The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Targeting the perivascular niche sensitizes disseminated tumour cells to chemotherapy
Open accessAbstract
The presence of disseminated tumour cells (DTCs) in bone marrow is predictive of poor metastasis-free survival of patients with breast cancer with localized disease. DTCs persist in distant tissues despite systemic administration of adjuvant chemotherapy. Many assume that this is because the majority of DTCs are quiescent. Here, we challenge this notion and provide evidence that the microenvironment of DTCs protects them from chemotherapy, independent of cell cycle status. We show that chemoresistant DTCs occupy the perivascular niche (PVN) of distant tissues, where they are protected from therapy by vascular endothelium. Inhibiting integrin-mediated interactions between DTCs and the PVN, driven partly by endothelial-derived von Willebrand factor and vascular cell adhesion molecule 1, sensitizes DTCs to chemotherapy. Importantly, chemosensitization is achieved without inducing DTC proliferation or exacerbating chemotherapy-associated toxicities, and ultimately results in prevention of bone metastasis. This suggests that prefacing adjuvant therapy with integrin inhibitors is a viable clinical strategy to eradicate DTCs and prevent metastasis. Carlson et al. show that DTCs within the PVN are protected from chemotherapy; targeting interactions between DTCs and the PVN enhances chemosensitivity and prevents bone metastasis.
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The perivascular niche regulates breast tumour dormancy
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Self-citationA CXCL1 Paracrine Network Links Cancer Chemoresistance and Metastasis
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Self-citationSun, Y., Campisi, J., Higano, C., Beer, T. M., Porter, P., Coleman, I., True, L., & Nelson, P. S. (2012) · Nature Medicine · doi:10.1038/nm.2890 · Cited by 793
Self-citationDNA Damage-Mediated Induction of a Chemoresistant Niche
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An integrin β3-KRAS-RalB complex drives tumour stemness and resistance to EGFR inhibition
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Self-citationHoxb5 marks long-term haematopoietic stem cells and reveals a homogenous perivascular niche
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Ganesh, K., & Massagué, J. (2021) · Nature Medicine · doi:10.1038/s41591-020-01195-4 · Cited by 1,051
The Extracellular Matrix Modulates the Metastatic Journey
Kai, F., Drain, A. P., & Weaver, V. M. (2019) · Developmental Cell · doi:10.1016/j.devcel.2019.03.026 · Cited by 537
Fu, T., Dai, L.-J., Wu, S.-Y., Xiao, Y., Ma, D., Jiang, Y.-Z., & Shao, Z.-M. (2021) · Journal of Hematology & Oncology · doi:10.1186/s13045-021-01103-4 · Cited by 480
Cancer progression and the invisible phase of metastatic colonization
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Metadata
- Authors
- Carlson, P., Dasgupta, A., Grzelak, C. A., Kim, J., Barrett, A., Coleman, I. M., Shor, R. E., Goddard, E. T., Dai, J., Schweitzer, E. M., Lim, A. R., Crist, S. B., Cheresh, D. A., Nelson, P. S., Hansen, K. C., & Ghajar, C. M.
- Venue
- Nature Cell Biology
- Published
- 2019-01-21
- Volume
- 21
- Issue
- 2
- Pages
- 238-250
- ISSN
- 1465-7392 (ISSN-L)
- 1476-4679
- OpenAlex
- W2908812320
- Cited by
- 251
- References
- 10
- FWCI
- 13.15
- Type
- journal article
- Language
- en
- Open access
- green
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- Carlson, P., Dasgupta, A., Grzelak, C. A., Kim, J., Barrett, A., Coleman, I. M., Shor, R. E., Goddard, E. T., Dai, J., Schweitzer, E. M., Lim, A. R., Crist, S. B., Cheresh, D. A., Nelson, P. S., Hansen, K. C., & Ghajar, C. M. (2019). Targeting the perivascular niche sensitizes disseminated tumour cells to chemotherapy. Nature Cell Biology. https://doi.org/10.1038/s41556-018-0267-0
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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