Cited by 634Cancer Immunotherapy and BiomarkersImmunotherapy and Immune ResponsesNanoparticle-Based Drug Delivery

The DOI matches its Crossref record; 139 of the 142 references it cites were found in a registry or an index.

Improving cancer immunotherapy through nanotechnology

Goldberg, Michael S.·2019·Nature reviews. Cancer

Open this paper in CoChat — free account

Abstract

The 2018 Nobel Prize in Physiology or Medicine was awarded to pioneers in the field of cancer immunotherapy, as the utility of leveraging a patient's coordinated and adaptive immune system to fight the patient's unique tumour has now been validated robustly in the clinic. Still, the proportion of patients who respond to immunotherapy remains modest (~15% objective response rate across indications), as tumours have multiple means of immune evasion. The immune system is spatiotemporally controlled, so therapies that influence the immune system should be spatiotemporally controlled as well, in order to maximize the therapeutic index. Nanoparticles and biomaterials enable one to program the location, pharmacokinetics and co-delivery of immunomodulatory compounds, eliciting responses that cannot be achieved upon administration of such compounds in solution. The convergence of cancer immunotherapy, nanotechnology, bioengineering and drug delivery is opportune, as each of these fields has matured independently to the point that it can now be used to complement the others substantively and rationally, rather than modestly and empirically. As a result, unmet needs increasingly can be addressed with deductive intention. This Review explores how nanotechnology and related approaches are being applied to augmenting both endogenous leukocytes and adoptively transferred ones by informing specificity, influencing localization and improving function.

Integrity signals

Registry

Crossref · 10.1038/s41568-019-0186-9

Cites

139 of 139 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Immunity, Inflammation, and Cancer
Grivennikov, S. I., Greten, F. R., & Karin, M. (2010) · Cell · doi:10.1016/j.cell.2010.01.025 · Cited by 10,755
Pembrolizumab versus Chemotherapy for PD-L1-Positive Non-Small-Cell Lung Cancer
Reck, M., Rodríguez-Abreu, D., Robinson, A. G., Hui, R., Csőszi, T., Fülöp, A., Gottfried, M., Peled, N., Tafreshi, A., Cuffe, S., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1606774 · Cited by 10,089
Understanding the tumor immune microenvironment (TIME) for effective therapy
Binnewies, M., Roberts, E. W., Kersten, K., Chan, V., Fearon, D. F., Merad, M., Coussens, L. M., Gabrilovich, D. I., Ostrand-Rosenberg, S., Hedrick, C. C., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0014-x · Cited by 6,145
Axicabtagene Ciloleucel CAR T-Cell Therapy in Refractory Large B-Cell Lymphoma
Neelapu, S. S., Locke, F. L., Bartlett, N. L., Lekakis, L. J., Miklos, D. B., Jacobson, C. A., Braunschweig, I., Oluwole, O. O., Siddiqi, T., Lin, Y., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1707447 · Cited by 6,030
Tisagenlecleucel in children and young adults with B-cell lymphoblastic leukemia
Maude, S. L., Laetsch, T. W., Buechner, J., Rives, S., Boyer, M., Bittencourt, H., Bader, P., Verneris, M. R., Stefanski, H. E., Myers, G. D., et al. (2018) · New England Journal of Medicine · doi:10.1056/nejmoa1709866 · Cited by 5,735
Primary, Adaptive, and Acquired Resistance to Cancer Immunotherapy
Sharma, P., Hu-Lieskovan, S., Wargo, J. A., & Ribas, A. (2017) · Cell · doi:10.1016/j.cell.2017.01.017 · Cited by 5,588
Analysis of nanoparticle delivery to tumours
Wilhelm, S., Tavares, A. J., Dai, Q., Ohta, S., Audet, J., Dvorak, H. F., & Chan, W. C. W. (2016) · Nature Reviews Materials · doi:10.1038/natrevmats.2016.14 · Cited by 5,218
mRNA vaccines — a new era in vaccinology
Pardi, N., Hogan, M. J., Porter, F. W., & Weissman, D. (2018) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2017.243 · Cited by 4,667
Nivolumab plus Ipilimumab versus Sunitinib in Advanced Renal-Cell Carcinoma
Motzer, R. J., Tannir, N. M., McDermott, D. F., Arén Frontera, O., Melichar, B., Choueiri, T. K., Plimack, E. R., Barthélémy, P., Porta, C., George, S., et al. (2018) · New England Journal of Medicine · doi:10.1056/nejmoa1712126 · Cited by 4,656
Genomic and Transcriptomic Features of Response to Anti-PD-1 Therapy in Metastatic Melanoma
Hugo, W., Zaretsky, J. M., Sun, L., Song, C., Moreno, B. H., Hu-Lieskovan, S., Berent-Maoz, B., Pang, J., Chmielowski, B., Cherry, G., et al. (2016) · Cell · doi:10.1016/j.cell.2016.02.065 · Cited by 3,448

Show all 142 references

Research works printed but not linked: 2

Luteijn, R. et al. SLC19A1 is a cyclic dinucleotide transporter. Preprint at bioRxiv https://www.biorxiv.org/content/10.1101/539767v1 (2019). · DOI
Nature Collection: Nobel Prize in Physiology or Medicine 2018, https://www.nature.com/collections/gqznlfngkz (2018).

Sorted by citations

Items 201–300 of 634

A Homotypic Membrane-Camouflaged Biomimetic Nanoplatform with Gold Nanocrystals for Synergistic Photothermal/Starvation/Immunotherapy
Li, Z., & Rong, L. (2021) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.1c04305 · Cited by 46
Magnetic Miniature Soft Robot with Reprogrammable Drug‐Dispensing Functionalities: Toward Advanced Targeted Combination Therapy
Yang, Z., Xu, C., Lee, J. X., & Lum, G. Z. (2024) · Advanced Materials · doi:10.1002/adma.202408750 · Cited by 51
Lipid nanoparticle‐mediated RNA delivery for immune cell modulation
Kim, E. H., Teerdhala, S. V., Padilla, M. S., Joseph, R. A., Li, J. J., Haley, R. M., & Mitchell, M. J. (2024) · European Journal of Immunology · doi:10.1002/eji.202451008 · Cited by 48
Impact of nanoparticle properties on immune cell interactions in the lymph node
Farooq, M. A., Johnston, A. P. R., & Trevaskis, N. L. (2024) · Acta Biomaterialia · doi:10.1016/j.actbio.2024.12.039 · Cited by 45
Reversal of the immunosuppressive tumor microenvironment by nanoparticle-based activation of immune-associated cells
Qi, F., Wang, M., Li, B., Lu, Z., Nie, G., & Li, S. (2020) · Acta Pharmacologica Sinica · doi:10.1038/s41401-020-0423-5 · Cited by 45
A Novel Immunomodulator Delivery Platform Based on Bacterial Biomimetic Vesicles for Enhanced Antitumor Immunity
Hua, L., Yang, Z., Li, W., Zhang, Q., Ren, Z., Ye, C., Zheng, X. W., Li, D., Long, Q., Bai, H., et al. (2021) · Advanced Materials · doi:10.1002/adma.202103923 · Cited by 45
Cell membrane-engineered nanoparticles for cancer therapy
Liu, W., & Huang, Y. (2022) · Journal of Materials Chemistry B · doi:10.1039/d2tb00709f · Cited by 44
Nanomedicine in Non-Small Cell Lung Cancer: From Conventional Treatments to Immunotherapy
García-Fernández, C., Fornaguera, C., & Borrós, S. (2020) · Cancers · doi:10.3390/cancers12061609 · Cited by 44
Nanomedicine enables spatiotemporally regulating macrophage-based cancer immunotherapy
Zhao, Y., Mamuti, M., An, H., Fang, X., Zhao, Y., & Wang, H. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.120552 · Cited by 44
The role of T-cells in head and neck squamous cell carcinoma: From immunity to immunotherapy
Damasio, M. P. S., Nascimento, C. S., de Andrade, L. M., de Oliveira, V. L., & Calzavara-Silva, C. E. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.1021609 · Cited by 46
NIR‐Activatable Heterostructured Nanoadjuvant CoP/NiCoP Executing Lactate Metabolism Interventions for Boosted Photocatalytic Hydrogen Therapy and Photoimmunotherapy
Yang, C., Zhang, J., Chang, M., Tan, J., Yuan, M., Bian, Y., Liu, B., Liu, Z., Wang, M., Ding, B., et al. (2023) · Advanced Materials · doi:10.1002/adma.202308774 · Cited by 43
Improving safety of cancer immunotherapy via delivery technology
Hu, D., Zhang, W., Tang, J., Zhou, Z., Liu, X., & Shen, Y. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.120407 · Cited by 43
Zebrafish Models for the Safety and Therapeutic Testing of Nanoparticles with a Focus on Macrophages
Pensado‐López, A., Fernández-Rey, J., Reimunde, P., Crecente‐Campo, J., Sanchez, L. E., & Torres, F. (2021) · Nanomaterials · doi:10.3390/nano11071784 · Cited by 46
Cyclodextrin nanosponges as potential anticancer drug delivery systems to be introduced into the market, compared with liposomes
Allahyari, S., Zahednezhad, F., Khatami, M., Hashemzadeh, N., Zakeri‐Milani, P., & Trotta, F. (2021) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2021.102931 · Cited by 43
Cancer Nanomedicines in an Evolving Oncology Landscape
Guo, P., Huang, J., & Moses, M. A. (2020) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2020.08.001 · Cited by 42
Synthetic multiepitope neoantigen DNA vaccine for personalized cancer immunotherapy
Yang, X., Fan, J., Wu, Y., Ma, Z., Huang, J., Zhang, Y., Zhou, Z. M., Mo, F., Liu, X., Yuan, H., et al. (2021) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2021.102443 · Cited by 42
Spherical Nucleic Acid Vaccine Structure Markedly Influences Adaptive Immune Responses of Clinically Utilized Prostate Cancer Targets
Teplensky, M. H., Dittmar, J. W., Qin, L., Wang, S., Evangelopoulos, M., Zhang, B., & Mirkin, C. A. (2021) · Advanced Healthcare Materials · doi:10.1002/adhm.202101262 · Cited by 42
Dual‐Responsive Supramolecular Polymeric Nanomedicine for Self‐Cascade Amplified Cancer Immunotherapy
Hu, W., Ye, B., Yu, G., Huang, Y., Wu, H., Ding, Y., Huang, F., Wang, W., & Mao, Z. (2024) · Advanced Science · doi:10.1002/advs.202305382 · Cited by 41
The advancements and prospective developments in anti-tumor targeted therapy
Leng, G., Duan, B., Liu, J., Song, L., Zhao, W., Wang, S., Hou, G., & Qu, J. (2024) · Neoplasia · doi:10.1016/j.neo.2024.101024 · Cited by 42
Moving Beyond the Pillars of Cancer Treatment: Perspectives From Nanotechnology
Siamof, C. M., Goel, S., & Cai, W. (2020) · Frontiers in Chemistry · doi:10.3389/fchem.2020.598100 · Cited by 41
Multifunctional Nano‐Biomaterials for Cancer Therapy via Inducing Enhanced Immunogenic Cell Death
Chen, Q., Li, C., & Wang, Q. (2023) · Small Methods · doi:10.1002/smtd.202201457 · Cited by 41
The Role of Different Immunocompetent Cell Populations in the Pathogenesis of Head and Neck Cancer—Regulatory Mechanisms of Pro- and Anti-Cancer Activity and Their Impact on Immunotherapy
Starska, K. (2023) · Cancers · doi:10.3390/cancers15061642 · Cited by 46
Biomaterials to regulate tumor extracellular matrix in immunotherapy
Zhang, Y., Dong, X., Zhang, Y., Chen, Z., Zhou, G., Chen, N., Shen, W., Yang, K., & Pei, P. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2024.10.010 · Cited by 40
Arginine-Based Poly(I:C)-Loaded Nanocomplexes for the Polarization of Macrophages Toward M1-Antitumoral Effectors
Dacoba, T. G., Anfray, C., Mainini, F., Allavena, P., Alonso, M. J., Andón, F. T., & Crecente‐Campo, J. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01412 · Cited by 41
Intracellular aggregation of peptide-reprogrammed small molecule nanoassemblies enhances cancer chemotherapy and combinatorial immunotherapy
Peng, J., Xiao, Y., Yang, Q., Liu, Q., Chen, Y., Shi, K., Hao, Y., Han, R., & Qian, Z. (2020) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2020.06.013 · Cited by 40
Plant Viruses and Bacteriophage-Based Reagents for Diagnosis and Therapy
Shukla, S., Hu, H., Cai, H., Chan, S. K., Boone, C. E., Beiss, V., Chariou, P. L., & Steinmetz, N. F. (2020) · Annual Review of Virology · doi:10.1146/annurev-virology-010720-052252 · Cited by 41
Development of a Localized Drug Delivery System with a Step-by-Step Cell Internalization Capacity for Cancer Immunotherapy
Li, X., Pan, J., Li, Y., Xu, F., Hou, J., Yang, G., & Zhou, S. (2022) · ACS Nano · doi:10.1021/acsnano.1c10892 · Cited by 41
Immunomodulating Hydrogels as Stealth Platform for Drug Delivery Applications
Rezaei, Z., Yilmaz‐Aykut, D., Tourk, F. M., Bassous, N. J., Barroso‐Zuppa, M., Shawl, A. I., Ashraf, S. M., Avcı, H., & Hassan, S. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14102244 · Cited by 41
Advances in kidney-targeted drug delivery systems
Chen, Z., Peng, H., & Zhang, C. (2020) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2020.119679 · Cited by 39
Tumor-permeated bioinspired theranostic nanovehicle remodels tumor immunosuppression for cancer therapy
Wang, H., Li, J., Wang, Z., Wang, Y., Xu, X., Gong, X., Wang, J., Zhang, Z., & Li, Y. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.120609 · Cited by 39
Polymersomes as a potential platform for cancer immunotherapy
Scheerstra, J. F., Wauters, A. C., Tel, J., Abdelmohsen, L. K. E. A., & van Hest, J. C. M. (2021) · Materials Today Advances · doi:10.1016/j.mtadv.2021.100203 · Cited by 41
Recent trends and advances in novel formulations as an armament in Bcl-2/Bax targeted breast cancer
Samia, S., Chary, P. S., Khan, O., & Mehra, N. K. (2024) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2024.123889 · Cited by 39
Nanotechnology enabled reactive species regulation in biosystems for boosting cancer immunotherapy
Zhang, M., Dai, Z., Theivendran, S., Gu, Z., Zhao, L., Song, H., Yang, Y., & Yu, C. (2020) · Nano Today · doi:10.1016/j.nantod.2020.101035 · Cited by 38
Engineered Multifunctional Nano‐ and Biological Materials for Cancer Immunotherapy
Brouillard, A., Deshpande, N., & Kulkarni, A. A. (2021) · Advanced Healthcare Materials · doi:10.1002/adhm.202001680 · Cited by 38
Recent Advances of Mesoporous Silica as a Platform for Cancer Immunotherapy
Yu, A., Dai, X., Wang, Z., Chen, H., Guo, B., & Huang, L. (2022) · Biosensors · doi:10.3390/bios12020109 · Cited by 38
Engineered drug delivery nanosystems for tumor microenvironment normalization therapy
Yang, B., Meng, F., Zhang, J., Chen, K., Meng, S., Cai, K., Zhao, Y., & Dai, L. (2023) · Nano Today · doi:10.1016/j.nantod.2023.101766 · Cited by 37
Immunostimulant citrus fruit-derived extracellular vesicle nanodrugs for malignant glioma immunochemotherapy
Li, J., Wang, X., Guo, H., Zhou, H., Sha, S., Yang, Y., Chen, J., Hao, X., Pan, J., Wang, Y., et al. (2024) · Chemical Engineering Journal · doi:10.1016/j.cej.2024.149463 · Cited by 36
Supramolecular co-assembly of self-adjuvanting nanofibrious peptide hydrogel enhances cancer vaccination by activating MyD88-dependent NF-κB signaling pathway without inflammation
Su, Q., Song, H., Huang, P., Zhang, C., Yang, J., Kong, D., & Wang, W. (2021) · Bioactive Materials · doi:10.1016/j.bioactmat.2021.03.041 · Cited by 37
Emerging Nanoparticle Strategies for Modulating Tumor-Associated Macrophage Polarization
Shi, L. D., & Gu, H. (2021) · Biomolecules · doi:10.3390/biom11121912 · Cited by 37
Progress in nanoparticle-based regulation of immune cells
Fan, Y.-N., Zhao, G., Zhang, Y., Ye, Q., Sun, Y., Shen, S., Liu, Y., Xu, C., & Wang, J. (2023) · Medical Review · doi:10.1515/mr-2022-0047 · Cited by 35
Pharmacological impact of microRNAs in head and neck squamous cell carcinoma: Prevailing insights on molecular pathways, diagnosis, and nanomedicine treatment
Bhattacharjee, B., Farhana, S. A., Rynjah, D., Hussain, S. M., Bora, S. C., Pegu, P., Sahu, R. K., & Khan, J. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1174330 · Cited by 35
Neutrophil-based Trojan horse containing polymer nano-therapeutics for sono-activatable ferroptosis-immunotherapy of orthotopic glioma
Ding, M., Zhu, A., Zhang, Y., Liu, J., Lin, L., Wang, X., & Li, J. (2024) · Nano Today · doi:10.1016/j.nantod.2024.102398 · Cited by 35
Realizing Cancer Precision Medicine by Integrating Systems Biology and Nanomaterial Engineering
Joo, J. I., Choi, M., Jang, S., Choi, S. R., Park, S., Shin, D., & Cho, K. (2020) · Advanced Materials · doi:10.1002/adma.201906783 · Cited by 35
Photoresponsive Polypeptide-Glycosylated Dendron Amphiphiles: UV-Triggered Polymersomes, OVA Release, and In Vitro Enhanced Uptake and Immune Response
Song, Y., Chen, Y., Li, P., & Dong, C. (2020) · Biomacromolecules · doi:10.1021/acs.biomac.0c01465 · Cited by 36
Enhancing Cancer Immunotherapy Treatment Goals by Using Nanoparticle Delivery System
Muluh, T. A., Chen, Z., Li, Y., Xiong, K., Jin, J., Fu, S., & Wu, J. (2021) · International Journal of Nanomedicine · doi:10.2147/ijn.s295300 · Cited by 35
Organizing Multi-Enzyme Systems into Programmable Materials for Biocatalysis
Seo, M., & Schmidt‐Dannert, C. (2021) · Catalysts · doi:10.3390/catal11040409 · Cited by 35
Advances in carbon nanomaterials for immunotherapy
Azevedo, S., Costa‐Almeida, R., Santos, S. G., Magalhães, F. D., & Pinto, A. M. (2022) · Applied Materials Today · doi:10.1016/j.apmt.2022.101397 · Cited by 35
Microfluidics‐Enabled Nanovesicle Delivers CD47/PD‐L1 Antibodies to Enhance Antitumor Immunity and Reduce Immunotoxicity in Lung Adenocarcinoma
Su, Z., Dong, S., Chen, Y., Huang, T., Qin, B., Yang, Q., Jiang, X., & Zou, C. (2023) · Advanced Science · doi:10.1002/advs.202206213 · Cited by 34
Anti-tumor immune potentiation targets-engineered nanobiotechnologies: Design principles and applications
Jiao, R., Lin, X., Zhang, Q., Zhang, Y., Qin, W., Yang, Q., Xu, C. S., Chen, F., & Zhang, K. (2023) · Progress in Materials Science · doi:10.1016/j.pmatsci.2023.101230 · Cited by 34
Bioactive metal-based nanomedicines for boosting anti-tumor immunity: Advance, challenge, and perspective
Pei, Z., Li, L., Yang, N., Sun, S., Jiang, N., & Cheng, L. (2024) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2024.215969 · Cited by 34
Cancer Nanomedicine Special Issue Review Anticancer Drug Delivery with Nanoparticles: Extracellular Vesicles or Synthetic Nanobeads as Therapeutic Tools for Conventional Treatment or Immunotherapy
Zocchi, M. R., Tosetti, F., Benelli, R., & Poggi, A. D. (2020) · Cancers · doi:10.3390/cancers12071886 · Cited by 35
Hydrogels for Engineering the Immune System
Li, X., Shou, Y., & Tay, A. K. P. (2021) · Advanced NanoBiomed Research · doi:10.1002/anbr.202000073 · Cited by 34
Remodeling tumor microenvironment with nanomedicines
Martin, J. D., Miyazaki, T., & Cabral, H. (2021) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1730 · Cited by 35
Silver Nanoparticles Exert Apoptotic Activity in Bladder Cancer 5637 Cells Through Alteration of Bax/Bcl-2 Genes Expression
Daei, S., Ziamajidi, N., Abbasalipourkabir, R., Aminzadeh, Z., & Vahabirad, M. (2022) · Chonnam Medical Journal · doi:10.4068/cmj.2022.58.3.102 · Cited by 36
Recent progress in cancer immunotherapy: Overview of current status and challenges
Darvishi, M., Tosan, F., Nakhaei, P., Manjili, D. A., Kharkouei, S. A., Alizadeh, A. M., Ilkhani, S., Khalafi, F., Zadeh, F. A., & Shafagh, S.-G. (2022) · Pathology - Research and Practice · doi:10.1016/j.prp.2022.154241 · Cited by 35
Biomedical applications of multinuclear Pt(II)/Ru(II)/Ir(III) metallo-supramolecular assemblies for intensive cancer therapy
Li, X., Zhao, X., Wang, W., Shi, Z., Zhang, Y., Tian, Q., Yao, Y., He, C., & Duan, C. (2023) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2023.215366 · Cited by 33
Bioresponsive engineered nanoparticles for immunomodulation
Hegde, M., Mishra, A., Banerjee, R., Bintee, B., Alqahtani, M. S., Abbas, M., Shanmugam, M. K., Drum, C. L., Sethi, G., Liu, L., et al. (2025) · BMC Medicine · doi:10.1186/s12916-025-04305-6 · Cited by 35
Nano‐Oncologicals: A Tortoise Trail Reaching New Avenues
Dacoba, T. G., Anthiya, S., Berrecoso, G., Fernández‐Mariño, I., Fernández‐Varela, C., Crecente‐Campo, J., Teijeiro‐Osorio, D., Torres, F., & Alonso, M. J. (2021) · Advanced Functional Materials · doi:10.1002/adfm.202009860 · Cited by 34
Nanomaterials with changeable physicochemical property for boosting cancer immunotherapy
Ni, Q., Xu, F., Wang, Y., Li, Y., Qing, G., Zhang, Y., Zhong, J., Li, J., & Liang, X. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.01.003 · Cited by 33
PEIGel: A biocompatible and injectable scaffold with innate immune adjuvanticity for synergized local immunotherapy
Xiao, Z., Wang, D., Wang, C., Chen, Z., Huang, C., Yuan, Y., Xie, L., Zhang, L., Xu, L., Zhang, M., et al. (2022) · Materials Today Bio · doi:10.1016/j.mtbio.2022.100297 · Cited by 34
Nanomaterials in Immunology: Bridging Innovative Approaches in Immune Modulation, Diagnostics, and Therapy
Croitoru, G.-A., Pîrvulescu, D.-C., Niculescu, A.-G., Epistatu, D., Rădulescu, M., Grumezescu, A. M., & Nicolae, C.-L. (2024) · Journal of Functional Biomaterials · doi:10.3390/jfb15080225 · Cited by 32
An erythrocyte-delivered photoactivatable oxaliplatin nanoprodrug for enhanced antitumor efficacy and immune response
Wang, N., Deng, Z., Zhu, Q., Zhao, J., Xie, K., Shi, P., Wang, Z., Chen, X., Wang, F., Shi, J., et al. (2021) · Chemical Science · doi:10.1039/d1sc02941j · Cited by 32
Nanotechnology-Based siRNA Delivery Systems to Overcome Tumor Immune Evasion in Cancer Immunotherapy
Deng, K., Yang, D., & Zhou, Y. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14071344 · Cited by 32
Trends and patterns in cancer nanotechnology research: A survey of NCI's caNanoLab and nanotechnology characterization laboratory
Ke, W., Crist, R. M., Clogston, J. D., Stern, S. T., Dobrovolskaia, M. A., Grodzinski, P. A., & Jensen, M. A. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114591 · Cited by 33
Nanotechnology‐Based CAR‐T Strategies for Improving Efficacy and Safety of Tumor Immunotherapy
Wang, X., Meng, F., Yen, Y., Li, R., & Liu, B. (2020) · Advanced Functional Materials · doi:10.1002/adfm.202004713 · Cited by 33
A Quenched Annexin V‐Fluorophore for the Real‐Time Fluorescence Imaging of Apoptotic Processes In Vitro and In Vivo
Kim, H., Kim, H. Y., Lee, E. Y., Choi, B. K., Jang, H., & Choi, Y. (2020) · Advanced Science · doi:10.1002/advs.202002988 · Cited by 31
Highway to Success—Developing Advanced Polymer Therapeutics
Ashford, M. B., England, R., & Akhtar, N. (2021) · Advanced Therapeutics · doi:10.1002/adtp.202000285 · Cited by 32
The effect of PEGylation on the efficacy and uptake of an immunostimulatory nanoparticle in the tumor immune microenvironment
Becicka, W. M., Bielecki, P. A., Lorkowski, M. E., Moon, T. J., Zhang, Y., Atukorale, P. U., Covarrubias, G., & Karathanasis, E. (2021) · Nanoscale Advances · doi:10.1039/d1na00308a · Cited by 33
Nanobody-armed T cells endow CAR-T cells with cytotoxicity against lymphoma cells
Wang, H., Wang, L., Li, Y., Li, G., Zhang, X., Jiang, D., Zhang, Y.-T. Y., Liu, L., Chu, Y., & Xu, G. (2021) · Cancer Cell International · doi:10.1186/s12935-021-02151-z · Cited by 31
New Advances in Nano-Drug Delivery Systems: Helicobacter pylori and Gastric Cancer
Zhu, X. Y., Su, T., Wang, S., Zhou, H.-Q., & Shi, W. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.834934 · Cited by 31
ROS-Responsive Nanocomplex of aPD-L1 and Cabazitaxel Improves Intratumor Delivery and Potentiates Radiation-Mediated Antitumor Immunity
Wang, J., Li, J., Wu, Y., Xu, X., Qian, X., Lei, Y., Liu, H., Zhang, Z., & Li, Y. (2022) · Nano Letters · doi:10.1021/acs.nanolett.2c03227 · Cited by 31
Advances in Nanotechnology for Cancer Immunoprevention and Immunotherapy: A Review
Koyande, N. P., Srivastava, R., Padmakumar, A., & Rengan, A. K. (2022) · Vaccines · doi:10.3390/vaccines10101727 · Cited by 32
Smart drug delivery systems to overcome drug resistance in cancer immunotherapy
Yi, W., Yan, D., Wang, D., & Li, Y. (2023) · Cancer Biology and Medicine · doi:10.20892/j.issn.2095-3941.2023.0009 · Cited by 31
GM-CSF augmented the photothermal immunotherapeutic outcome of self-driving gold nanoparticles against a mouse CT-26 colon tumor model
Dai, J., Li, J., Zhang, Y., Wen, Q., Lu, Y., Fan, Y., Zeng, F., Qian, Z., Zhang, Y., & Fu, S. (2023) · Biomaterials Research · doi:10.1186/s40824-023-00430-6 · Cited by 30
Targeting activation of cGAS-STING signaling pathway by engineered biomaterials for enhancing cancer immunotherapy
Liang, J., Jin, X., Deng, X., Huang, Q., Zhang, S., Chen, W., & Zhang, X. (2024) · Materials Today · doi:10.1016/j.mattod.2024.07.004 · Cited by 30
In situ extended immune activation instantly after tumor resection by oncolytic virus controls postoperative tumor recurrence
Guo, C., Gao, T., Xue, B., Zhang, L., Wang, S., Xiao, R., Kong, L., Zhang, Y., Xin, Q., Cao, Y., et al. (2025) · Cell Reports Medicine · doi:10.1016/j.xcrm.2025.102399 · Cited by 30
Organoid Polymer Functionality and Mode of Klebsiella pneumoniae Membrane Antigen Presentation Regulates Ex Vivo Germinal Center Epigenetics in Young and Aged B Cells
Graney, P. L., Lai, K., Post, S. E., Brito, I., Cyster, J. G., & Singh, A. K. (2020) · Advanced Functional Materials · doi:10.1002/adfm.202001232 · Cited by 30
In situ tuning proangiogenic factor-mediated immunotolerance synergizes the tumoricidal immunity via a hypoxia-triggerable liposomal bio-nanoreactor
Chen, C., Zhang, S., Zhang, R., Sun, P., Shi, C., Abdalla, M., Li, A., Xu, J., Du, W., Zhang, J., et al. (2020) · Theranostics · doi:10.7150/thno.50806 · Cited by 30
The combination of in situ photodynamic promotion and ion-interference to improve the efficacy of cancer therapy
Yang, P., Chang, Y., Zhang, J., Gao, F., Liu, X., Wei, Q., Ma, X., & Guo, Y. (2022) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2022.08.125 · Cited by 30
Biomembrane nanostructures: Multifunctional platform to enhance tumor chemoimmunotherapy via effective drug delivery
Jiang, X., Wu, L., Zhang, M., Zhang, T., Chen, C., Wu, Y., Yin, C., & Gao, J. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.08.002 · Cited by 30
Exploring nanocarriers as innovative materials for advanced drug delivery strategies in onco-immunotherapies
Tiwari, P., Shukla, R. P., Yadav, D. K., Panwar, D., Agarwal, N., Kumar, A., Singh, N., Bakshi, A. K., Marwaha, D., Gautam, S., et al. (2024) · Journal of Molecular Graphics and Modelling · doi:10.1016/j.jmgm.2024.108702 · Cited by 29
Advances in Immunomodulatory Mesoporous Silica Nanoparticles for Inflammatory and Cancer Therapies
Gu, B., Zhao, Q. P., & Ao, Y. (2024) · Biomolecules · doi:10.3390/biom14091057 · Cited by 29
Application of quantum dots in cancer diagnosis and treatment: Advances and perspectives
Li, M., Huang, Y. H., Shen, C., Wang, Y., Lin, Y., Wang, Z., Chen, N., & Luo, Y. (2024) · Nano Research · doi:10.26599/nr.2025.94907163 · Cited by 29
Nanomedicines modulating myeloid-derived suppressor cells for improving cancer immunotherapy
Dai, X., Ren, L. F., Liu, M., Cai, H., Zhang, H., Gong, Q., Gu, Z., & Luo, K. (2021) · Nano Today · doi:10.1016/j.nantod.2021.101163 · Cited by 29
Immunomodulatory and Antitumoral Activity of Gold Nanoparticles Synthesized by Red Algae Aqueous Extracts
González-Ballesteros, N., Diego-González, L., Lastra, M., Grimaldi, M., Cavazza, A., Bigi, F., Rodríguez-Argüelles, M. C., & Simón‐Vázquez, R. (2022) · Marine Drugs · doi:10.3390/md20030182 · Cited by 29
Lignin-assisted construction of sub-10 nm supramolecular self-assembly for photothermal immunotherapy and potentiating anti-PD-1 therapy against primary and distant breast tumors
Fan, X., Yue, T., Liu, A., Xie, X., Fang, W., Wei, Y., Zheng, H., Zheng, H., Zhou, M., Piao, J., et al. (2022) · Asian Journal of Pharmaceutical Sciences · doi:10.1016/j.ajps.2022.07.002 · Cited by 29
Synthetic lethal approaches to target cancers with loss of PTEN function
Ertay, A., Ewing, R. M., & Wang, Y. (2023) · Genes & Diseases · doi:10.1016/j.gendis.2022.12.015 · Cited by 29
Nanobiomaterials: exploring mechanistic roles in combating microbial infections and cancer
Rawat, N., Ahmad, N., Raturi, P., Singhvi, N., Sahai, N., & Kothiyal, P. (2023) · Discover Nano · doi:10.1186/s11671-023-03946-x · Cited by 29
Lipid-based nanoparticles for cancer immunotherapy
Fan, S., Han, H., Yan, Z., Lu, Y., He, B., & Zhang, Q. (2023) · Medical Review · doi:10.1515/mr-2023-0020 · Cited by 30
Cuproptosis Nanomedicine: Clinical challenges and opportunities for anti-tumor therapy
Liu, Y., Chen, G., You, X., & Wang, X. (2024) · Chemical Engineering Journal · doi:10.1016/j.cej.2024.153373 · Cited by 28
Design Strategies for Hyaluronic Acid-based Drug Delivery Systems in Cancer Immunotherapy
Rodella, G., Véronique Préat, A., Gallez, B., & Malfanti, A. (2025) · Journal of Controlled Release · doi:10.1016/j.jconrel.2025.113784 · Cited by 28
Exploiting Current Understanding of Hypoxia Mediated Tumour Progression for Nanotherapeutic Development
Feng, J., Byrne, N. M., Al-Jamal, W. T., & Coulter, J. A. (2019) · Cancers · doi:10.3390/cancers11121989 · Cited by 29
Engineering immunogenic cell death with nanosized drug delivery systems improving cancer immunotherapy
Yan, W., Lang, T., Qi, X., & Li, Y. (2020) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2020.06.007 · Cited by 28
Targeted Activation of T Cells with IL-2-Coupled Nanoparticles
Raker, V., Becker, C., Landfester, K., & Steinbrink, K. (2020) · Cells · doi:10.3390/cells9092063 · Cited by 28
Nanotechnology-enabled Chemodynamic Therapy and Immunotherapy
Wang, T., Xu, X., & Zhang, K. (2021) · Current Cancer Drug Targets · doi:10.2174/1568009621666210219101552 · Cited by 28
Immunotherapy for Tumor Metastasis by Artificial Antigen-Presenting Cells via Targeted Microenvironment Regulation and T-Cell Activation
Lu, Y., Li, L., Du, J., Chen, J., Xu, X., Yang, X., Ding, C., & Mao, C. (2021) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.1c17498 · Cited by 28
Recent Advances in Engineering Nanomedicines for Second Near-Infrared Photothermal-Combinational Immunotherapy
Wang, F., Zhu, J., Wang, Y.-T., & Li, J. (2022) · Nanomaterials · doi:10.3390/nano12101656 · Cited by 28
Image-guided in situ cancer vaccination with combination of multi-functional nano-adjuvant and an irreversible electroporation technique
Han, J., Lee, Y. Y., Shin, H. E., Han, J., Kang, J. M., Wang, C. J., Park, J., Kim, S.-N., Yoon, J.-H., Kwon, H., et al. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2022.121762 · Cited by 28
Cancer immunotherapies revisited: state of the art of conventional treatments and next-generation nanomedicines
García-Fernández, C., Saz, A., Fornaguera, C., & Borrós, S. (2021) · Cancer Gene Therapy · doi:10.1038/s41417-021-00333-5 · Cited by 30
The Comprehensive “Omics” Approach from Metabolomics to Advanced Omics for Development of Immune Checkpoint Inhibitors: Potential Strategies for Next Generation of Cancer Immunotherapy
Yoon, S. J., Lee, C. B., Chae, S. U., Jo, S. J., & Bae, S. K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22136932 · Cited by 27

Authors: Goldberg, M. S.
Affiliations: Massachusetts Institute of Technology (US)
Corresponding author: Goldberg, Michael S.
ORCID: Goldberg, Michael S.
Venue: Nature reviews. Cancer
Publisher: Springer Science and Business Media LLC
Published: 2019-09-06
Volume: 19
Issue: 10
Pages: 587-602
ISSN: 1474-175X (ISSN-L)
1474-1768
DOI: 10.1038/s41568-019-0186-9
OpenAlex: W2972159813
Cited by: 628
References: 142
Citations by year: 2026: 44 · 2025: 67 · 2024: 81 · 2023: 98 · 2022: 114 · 2021: 122 · 2020: 92 · 2019: 10
FWCI: 8.06
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature reviews. Cancer (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Keywords: cancer immunotherapy, nanotechnology, nanoparticles, biomaterials, drug delivery, immune evasion, spatiotemporal control, pharmacokinetics, co-delivery, adoptive immunotherapy, tumor targeting, nanomedicine
MeSH terms: Animals, Biocompatible Materials, Humans, Immune System, Immunologic Factors, Immunotherapy, Leukocytes, Neoplasms, Nucleic Acids, T-Lymphocytes, Drug Delivery Systems, Adoptive Transfer, Nanomedicine, Nanoparticles

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Improving cancer immunotherapy through nanotechnology

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks