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Systematic analysis of ribophagy in human cells reveals bystander flux during selective autophagy
Open accessAbstract
Ribosomes are abundant cellular machines 1,2 that are regulated by assembly, supernumerary subunit turnover and nascent chain quality control mechanisms 1-5 . Moreover, nitrogen starvation in yeast has been reported to promote selective ribosome delivery to the vacuole in an autophagy conjugation system dependent manner, a process called 'ribophagy' 6,7 . However, whether ribophagy in mammals is selective or regulated is unclear. Using Ribo-Keima flux reporters, we find that starvation or mTOR inhibition promotes VPS34-dependent ribophagic flux, which, unlike yeast, is largely independent of ATG8 conjugation and occurs concomitantly with other cytosolic protein autophagic flux reporters 8,9 . Ribophagic flux was not induced upon inhibition of translational elongation or nascent chain uncoupling, but was induced in a comparatively selective manner under proteotoxic stress induced by arsenite 10 or chromosome mis-segregation 11 , dependent upon VPS34 and ATG8 conjugation. Unexpectedly, agents typically used to induce selective autophagy also promoted increased ribosome and cytosolic protein reporter flux, suggesting significant bulk or 'bystander' autophagy during what is often considered selective autophagy 12,13 . These results emphasize the importance of monitoring non-specific cargo flux when assessing selective autophagy pathways.
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“NUFIP1 has been identified as one of the receptors involved in this process, particularly in conditions requiring ribosomal recycling [212].”
From Ribosome Biogenesis as a Putative Bottleneck to Skeletal Muscle Hypertrophy: Mechanisms, Human Evidence, and Practical Modulators (2026) · cites this paper as [212]
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“Although excessive activation of ribophagy could compromise anabolic potential, a basal level of selective turnover is likely necessary to maintain a functional ribosomal pool during repeated cycles of loading and recovery [211,212].”
From Ribosome Biogenesis as a Putative Bottleneck to Skeletal Muscle Hypertrophy: Mechanisms, Human Evidence, and Practical Modulators (2026) · cites this paper as [212]
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Metadata
- Authors
- An, H., & Harper, J. W.
- Affiliations
- Harvard University (US)
- Corresponding author
- Harper, J. Wade
- Venue
- Nature Cell Biology
- Published
- 2017-12-11
- Volume
- 20
- Issue
- 2
- Pages
- 135-143
- ISSN
- 1465-7392 (ISSN-L)
- 1476-4679
- PMC
- PMC5786475
- OpenAlex
- W2774010248
- Cited by
- 181
- References
- 35
- Citations by year
- 2026: 13 · 2025: 17 · 2024: 25 · 2023: 13 · 2022: 17 · 2021: 25 · 2020: 27 · 2019: 29 · 2018: 15
- FWCI
- 15.20
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Nature Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- Funders
- National Institute of General Medical Sciences (R01GM095567)
- National Institute of Neurological Disorders and Stroke (R37NS083524)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
- Keywords
- ribophagy, selective autophagy, ribosome turnover, Vps34, ATG5, nutrient deprivation, mTOR inhibition, proteotoxic stress, arsenite, chromosome missegregation
- MeSH terms
- Autophagy-Related Protein 8 Family, Autophagy, Humans, Ribosomes, Vacuoles, Chromosome Segregation, Bystander Effect, Class III Phosphatidylinositol 3-Kinases, TOR Serine-Threonine Kinases
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