Myelin-reactive B cells exacerbate CD4+ T cell-driven CNS autoimmunity in an IL-23-dependent manner

Fazazi, Mohamed Reda; Doss, Prenitha Mercy Ignatius Arokia; Pereira, Resel; Fudge, Neva; Regmi, Aryan; Joly-Beauparlant, Charles; Akbar, Irshad; Yeola, Asmita Pradeep; Mailhot, Benoit; Baillargeon, Joanie; Grenier, Philippe; Bertrand, Nicolas; Lacroix, Steve; Droit, Arnaud; Moore, Craig S.; Rojas, Olga L.; Rangachari, Manu

doi:10.1038/s41467-024-49259-0

Myelin-reactive B cells exacerbate CD4+ T cell-driven CNS autoimmunity in an IL-23-dependent manner

B cells and T cells collaborate in multiple sclerosis (MS) pathogenesis. IgH [MOG] mice possess a B cell repertoire skewed to recognize myelin oligodendrocyte glycoprotein (MOG). Here, we show that upon immunization with the T cell-obligate autoantigen, MOG [35-55] , IgH [MOG] mice develop rapid …