The DOI matches its Crossref record; 102 of the 102 references it cites were found in a registry or an index.
Tracking virus outbreaks in the twenty-first century
Open accessAbstract
Emerging viruses have the potential to impose substantial mortality, morbidity and economic burdens on human populations. Tracking the spread of infectious diseases to assist in their control has traditionally relied on the analysis of case data gathered as the outbreak proceeds. Here, we describe how many of the key questions in infectious disease epidemiology, from the initial detection and characterization of outbreak viruses, to transmission chain tracking and outbreak mapping, can now be much more accurately addressed using recent advances in virus sequencing and phylogenetics. We highlight the utility of this approach with the hypothetical outbreak of an unknown pathogen, ‘Disease X’, suggested by the World Health Organization to be a potential cause of a future major epidemic. We also outline the requirements and challenges, including the need for flexible platforms that generate sequence data in real-time, and for these data to be shared as widely and openly as possible. This Review Article describes how recent advances in viral genome sequencing and phylogenetics have enabled key issues associated with outbreak epidemiology to be more accurately addressed, and highlights the requirements and challenges for generating, sharing and using such data when tackling a viral outbreak.
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Cites
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Self-citation
Cited by
Upham, N. S., Esselstyn, J. A., & Jetz, W. (2019) · PLOS Biology · doi:10.1371/journal.pbio.3000494 · Cited by 1,201
A Genomic Perspective on the Origin and Emergence of SARS-CoV-2
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Self-citationEstablishment and lineage dynamics of the SARS-CoV-2 epidemic in the UK
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Amplification-free CRISPR/Cas detection technology: challenges, strategies, and perspectives
Li, H., Xie, Y., Chen, F., Bai, H., Xiu, L., Zhou, X., Guo, X., Hu, Q., & Yin, K. (2023) · Chemical Society Reviews · doi:10.1039/d2cs00594h · Cited by 346
Metadata
- Authors
- Grubaugh, N. D., Ladner, J. T., Lemey, P., Pybus, O. G., Rambaut, A., Holmes, E. C., & Andersen, K. G.
- Venue
- Nature Microbiology
- Published
- 2018-12-13
- Volume
- 4
- Issue
- 1
- Pages
- 10-19
- ISSN
- 2058-5276 (ISSN-L)
- OpenAlex
- W2902664755
- Cited by
- 485
- References
- 102
- FWCI
- 31.81
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Grubaugh, N. D., Ladner, J. T., Lemey, P., Pybus, O. G., Rambaut, A., Holmes, E. C., & Andersen, K. G. (2018). Tracking virus outbreaks in the twenty-first century. Nature Microbiology. https://doi.org/10.1038/s41564-018-0296-2
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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