Nitric oxide controls shoot meristem activity via regulation of DNA methylation
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Abstract
Despite the importance of Nitric Oxide (NO) as signaling molecule in both plant and animal development, the regulatory mechanisms downstream of NO remain largely unclear. Here, we show that NO is involved in Arabidopsis shoot stem cell control via modifying expression and activity of ARGONAUTE 4 ( AGO4 ), a core component of the RNA-directed DNA Methylation (RdDM) pathway. Mutations in components of the RdDM pathway cause meristematic defects, and reduce responses of the stem cell system to NO signaling. Importantly, we find that the stem cell inducing WUSCHEL transcription factor directly interacts with AGO4 in a NO dependent manner, explaining how these two signaling systems may converge to modify DNA methylation patterns. Taken together, our results reveal that NO signaling plays an important role in controlling plant stem cell homeostasis via the regulation of de novo DNA methylation.
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- Authors
- Zeng, J., Zhao, X., Liang, Z., Hidalgo, I., Gebert, M., Fan, P., Wenzl, C., Gornik, S. G., & Lohmann, J. U.
- Affiliations
- Heidelberg University (DE)
- Corresponding author
- Lohmann, Jan U.
- ORCID
- Venue
- Nature Communications
- Published
- 2023-12-04
- Volume
- 14
- Issue
- 1
- Pages
- 8001-8001
- ISSN
- 2041-1723 (ISSN-L)
- PMC
- PMC10696095
- OpenAlex
- W4389298262
- Cited by
- 36
- References
- 78
- Citations by year
- 2026: 16 · 2025: 15 · 2024: 5
- FWCI
- 5.67
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Nature Communications (publishedVersion, cc-by)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- H2020 European Research Council (810296)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant tissue culture and regeneration
- Keywords
- nitric oxide signaling, shoot meristem, stem cell homeostasis, RNA-directed DNA methylation, DNA methylation, WUSCHEL, Arabidopsis thaliana, de novo methylation, plant development
- MeSH terms
- Nitric Oxide, RNA, Arabidopsis, Gene Expression Regulation, Plant, Meristem, DNA Methylation, Arabidopsis Proteins
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