The DOI matches its Crossref record; 80 of the 80 references it cites were found in a registry or an index.
Dissecting esophageal squamous-cell carcinoma ecosystem by single-cell transcriptomic analysis
Open accessAbstract
Esophageal squamous-cell carcinoma (ESCC), one of the most prevalent and lethal malignant disease, has a complex but unknown tumor ecosystem. Here, we investigate the composition of ESCC tumors based on 208,659 single-cell transcriptomes derived from 60 individuals. We identify 8 common expression programs from malignant epithelial cells and discover 42 cell types, including 26 immune cell and 16 nonimmune stromal cell subtypes in the tumor microenvironment (TME), and analyse the interactions between cancer cells and other cells and the interactions among different cell types in the TME. Moreover, we link the cancer cell transcriptomes to the somatic mutations and identify several markers significantly associated with patients’ survival, which may be relevant to precision care of ESCC patients. These results reveal the immunosuppressive status in the ESCC TME and further our understanding of ESCC.
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Cited by
Li, J., Li, L., You, P., Wei, Y., & Xu, B. (2023) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2023.02.009 · Cited by 55
Immunosuppression and phenotypic plasticity in an atlas of human hepatocholangiocarcinoma
Li, Y., Xun, Z., Long, J., Sun, H., Yang, X., Wang, Y., Wang, Y., Xue, J., Zhang, N., Zhang, J., et al. (2024) · Hepatobiliary Surgery and Nutrition · doi:10.21037/hbsn-23-400 · Cited by 2
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Metadata
- Authors
- Zhang, X., Peng, L., Luo, Y., Zhang, S., Pu, Y., Chen, Y., Guo, W., Yao, J., Shao, M., Fan, W., Cui, Q., Xi, Y., Sun, Y., Niu, X., Zhao, X., Chen, L., Wang, Y., Liu, Y., Yang, X., Wang, C., Zhong, C., Tan, W., Wang, J., Wu, C., & Lin, D.
- Venue
- Nature Communications
- Published
- 2021-09-06
- Volume
- 12
- Issue
- 1
- Pages
- 5291-5291
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W3196701377
- Cited by
- 363
- References
- 80
- FWCI
- 15.30
- Type
- journal article
- Language
- en
- Open access
- gold
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- Zhang, X., Peng, L., Luo, Y., Zhang, S., Pu, Y., Chen, Y., Guo, W., Yao, J., Shao, M., Fan, W., Cui, Q., Xi, Y., Sun, Y., Niu, X., Zhao, X., Chen, L., Wang, Y., Liu, Y., Yang, X., . . . Lin, D. (2021). Dissecting esophageal squamous-cell carcinoma ecosystem by single-cell transcriptomic analysis. Nature Communications. https://doi.org/10.1038/s41467-021-25539-x
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