The DOI matches its Crossref record; 68 of the 68 references it cites were found in a registry or an index.
Single cell and spatial sequencing define processes by which keratinocytes and fibroblasts amplify inflammatory responses in psoriasis
Open accessAbstract
The immunopathogenesis of psoriasis, a common chronic inflammatory disease of the skin, is incompletely understood. Here we demonstrate, using a combination of single cell and spatial RNA sequencing, IL-36 dependent amplification of IL-17A and TNF inflammatory responses in the absence of neutrophil proteases, which primarily occur within the supraspinous layer of the psoriatic epidermis. We further show that a subset of SFRP2+ fibroblasts in psoriasis contribute to amplification of the immune network through transition to a pro-inflammatory state. The SFRP2+ fibroblast communication network involves production of CCL13, CCL19 and CXCL12, connected by ligand-receptor interactions to other spatially proximate cell types: CCR2+ myeloid cells, CCR7+LAMP3+ dendritic cells, and CXCR4 expressed on both CD8+ Tc17 cells and keratinocytes, respectively. The SFRP2+ fibroblasts also express cathepsin S, further amplifying inflammatory responses by activating IL-36G in keratinocytes. These data provide an in-depth view of psoriasis pathogenesis, which expands our understanding of the critical cellular participants to include inflammatory fibroblasts and their cellular interactions.
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Self-citationDevelopment, cytokine profile and function of human interleukin 17-producing helper T cells
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CXCL12+ dermal fibroblasts promote neutrophil recruitment and host defense by recognition of IL-17
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Seq-Scope: Repurposing Illumina sequencing flow cells for high-resolution spatial transcriptomics
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Metadata
- Authors
- Ma, F., Plazyo, O., Billi, A. C., Tsoi, L. C., Xing, X., Wasikowski, R., Gharaee-Kermani, M., Hile, G., Jiang, Y., Harms, P. W., Xing, E., Kirma, J., Xi, J., Hsu, J.-E., Sarkar, M. K., Chung, Y., Di Domizio, J., Gilliet, M., Ward, N. L., Maverakis, E., Klechevsky, E., Voorhees, J. J., Elder, J. T., Lee, J. H., Kahlenberg, J. M., Pellegrini, M., Modlin, R. L., & Gudjonsson, J. E.
- Venue
- Nature Communications
- Published
- 2023-06-12
- Volume
- 14
- Issue
- 1
- Pages
- 3455-3455
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W4380368096
- Cited by
- 284
- References
- 68
- FWCI
- 24.90
- Type
- journal article
- Language
- en
- Open access
- gold
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- The paper
- Ma, F., Plazyo, O., Billi, A. C., Tsoi, L. C., Xing, X., Wasikowski, R., Gharaee-Kermani, M., Hile, G., Jiang, Y., Harms, P. W., Xing, E., Kirma, J., Xi, J., Hsu, J.-E., Sarkar, M. K., Chung, Y., Di Domizio, J., Gilliet, M., Ward, N. L., . . . Gudjonsson, J. E. (2023). Single cell and spatial sequencing define processes by which keratinocytes and fibroblasts amplify inflammatory responses in psoriasis. Nature Communications. https://doi.org/10.1038/s41467-023-39020-4
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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