The challenge of identifying senescent cells

Gil, Jesús

doi:10.1038/s41556-023-01267-w

Cited by 58Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model OrganismsSingle-cell and spatial transcriptomics

The challenge of identifying senescent cells

Gil, Jesús·2023·Nature Cell Biology

DOI 10.1038/s41556-023-01267-w

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There is currently no single marker that is unique for senescent cells.
“Unfortunately, there is currently no single marker that is unique for senescent cells.19”
From Single-cell senescence identification reveals senescence heterogeneity, trajectory, and modulators (2024) · cites this paper as [19]
These markers are not universal, as some cell types express these markers at non-senescent stage.
“While these markers identify senescent cells in most of the biological contexts, they are not universal, as some cell types express these markers at non-senescent stage.7,19,21”
From Single-cell senescence identification reveals senescence heterogeneity, trajectory, and modulators (2024) · cites this paper as [19]

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Cellular Senescence: Defining a Path Forward
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Authors: Gil, J.
Affiliations: MRC London Institute of Medical Sciences (GB)
Corresponding author: Gil, Jesús
ORCID: Gil, Jesús
Venue: Nature Cell Biology
Publisher: Springer Science and Business Media LLC
Published: 2023-10-26
Volume: 25
Issue: 11
Pages: 1554-1556
ISSN: 1465-7392 (ISSN-L)
1476-4679
DOI: 10.1038/s41556-023-01267-w
OpenAlex: W4387966314
Cited by: 58
References: 15
Citations by year: 2026: 14 · 2025: 20 · 2024: 24
FWCI: 10.31
Type: journal article
Language: en
Open access: closed
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Nature Cell Biology (publishedVersion)
PubMed (publishedVersion)
Spiral (Imperial College London) (submittedVersion)
Funders: Cancer Research UK (28647)
Topics: Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Single-cell and spatial transcriptomics
Keywords: cellular senescence, senescence markers, senescence-associated heterochromatin foci, senescence-associated secretory phenotype, emerging technologies

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