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Cited by 37Intestinal and Peritoneal AdhesionsHydrogels: synthesis, properties, applicationsSurgical Sutures and Adhesives

Sprayable anti-adhesive hydrogel for peritoneal macrophage scavenging in post-surgical applications

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Song, Wonmoon, Lee, Changyub, Jeong, Haein, Kim, Seoyeon, Hwang, Nathaniel S.·2024·Nature Communications
DOI 10.1038/s41467-024-52753-0PMC PMC11436759
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Abstract

Post-surgical adhesions frequently occur after intra-abdominal surgery, leading to severe complications. Despite the development of various types of adhesion barriers to address post-surgical adhesions, several limitations persist, including off-target localization, handling difficulties, and potential immunogenicity. Here, we report a spray-type adhesion barrier for broad, fast application, forming two sequential networks. The first network is formed by a polyelectrolyte complex of sulfated hyaluronic acid and chitosan, while the second network is established through pluronic® F127 thermogelation. This sprayable barrier served as both a physical protector for the damaged peritoneum and an immunomodulator for peritoneal macrophages, as evidenced its effectiveness in a rat ischemic button model. Taken together, this efficient adhesion barrier presents a promising solution for post-surgical adhesions. Despite advances in adhesion barriers, challenges like off-targeting and handling issues persist. Here, authors report a sprayable adhesion barrier that quickly covers large areas, preventing postsurgical adhesions by scavenging peritoneal macrophages and exerting anti-inflammatory effects.

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  • The sHA/chitosan hydrogel forms a conformal gel film upon contact and modulates local inflammation by promoting an anti-inflammatory M2 macrophage phenotype.

    “This hydrogel, delivered via a dual-syringe sprayer, forms a conformal gel film upon contact and modulates local inflammation by promoting an anti-inflammatory (M2) macrophage phenotype.”

    From Biomaterials in Postoperative Adhesion Barriers and Uterine Tissue Engineering (2025) · cites this paper as [120]

  • An experimental sprayable dual-network hydrogel composed of sulfated hyaluronic acid and chitosan demonstrated superior adhesion prevention to Seprafilm in a rat ischemic button model.

    “Similarly, an experimental sprayable dual-network hydrogel composed of sulfated hyaluronic acid (sHA) and chitosan demonstrated superior adhesion prevention to Seprafilm® in a rat ischemic button model.”

    From Biomaterials in Postoperative Adhesion Barriers and Uterine Tissue Engineering (2025) · cites this paper as [120]

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Cited by

Sorted by citations

Authors
Song, W., Lee, C., Jeong, H., Kim, S., & Hwang, N. S.
Affiliations
Seoul National University (KR)
Corresponding author
Hwang, Nathaniel S.
ORCID
Venue
Nature Communications
Publisher
Springer Science and Business Media LLC
Published
2024-09-27
Volume
15
Issue
1
Pages
8364-8364
ISSN
2041-1723 (ISSN-L)
DOI
10.1038/s41467-024-52753-0
PMC
PMC11436759
OpenAlex
W4402922918
Cited by
37
References
2
Citations by year
2026: 16 · 2025: 21
FWCI
14.42
Type
journal article
Language
en
Open access
Licence
Locations
  • Nature Communications (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • RePEc: Research Papers in Economics (submittedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Ministry of Science, ICT and Future Planning (21A0301L1-21, NRF- 2021R1A2C2008821)
Topics
  • Health Sciences › Medicine › Surgery › Intestinal and Peritoneal Adhesions
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
  • Health Sciences › Medicine › Surgery › Surgical Sutures and Adhesives
Keywords
postoperative adhesions, anti-adhesion barrier, sprayable hydrogel, peritoneal macrophages, chitosan, polyelectrolyte complexes, Pluronic F127, thermogelation, immunomodulation, anti-inflammatory activity
MeSH terms
Tissue Adhesions, Animals, Disease Models, Animal, Hyaluronic Acid, Male, Peritoneum, Postoperative Complications, Rats, Sprague-Dawley, Macrophages, Peritoneal, Hydrogels, Poloxamer, Chitosan, Mice, Rats

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