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Senescence-associated lysosomal dysfunction impairs cystine deprivation-induced lipid peroxidation and ferroptosis

Loo, Tze Mun, Zhou, Xiangyu, Tanaka, Yoko, Sugawara, Sho, Yamauchi, Shota, Kawasaki, Hiroko, Matsuoka, Yuta, Sugiura, Yuki, Sakuma, Shinya, Yamanishi, Yoko, Yotsumoto, Satoshi, Dodo, Kosuke, Shirasaki, Yoshitaka, Kamatani, Takashi, Takahashi, Akiko·2025·Nature Communications
DOI 10.1038/s41467-025-61894-9PMC PMC12307602
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Metadata

Authors
Loo, T. M., Zhou, X., Tanaka, Y., Sugawara, S., Yamauchi, S., Kawasaki, H., Matsuoka, Y., Sugiura, Y., Sakuma, S., Yamanishi, Y., Yotsumoto, S., Dodo, K., Shirasaki, Y., Kamatani, T., & Takahashi, A.
Venue
Nature Communications
Publisher
Springer Science and Business Media LLC
Published
2025-07-29
Volume
16
Issue
1
ISSN
2041-1723
DOI
10.1038/s41467-025-61894-9
PMC
PMC12307602
Cited by
35
References
16
Language
en
Licence
Funders
  • MEXT | Japan Science and Technology Agency (JPMJMS2217, JPMJMS2022)
  • MEXT | JST | Center of Innovation Program (JPMJPF2202)
  • Japan Agency for Medical Research and Development (24gm1710013h0001)
  • MEXT | Japan Society for the Promotion of Science (23K17420, 25K02523)
  • Astellas Foundation for Research on Metabolic Disorders (2022S1015)
  • Takeda Medical Research Foundation (2023095586)

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