The DOI matches its Crossref record; 66 of the 66 references it cites were found in a registry or an index.
Dual-function injectable angiogenic biomaterial for the repair of brain tissue following stroke
Open accessAbstract
Stroke is the primary cause of disability due to the brain's limited ability to regenerate damaged tissue. After stroke, an increased inflammatory and immune response coupled with severely limited angiogenesis and neuronal growth results in a stroke cavity devoid of normal brain tissue. In the adult, therapeutic angiogenic materials have been used to repair ischaemic tissues through the formation of vascular networks. However, whether a therapeutic angiogenic material can regenerate brain tissue and promote neural repair is poorly understood. Here we show that the delivery of an engineered immune-modulating angiogenic biomaterial directly to the stroke cavity promotes tissue formation de novo, and results in axonal networks along thee generated blood vessels. This regenerated tissue produces functional recovery through the established axonal networks. Thus, this biomaterials approach generates a vascularized network of regenerated functional neuronal connections within previously dead tissue and lays the groundwork for the use of angiogenic materials to repair other neurologically diseased tissues.Stimulation of angiogenesis after stroke is not always an effective therapy. An injectable hydrogel with pro-angiogenic and immune-modulating factors is now shown to support blood vessel, axonal and functional recovery following stroke.
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“5b(3), while showing a significantly increased use of contralateral digits in handling the pieces of food (Fig.”
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Self-Healing Injectable Hydrogels for Tissue Regeneration
Bertsch, P., Diba, M., Mooney, D. J., & Leeuwenburgh, S. C. G. (2023) · Chemical Reviews · doi:10.1021/acs.chemrev.2c00179 · Cited by 892
Design Challenges in Polymeric Scaffolds for Tissue Engineering
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Metadata
- Authors
- Nih, L. R., Gojgini, S., Carmichael, S. T., & Segura, T.
- Venue
- Nature Materials
- Published
- 2018-05-21
- Volume
- 17
- Issue
- 7
- Pages
- 642-651
- ISSN
- 1476-1122 (ISSN-L)
- 1476-4660
- OpenAlex
- W2803995469
- Cited by
- 323
- References
- 66
- FWCI
- 10.94
- Type
- journal article
- Language
- en
- Open access
- green
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- Nih, L. R., Gojgini, S., Carmichael, S. T., & Segura, T. (2018). Dual-function injectable angiogenic biomaterial for the repair of brain tissue following stroke. Nature Materials. https://doi.org/10.1038/s41563-018-0083-8
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
