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A P53-Phosphoinositide Signalosome Regulates Nuclear AKT Activation
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Abstract
The tumour suppressor p53 and PI3K-AKT pathways have fundamental roles in the regulation of cell growth and apoptosis, and are frequently mutated in cancer. Here, we show that genotoxic stress induces nuclear AKT activation through a p53-dependent mechanism that is distinct from the canonical membrane-localized PI3K-AKT pathway. Following genotoxic stress, a nuclear PI3K binds p53 in the non-membranous nucleoplasm to generate a complex of p53 and phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P 3), which recruits AKT, PDK1 and mTORC2 to activate AKT and phosphorylate FOXO proteins, thereby inhibiting DNA damage-induced apoptosis. Wild-type p53 activates nuclear AKT in an on/off fashion following stress, whereas mutant p53 dose-dependently stimulates high basal AKT activity. The p53-PtdIns(3,4,5)P 3 complex is dephosphorylated to p53-phosphatidylinositol 4,5-bisphosphate by PTEN to inhibit AKT activation. The nuclear p53-phosphoinositide signalosome is distinct from the canonical membrane-localized pathway and insensitive to PI3K inhibitors currently in the clinic, which underscores its therapeutic relevance.
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“While years of research have primarily investigated AKT signaling at the cell membrane, recent works by Chen et al. [71] and Choi et al. [61] have revealed that, under genotoxic stress, IPMK-generated nuclear PIP3 binds to p53, which activates nuclear AKT signaling and suppresses apoptosis.”
From From Obscurity to Prominence: IPMK’s Expanding Role in Cellular Signaling, Physiology, and Disease (2025) · cites this paper as [71]
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Metadata
- Authors
- Chen, M., Choi, S., Wen, T., Chen, C., Thapa, N., Lee, J. H., Cryns, V. L., & Anderson, R. A.
- Affiliations
- University of Wisconsin–Madison (US)
- Corresponding author
- Cryns, Vincent L.
- Anderson, Richard A.
- Venue
- Nature Cell Biology
- Published
- 2022-07
- Volume
- 24
- Issue
- 7
- Pages
- 1099-1113
- ISSN
- 1465-7392 (ISSN-L)
- 1476-4679
- PMC
- PMC9833102
- OpenAlex
- W4284709570
- Cited by
- 117
- References
- 73
- Citations by year
- 2026: 20 · 2025: 44 · 2024: 27 · 2023: 18 · 2022: 7
- FWCI
- 7.84
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- Nature Cell Biology (publishedVersion)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Department of Defense (W81XWH-17-1-025, W81XWH-17-1-0259)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › FOXO transcription factor regulation
- Keywords
- p53, PI3K/Akt signaling, phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 4,5-bisphosphate, PTEN, PDK1, mTORC2, genotoxic stress, DNA damage-induced apoptosis, tumour suppressor
- MeSH terms
- Cell Nucleus, Phosphatidylinositols, Tumor Suppressor Protein p53, Phosphatidylinositol 3-Kinases, Proto-Oncogene Proteins c-akt
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