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Cited by 52Cancer-related Molecular PathwaysPI3K/AKT/mTOR signaling in cancerProtein Kinase Regulation and GTPase Signaling

Inositol Polyphosphate Multikinase Is a Coactivator of P53-Mediated Transcription and Cell Death

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Xu, Risheng, Sen, Nilkantha, Paul, Bindu D., Snowman, Adele M., Rao, Feng, Vandiver, M. Scott, Xu, Jing, Snyder, Solomon H.·2013·Science Signaling
DOI 10.1126/scisignal.2003405PMC PMC4108196
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Abstract

By promoting p53 acetylation and activation, IPMK contributes to DNA damage–induced cell death.

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  1. [1]Vousden KH Lu X Live or let die: The cell’s response to p53 Nat Rev Cancer 2 594 604 2002 12154352
  2. [2]Chen Z Trotman LC Shaffer D Lin HK Dotan ZA Niki M Koutcher JA Scher HI Ludwig T Gerald W Cordon-Cardo C Pandolfi PP Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis Nature 436 725 730 2005 16079851 PMC1939938
  3. [3]Collado M Gil J Efeyan A Guerra C Schuhmacher AJ Barradas M Benguría A Zaballos A Flores JM Barbacid M Beach D Serrano M Tumour biology: Senescence in premalignant tumours Nature 436 642 2005 16079833
  4. [4]Bartkova J Horejsí Z Sehested M Nesland JM Rajpert-De Meyts E Skakkebaek NE Stucki M Jackson S Lukas J Bartek J DNA damage response mediators MDC1 and 53BP1: Constitutive activation and aberrant loss in breast and lung cancer, but not in testicular germ cell tumours Oncogene 26 7414 7422 2007 17546051
  5. [5]Voorhoeve PM le Sage C Schrier M Gillis AJ Stoop H Nagel R Liu YP van Duijse J Drost J Griekspoor A Zlotorynski E Yabuta N De Vita G Nojima H Looijenga LH Agami R A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors Cell 124 1169 1181 2006 16564011
  6. [7]Drost J Mantovani F Tocco F Elkon R Comel A Holstege H Kerkhoven R Jonkers J Voorhoeve PM Agami R Del Sal G BRD7 is a candidate tumour suppressor gene required for p53 function Nat Cell Biol 12 380 389 2010 20228809
  7. [9]Saiardi A Erdjument-Bromage H Snowman AM Tempst P Snyder SH Synthesis of diphosphoinositol pentakisphosphate by a newly identified family of higher inositol polyphosphate kinases Curr Biol 9 1323 1326 1999 10574768
  8. [10]Leyman A Pouillon V Bostan A Schurmans S Erneux C Pesesse X The absence of expression of the three isoenzymes of the inositol 1,4,5-trisphosphate 3-kinase does not prevent the formation of inositol pentakisphosphate and hexakisphosphate in mouse embryonic fibroblasts Cell Signal 19 1497 1504 2007 17355905
  9. [11]Chakraborty A Koldobskiy MA Bello NT Maxwell M Potter JJ Juluri KR Maag D Kim S Huang AS Dailey MJ Saleh M Snowman AM Moran TH Mezey E Snyder SH Inositol pyrophosphates inhibit Akt signaling, thereby regulating insulin sensitivity and weight gain Cell 143 897 910 2010 21145457 PMC3052691
  10. [12]Prasad A Jia Y Chakraborty A Li Y Jain SK Zhong J Roy SG Loison F Mondal S Sakai J Blanchard C Snyder SH Luo HR Inositol hexakisphosphate kinase 1 regulates neutrophil function in innate immunity by inhibiting phosphatidylinositol-(3,4,5)-trisphosphate signaling Nat Immunol 12 752 760 2011 21685907 PMC3140608
  11. [13]Saiardi A Sciambi C McCaffery JM Wendland B Snyder SH Inositol pyrophosphates regulate endocytic trafficking Proc Natl Acad Sci USA 99 14206 14211 2002 12391334 PMC137862
  12. [14]Luo HR Huang YE Chen JC Saiardi A Iijima M Ye K Huang Y Nagata E Devreotes P Snyder SH Inositol pyrophosphates mediate chemotaxis in Dictyostelium via pleckstrin homology domain-PtdIns(3,4,5)P3 interactions Cell 114 559 572 2003 13678580
  13. [15]Ponnusamy S Alderson NL Hama H Bielawski J Jiang JC Bhandari R Snyder SH Jazwinski SM Ogretmen B Regulation of telomere length by fatty acid elongase 3 in yeast. Involvement of inositol phosphate metabolism and Ku70/80 function J Biol Chem 283 27514 27524 2008 18694931 PMC2562072
  14. [16]Saiardi A Resnick AC Snowman AM Wendland B Snyder SH Inositol pyrophosphates regulate cell death and telomere length through phosphoinositide 3-kinase-related protein kinases Proc Natl Acad Sci USA 102 1911 1914 2005 15665079 PMC548528
  15. [17]Maag D Maxwell MJ Hardesty DA Boucher KL Choudhari N Hanno AG Ma JF Snowman AS Pietropaoli JW Xu R Storm PB Saiardi A Snyder SH Resnick AC Inositol polyphosphate multikinase is a physiologic PI3-kinase that activates Akt/PKB Proc Natl Acad Sci USA 108 1391 1396 2011 21220345 PMC3029688
  16. [18]Blind RD Suzawa M Ingraham HA Direct modification and activation of a nuclear receptor–PIP2 complex by the inositol lipid kinase IPMK Sci Signal 5 ra44 2012 22715467 PMC3395721
  17. [19]Kim S Kim SF Maag D Maxwell MJ Resnick AC Juluri KR Chakraborty A Koldobskiy MA Cha SH Barrow R Snowman AM Snyder SH Amino acid signaling to mTOR mediated by inositol polyphosphate multikinase Cell Metab 13 215 221 2011 21284988 PMC3042716
  18. [20]Gancedo C Flores CL Moonlighting proteins in yeasts Microbiol Mol Biol Rev 72 197 210 2008 18322039 PMC2268286
  19. [21]Bechet J Greenson M Wiame JM Mutations affecting the repressibility of arginine biosynthetic enzymes in Saccharomyces cerevisiae Eur J Biochem 12 31 39 1970 5434281
  20. [22]Dubois E Messenguy F Pleiotropic function of ArgRIIIp (Arg82p), one of the regulators of arginine metabolism in Saccharomyces cerevisiae. Role in expression of cell-type-specific genes Mol Gen Genet 243 315 324 1994 8043104
  21. [23]Messenguy F Dubois E Genetic evidence for a role for MCM1 in the regulation of arginine metabolism in Saccharomyces cerevisiae Mol Cell Biol 13 2586 2592 1993 8455631 PMC359592
  22. [25]Steger DJ Haswell ES Miller AL Wente SR O’Shea EK Regulation of chromatin remodeling by inositol polyphosphates Science 299 114 116 2003 12434012 PMC1458531
  23. [27]Resnick AC Snowman AM Kang BN Hurt KJ Snyder SH Saiardi A Inositol polyphosphate multikinase is a nuclear PI3-kinase with transcriptional regulatory activity Proc Natl Acad Sci USA 102 12783 12788 2005 16123124 PMC1200306
  24. [28]Gordaliza M García PA del Corral JM Castro MA Gómez-Zurita MA Podophyllotoxin: Distribution, sources, applications and new cytotoxic derivatives Toxicon 44 441 459 2004 15302526
  25. [29]Hande KR Etoposide: Four decades of development of a topoisomerase II inhibitor Eur J Cancer 34 1514 1521 1998 9893622
  26. [30]el-Deiry WS Tokino T Velculescu VE Levy DB Parsons R Trent JM Lin D Mercer WE Kinzler KW Vogelstein B WAF1, a potential mediator of p53 tumor suppression Cell 75 817 825 1993 8242752
  27. [31]Miyashita T Reed JC Tumor suppressor p53 is a direct transcriptional activator of the human bax gene Cell 80 293 299 1995 7834749
  28. [32]Nakano K Vousden KH PUMA, a novel proapoptotic gene, is induced by p53 Mol Cell 7 683 694 2001 11463392
  29. [33]Oltvai ZN Milliman CL Korsmeyer SJ Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death Cell 74 609 619 1993 8358790
  30. [34]Yu J Wang Z Kinzler KW Vogelstein B Zhang L PUMA mediates the apoptotic response to p53 in colorectal cancer cells Proc Natl Acad Sci USA 100 1931 1936 2003 12574499 PMC149936
  31. [35]Longley DB Harkin DP Johnston PG 5-Fluorouracil: Mechanisms of action and clinical strategies Nat Rev Cancer 3 330 338 2003 12724731
  32. [36]Tan C Tasaka H Yu KP Murphy ML Karnofsky DA Daunomycin, an anti-tumor antibiotic, in the treatment of neoplastic disease. Clinical evaluation with special reference to childhood leukemia Cancer 20 333 353 1967 4290058
  33. [37]Barlev NA Liu L Chehab NH Mansfield K Harris KG Halazonetis TD Berger SL Acetylation of p53 activates transcription through recruitment of coactivators/histone acetyltransferases Mol Cell 8 1243 1254 2001 11779500
  34. [38]Gu W Roeder RG Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain Cell 90 595 606 1997 9288740
  35. [40]Tang Y Zhao W Chen Y Zhao Y Gu W Acetylation is indispensable for p53 activation Cell 133 612 626 2008 18485870 PMC2914560
  36. [42]Endo-Streeter S Tsui MK Odom AR Block J York JD Structural studies and protein engineering of inositol phosphate multikinase J Biol Chem 287 35360 35369 2012 22896696 PMC3471723
  37. [43]Holmes W Jogl G Crystal structure of inositol phosphate multikinase 2 and implications for substrate specificity J Biol Chem 281 38109 38116 2006 17050532
  38. [45]Morrison BH Bauer JA Hu J Grane RW Ozdemir AM Chawla-Sarkar M Gong B Almasan A Kalvakolanu DV Lindner DJ Inositol hexakisphosphate kinase 2 sensitizes ovarian carcinoma cells to multiple cancer therapeutics Oncogene 21 1882 1889 2002 11896621 PMC2043497
  39. [46]Morrison BH Haney R Lamarre E Drazba J Prestwich GD Lindner DJ Gene deletion of inositol hexakisphosphate kinase 2 predisposes to aerodigestive tract carcinoma Oncogene 28 2383 2392 2009 19430495 PMC3171149
  40. [47]Koldobskiy MA Chakraborty A Werner JK Jr Snowman AM Juluri KR Vandiver MS Kim S Heletz S Snyder SH p53-mediated apoptosis requires inositol hexakisphosphate kinase-2 Proc Natl Acad Sci USA 107 20947 20951 2010 21078964 PMC3000257
  41. [48]Morrison BH Bauer JA Kalvakolanu DV Lindner DJ Inositol hexakisphosphate kinase 2 mediates growth suppressive and apoptotic effects of interferon-β in ovarian carcinoma cells J Biol Chem 276 24965 24970 2001 11337497 PMC2025680
  42. [49]Bosch D Saiardi A Arginine transcriptional response does not require inositol phosphate synthesis J Biol Chem 287 38347 38355 2012 22992733 PMC3488103
  43. [50]Dubois E Dewaste V Erneux C Messenguy F Inositol polyphosphate kinase activity of Arg82/ArgRIII is not required for the regulation of the arginine metabolism in yeast FEBS Lett 486 300 304 2000 11119723
  44. [52]Bae BI Xu H Igarashi S Fujimuro M Agrawal N Taya Y Hayward SD Moran TH Montell C Ross CA Snyder SH Sawa A p53 mediates cellular dysfunction and behavioral abnormalities in Huntington’s disease Neuron 47 29 41 2005 15996546
  45. [53]Cheng T Liu D Griffin JH Fernández JA Castellino F Rosen ED Fukudome K Zlokovic BV Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective Nat Med 9 338 342 2003 12563316
  46. [55]Nowak DE Tian B Brasier AR Two-step cross-linking method for identification of NF-κB gene network by chromatin immunoprecipitation Biotechniques 39 715 725 2005 16315372
  47. [56]Colell A Ricci JE Tait S Milasta S Maurer U Bouchier-Hayes L Fitzgerald P Guio-Carrion A Waterhouse NJ Li CW Mari B Barbry P Newmeyer DD Beere HM Green DR GAPDH and autophagy preserve survival after apoptotic cytochrome c release in the absence of caspase activation Cell 129 983 997 2007 17540177
  48. [57]Frade JM Rodríguez-Tébar A Barde YA Induction of cell death by endogenous nerve growth factor through its p75 receptor Nature 383 166 168 1996 8774880

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Authors
Xu, R., Sen, N., Paul, B. D., Snowman, A. M., Rao, F., Vandiver, M. S., Xu, J., & Snyder, S. H.
Affiliations
Johns Hopkins University (US)
Corresponding author
  • Xu, Risheng
  • Sen, Nilkantha
  • Snyder, Solomon H.
ORCID
Venue
Science Signaling
Publisher
American Association for the Advancement of Science (AAAS)
Published
2013-04-02
Volume
6
Issue
269
Pages
ra22-ra22
ISSN
  • 1937-9145 (ISSN-L)
  • 1945-0877
DOI
10.1126/scisignal.2003405
PMC
PMC4108196
OpenAlex
W2114706877
Cited by
52
References
9
Citations by year
2026: 1 · 2025: 5 · 2024: 3 · 2023: 2 · 2022: 4 · 2021: 2 · 2020: 2 · 2019: 5 · 2018: 2 · 2017: 6 · 2016: 5 · 2015: 6 · 2014: 5 · 2013: 4
FWCI
3.57
Type
journal article
Language
en
Open access
Locations
  • Science Signaling (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute on Drug Abuse (P50DA000266, DA000266)
Topics
  • Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Keywords
inositol polyphosphate multikinase, p53, transcriptional coactivator, P300, p53 acetylation, apoptosis, cell death, tumor suppression, transcriptional complex
MeSH terms
p300-CBP-Associated Factor, Acetylation, Animals, Antineoplastic Agents, Cell Survival, Cells, Cultured, Embryo, Mammalian, Etoposide, Fibroblasts, Humans, Promoter Regions, Genetic, Protein Binding, Proto-Oncogene Proteins, Transcription, Genetic, Blotting, Western, Trans-Activators, Tumor Suppressor Protein p53, Phosphotransferases (Alcohol Group Acceptor), Mice, Knockout, Reverse Transcriptase Polymerase Chain Reaction, RNA Interference, HCT116 Cells, Cell Line, Tumor, p300-CBP Transcription Factors, Apoptosis Regulatory Proteins, bcl-2-Associated X Protein, Mice

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