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The long lives of primates and the ‘invariant rate of ageing’ hypothesis

Colchero, Fernando, Aburto, José Manuel, Archie, Elizabeth A., Boesch, Christophe, Breuer, Thomas, Campos, Fernando A., Collins, Anthony, Conde, Dalia A., Cords, Marina, Crockford, Catherine, Thompson, Melissa Emery, Fedigan, Linda M., Fichtel, Claudia, Groenenberg, Milou, Hobaiter, Catherine, Kappeler, Peter M., Lawler, Richard R., Lewis, Rebecca J., Machanda, Zarin P., Manguette, Marie L., Muller, Martin N., Packer, Craig, Parnell, Richard J., Perry, Susan, Pusey, Anne E., Robbins, Martha M., Seyfarth, Robert M., Silk, Joan B., Staerk, Johanna, Stoinski, Tara S., Stokes, Emma J., Strier, Karen B., Strum, Shirley C., Tung, Jenny, Villavicencio, Francisco, Wittig, Roman M., Wrangham, Richard W., Zuberbühler, Klaus, Vaupel, James W., Alberts, Susan C.·2021·Nature Communications
DOI 10.1038/s41467-021-23894-3PMC PMC8209124

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Abstract

Is it possible to slow the rate of ageing, or do biological constraints limit its plasticity? We test the ‘invariant rate of ageing’ hypothesis, which posits that the rate of ageing is relatively fixed within species, with a collection of 39 human and nonhuman primate datasets across seven genera. We first recapitulate, in nonhuman primates, the highly regular relationship between life expectancy and lifespan equality seen in humans. We next demonstrate that variation in the rate of ageing within genera is orders of magnitude smaller than variation in pre-adult and age-independent mortality. Finally, we demonstrate that changes in the rate of ageing, but not other mortality parameters, produce striking, species-atypical changes in mortality patterns. Our results support the invariant rate of ageing hypothesis, implying biological constraints on how much the human rate of ageing can be slowed.

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Authors
Colchero, F., Aburto, J. M., Archie, E. A., Boesch, C., Breuer, T., Campos, F. A., Collins, A., Conde, D. A., Cords, M., Crockford, C., Thompson, M. E., Fedigan, L. M., Fichtel, C., Groenenberg, M., Hobaiter, C., Kappeler, P. M., Lawler, R. R., Lewis, R. J., Machanda, Z. P., Manguette, M. L., Muller, M. N., Packer, C., Parnell, R. J., Perry, S., Pusey, A. E., Robbins, M. M., Seyfarth, R. M., Silk, J. B., Staerk, J., Stoinski, T. S., Stokes, E. J., Strier, K. B., Strum, S. C., Tung, J., Villavicencio, F., Wittig, R. M., Wrangham, R. W., Zuberbühler, K., Vaupel, J. W., & Alberts, S. C.
Venue
Nature Communications
Publisher
Springer Science and Business Media LLC
Published
2021-06-16
Volume
12
Issue
1
ISSN
2041-1723
DOI
10.1038/s41467-021-23894-3
PMC
PMC8209124
Cited by
94
References
3
Language
en
Licence
Funders
Max Planck Institute of Demographic Research the Duke University Population Research Institute

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