How does spaceflight affect the acquired immune system?
Open accessAbstract
The impact of spaceflight on the immune system has been investigated extensively during spaceflight missions and in model experiments conducted on Earth. Data suggest that the spaceflight environment may affect the development of acquired immunity, and immune responses. Herein we summarize and discuss the influence of the spaceflight environment on acquired immunity. Bone marrow and the thymus, two major primary lymphoid organs, are evidently affected by gravitational change during spaceflight. Changes in the microenvironments of these organs impair lymphopoiesis, and thereby may indirectly impinge on acquired immunity. Acquired immune responses may also be disturbed by gravitational fluctuation, stressors, and space radiation both directly and in a stress hormone-dependent manner. These changes may affect acquired immune responses to pathogens, allergens, and tumors.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Spaceflight has been shown to have differential inflammatory effects on crew and experimental systems in missions of a few months, and thus the influence of NTE related to immune response and synergies with other flight factors should be a concern for long-term missions.
“Spaceflight has been shown to have differential inflammatory effects on crew and experimental systems in missions of duration of few months (Akiyama et al., 2020;Gueguinou et al., 2009), and thus the influence of NTE related to immune response and synergies with other flight factors should be a concern for long-term missions.”
From A proposed change to astronaut exposures limits is a giant leap backwards for radiation protection (2021) · cites this paper as Akiyama et al., 2020
Split into 2 atoms — 0 confirmed, 2 partially supported, 0 disputed, 0 misattributed, 0 unverifiable. Expand the claim to see per-atom verdicts.
Experimental — accuracy not yet measuredWhile in space, astronauts experience fluctuations of gravity that can cause dysregulation of CD8+ T cell infiltration in ganglions.
“Likewise, while in space, astronauts experience fluctuations of gravity that can cause dysregulation of CD8+ T cell infiltration in ganglions.”
From Key points for the development of antioxidant cocktails to prevent cellular stress and damage caused by reactive oxygen species (ROS) during manned space missions (2021) · cites this paper as [101]
The section on immune-cell responses says T cells respond to gravitational fluctuation, and the section on disease describes CD8 T-cell infiltration in ganglia during HSV-1 latency. It does not say that gravity fluctuations dysregulate CD8 T-cell infiltration in astronauts’ ganglia; it only suggests that space-induced immune impairment may affect viral latency. Page numbers are unavailable in our copy. (LLM, conf=0.84)
Experimental — accuracy not yet measuredHostile spaceflight environments impair lymphopoiesis in lymphoid organs, mainly the thymus, impairing the acquired immune system and increasing susceptibility to infection.
“Additionally, these hostile spaceflight environments impair lymphopoiesis in lymphoid organs, mainly the thymus, impairing the acquired immune system even further and increasing susceptibility to infection101.”
From Key points for the development of antioxidant cocktails to prevent cellular stress and damage caused by reactive oxygen species (ROS) during manned space missions (2021) · cites this paper as [101]
The Abstract (page unavailable) says spaceflight-related changes in the bone marrow and thymus impair lymphopoiesis and may impinge on acquired immunity. The section “Impact of spaceflight on the development of acquired immunity” reports reduced thymic T-cell output after spaceflight. But “Effects of spaceflight on immunity and the onset of disease” says it remains unclear whether long-term microgravity promotes infectious disease, so the claimed increase in susceptibility to infection is more definite than the source supports. (LLM, conf=0.87)
Experimental — accuracy not yet measuredThis dysregulation can permit reactivation and/or shedding of latent viruses like herpes simplex virus (HSV), varicella zoster virus, Epstein-Barr virus, and human cytomegalovirus.
“This dysregulation can permit reactivation and/or shedding of latent viruses like herpes simplex virus (HSV), varicella zoster virus, Epstein–Barr virus, and human cytomegalovirus101 that would otherwise be easily kept at bay by a functional adaptive immune system.”
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Multilineage potential of adult human mesenchymal stem cells
Pittenger, M. F., Mackay, A. M., Beck, S. C., Jaiswal, R. K., Douglas, R., Mosca, J. D., Moorman, M. A., Simonetti, D. W., Craig, S., & Marshak, D. R. (1999) · Science · doi:10.1126/science.284.5411.143 · Cited by 21,052 · see citing works
Pathogen Recognition and Innate Immunity
Akira, S., Uematsu, S., & Takeuchi, O. (2006) · Cell · doi:10.1016/j.cell.2006.02.015 · Cited by 11,974 · see citing works
Hill (2014) · doi:10.1038/nrgastro.2014.66 · Cited by 9,592 · see citing works
Dietary Modulation of the Human Colonic Microbiota: Introducing the Concept of Prebiotics
Gibson, G. R., & Roberfroid, M. B. (1995) · Journal of Nutrition · doi:10.1093/jn/125.6.1401 · Cited by 7,659 · see citing works
(1992) · Applied Ergonomics · doi:10.1016/0003-6870(92)90318-p · Cited by 5,774 · see citing works
Gibson, G. R., Hutkins, R., Sanders, M. E., Prescott, S. L., Reimer, R. A., Salminen, S. J., Scott, K., Stanton, C., Swanson, K. S., Cani, P. D., et al. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.75 · Cited by 5,634 · see citing works
Mesenchymal and haematopoietic stem cells form a unique bone marrow niche
Méndez‐Ferrer, S., Michurina, T. V., Ferraro, F., Mazloom, A. R., MacArthur, B. D., Lira, S. A., Scadden, D. T., Ma’ayan, A., Enikolopov, G., & Frenette, P. S. (2010) · Nature · doi:10.1038/nature09262 · Cited by 3,381 · see citing works
Weissman, I. L. (2000) · Cell · doi:10.1016/s0092-8674(00)81692-x · Cited by 1,827 · see citing works
The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight
Garrett-Bakelman, F. E., Darshi, M., Green, S. J., Gur, R. C., Lin, L., Macias, B. R., McKenna, M. J., Meydan, C., Mishra, T., Nasrini, J., et al. (2019) · Science · doi:10.1126/science.aau8650 · Cited by 1,128 · see citing works
Gut microbiota-derived short-chain Fatty acids, T cells, and inflammation
Kim, C. H., Park, J., & Kim, M. (2014) · Immune Network · doi:10.4110/in.2014.14.6.277 · Cited by 704 · see citing works
Whitley, R. J., & Roizman, B. (2002) · Wiley Encyclopedia of Molecular Medicine · doi:10.1002/0471203076.emm0597 · Cited by 700 · see citing works
Immunity and immunopathology to viruses: what decides the outcome?
Rouse, B. T., & Sehrawat, S. (2010) · Nature reviews. Immunology · doi:10.1038/nri2802 · Cited by 614 · see citing works
Launching the T-cell-lineage developmental programme
Rothenberg, E. V., Moore, J. E., & Yui, M. A. (2007) · Nature reviews. Immunology · doi:10.1038/nri2232 · Cited by 475 · see citing works
Mizoguchi, T., Pinho, S., Ahmed, J. U., Kunisaki, Y., Hanoun, M., Mendelson, A., Ono, N., Kronenberg, H. M., & Frenette, P. S. (2014) · Developmental Cell · doi:10.1016/j.devcel.2014.03.013 · Cited by 441 · see citing works
Crucian, B. E., Choukèr, A., Simpson, R. J., Mehta, S., Marshall, G., Smith, S. M., Zwart, S. R., Heer, M., Ponomarev, S., Whitmire, A., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01437 · Cited by 421 · see citing works
Khanna, K. M., Bonneau, R. H., Kinchington, P. R., & Hendricks, R. L. (2003) · Immunity · doi:10.1016/s1074-7613(03)00112-2 · Cited by 403 · see citing works
Knickelbein, J. E., Khanna, K. M., Yee, M. B., Baty, C. J., Kinchington, P. R., & Hendricks, R. L. (2008) · Science · doi:10.1126/science.1164164 · Cited by 395 · see citing works
COOPERATION BETWEEN CD4+AND CD8+T CELLS: When, Where, and How
Castellino, F., & Germain, R. N. (2006) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115825 · Cited by 375 · see citing works
Human Pathophysiological Adaptations to the Space Environment
Demontis, G. C., Germani, M. M., Caiani, E. G., Barravecchia, I., Passino, C., & Angeloni, D. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00547 · Cited by 354 · see citing works
Abramson, J., & Anderson, G. (2017) · Annual Review of Immunology · doi:10.1146/annurev-immunol-051116-052320 · Cited by 337 · see citing works
Cogoli, A., Tschopp, A., & Fuchs-Bislin, P. (1984) · Science · doi:10.1126/science.6729481 · Cited by 314 · see citing works
Effects of 1- and 6-month spaceflight on bone mass and biochemistry in two humans
Collet, P., Uebelhart, D., Vico, L., Moro, L., Hartmann, D. J., Roth, M., & Alexandre, C. (1997) · Bone · doi:10.1016/s8756-3282(97)00052-5 · Cited by 288 · see citing works
Guéguinou, N., Huin-Schohn, C., Bascove, M., Bueb, J.-L., Tschirhart, E., Legrand-Frossi, C., & Frippiat, J.-P. (2009) · Journal of Leukocyte Biology · doi:10.1189/jlb.0309167 · Cited by 280 · see citing works
Hindlimb unloading: rodent analog for microgravity
Globus, R. K., & Morey, E. R. (2016) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00997.2015 · Cited by 273 · see citing works
The impact of microgravity on bone in humans
Grimm, D. G., Grosse, J., Wehland, M., Mann, V., Reseland, J. E., Sundaresan, A., & Corydon, T. J. (2016) · Bone · doi:10.1016/j.bone.2015.12.057 · Cited by 273 · see citing works
Alterations in adaptive immunity persist during long-duration spaceflight
Crucian, B. E., Stowe, R. P., Mehta, S. K., Quiriarte, H. D., Pierson, D. L., & Sams, C. F. (2015) · npj Microgravity · doi:10.1038/npjmgrav.2015.13 · Cited by 255 · see citing works
Daily Probiotic’s (Lactobacillus casei Shirota) Reduction of Infection Incidence in Athletes
Gleeson, M., Bishop, N. C., Oliveira, M., & Tauler, P. (2011) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.21.1.55 · Cited by 239 · see citing works
Skeletal changes during and after spaceflight
Vico, L., & Hargens, A. (2018) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2018.37 · Cited by 236 · see citing works
Verjans, G. M. G. M., Hintzen, R. Q., van Dun, J. M., Poot, A. M., Milikan, J. C. M., Laman, J. D., Langerak, A. W., Kinchington, P. R., & Osterhaus, A. D. M. E. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610847104 · Cited by 235 · see citing works
Incidence of clinical symptoms during long-duration orbital spaceflight
Crucian, B., Babiak-Vazquez, A., Johnston, S., Pierson, D., Ott, C. M., & Sams, C. (2016) · International Journal of General Medicine · doi:10.2147/ijgm.s114188 · Cited by 223 · see citing works
Delp, M. D., Charvat, J. M., Limoli, C. L., Globus, R. K., & Ghosh, P. (2016) · Scientific Reports · doi:10.1038/srep29901 · Cited by 219 · see citing works
Tissue‐resident memory T cells
Shin, H., & Iwasaki, A. (2013) · Immunological Reviews · doi:10.1111/imr.12087 · Cited by 206 · see citing works
Immunological memory: lessons from the past and a look to the future
Farber, D. L., Netea, M. G., Radbruch, A., Rajewsky, K., & Zinkernagel, R. M. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2016.13 · Cited by 200 · see citing works
Asano, Y., Suga, S., Yoshikawa, T., Kobayashi, I., Yazaki, T., Shibata, M., Tsuzuki, K., & Ito, S. (1994) · PEDIATRICS · doi:10.1542/peds.94.4.524 · Cited by 200 · see citing works
Immune System Dysregulation Occurs During Short Duration Spaceflight On Board the Space Shuttle
Crucian, B., Stowe, R., Mehta, S., Uchakin, P., Quiriarte, H., Pierson, D., & Sams, C. (2013) · Journal of Clinical Immunology · doi:10.1007/s10875-012-9824-7 · Cited by 196 · see citing works
Crucian, B. E., Zwart, S. R., Mehta, S., Uchakin, P., Quiriarte, H. D., Pierson, D., Sams, C. F., & Smith, S. M. (2014) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2013.0129 · Cited by 195 · see citing works
Latent virus reactivation in astronauts on the international space station
Mehta, S. K., Laudenslager, M. L., Stowe, R. P., Crucian, B. E., Feiveson, A. H., Sams, C. F., & Pierson, D. L. (2017) · npj Microgravity · doi:10.1038/s41526-017-0015-y · Cited by 188 · see citing works
Fructans: Prebiotics and immunomodulators
Peshev, D., & Van den Ende, W. (2014) · Journal of Functional Foods · doi:10.1016/j.jff.2014.04.005 · Cited by 175 · see citing works
Effects of spaceflight on innate immune function and antioxidant gene expression
Baqai, F. P., Gridley, D. S., Slater, J. M., Luo‐Owen, X., Stodieck, L., Ferguson, V. L., Chapes, S. K., & Pecaut, M. J. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.91361.2008 · Cited by 174 · see citing works
Herpes Virus Reactivation in Astronauts During Spaceflight and Its Application on Earth
Rooney, B. V., Crucian, B. E., Pierson, D. L., Laudenslager, M. L., & Mehta, S. K. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.00016 · Cited by 174 · see citing works
A comparison of herpes simplex virus type 1 and varicella-zoster virus latency and reactivation
Kennedy, P. G. E., Rovnak, J., Badani, H., & Cohrs, R. J. (2015) · Journal of General Virology · doi:10.1099/vir.0.000128 · Cited by 164 · see citing works
Molecular control over thymic involution: From cytokines and micro RNA to aging and adipose tissue
Dooley, J., & Liston, A. (2012) · European Journal of Immunology · doi:10.1002/eji.201142305 · Cited by 159 · see citing works
West, N. P., Horn, P. L., Pyne, D. B., Gebski, V. J., Lahtinen, S. J., Fricker, P. A., & Cripps, A. W. (2014) · Clinical Nutrition · doi:10.1016/j.clnu.2013.10.002 · Cited by 159 · see citing works
Changes in neutrophil functions in astronauts
Kaur, I., Simons, E. R., Castro, V. A., Ott, C. M., & Pierson, D. L. (2003) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2003.10.005 · Cited by 158 · see citing works
Leukocyte subsets and neutrophil function after short-term spaceflight
Stowe, R. P., Sams, C. F., Mehta, S. K., Kaur, I., Jones, M. L., Feeback, D. L., & Pierson, D. L. (1999) · Journal of Leukocyte Biology · doi:10.1002/jlb.65.2.179 · Cited by 152 · see citing works
Meyers, V. E., Zayzafoon, M., Gonda, S. R., Gathings, W. E., & McDonald, J. M. (2004) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20229 · Cited by 149 · see citing works
Immune control of herpes simplex virus during latency
Khanna, K. M., Lepisto, A. J., Decman, V., & Hendricks, R. L. (2004) · Current Opinion in Immunology · doi:10.1016/j.coi.2004.05.003 · Cited by 147 · see citing works
Crucian, B. E., Cubbage, M. L., & Sams, C. F. (2000) · Journal of Interferon & Cytokine Research · doi:10.1089/10799900050044741 · Cited by 137 · see citing works
Boehm, T. L. J., Hess, I., & Swann, J. B. (2012) · Trends in Immunology · doi:10.1016/j.it.2012.02.005 · Cited by 136 · see citing works
Microgravity Potentiates Stem Cell Proliferation While Sustaining the Capability of Differentiation
Yuge, L., Kajiume, T., Tahara, H., Kawahara, Y., Umeda, C., Yoshimoto, R. U., Wu, S., Yamaoka, K., Asashima, M., Kataoka, K., et al. (2006) · Stem Cells and Development · doi:10.1089/scd.2006.15.921 · Cited by 134 · see citing works
Overview of the NASA Space Radiation Laboratory
La Tessa, C., Sivertz, M., Chiang, I.-H., Lowenstein, D., & Rusek, A. (2016) · Life Sciences in Space Research · doi:10.1016/j.lssr.2016.10.002 · Cited by 133 · see citing works
Reactivation of latent viruses is associated with increased plasma cytokines in astronauts
Mehta, S. K., Crucian, B. E., Stowe, R. P., Simpson, R. J., Ott, C. M., Sams, C., & Pierson, D. L. (2012) · Cytokine · doi:10.1016/j.cyto.2012.09.019 · Cited by 120 · see citing works
Shiba, D., Mizuno, H., Yumoto, A., Shimomura, M., Kobayashi, H., Morita, H., Shimbo, M., Hamada, M., Kudo, T., Shinohara, M., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-10998-4 · Cited by 104 · see citing works
Tolerance has its limits: how the thymus copes with infection
Nunes-Alves, C., Nóbrega, C., Behar, S. M., & Correia‐Neves, M. (2013) · Trends in Immunology · doi:10.1016/j.it.2013.06.004 · Cited by 102 · see citing works
Chen, Z., Luo, Q., Lin, C., Kuang, D., & Song, G. (2016) · Scientific Reports · doi:10.1038/srep30322 · Cited by 99 · see citing works
Terrestrial stress analogs for spaceflight associated immune system dysregulation
Crucian, B. E., Simpson, R. J., Mehta, S. K., Stowe, R., Choukèr, A., Hwang, S., Actor, J. K., Salam, A. P., Pierson, D. L., & Sams, C. F. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.01.011 · Cited by 98 · see citing works
A New Chance of Preventing Winter Diseases by the Administration of Synbiotic Formulations
Pregliasco, F. E., Anselmi, G., Fonte, L., Giussani, F., Schieppati, S., & Soletti, L. (2008) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e31817e1c91 · Cited by 89 · see citing works
Ribeiro, R. M., & Perelson, A. S. (2007) · Immunological Reviews · doi:10.1111/j.1600-065x.2006.00493.x · Cited by 87 · see citing works
Lymphocyte reactivity during spaceflight
Cogoli, A., & Tschopp, A. (1985) · Immunology Today · doi:10.1016/0167-5699(85)90151-3 · Cited by 86 · see citing works
Pecaut, M. J., Nelson, G. A., Peters, L. L., Kostenuik, P. J., Bateman, T. A., Morony, S., Stodieck, L., Lacey, D. L., Simske, S. J., & Gridley, D. S. (2003) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01052.2002 · Cited by 82 · see citing works
Montoro, J., Mullol, J., Jauregui, I., Davila, I. J., Ferrer, M., Bartra, J., del Cuvillo, A., Sastre, J., & Valero, A. (2009) · PubMed · Cited by 81 · see citing works
Crucian, B. E., Johnston, S. L., Mehta, S. K., Stowe, R., Uchakin, P., Quiriarte, H. D., Pierson, D. L., Laudenslager, M. L., & Sams, C. F. (2016) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2015.12.021 · Cited by 81 · see citing works
Thymic Atrophy: Experimental Studies and Therapeutic Interventions
Majumdar, S., & Nandi, D. (2017) · Scandinavian Journal of Immunology · doi:10.1111/sji.12618 · Cited by 81 · see citing works
Alterations in hematologic indices during long-duration spaceflight
Kunz, H., Quiriarte, H., Simpson, R. J., Ploutz-Snyder, R., McMonigal, K., Sams, C., & Crucian, B. (2017) · BMC Hematology · doi:10.1186/s12878-017-0083-y · Cited by 80 · see citing works
Gridley, D. S., Nelson, G. A., Peters, L. L., Kostenuik, P. J., Bateman, T. A., Morony, S., Stodieck, L., Lacey, D. L., Simske, S. J., & Pecaut, M. J. (2003) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01053.2002 · Cited by 77 · see citing works
Gaignier, F., Schenten, V., Bittencourt, M. D. C., Gauquelin‐Koch, G., Frippiat, J., & Legrand-Frossi, C. (2014) · PLoS ONE · doi:10.1371/journal.pone.0092664 · Cited by 71 · see citing works
Development of prebiotic food products and health benefits
Rolim, P. M. (2015) · Food Science and Technology · doi:10.1590/1678-457x.6546 · Cited by 67 · see citing works
Human cellular immune responsiveness following space flight.
TAYLOR, G. R., & Dardano, J. R. (1983) · PubMed · Cited by 65 · see citing works
Changes in Mouse Thymus and Spleen after Return from the STS-135 Mission in Space
Gridley, D. S., Mao, X. W., Stodieck, L., Ferguson, V. L., Bateman, T. A., Moldovan, M., Cunningham, C. E., Jones, T., Slater, J. M., & Pecaut, M. J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0075097 · Cited by 64 · see citing works
Tauber, S., Hauschild, S., Paulsen, K., Gutewort, A., Raig, C., Breuer, E., Biskup, J., Philpot, C., Lier, H., Engelmann, F., et al. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000373930 · Cited by 63 · see citing works
Zhou, Y., Ni, H., Li, M., Sanzari, J. K., Diffenderfer, E. S., Lin, L., Kennedy, A. R., & Weissman, D. (2012) · PLoS ONE · doi:10.1371/journal.pone.0044329 · Cited by 60 · see citing works
The simulated microgravity enhances the differentiation of mesenchymal stem cells into neurons
Chen, J., Liu, R., Yang, Y., Li, J., Zhang, X., Li, J., Wang, Z., & Ma, J. (2011) · Neuroscience Letters · doi:10.1016/j.neulet.2011.10.014 · Cited by 58 · see citing works
Tascher, G., Gerbaix, M., Maes, P., Chazarin, B., Ghislin, S., Николаевна, А. Е., Vassilieva, G. Y., Ouzren-Zarhloul, N., Gauquelin‐Koch, G., Vico, L., et al. (2018) · The FASEB Journal · doi:10.1096/fj.201801463r · Cited by 53 · see citing works
Decreases in thymopoiesis of astronauts returning from space flight
Benjamin, C. L., Stowe, R. P., John, L. S. S., Sams, C. F., Mehta, S. K., Crucian, B. E., Pierson, D. L., & Komanduri, K. V. (2016) · JCI Insight · doi:10.1172/jci.insight.88787 · Cited by 52 · see citing works
Duration of simulated microgravity affects the differentiation of mesenchymal stem cells
Li, X., Li, Y., & Chen, J. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.6357 · Cited by 51 · see citing works
Natural killer cells after altaïr mission
Konstantinova, I. V., Петровна, Р. М., Meshkov, D., Peres, C. A., Husson, D., & Schmitt, D. (1995) · Acta Astronautica · doi:10.1016/0094-5765(95)00161-1 · Cited by 50 · see citing works
Novoselova, E. G., Lunin, S. M., Khrenov, M. O., Parfenyuk, S. B., Novoselova, T. V., Shenkman, B. S., & Fesenko, E. E. (2014) · Immunobiology · doi:10.1016/j.imbio.2014.10.021 · Cited by 49 · see citing works
B cell homeostasis is maintained during long-duration spaceflight
Spielmann, G., Agha, N. H., Kunz, H., Simpson, R. J., Crucian, B. E., Mehta, S. K., Laughlin, M. S., & Campbell, J. P. (2018) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00789.2018 · Cited by 47 · see citing works
Spaceflight modulates gene expression in the whole blood of astronauts
Barrila, J., Ott, C. M., LeBlanc, C. L., Mehta, S. K., Crabbé, A., Stafford, P., Pierson, D. L., & Nickerson, C. A. (2016) · npj Microgravity · doi:10.1038/npjmgrav.2016.39 · Cited by 47 · see citing works
Longitudinal study of astronaut health: Mortality in the years 1959–1991
Peterson, L. E., Pepper, L. J., Hamm, P. B., & Gilbert, S. L. (1993) · Radiation Research · doi:10.2307/3578364 · Cited by 46 · see citing works
Detection of space radiation-induced double strand breaks as a track in cell nucleus
Ohnishi, T., Takahashi, A., Nagamatsu, A., Omori, K., Suzuki, H., Shimazu, T., & Ishioka, N. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.09.114 · Cited by 45 · see citing works
Self-citationSpecific Immunologic Countermeasure Protocol for Deep-Space Exploration Missions
Makedonas, G., Mehta, S. K., Choukèr, A., Simpson, R. J., Marshall, G. D., Orange, J. S., Auñón-Chancellor, S. M., Smith, S. M., Zwart, S. R., Stowe, R. P., et al. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02407 · Cited by 44 · see citing works
Hindlimb suspension and spe-like radiation impairs clearance of bacterial infections
Li, M., Holmes, V., Zhou, Y., Ni, H., Sanzari, J. K., Kennedy, A. R., & Weissman, D. (2014) · PLoS ONE · doi:10.1371/journal.pone.0085665 · Cited by 43 · see citing works
Effects of spaceflight on the immunoglobulin repertoire of unimmunized C57BL/6 mice
Ward, C., Rettig, T. A., Hlavacek, S., Bye, B. A., Pecaut, M. J., & Chapes, S. K. (2017) · Life Sciences in Space Research · doi:10.1016/j.lssr.2017.11.003 · Cited by 42 · see citing works
Horie, K., Kato, T., Kudo, T., Sasanuma, H., Miyauchi, M., Akiyama, N., Miyao, T., Seki, T., Ishikawa, T., Takakura, Y., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-56432-9 · Cited by 41 · see citing works
Self-citationUse of animal models for space flight physiology studies, with special focus on the immune system.
Sonnenfeld, G. (2005) · PubMed · Cited by 40 · see citing works
Hada, M., Ikeda, H., Rhone, J., Beitman, A., Plante, I., Souda, H., Yoshida, Y., Held, K. D., Fujiwara, K., Saganti, P. B., et al. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms20010043 · Cited by 40 · see citing works
Self-citationModel microgravity enhances endothelium differentiation of mesenchymal stem cells
Zhang, X., Nan, Y., Wang, H., Chen, J., Wang, N., Xie, J., Ma, J., & Wang, Z. (2012) · Die Naturwissenschaften · doi:10.1007/s00114-012-1002-5 · Cited by 40 · see citing works
Ikeda, H., Muratani, M., Hidema, J., Hada, M., Fujiwara, K., Souda, H., Yoshida, Y., & Takahashi, A. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20194791 · Cited by 34 · see citing works
Self-citationMortality Among U.S. Astronauts: 1980–2009
Reynolds, R. J., & Day, S. M. (2010) · Aviation Space and Environmental Medicine · doi:10.3357/asem.2847.2010 · Cited by 30 · see citing works
Risk of cancer mortality among the Longitudinal Study of Astronaut Health (LSAH) participants.
Hamm, P., Billica, R. D., Johnson, G. S., Wear, M. L., & Pool, S. L. (1998) · PubMed · Cited by 28 · see citing works
Detection of DNA Damage Induced by Space Radiation in Mir and Space Shuttle
Ohnishi, T., Ohnishi, K., Takahashi, A., TANIGUCHI, Y., Sato, M., Nakano, T., & Nagaoka, S. (2002) · Journal of Radiation Research · doi:10.1269/jrr.43.s133 · Cited by 27 · see citing works
Self-citationIkeda, H., Souda, H., Puspitasari, A., Held, K. D., Hidema, J., Nikawa, T., Yoshida, Y., Kanai, T., & Takahashi, A. (2017) · Life Sciences in Space Research · doi:10.1016/j.lssr.2017.01.003 · Cited by 26 · see citing works
Self-citationHorie, K., Sasanuma, H., Kudo, T., Fujita, S.-I., Miyauchi, M., Miyao, T., Seki, T., Akiyama, N., Takakura, Y., Shimbo, M., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-44067-9 · Cited by 25 · see citing works
Self-citationDesign and current status of the longitudinal study of astronaut health.
Hamm, P., NICOGOSSIAN, A. E., Pool, S. L., Wear, M. L., & Billica, R. D. (2000) · PubMed · Cited by 25 · see citing works
Matsuda, C., Kato, T., Inoue-Suzuki, S., Kikuchi, J., Ohta, T., Kagawa, M., Hattori, M., Kobayashi, H., Shiba, D., Shirakawa, M., et al. (2019) · npj Microgravity · doi:10.1038/s41526-019-0077-0 · Cited by 23 · see citing works
Self-citationCorrection: Changes in Mouse Thymus and Spleen after Return from the STS-135 Mission in Space
Gridley, D. S., Mao, X. W., Stodieck, L., Ferguson, V. L., Bateman, T. A., Moldovan, M., Cunningham, C. E., Jones, T., Slater, J. M., & Pecaut, M. J. (2013) · PLoS ONE · doi:10.1371/annotation/e66bdc4e-2409-4582-b163-7bc182db275e · Cited by 19 · see citing works
Tumor growth and immune function in mice during hind-limb unloading.
Lee, E. H., Ding, W., Kulkarni, A. D., & Granstein, R. D. (2005) · PubMed · Cited by 16 · see citing works
Ikeda, H., Souda, H., Puspitasari, A., Held, K. D., Hidema, J., Nikawa, T., Yoshida, Y., Kanai, T., & Takahashi, A. (2016) · Biological Sciences in Space · doi:10.2187/bss.30.8 · Cited by 15 · see citing works
Self-citationTakahashi, A., Wakihata, S., Ma, L., Adachi, T., Hirose, H., Yoshida, Y., & Ohira, Y. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19123959 · Cited by 5 · see citing works
Self-citationМихайлович, Г. П., Gershovich, I. G., & Buravkova, L. B. (2013) · PubMed · Cited by 4 · see citing works
Михайлович, Г. П., Gershovich, Y. G., & Буравкова, Л. Б. (2013) · Human Physiology · doi:10.7868/s0131164613050068 · Cited by 3 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Turroni, S., Magnani, M., Pukar, K. C., Lesnik, P., Vidal, H., & Heer, M. A. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.553929 · Cited by 120 · see citing works
Wide range applications of spirulina: from earth to space missions
Fais, G., Manca, A., Bolognesi, F., Borselli, M., Concas, A., Busutti, M., Broggi, G., Sanna, P., Castillo-Aleman, Y. M., Rivero-Jiménez, R. A., et al. (2022) · Marine Drugs · doi:10.3390/md20050299 · Cited by 98 · see citing works
Gómez, X., Sanon, S., Zambrano, K., Asquel, S., Bassantes, M., Morales, J. E., Otáñez, G., Pomaquero, C., Villarroel, S., Zurita, A., et al. (2021) · npj Microgravity · doi:10.1038/s41526-021-00162-8 · Cited by 92 · see citing works
Susilowati, E., & Azzasyofia, M. (2020) · International Journal of Science and Society · doi:10.54783/ijsoc.v2i3.117 · Cited by 93 · see citing works
Role of Apoptosis in Wound Healing and Apoptosis Alterations in Microgravity
Riwaldt, S., Corydon, T. J., Pantalone, D., Sahana, J., Wise, P. M., Wehland, M., Krüger, M., Melnik, D., Kopp, S., Infanger, M., et al. (2021) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.679650 · Cited by 95 · see citing works
3D Culture Systems for Exploring Cancer Immunology
Fitzgerald, A. A., Li, E., & Weiner, L. M. (2020) · Cancers · doi:10.3390/cancers13010056 · Cited by 81 · see citing works
The influence of spaceflight and simulated microgravity on bacterial motility and chemotaxis
Acres, J. M., Youngapelian, M. J., & Nadeau, J. (2021) · npj Microgravity · doi:10.1038/s41526-021-00135-x · Cited by 79 · see citing works
May the Force Be with You (Or Not): The Immune System under Microgravity
ElGindi, M., Sapudom, J., Ibrahim, I. H., Al‐Sayegh, M., Chen, W., Garcia‐Sabaté, A., & Teo, J. C. M. (2021) · Cells · doi:10.3390/cells10081941 · Cited by 72 · see citing works
The Fight against Cancer by Microgravity: The Multicellular Spheroid as a Metastasis Model
Grimm, D. G., Schulz, H., Krüger, M., Cortés-Sánchez, J. L., Egli, M., Kraus, A., Sahana, J., Corydon, T. J., Hemmersbach, R., Wise, P. M., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23063073 · Cited by 72 · see citing works
Kim, J., Tierney, B. T., Overbey, E. G., Dantas, E., Fuentealba, M., Park, J., Narayanan, S. A., Wu, F., Najjar, D., Chin, C. R., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-49211-2 · Cited by 71 · see citing works
A New Era for Space Life Science: International Standards for Space Omics Processing
Rutter, L. A., Barker, R. J., Bezdan, D., Cope, H., Costes, S. V., Degoricija, L., Fisch, K. M., Gabitto, M. I., Gebre, S., Giacomello, S., et al. (2020) · Patterns · doi:10.1016/j.patter.2020.100148 · Cited by 62 · see citing works
Genomic Changes Driven by Radiation-Induced DNA Damage and Microgravity in Human Cells
Beheshti, A., McDonald, J. T., Hada, M., Takahashi, A., Mason, C. E., & Mognato, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910507 · Cited by 60 · see citing works
Self-citationTascher, G., Gerbaix, M., Maes, P., Chazarin, B., Ghislin, S., Николаевна, А. Е., Vassilieva, G. Y., Ouzren-Zarhloul, N., Gauquelin‐Koch, G., Vico, L., et al. (2018) · The FASEB Journal · doi:10.1096/fj.201801463r · Cited by 53 · see citing works
Zhang, Z., Wu, H., Zhang, A., Tan, M., Yan, S., & Jiang, D. (2024) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2024.135587 · Cited by 52 · see citing works
Sun, Y., Kuang, Y., & Zuo, Z. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052333 · Cited by 39 · see citing works
Spatial multi-omics of human skin reveals KRAS and inflammatory responses to spaceflight
Park, J., Overbey, E. G., Narayanan, S. A., Kim, J., Tierney, B. T., Damle, N., Najjar, D., Ryon, K. A., Proszynski, J., Kleinman, A. S., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-48625-2 · Cited by 40 · see citing works
A proposed change to astronaut exposures limits is a giant leap backwards for radiation protection
Cucinotta, F. A., Schimmerling, W., Blakely, E. A., & Hei, T. K. (2021) · Life Sciences in Space Research · doi:10.1016/j.lssr.2021.07.005 · Cited by 35 · see citing works
Space Medicines for Space Health
Tran, Q. D., Tran, V., Toh, L. S., Williams, P. M., Tran, N. N., & Hessel, V. (2022) · ACS Medicinal Chemistry Letters · doi:10.1021/acsmedchemlett.1c00681 · Cited by 37 · see citing works
Tang, J., & Zhao, X. (2024) · Molecules · doi:10.3390/molecules29061201 · Cited by 36 · see citing works
Prospective Use of Probiotics to Maintain Astronaut Health during Spaceflight
Bharindwal, S., Goswami, N., Jha, P., Pandey, S., & Jobby, R. (2023) · Life · doi:10.3390/life13030727 · Cited by 35 · see citing works
Spaceflight alters host-gut microbiota interactions
González, E., Lee, M., Tierney, B. T., Lytell, N., Flores, P., Mishra, M., Beckett, L., Finkelstein, A., Mo, A., Walton, P., et al. (2024) · npj Biofilms and Microbiomes · doi:10.1038/s41522-024-00545-1 · Cited by 36 · see citing works
Spaceflight virology: what do we know about viral threats in the spaceflight environment?
Pavletić, B., Runzheimer, K., Siems, K., Koch, S., Cortesão, M., Ramos-Nascimento, A., & Moeller, R. (2022) · Astrobiology · doi:10.1089/ast.2021.0009 · Cited by 30 · see citing works
Next generation of astronauts or ESA astronaut 2.0 concept and spotlight on immunity
Jacob, P., Oertlin, C., Baselet, B., Westerberg, L. S., Frippiat, J., & Baatout, S. (2023) · npj Microgravity · doi:10.1038/s41526-023-00294-z · Cited by 34 · see citing works
Wadhwa, A., Moreno‐Villanueva, M., Crucian, B. E., & Wu, H. (2024) · Immunity & Ageing · doi:10.1186/s12979-024-00449-w · Cited by 37 · see citing works
Microbial Pathogenicity in Space
Simões, M. F., & Antunes, A. (2021) · Pathogens · doi:10.3390/pathogens10040450 · Cited by 33 · see citing works
Integrated RNA-seq Analysis Indicates Asynchrony in Clock Genes between Tissues under Spaceflight
Fujita, S.-I., Rutter, L. A., Ong, Q., & Muratani, M. (2020) · Life · doi:10.3390/life10090196 · Cited by 30 · see citing works
Garzón, N. A. L., Fernández, M. V. P., T., J. S. S., Nati-Castillo, H. A., Arias-Intriago, M., Salazar-Santoliva, C., & Izquierdo‐Condoy, J. S. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26073058 · Cited by 29 · see citing works
Spaceflight Stressors and Skin Health
Radstake, W. E., Baselet, B., Baatout, S., & Verslegers, M. (2022) · Biomedicines · doi:10.3390/biomedicines10020364 · Cited by 27 · see citing works
Microgravity-induced stress mechanisms in human stem cell-derived cardiomyocytes
Acharya, A., Nemade, H., Papadopoulos, S., Hescheler, J., Neumaier, F., Schneider, T., Prasad, K. R., Khan, K., Hemmersbach, R., Gusmao, E. G., et al. (2022) · iScience · doi:10.1016/j.isci.2022.104577 · Cited by 27 · see citing works
la Torre, G. G. D., Groemer, G. E., Diaz‐Artiles, A., Pattyn, N., Cutsem, J. V., Musilova, M., Kopeć, W., Schneider, S., Abeln, V., Larose, T. L., et al. (2024) · npj Microgravity · doi:10.1038/s41526-024-00437-w · Cited by 25 · see citing works
Medina, J. S. G., Sienkiewicz, K., Narayanan, S. A., Overbey, E. G., Grigorev, K. A., Ryon, K. A., Burke, M., Proszynski, J., Tierney, B. T., Schmidt, C. M., et al. (2024) · Precision Clinical Medicine · doi:10.1093/pcmedi/pbae007 · Cited by 25 · see citing works
Yamanouchi, S., Rhone, J., Mao, J., Fujiwara, K., Saganti, P. B., Takahashi, A., & Hada, M. (2020) · Life · doi:10.3390/life10090187 · Cited by 25 · see citing works
Self-citationAstroimmunology: the effects of spaceflight and its associated stressors on the immune system
Winer, D. A., Du, H., Kim, J., Chang, V., Burke, M., Winer, S., Costes, S. V., Frippiat, J., Sams, C. F., Paul, A. M., et al. (2025) · Nature reviews. Immunology · doi:10.1038/s41577-025-01226-6 · Cited by 26 · see citing works
Hibernation as a Tool for Radiation Protection in Space Exploration
Puspitasari, A., Cerri, M., Takahashi, A., Yoshida, Y., Hanamura, K., & Tinganelli, W. (2021) · Life · doi:10.3390/life11010054 · Cited by 24 · see citing works
Self-citationRadstake, W. E., Gautam, K., Miranda, S., Vermeesen, R., Tabury, K., Rehnberg, E., Buset, J., Janssen, A., Leysen, L., Neefs, M., et al. (2023) · Cells · doi:10.3390/cells12020246 · Cited by 23 · see citing works
Cancer Studies under Space Conditions: Finding Answers Abroad
Cortés-Sánchez, J. L., Callant, J., Krüger, M., Sahana, J., Kraus, A., Baselet, B., Infanger, M., Baatout, S., & Grimm, D. G. (2021) · Biomedicines · doi:10.3390/biomedicines10010025 · Cited by 22 · see citing works
3D microenvironment attenuates simulated microgravity-mediated changes in T cell transcriptome
ElGindi, M., Sapudom, J., Laws, P., Garcia‐Sabaté, A., Daqaq, M. F., & Teo, J. C. M. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04531-8 · Cited by 20 · see citing works
Gravity, Microgravity and Artificial Gravity: Physiological Effects, Implementation and Applications
Goswami, N., Blaber, A. P., Valenti, G., Hinghofer-Szalkay, H., Evans, J., Bailey, D. M., Vernikos, J., Choukér, A., Green, D. A., White, O., et al. (2026) · Physiological Reviews · doi:10.1152/physrev.00055.2024 · Cited by 25 · see citing works
Infections in long-duration space missions
Cowen, D., Zhang, R., & Komorowski, M. (2024) · The Lancet Microbe · doi:10.1016/s2666-5247(24)00098-3 · Cited by 22 · see citing works
Immunity in Space: Prokaryote Adaptations and Immune Response in Microgravity
Green, M. J., Aylott, J. W., Williams, P. M., Ghaemmaghami, A. M., & Williams, P. M. (2021) · Life · doi:10.3390/life11020112 · Cited by 21 · see citing works
Transcriptomic Effects on the Mouse Heart Following 30 Days on the International Space Station
Veliz, A. L., Mamoun, L., Hughes, L., Vega, R., Holmes, B., Monteon, A., Bray, J. M., Pecaut, M. J., & Kearns‐Jonker, M. (2023) · Biomolecules · doi:10.3390/biom13020371 · Cited by 21 · see citing works
Zhang, J., Yang, H., Sun, Y., Yan, B., Chen, W., & Fan, D. (2024) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.13418 · Cited by 20 · see citing works
Silvani, G., Bradbury, P., Basirun, C., Mehner, C., Zalli, D., Poole, K., & Chou, J. (2022) · npj Microgravity · doi:10.1038/s41526-022-00207-6 · Cited by 20 · see citing works
Overbey, E. G., Das, S., Cope, H., Madrigal, P., Andrusivová, Ž., Frapard, S., Klotz, R., Bezdan, D., Gupta, A. E., Scott, R. T., et al. (2022) · Cell Reports Methods · doi:10.1016/j.crmeth.2022.100325 · Cited by 22 · see citing works
Bonnefoy, J., Ghislin, S., Beyrend, J., Coste, F., Calcagno, G., Lartaud, I., Gauquelin‐Koch, G., Poussier, S., & Frippiat, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22062961 · Cited by 19 · see citing works
Nickerson, C. A., McLean, R. J. C., Barrila, J., Yang, J., Thornhill, S. G., Banken, L., Porterfield, D. M., Poste, G. H., Pellis, N. R., & Ott, C. M. (2024) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00144-23 · Cited by 18 · see citing works
Jacob, P., Bonnefoy, J., Ghislin, S., & Frippiat, J. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.952928 · Cited by 18 · see citing works
Transcriptomics analysis reveals molecular alterations underpinning spaceflight dermatology
Cope, H., Elsborg, J., Demharter, S., McDonald, J. T., Wernecke, C., Parthasarathy, H., Unadkat, H., Chatrathi, M., Claudio, J., Reinsch, S. S., et al. (2024) · Communications Medicine · doi:10.1038/s43856-024-00532-9 · Cited by 18 · see citing works
Impact of microgravity and lunar gravity on murine skeletal and immune systems during space travel
Okamura, Y., Gochi, K., Ishikawa, T., Hayashi, T., Fuseya, S., Suzuki, R., Kanai, M., Inoue, Y., Murakami, Y., Sadaki, S., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-79315-0 · Cited by 20 · see citing works
Self-citationInfluence of the spaceflight environment on macrophage lineages
An, R., Blackwell, V. K., Harandi, B. F., Gibbons, A. C., Siu, O., Irby, I., Rees, A., Cornejal, N., Sattler, K. M., Sheng, T., et al. (2024) · npj Microgravity · doi:10.1038/s41526-023-00293-0 · Cited by 13 · see citing works
Wang, J. L., Rosenbaum, J. J., Prasad, A. N., Raad, R. J., Putman, E. J., Harrington, A. D., Aintablian, H., & Hynek, B. M. (2025) · GeoHealth · doi:10.1029/2024gh001213 · Cited by 14 · see citing works
Gallardo-Dodd, C. J., Oertlin, C., Record, J., Galvani, R. G. A., Sommerauer, C., Kuznetsov, N. V., Doukoumopoulos, E., Ali, L., Oliveira, M. M. S., Seitz, C., et al. (2023) · Science Advances · doi:10.1126/sciadv.adg1610 · Cited by 11 · see citing works
Simulated Microgravity Affects Pro-Resolving Properties of Primary Human Monocytes
Leuti, A., Fava, M., Pellegrini, N., Forte, G., Fanti, F., Valle, F., Dominicis, N. D., Sergi, M., & Maccarrone, M. (2024) · Cells · doi:10.3390/cells13010100 · Cited by 11 · see citing works
Fonte, C., Jacob, P., Vanet, A., Ghislin, S., & Frippiat, J. (2023) · Immunity & Ageing · doi:10.1186/s12979-023-00393-1 · Cited by 10 · see citing works
Medical Astro-Microbiology: Current Role and Future Challenges
McDonagh, F., Cormican, M., Morris, D., Burke, L. P., Singh, N. K., Venkateswaran, K. J., & Miliotis, G. (2023) · Journal of the Indian Institute of Science · doi:10.1007/s41745-023-00360-1 · Cited by 10 · see citing works
Song, C., Kang, T., Gao, K., Shi, X., Zhang, M., Zhao, L., Zhou, L., & Guo, J. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e19355 · Cited by 9 · see citing works
Andrade, M. R., Azeez, T. A., Montgomery, M. M., Caldwell, J. T., Park, H., Kwok, A. T., Borg, A. M., Narayanan, S. A., Willey, J. S., Delp, M. D., et al. (2023) · The FASEB Journal · doi:10.1096/fj.202300506rr · Cited by 9 · see citing works
Kunitskaya, A., Piret, J. M., Buckley, N. D., & Low‐Décarie, É. (2022) · Acta Astronautica · doi:10.1016/j.actaastro.2022.09.019 · Cited by 7 · see citing works
Oral Health of Astronauts in Short- and Long-Term Missions in Space
FABBRO, M. D., Khijmatgar, S., Vandenberghe, B., Kijak, E., Kulesa-Mrowiecka, M., Singhal, I., Lorusso, F., Xavier, B. B., Sampson, V., Marfia, G., et al. (2025) · Aerospace Medicine and Human Performance · doi:10.3357/amhp.6372.2025 · Cited by 8 · see citing works
Thymus ad astra, or spaceflight-induced thymic involution
Muramatsu, W., Maryanovich, M., Akiyama, T., & Karagiannis, G. S. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1534444 · Cited by 6 · see citing works
Self-citationJasemi, S., Simula, E. R., Lin, Y., Satta, R. R., Rubino, C., Cossu, A., Fais, M., Noli, M., & Sechi, L. A. (2025) · Cancers · doi:10.3390/cancers17172737 · Cited by 6 · see citing works
Dermatologic Considerations for Spaceflight and Space Exploration
Zhao, M., Aintablian, H., Satcher, R. L., Daneshjou, R., & Rosenbach, M. A. (2024) · JID Innovations · doi:10.1016/j.xjidi.2024.100293 · Cited by 6 · see citing works
Designing a Novel Monitoring Approach for the Effects of Space Travel on Astronauts’ Health
Sakharkar, A., & Yang, J. P. (2023) · Life · doi:10.3390/life13020576 · Cited by 6 · see citing works
Morphogenesis in space offers challenges and opportunities for soft matter and biophysics
Amar, M. B., Ciarletta, P., & Haas, P. A. (2023) · Communications Physics · doi:10.1038/s42005-023-01242-9 · Cited by 7 · see citing works
Fisher, R., Baselet, B., Vermeesen, R., Moreels, M., Baatout, S., Rahiman, F., Miles, X., Nair, S., du Plessis, P., Engelbrecht, M., et al. (2020) · Frontiers in Physics · doi:10.3389/fphy.2020.568124 · Cited by 6 · see citing works
Pharmacological Innovations in Space: Challenges and Future Perspectives
Aksoyalp, Z. Ş., Temel, A., & Karpuz, M. (2024) · Pharmaceutical Research · doi:10.1007/s11095-024-03788-x · Cited by 6 · see citing works
Zhao, M., Ma, X., Zuo, Z., Wang, Y., Fang, Y., & Sun, Y. (2025) · Life Sciences · doi:10.1016/j.lfs.2025.123842 · Cited by 4 · see citing works
Receptors Implicated in Microgravity-Induced Bone Loss
Martinez, E. F., Pelegrine, A. A., & Holliday, L. S. (2024) · Receptors · doi:10.3390/receptors3020014 · Cited by 4 · see citing works
Spaceflight associated dry eye syndrome (SADES): Outflow biophysics and infection risk
Lee, R. S., Ong, J., Waisberg, E., Fanning, S. L., & Lee, A. G. (2025) · Journal of Space Safety Engineering · doi:10.1016/j.jsse.2025.04.004 · Cited by 4 · see citing works
Lipid Signalling in Human Immune Response and Bone Remodelling under Microgravity
Fava, M., Leuti, A., & Maccarrone, M. (2020) · Applied Sciences · doi:10.3390/app10124309 · Cited by 4 · see citing works
Impact of Microgravity on the Skin and the Process of Wound Healing
Yang, J., Sun, P., Jiang, N., Yue, Y., Li, Z., Guo, S., Chen, Z., Li, B., Chai, S., Lu, S.-Y., et al. (2021) · Microgravity Science and Technology · doi:10.1007/s12217-021-09907-2 · Cited by 4 · see citing works
HUMAN SIDE OF SPACE EXPLORATION AND HABITATION
Duda, K. R., Newman, D. J., Zhang, J., Meirhaeghe, N., & Zhou, H. L. (2021) · Wiley eBooks · doi:10.1002/9781119636113.ch56 · Cited by 5 · see citing works
Zaccaria, T., Bulut, O. P., Ferreira, A. V., Dona, M., Langereis, J. D., Mesman, R., Wesseling, J., van Niftrik, L., Netea, M. G., Rettberg, P., et al. (2025) · mBio · doi:10.1128/mbio.01099-25 · Cited by 3 · see citing works
Microgravity and cancer cells: from molecular mechanisms to therapeutic strategies
Jian, Y., Zhang, S., Xu, Y., He, C., Cai, Z., Wang, Z., & Chen, Q. (2026) · Cell Death Discovery · doi:10.1038/s41420-025-02836-8 · Cited by 3 · see citing works
Han, Y., Shi, S., Liu, S., & Gu, X. (2023) · Mathematical Biosciences & Engineering · doi:10.3934/mbe.2023374 · Cited by 3 · see citing works
Immunization induces inflammation in the mouse heart during spaceflight
Veliz, A. L., Hughes, L., Carrillo, D., Pecaut, M. J., & Kearns‐Jonker, M. (2025) · BMC Genomics · doi:10.1186/s12864-025-11426-y · Cited by 3 · see citing works
Adkins, A. M., Luyo, Z. N. M., Boden, A. F., Heerbrandt, R. S., Britten, R. A., Wellman, L. L., & Sanford, L. D. (2025) · Life · doi:10.3390/life15050747 · Cited by 3 · see citing works
Spaceflight exposome/microgravity effects on the psychoimmunoneuroendocrine system
Capri, M., Montano, N., Piccirillo, S., Narici, M. V., Ferranti, F., & Maccarrone, M. (2025) · npj Microgravity · doi:10.1038/s41526-025-00487-8 · Cited by 3 · see citing works
Phetruen, T., Thongdechsri, S., Khongthongdam, M., Channumsin, S., Meemon, K., & Chanarat, S. (2025) · Applied and Environmental Microbiology · doi:10.1128/aem.01435-25 · Cited by 3 · see citing works
Dynamic cellular responses to gravitational forces: Exploring the impact on white blood cell(s)
Murali, A., & Sarkar, R. R. (2024) · Biomicrofluidics · doi:10.1063/5.0216617 · Cited by 3 · see citing works
Schaefer, K., Dambuza, I. M., Dall’Angelo, S., Yuecel, R., Jaspars, M., Trembleau, L., Zanda, M., Brown, G. D., Netea, M. G., & Gow, N. A. R. (2020) · Microorganisms · doi:10.3390/microorganisms8071066 · Cited by 3 · see citing works
Piloted space flight and post-genomic technologies
Larina, I. M., Pastushkova, L. K., Kononikhin, A. S., Николаев, Е. Н., & Orlov, O. I. (2019) · REACH · doi:10.1016/j.reach.2020.100034 · Cited by 3 · see citing works
Medina, J. S. G., Narayanan, S., Sienkiewicz, K., Overbey, E. G., Grigorev, K. A., Ryon, K. A., Proszynski, J., Burke, M., Schmidt, C. M., Tierney, B. T., et al. (2023) · Research Square · doi:10.21203/rs.3.rs-2928049/v1 · Cited by 3 · see citing works
Lee, R. S., Kumar, R., Shah, J., Ong, J., Waisberg, E., & Tavakkoli, A. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17070847 · Cited by 3 · see citing works
Blum, R. C., Omrani, D., Kunitskaya, A., Snyder, J., Bui, C., Williams, P. M., Loftus, D. J., & Rothschild, L. J. (2026) · Frontiers in Space Technologies · doi:10.3389/frspt.2025.1692554 · Cited by 2 · see citing works
Ishii, H., Endo, R., Hamanaka, S., Hidaka, N., Miyauchi, M., Hagiwara, N., Miyao, T., Yamamori, T., Aiba, T., Akiyama, N., et al. (2024) · npj Microgravity · doi:10.1038/s41526-024-00423-2 · Cited by 2 · see citing works
Self-citationBuilding Better (Space) Babies: Bioastronautics, Bioethics, and Off-World Ectogenesis
Kendal, E. S. (2024) · Emerald Group Publishing Limited eBooks · doi:10.1108/978-1-83797-635-520241012 · Cited by 2 · see citing works
Cahill, B., & Braddock, M. (2022) · Journal of Human Earth and Future · doi:10.28991/hef-2022-03-03-04 · Cited by 2 · see citing works
Impacts of the Spaceflight to the Immune System
Sultonov, D. M., & Kim, Y. H. (2021) · The Korean Journal of Aerospace and Environmental Medicine · doi:10.46246/kjasem.210016 · Cited by 2 · see citing works
Space Medicine: Inspiring a new generation of physicians
Mian, A., & Mian, M. A. (2022) · Postgraduate Medical Journal · doi:10.1136/pmj-2022-141875 · Cited by 3 · see citing works
PATEL, O. V., Partridge, C., & Plaut, K. I. (2023) · Biomolecules · doi:10.3390/biom13050872 · Cited by 2 · see citing works
Fullstone, T. L., Fischer, L. F. J., Bohmeier, M., Frings‐Meuthen, P., Crucian, B. E., & Rathert, P. (2025) · Scientific Reports · doi:10.1038/s41598-025-17930-1 · Cited by 1 · see citing works
Microgravity-induced immune dysregulation: phase-specific profiles of differential gene expression.
Pelchat, M., Trudel, G., Rocheleau, L., Stratis, D., & Laneuville, O. (2025) · Biochemistry and Cell Biology · doi:10.1139/bcb-2025-0136 · Cited by 1 · see citing works
Gut microbiota and intervention of probiotics in spaceflight
Pradeep, N., Green, S. J., & Chaudhary, A. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-32904-3.00024-8 · Cited by 1 · see citing works
Trovão, N. S., Lucaci, A. G., Pradeep, N., Sethi, M., Bono, L. M., Singh, R. S., Clark, K. B., Zaksas, V., Burke, M., Caicedo, A., et al. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-32904-3.00009-1 · Cited by 1 · see citing works
Spaceflight alters the immune regulatory functions of neutrophil granulocytes on T lymphocytes
Tavukçuoğlu, E., Yanık, H., Güven, H. E., Yılmaz, K. B., & Esendağlı, G. (2025) · iScience · doi:10.1016/j.isci.2025.114380 · Cited by 1 · see citing works
Zhang, Y., Wang, S., Chen, J., Zhou, Y., Yu, X., Peng, R., Lu, L., Li, S., Tian, Z., Zhang, N., et al. (2025) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2025.110216 · Cited by 1 · see citing works
Lee, R. S., Ong, J., Waisberg, E., Suh, A., Kadipasaoglu, C. M., Mader, T. H., Gibson, C. R., Berdahl, J. P., Lee, A. G., Lee, A. G., et al. (2025) · Experimental Eye Research · doi:10.1016/j.exer.2025.110513 · Cited by 1 · see citing works
Llanos, P. J., Andrijauskaite, K., Duraisamy, V. V., Gangadharan, S. N., Morris, J., & Wargovich, M. J. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.05.13.443970 · Cited by 1 · see citing works
- Authors
- Akiyama, T., Horie, K., Hinoi, E., Hiraiwa, M., Kato, A., Maekawa, Y., Takahashi, A., & Furukawa, S.
- Affiliations
- RIKEN Center for Integrative Medical Sciences (JP)
- Gifu Pharmaceutical University (JP)
- Kanazawa University (JP)
- Institute of Medical Science, The University of Tokyo (JP)
- Gifu University (JP)
- Gunma University (JP)
- Japan Aerospace Exploration Agency (JP)
- Corresponding author
- Akiyama, Taishin
- ORCID
- Venue
- npj Microgravity
- Published
- 2020-05-07
- Volume
- 6
- Issue
- 1
- Pages
- 14-14
- ISSN
- 2373-8065 (ISSN-L)
- PMC
- PMC7206142
- OpenAlex
- W3022626511
- Cited by
- 132
- References
- 102
- Citations by year
- 2026: 9 · 2025: 28 · 2024: 31 · 2023: 18 · 2022: 15 · 2021: 20 · 2020: 9 · 2019: 1 · 2018: 1
- FWCI
- 1.98
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- npj Microgravity (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology (JP15H05935, JP15K21745, 16H01631, 18H04989, JP15H05945, 18H04968)
- Japan Society for the Promotion of Science (19K21582, 15H05935, 15K21745, 20H03478, 20H03441)
- Japan Aerospace Exploration Agency (JP15K21745)
- Institute of Space and Astronautical Science (JP15K21745, JP15H05943, JP15H05945, JP15H05935)
- Topics
- Health Sciences › Medicine › Physiology › Spaceflight effects on biology
- Life Sciences › Immunology and Microbiology › Immunology › Immunotoxicology and immune responses
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- spaceflight, adaptive immunity, immune system, microgravity, bone marrow, thymus, lymphocyte development, stress hormones, space radiation, immune response to pathogens, antitumor immunity, allergen response
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
