cyclin dependent kinases in cancer biology

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Transcriptional regulation of protein synthesis by mediator kinase represents a therapeutic vulnerability in MYC-driven medulloblastoma

Wang, D., Ritz, C., Luo, Y., Suresh, A., Pierce, A. M., Veo, B. L., Brunt, B., Dahl, N. A., Serkova, N. J., Venkataraman, S., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-64937-3 · Cited by 4 · see citing works

Effect of epigenetic changes in hypoxia induced factor (HIF) gene across cancer types

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A Novel Predictive Model for Adrenocortical Carcinoma Based on Hypoxia- and Ferroptosis-Related Gene Expression

Zhang, T., Song, X., Qiao, J., Zhu, R., Ren, Y., & Shan, P. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.856606 · Cited by 4 · see citing works

Timing of Blood Sample Processing Affects the Transcriptomic and Epigenomic Profiles in CD4+ T-cells of Atopic Subjects

Alhamdan, F., Laubhahn, K., Happle, C., Habener, A., Jirmo, A. C., Thölken, C., Conca, R., Chung, H., Hansen, G., Potaczek, D. P., et al. (2022) · Cells · doi:10.3390/cells11192958 · Cited by 3 · see citing works

scVMAP: a comprehensive platform for integrating single-cell chromatin accessibility regions with causal variants

Yu, Z., Qian, F., Fang, Q.-L., Meng, X., Li, Y., Feng, C., Li, L., Li, B., Feng, Y.-R., Jiang, H., et al. (2025) · Nucleic Acids Research · doi:10.1093/nar/gkaf1112 · Cited by 2 · see citing works

Mediator kinase inhibition suppresses hyperactive interferon signaling in Down syndromePreprint

Cozzolino, K., Sanford, L., Hunter, S., Molison, K., Erickson, B., Courvan, M. C., Jones, T., Ajit, D., Galbraith, M. D., Espinosa, J. M., et al. (2024) · eLife · doi:10.7554/elife.100197 · Cited by 2 · see citing works

Hypoxia leads to reduced mito-nuclear gene expression and increased mtDNA transcriptional pausing in human cells

Shtolz, N., Dadon, S., & Mishmar, D. (2026) · Communications Biology · doi:10.1038/s42003-025-09457-y · Cited by 1 · see citing works

HIF-1–regulated TPM3 links hypoxia to motility and invasion beyond the hypoxic fraction in triple-negative breast cancer

Zhou, C., Crusher, J. T., Friesen, K., Twigger, S. A., Petrosyan, E., Booker, G., Samuel, P., Parkes, E. E., & Hammond, E. M. (2026) · npj Breast Cancer · doi:10.1038/s41523-026-00927-y · Cited by 1 · see citing works

Long Non-Coding RNAs in Hypoxia and Oxidative Stress: Novel Insights Investigating a Piglet Model of Perinatal Asphyxia

Tune, B. G., Melheim, M., Atneosen‐Åsegg, M., Dotinga, B. M., Saugstad, O. D., Solberg, R., & Baumbusch, L. O. (2023) · Biology · doi:10.3390/biology12040549 · Cited by 1 · see citing works

Ubiquitin ligase TRAIP plays an essential role during the S-phase of unperturbed cell cycle in the resolution of DNA replication – transcription conflictsPreprint

Scaramuzza, S., Sadurnì, M. M., Poovathumkadavil, D., Natsume, T., Rojas, P., Kanemaki, M. T., Saponaro, M., & Gambus, A. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.03.23.485338 · Cited by 1 · see citing works

Role of sphingolipids in inflammatory carciongensis

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Targeting hypoxia-induced circSTT3A decreases breast cancer stem cell formation via degradation of PGK1 protein and serine synthesisPreprint

Xu, M.-Z., Liu, M.-R., Zhou, X.-Y., Qin, Y.-L., Yang, L.-P., Wen, S., Qiu, Y., Jin, T., Chen, S., Tang, R., et al. (2023) · bioRxiv · doi:10.1101/2023.04.28.538664

Transcriptional Regulation of Protein Synthesis by Mediator Kinase in MYC-driven MedulloblastomaPreprint

Wang, D., Ritz, C., Pierce, A. M., Brunt, B., Luo, Y., Dahl, N. A., Venkataraman, S., Danis, E. P., Kuś, K., Mazan, M. M., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.03.08.584103

Mediator kinase inhibition suppresses hyperactive interferon signaling in Down syndromePreprint

Cozzolino, K., Sanford, L., Hunter, S., Molison, K., Erickson, B., Jones, T., Courvan, M. C., Ajit, D., Galbraith, M. D., Espinosa, J. M., et al. (2024) · eLife · doi:10.7554/elife.100197.1

PRMT5-mediated histone methylation regulates alternative splicing via MECP2-PTBP1 to promote EMT in breast cancer hypoxiaPreprint

Mutnuru, S. A., Yadav, P., Kakani, P., Dhamdhere, S. G., Kumari, P., Agarwal, S., Samaiya, A., & Shukla, S. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.10.16.618678

Mediator kinase inhibition suppresses hyperactive interferon signaling in Down syndromePreprint

Cozzolino, K., Sanford, L., Hunter, S., Molison, K., Erickson, B., Courvan, M. C., Jones, T., Ajit, D., Galbraith, M. D., Espinosa, J. M., et al. (2025) · eLife · doi:10.7554/elife.100197.2

ADH1C Down-Regulation Is a Key Hypoxia Response in Colon Epithelium

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Mechanisms controlling transcription in hypoxia; an unexpected role of NF-κB

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Impeding hypoxia-driven tumor progression in hepatocellular carcinoma: clinical and pre-clinical analyses using 2D and 3D in vitro models

Payo‐Serafín, T., Méndez‐Blanco, C., Martínez‐Geijo, J., Kopsida, M., San‐Miguel, B., Ortiz-de-Urbina, J. J., Palomo, A. G., Heindryckx, F., & Mauriz, J. L. (2026) · Biology Direct · doi:10.1186/s13062-026-00796-2

Hypoxia-responsive interaction between P-TEFb, BHLHE40, and Tim8-Tim13 regulates hypoxic gene transcription

Soliman, S. H. A., Fabritiis, S. D., Iwanaszko, M., Lin, L. A., Das, M., Gold, S. R., Andersen, G. D., Chakrabarty, R. P., Chandel, N. S., & Shilatifard, A. (2026) · Science Advances · doi:10.1126/sciadv.adz9295

Novel Exploratory Transcriptomic Candidates as Biomarkers and Cancer Hallmark Fingerprints for Ovarian Endometroid and Clear Cell Carcinomas in Women

Kordowitzki, P., & Ying, K. (2026) · Antioxidants · doi:10.3390/antiox15080979

Integrative RNA-Seq Analysis Reveals Stress Type-Dependent lncRNA-Centered Co-Expression Networks Across Human Cellular Stress Contexts

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HIF1A recruits primate-specific endogenous retroviruses into the human hypoxic and immune responsesPreprint

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Molecular and Clinical Tumor Biology

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