Latent virus reactivation in astronauts on the international space station

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Crewmember microbiome may influence microbial composition of ISS habitable surfaces

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Key points for the development of antioxidant cocktails to prevent cellular stress and damage caused by reactive oxygen species (ROS) during manned space missions

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Muscle unloading: A comparison between spaceflight and ground‐based models

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Longitudinal multi-omics analysis of host microbiome architecture and immune responses during short-term spaceflight

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The Future of Personalized Medicine in Space: From Observations to Countermeasures

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Long-term human spaceflight and inflammaging: Does it promote aging?

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Herpesviral Latency—Common Themes

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Countermeasures-based Improvements in Stress, Immune System Dysregulation and Latent Herpesvirus Reactivation onboard the International Space Station – Relevance for Deep Space Missions and Terrestrial Medicine

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Understanding the Complexities and Changes of the Astronaut Microbiome for Successful Long-Duration Space Missions

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Investigation of Spaceflight Induced Changes to Astronaut Microbiomes

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Molecular and physiological changes in the SpaceX Inspiration4 civilian crew

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Single-cell multi-ome and immune profiles of the Inspiration4 crew reveal conserved, cell-type, and sex-specific responses to spaceflight

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The influence of spaceflight on the astronaut salivary microbiome and the search for a microbiome biomarker for viral reactivation

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Influence of Social Isolation During Prolonged Simulated Weightlessness by Hindlimb Unloading

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DNA Damage Baseline Predicts Resilience to Space Radiation and Radiotherapy

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Alterations in Saliva and Plasma Cytokine Concentrations During Long-Duration Spaceflight

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Single-cell analysis identifies conserved features of immune dysfunction in simulated microgravity and spaceflight

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B cell homeostasis is maintained during long-duration spaceflight

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The current state and future trends of space nutrition from a perspective of astronauts' physiology

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Dermatitis during Spaceflight Associated with HSV-1 Reactivation

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Simulated microgravity suppresses MAPK pathway‐mediated innate immune response to bacterial infection and induces gut microbiota dysbiosis

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Exercise as a countermeasure for latent viral reactivation during long duration space flight

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Proteomic characterization of Aspergillus fumigatus isolated from air and surfaces of the International Space Station

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Spaceflight Modulates the Expression of Key Oxidative Stress and Cell Cycle Related Genes in Heart

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Impact of diet on human nutrition, immune response, gut microbiome, and cognition in an isolated and confined mission environment

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Sex differences in stress and immune responses during confinement in Antarctica

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Myalgic Encephalomyelitis/Chronic Fatigue Syndrome as a Hyper-Regulated Immune System Driven by an Interplay Between Regulatory T Cells and Chronic Human Herpesvirus Infections

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Beyond Low-Earth Orbit: Characterizing Immune and microRNA Differentials following Simulated Deep Spaceflight Conditions in Mice

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Human immune system adaptations to simulated microgravity revealed by single-cell mass cytometry

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Challenges for the human immune system after leaving Earth

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Prolonged exposure to simulated microgravity diminishes dendritic cell immunogenicity

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Spaceflight virology: what do we know about viral threats in the spaceflight environment?

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Psychological and biological challenges of the Mars mission viewed through the construct of the evolution of fundamental human needs

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Next generation of astronauts or ESA astronaut 2.0 concept and spotlight on immunity

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Synergistic interplay between radiation and microgravity in spaceflight-related immunological health risks

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Plasticity of the human IgM repertoire in response to long‐term spaceflight

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Salivary antimicrobial proteins and stress biomarkers are elevated during a 6-month mission to the International Space Station

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Astrocytes regulate vascular endothelial responses to simulated deep space radiation in a human organ-on-a-chip model

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Extraterrestrial Gynecology: Could Spaceflight Increase the Risk of Developing Cancer in Female Astronauts? An Updated Review

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The International Space Station has a unique and extreme microbial and chemical environment driven by use patterns

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Effects of microgravity and other space stressors in immunosuppression and viral reactivation with potential nervous system involvement

Sundaresan, A., Mann, V., Mehta, S. K., Crucian, B. E., Doursout, M., & Devakottai, S. (2019) · Neurology India · doi:10.4103/0028-3886.259125 · Cited by 28

Dermatologic manifestations in spaceflight: a review

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The Effects of Simulated Microgravity on Macrophage Phenotype

Ludtka, C., Moore, E., & Allen, J. B. (2021) · Biomedicines · doi:10.3390/biomedicines9091205 · Cited by 26

Immunological Aspects of Isolation and Confinement

Ponomarev, S. A., Kalinin, S., Sadova, A. A., Петровна, Р. М., Дмитриевна, О. К., & Crucian, B. E. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.697435 · Cited by 26

Astroimmunology: the effects of spaceflight and its associated stressors on the immune system

Winer, D. A., Du, H., Kim, J., Chang, V., Burke, M., Winer, S., Costes, S. V., Frippiat, J., Sams, C. F., Paul, A. M., et al. (2025) · Nature reviews. Immunology · doi:10.1038/s41577-025-01226-6 · Cited by 30

Hibernation as a Tool for Radiation Protection in Space Exploration

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Mammalian and Invertebrate Models as Complementary Tools for Gaining Mechanistic Insight on Muscle Responses to Spaceflight

Cahill, T., Cope, H., Bass, J. J., Overbey, E. G., Gilbert, R., da Silveira, W. A., Paul, A. M., Mishra, T., Herranz, R., Reinsch, S. S., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22179470 · Cited by 22

Immunity in Space: Prokaryote Adaptations and Immune Response in Microgravity

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Skin Microbial Changes during Space Flights: A Systematic Review

Tozzo, P., Delicati, A., & Caenazzo, L. (2022) · Life · doi:10.3390/life12101498 · Cited by 21

Gravity’s effect on biology

Narayanan, S. A. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1199175 · Cited by 20

Gravitational Experimental Platform for Animal Models, a New Platform at ESA’s Terrestrial Facilities to Study the Effects of Micro- and Hypergravity on Aquatic and Rodent Animal Models

Bonnefoy, J., Ghislin, S., Beyrend, J., Coste, F., Calcagno, G., Lartaud, I., Gauquelin‐Koch, G., Poussier, S., & Frippiat, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22062961 · Cited by 22

Spaceflight validation of technology for point-of-care monitoring of peripheral blood WBC and differential in astronauts during space missions

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Multi-system responses to altered gravity and spaceflight: Insights from Drosophila melanogaster

Iyer, J. S., Mhatre, S. D., Gilbert, R., & Bhattacharya, S. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104880 · Cited by 22

“The Smartphone’s Guide to the Galaxy”: In Situ Analysis in Space

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Cells´ Flow and Immune Cell Priming under alternating g-forces in Parabolic Flight

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Vitamin D and COVID-19: Lessons from Spaceflight Analogs

Zwart, S. R., & Smith, S. M. (2020) · Journal of Nutrition · doi:10.1093/jn/nxaa233 · Cited by 18

Validating an Automated Nucleic Acid Extraction Device for Omics in Space Using Whole Cell Microbial Reference Standards

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Transcriptomics analysis reveals potential mechanisms underlying mitochondrial dysfunction and T cell exhaustion in astronauts’ blood cells in space

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Simulated microgravity disarms human NK-cells and inhibits anti-tumor cytotoxicity in vitro

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Modulation of Iberian Ribbed Newt Complement Component C3 by Stressors Similar to those Encountered during a Stay Onboard the International Space Station

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Women in space: A review of known physiological adaptations and health perspectives

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The Lungs in Space: A Review of Current Knowledge and Methodologies

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Simulated Microgravity Disrupts Nuclear Factor κB Signaling and Impairs Murine Dendritic Cell Phenotype and Function

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Radiation and microgravity – Associated stress factors and carcinogensis

Moreno‐Villanueva, M., & Wu, H. (2019) · REACH · doi:10.1016/j.reach.2019.100027 · Cited by 18

Managing Hemostasis in Space

White, N. J., & Wenthe, A. (2023) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.123.318783 · Cited by 17

Contemporary review of dermatologic conditions in space flight and future implications for long-duration exploration missions

Nguyen, C. N., & Urquieta, E. (2022) · Life Sciences in Space Research · doi:10.1016/j.lssr.2022.10.004 · Cited by 12

Endocrine adaptations across physical and psychological stressors in long-term space flights

Angeloni, D., & Demontis, G. C. (2020) · Current Opinion in Endocrine and Metabolic Research · doi:10.1016/j.coemr.2019.12.005 · Cited by 13

Adaptation to simulated microgravity in Streptococcus mutans

Fernander, M., Parsons, P., Khaled, B., Bradley, A., Graves, J. L., & Thomas, M. D. (2022) · npj Microgravity · doi:10.1038/s41526-022-00205-8 · Cited by 12

Exposure of volunteers to microgravity by dry immersion bed over 21 days results in gene expression changes and adaptation of T cells

Gallardo-Dodd, C. J., Oertlin, C., Record, J., Galvani, R. G. A., Sommerauer, C., Kuznetsov, N. V., Doukoumopoulos, E., Ali, L., Oliveira, M. M. S., Seitz, C., et al. (2023) · Science Advances · doi:10.1126/sciadv.adg1610 · Cited by 13

The Variability of the Salivary Antimicrobial Peptide Profile: Impact of Lifestyle

Gallo, M. L., Ferrari, E., Giovati, L., Pertinhez, T. A., Artesani, L., Conti, S., & Ciociola, T. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252111501 · Cited by 12

Overexpression of catalase in mitochondria mitigates changes in hippocampal cytokine expression following simulated microgravity and isolation

Rubinstein, L., Schreurs, A., Torres, S. M., Steczina, S., Lowe, M. G., Kiffer, F. C., Allen, A. R., Ronca, A. E., Sowa, M. B., Globus, R. K., et al. (2021) · npj Microgravity · doi:10.1038/s41526-021-00152-w · Cited by 11

International standard measures during the VaPER bed rest study

Clement, G. R., Crucian, B. E., Downs, M. E., Krieger, S., Laurie, S. S., Lee, S. M. C., Mulder, E. R., Roma, P. G., Sibonga, J. D., Smith, S. M., et al. (2021) · Acta Astronautica · doi:10.1016/j.actaastro.2021.10.017 · Cited by 11

Long-Duration Space Travel Support Must Consider Wider Influences to Conserve Microbiota Composition and Function

Al, K. F., Chmiel, J. A., Stuivenberg, G. A., Reid, G., & Burton, J. P. (2022) · Life · doi:10.3390/life12081163 · Cited by 12

SARS-CoV-2 Pandemic Impacts on NASA Ground Operations to Protect ISS Astronauts

Makedonas, G., Mehta, S. K., Scheuring, R. A., Haddon, R., & Crucian, B. E. (2020) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2020.08.064 · Cited by 11

Zoster patients on earth and astronauts in space share similar immunologic profiles

Kunz, H., Makedonas, G., Mehta, S. K., Tyring, S. K., Vangipuram, R., Quiriarte, H. D., Nelman-Gonzalez, M. A., Pierson, D. L., & Crucian, B. E. (2019) · Life Sciences in Space Research · doi:10.1016/j.lssr.2019.10.001 · Cited by 11

Immune system dysregulation preceding a case of laboratory-confirmed zoster/dermatitis on board the International Space Station

Mehta, S. K., Suresh, R., Brandt, K., Diak, D. M., Smith, S. M., Zwart, S. R., Douglas, G. L., Nelman-Gonzalez, M. A., Clemett, S. J., Brunstetter, T. J., et al. (2024) · Journal of Allergy and Clinical Immunology Global · doi:10.1016/j.jacig.2024.100244 · Cited by 10

The impact of short-term confinement on human innate immunity

Ponomarev, S. A., Sadova, A. A., Петровна, Р. М., Дмитриевна, О. К., Vlasova, D. D., Михайловна, Ш. С., Николаевна, А. Е., Валерьевна, К. О., Germanov, N. S., Galina, V. S., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-12380-5 · Cited by 10

Mechanistic Clues to Overcome Spaceflight-Induced Immune Dysregulation

Makedonas, G., Choukèr, A., Mehta, S. K., Simpson, R. J., Stowe, R., Sams, C. F., Pierson, D. L., & Crucian, B. E. (2018) · Current Pathobiology Reports · doi:10.1007/s40139-018-0178-6 · Cited by 10

Medical Astro-Microbiology: Current Role and Future Challenges

McDonagh, F., Cormican, M., Morris, D., Burke, L. P., Singh, N. K., Venkateswaran, K. J., & Miliotis, G. (2023) · Journal of the Indian Institute of Science · doi:10.1007/s41745-023-00360-1 · Cited by 10

Solar ultraviolet light collector for germicidal irradiation on the moon

Lombini, M., Schreiber, W., Albertini, R., Alessi, E. M., Attinà, P., Bianco, A. G., Cascone, E., Colucci, M. E., Cortecchia, F., Caprio, V. D., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-35438-4 · Cited by 10

Palmer Station, Antarctica: A ground-based spaceflight analog suitable for validation of biomedical countermeasures for deep space missions

Diak, D. M., Krieger, S., Gutierrez, C. L., Mehta, S. K., Nelman-Gonzalez, M. A., Babiak-Vazquez, A., Young, M., Oswald, T. M., Choukèr, A., Johnson, J., et al. (2023) · Life Sciences in Space Research · doi:10.1016/j.lssr.2023.08.001 · Cited by 9

Venous Thromboembolism in Exploration Class Human Spaceflight

Levasseur, S., Purvis, N., Trozzo, S., Chung, S. H., Ades, M., & Drudi, L. M. (2023) · Aerospace Medicine and Human Performance · doi:10.3357/amhp.6290.2024 · Cited by 9

Risk of Permanent Corneal Injury in Microgravity: Spaceflight-Associated Hazards, Challenges to Vision Restoration, and Role of Biotechnology in Long-Term Planetary Missions

Shah, J., Ong, J., Lee, R. S., Suh, A., Waisberg, E., Gibson, C. R., Berdahl, J. P., & Mader, T. H. (2025) · Life · doi:10.3390/life15040602 · Cited by 9

Functional foods for astronauts: Enhancing health and performance in microgravity and extreme environments

Sonali, L., Raj, M. P. D., Pavithra, R., Kanimozhi, N. V., Suneetha, C., Shri, B. R., & Sukumar, M. (2025) · Space habitation. · doi:10.1016/j.spaceh.2025.100005 · Cited by 10

Oscillatory-Flow PCR Microfluidic Chip Driven by Low Speed Biaxial Centrifugation

Fan, Y., Dai, R., Lu, S., Liu, X., Zhou, T., Yang, C., Hu, X., Lv, X., & Li, X. (2023) · Biosensors · doi:10.3390/bios13050555 · Cited by 9

Integrated analysis of miRNAome and transcriptome reveals that microgravity induces the alterations of critical functional gene modules via the regulation of miRNAs in short-term space-flown C. elegans

He, X., Zhao, L., Huang, B., Zhang, G., Ye, L., Mi, D., & Sun, Y. (2024) · Life Sciences in Space Research · doi:10.1016/j.lssr.2024.07.001 · Cited by 10

Antiviral treatment with valacyclovir reduces virus shedding in saliva of Antarctic expeditioners

Mehta, S. K., Diak, D. M., Rooney, B. V., Krieger, S., Nelman-Gonzalez, M. A., Locke, J. P., Nagel, M. A., Young, M., & Crucian, B. E. (2023) · Frontiers in Virology · doi:10.3389/fviro.2023.1157659 · Cited by 8

Meta-analysis of health research data from greater than three months International Space Station missions

Kunitskaya, A., Piret, J. M., Buckley, N. D., & Low‐Décarie, É. (2022) · Acta Astronautica · doi:10.1016/j.actaastro.2022.09.019 · Cited by 8

Salivary Immunoglobulin a Alterations in Health and Disease: A Bibliometric Analysis of Diagnostic Trends from 2009 to 2024

Jankowski, J., & Nijakowski, K. (2024) · Antibodies · doi:10.3390/antib13040098 · Cited by 14

Changes in Immune Function during Initial Military Training

Hatch‐McChesney, A., Radcliffe, P. N., Pitts, K. P., Karis, A. J., O'Brien, R. P., Krieger, S., Nelman-Gonzalez, M. A., Diak, D. M., Mehta, S. K., Crucian, B. E., et al. (2022) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000003079 · Cited by 7

Abstract # 1855 Latent virus reactivation in astronauts during international space station

Mehta, S. K., Laudenslager, M. L., Stowe, R. P., Crucian, B. E., Feiveson, A. H., Sams, C., & Pierson, D. L. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.07.134

Multiple latent viruses reactivate in astronauts during Space Shuttle missions

Mehta, S. K., Laudenslager, M. L., Stowe, R. P., Crucian, B. E., Sams, C., & Pierson, D. L. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.05.014 · Cited by 176

Latent Virus Reactivation in Space Shuttle Astronauts

Mehta, S. K., Crucian, B. E., Stowe, R. P., Sams, C., Castro, V. A., & Pierson, D. L. (2011) · NASA STI Repository (National Aeronautics and Space Administration)

Herpes Virus Reactivation in Astronauts During Spaceflight and Its Application on Earth

Rooney, B. V., Crucian, B. E., Pierson, D. L., Laudenslager, M. L., & Mehta, S. K. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.00016 · Cited by 174

AB014. Dormant viruses activate during spaceflight—NASA investigates

Mehta, S. K. (2020) · Pediatric Medicine · doi:10.21037/pm.2020.ab014