The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Biomaterials and engineered microenvironments to control YAP/TAZ-dependent cell behaviour
Open accessAbstract
Mechanical signals are increasingly recognized as overarching regulators of cell behaviour, controlling stemness, organoid biology, tissue development and regeneration. Moreover, aberrant mechanotransduction is a driver of disease, including cancer, fibrosis and cardiovascular defects. A central question remains how cells compute a host of biomechanical signals into meaningful biological behaviours. Biomaterials and microfabrication technologies are essential to address this issue. Here we review a large body of evidence that connects diverse biomaterial-based systems to the functions of YAP/TAZ, two highly related mechanosensitive transcriptional regulators. YAP/TAZ orchestrate the response to a suite of engineered microenviroments, emerging as a universal control system for cells in two and three dimensions, in static or dynamic fashions, over a range of elastic and viscoelastic stimuli, from solid to fluid states. This approach may guide the rational design of technological and material-based platforms with dramatically improved functionalities and inform the generation of new biomaterials for regenerative medicine applications.Biomaterials have been utilized widely to study cellular mechanotransduction. This Review discusses how cells respond to mechanical cues elicited by a range of biomaterial characteristics via YAP/TAZ mechanosensitive transcriptional factor activity.
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1 retracted
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Cellular mechanotransduction in health and diseases: from molecular mechanism to therapeutic targets
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Loebel, C., Mauck, R. L., & Burdick, J. A. (2019) · Nature Materials · doi:10.1038/s41563-019-0307-6 · Cited by 402
Engineering Stem Cell Self-organization to Build Better Organoids
Brassard, J. A., & Lutolf, M. P. (2019) · Cell Stem Cell · doi:10.1016/j.stem.2019.05.005 · Cited by 373
Advances in Hydrogels in Organoids and Organs‐on‐a‐Chip
Liu, H., Wang, Y., Cui, K., Guo, Y., Zhang, X., & Qin, J. (2019) · Advanced Materials · doi:10.1002/adma.201902042 · Cited by 353
Bioengineering Approaches for the Advanced Organoid Research
Yi, S. A., Zhang, Y., Rathnam, C., Pongkulapa, T., & Lee, K. (2021) · Advanced Materials · doi:10.1002/adma.202007949 · Cited by 218
Metadata
- Authors
- Brusatin, G., Panciera, T., Gandin, A., Citron, A., & Piccolo, S.
- Venue
- Nature Materials
- Published
- 2018-10-29
- Volume
- 17
- Issue
- 12
- Pages
- 1063-1075
- ISSN
- 1476-1122 (ISSN-L)
- 1476-4660
- OpenAlex
- W2896782101
- Cited by
- 272
- References
- 16
- FWCI
- 12.41
- Type
- journal article
- Language
- en
- Open access
- green
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