Cited by 634Cancer Immunotherapy and BiomarkersImmunotherapy and Immune ResponsesNanoparticle-Based Drug Delivery

The DOI matches its Crossref record; 139 of the 142 references it cites were found in a registry or an index.

Improving cancer immunotherapy through nanotechnology

Goldberg, Michael S.·2019·Nature reviews. Cancer

Open this paper in CoChat — free account

Abstract

The 2018 Nobel Prize in Physiology or Medicine was awarded to pioneers in the field of cancer immunotherapy, as the utility of leveraging a patient's coordinated and adaptive immune system to fight the patient's unique tumour has now been validated robustly in the clinic. Still, the proportion of patients who respond to immunotherapy remains modest (~15% objective response rate across indications), as tumours have multiple means of immune evasion. The immune system is spatiotemporally controlled, so therapies that influence the immune system should be spatiotemporally controlled as well, in order to maximize the therapeutic index. Nanoparticles and biomaterials enable one to program the location, pharmacokinetics and co-delivery of immunomodulatory compounds, eliciting responses that cannot be achieved upon administration of such compounds in solution. The convergence of cancer immunotherapy, nanotechnology, bioengineering and drug delivery is opportune, as each of these fields has matured independently to the point that it can now be used to complement the others substantively and rationally, rather than modestly and empirically. As a result, unmet needs increasingly can be addressed with deductive intention. This Review explores how nanotechnology and related approaches are being applied to augmenting both endogenous leukocytes and adoptively transferred ones by informing specificity, influencing localization and improving function.

Integrity signals

Registry

Crossref · 10.1038/s41568-019-0186-9

Cites

139 of 139 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Immunity, Inflammation, and Cancer
Grivennikov, S. I., Greten, F. R., & Karin, M. (2010) · Cell · doi:10.1016/j.cell.2010.01.025 · Cited by 10,755
Pembrolizumab versus Chemotherapy for PD-L1-Positive Non-Small-Cell Lung Cancer
Reck, M., Rodríguez-Abreu, D., Robinson, A. G., Hui, R., Csőszi, T., Fülöp, A., Gottfried, M., Peled, N., Tafreshi, A., Cuffe, S., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1606774 · Cited by 10,089
Understanding the tumor immune microenvironment (TIME) for effective therapy
Binnewies, M., Roberts, E. W., Kersten, K., Chan, V., Fearon, D. F., Merad, M., Coussens, L. M., Gabrilovich, D. I., Ostrand-Rosenberg, S., Hedrick, C. C., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0014-x · Cited by 6,145
Axicabtagene Ciloleucel CAR T-Cell Therapy in Refractory Large B-Cell Lymphoma
Neelapu, S. S., Locke, F. L., Bartlett, N. L., Lekakis, L. J., Miklos, D. B., Jacobson, C. A., Braunschweig, I., Oluwole, O. O., Siddiqi, T., Lin, Y., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1707447 · Cited by 6,030
Tisagenlecleucel in children and young adults with B-cell lymphoblastic leukemia
Maude, S. L., Laetsch, T. W., Buechner, J., Rives, S., Boyer, M., Bittencourt, H., Bader, P., Verneris, M. R., Stefanski, H. E., Myers, G. D., et al. (2018) · New England Journal of Medicine · doi:10.1056/nejmoa1709866 · Cited by 5,735
Primary, Adaptive, and Acquired Resistance to Cancer Immunotherapy
Sharma, P., Hu-Lieskovan, S., Wargo, J. A., & Ribas, A. (2017) · Cell · doi:10.1016/j.cell.2017.01.017 · Cited by 5,588
Analysis of nanoparticle delivery to tumours
Wilhelm, S., Tavares, A. J., Dai, Q., Ohta, S., Audet, J., Dvorak, H. F., & Chan, W. C. W. (2016) · Nature Reviews Materials · doi:10.1038/natrevmats.2016.14 · Cited by 5,218
mRNA vaccines — a new era in vaccinology
Pardi, N., Hogan, M. J., Porter, F. W., & Weissman, D. (2018) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2017.243 · Cited by 4,667
Nivolumab plus Ipilimumab versus Sunitinib in Advanced Renal-Cell Carcinoma
Motzer, R. J., Tannir, N. M., McDermott, D. F., Arén Frontera, O., Melichar, B., Choueiri, T. K., Plimack, E. R., Barthélémy, P., Porta, C., George, S., et al. (2018) · New England Journal of Medicine · doi:10.1056/nejmoa1712126 · Cited by 4,656
Genomic and Transcriptomic Features of Response to Anti-PD-1 Therapy in Metastatic Melanoma
Hugo, W., Zaretsky, J. M., Sun, L., Song, C., Moreno, B. H., Hu-Lieskovan, S., Berent-Maoz, B., Pang, J., Chmielowski, B., Cherry, G., et al. (2016) · Cell · doi:10.1016/j.cell.2016.02.065 · Cited by 3,448

Show all 142 references

Research works printed but not linked: 2

Luteijn, R. et al. SLC19A1 is a cyclic dinucleotide transporter. Preprint at bioRxiv https://www.biorxiv.org/content/10.1101/539767v1 (2019). · DOI
Nature Collection: Nobel Prize in Physiology or Medicine 2018, https://www.nature.com/collections/gqznlfngkz (2018).

Sorted by citations

Macrophages as tools and targets in cancer therapy
Mantovani, A., Allavena, P., Marchesi, F., & Garlanda, C. (2022) · Nature Reviews Drug Discovery · doi:10.1038/s41573-022-00520-5 · Cited by 1,807
mRNA vaccines for infectious diseases: principles, delivery and clinical translation
Chaudhary, N., Weissman, D., & Whitehead, K. A. (2021) · Nature Reviews Drug Discovery · doi:10.1038/s41573-021-00283-5 · Cited by 1,555
The evolution of commercial drug delivery technologies
Vargason, A. M., Anselmo, A. C., & Mitragotri, S. (2021) · Nature Biomedical Engineering · doi:10.1038/s41551-021-00698-w · Cited by 1,361
DNA damage response signaling pathways and targets for radiotherapy sensitization in cancer
Huang, R., & Zhou, P. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-0150-x · Cited by 1,288
Improving cancer immunotherapy using nanomedicines: progress, opportunities and challenges
Martin, J. D., Cabral, H., Stylianopoulos, T., & Jain, R. K. (2020) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-019-0308-z · Cited by 691
Immunogenic Cell Death Activates the Tumor Immune Microenvironment to Boost the Immunotherapy Efficiency
Li, Z., Lai, X., Fu, S., Ren, L. F., Cai, H., Zhang, H., Gu, Z., Ma, X., & Luo, K. (2022) · Advanced Science · doi:10.1002/advs.202201734 · Cited by 704
Vaccination with early ferroptotic cancer cells induces efficient antitumor immunity
Efimova, I., Catanzaro, E., der Meeren, L. V., Turubanova, V. D., Hammad, H., Mishchenko, T. A., Vedunova, M. V., Fimognari, C., Bachert, C., Coppieters, F., et al. (2020) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2020-001369 · Cited by 552
Multifunctional biomolecule nanostructures for cancer therapy
Wang, J., Li, Y., & Nie, G. (2021) · Nature Reviews Materials · doi:10.1038/s41578-021-00315-x · Cited by 513
Multifunctional mesoporous silica nanoparticles for biomedical applications
Xu, B., Li, S., Shi, R., & Liu, H. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01654-7 · Cited by 500
Recent Advances in Hyperthermia Therapy‐Based Synergistic Immunotherapy
Chang, M., Hou, Z., Wang, M., Li, C., & Lin, J. (2020) · Advanced Materials · doi:10.1002/adma.202004788 · Cited by 457
Activatable polymer nanoagonist for second near-infrared photothermal immunotherapy of cancer
Jiang, Y., Huang, J., Xu, C., & Pu, K. (2021) · Nature Communications · doi:10.1038/s41467-021-21047-0 · Cited by 444
cGAS-STING pathway in cancer biotherapy
Wang, Y., Luo, J., Alu, A., Han, X., Wei, Y., & Wei, X. (2020) · Molecular Cancer · doi:10.1186/s12943-020-01247-w · Cited by 412
Chemical and Biomolecular Strategies for STING Pathway Activation in Cancer Immunotherapy
Garland, K. M., Sheehy, T. L., & Wilson, J. T. (2022) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00750 · Cited by 372
Near-infrared photoactivated nanomedicines for photothermal synergistic cancer therapy
Sun, H., Zhang, Q., Li, J., Peng, S., Wang, X., & Cai, R. (2021) · Nano Today · doi:10.1016/j.nantod.2020.101073 · Cited by 336
Phenolic-enabled nanotechnology: versatile particle engineering for biomedicine
Wu, D., Zhou, J., Creyer, M. N., Yim, W., Chen, Z., Messersmith, P. B., & Jokerst, J. V. (2021) · Chemical Society Reviews · doi:10.1039/d0cs00908c · Cited by 322
Nanomaterials for T-cell cancer immunotherapy
Gong, N., Sheppard, N. C., Billingsley, M. M., June, C. H., & Mitchell, M. J. (2021) · Nature Nanotechnology · doi:10.1038/s41565-020-00822-y · Cited by 316
COVID-19 mRNA vaccines: Platforms and current developments
Szabó, G. T., Mahiny, A. J., & Vlatkovic, I. (2022) · Molecular Therapy · doi:10.1016/j.ymthe.2022.02.016 · Cited by 308
Molecular and nanoengineering approaches towards activatable cancer immunotherapy
Zhang, C., & Pu, K. (2020) · Chemical Society Reviews · doi:10.1039/c9cs00773c · Cited by 301
Carbon-based nanozymes: Design, catalytic mechanism, and bioapplication
Sun, Y., Xu, B., Pan, X., Wang, H., Wu, Q., Li, S., Jiang, B., & Liu, H. (2022) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2022.214896 · Cited by 292
Personalized Cancer Vaccines: Clinical Landscape, Challenges, and Opportunities
Shemesh, C. S., Hsu, J., Hosseini, I., Shen, B., Rotte, A., Twomey, P. L., Girish, S., & Wu, B. M. (2020) · Molecular Therapy · doi:10.1016/j.ymthe.2020.09.038 · Cited by 292
Cancer nanotechnology: current status and perspectives
Kemp, J. A., & Kwon, Y. J. (2021) · Nano Convergence · doi:10.1186/s40580-021-00282-7 · Cited by 290
Delivery of mRNA vaccine with a lipid-like material potentiates antitumor efficacy through Toll-like receptor 4 signaling
Zhang, H., You, X., Wang, X., Cui, L., Wang, Z., Xu, F., Li, M., Yang, Z., Liu, J., Huang, P., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2005191118 · Cited by 252
Advanced nanomedicines for the treatment of inflammatory diseases
Brusini, R., Varna, M., & Couvreur, P. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.07.010 · Cited by 250
Chemically and Biologically Engineered Bacteria‐Based Delivery Systems for Emerging Diagnosis and Advanced Therapy
Li, Z., Wang, Y., Liu, J., Rawding, P. A., Bu, J., Hong, S., & Hu, Q. (2021) · Advanced Materials · doi:10.1002/adma.202102580 · Cited by 247
A Polymer Multicellular Nanoengager for Synergistic NIR‐II Photothermal Immunotherapy
Xu, C., Jiang, Y., Han, Y., Pu, K., & Zhang, R. (2021) · Advanced Materials · doi:10.1002/adma.202008061 · Cited by 236
The Coppery Age: Copper (Cu)‐Involved Nanotheranostics
Dong, C., Feng, W., Xu, W., Yu, L., Xiang, H., Chen, Y., & Zhou, J. (2020) · Advanced Science · doi:10.1002/advs.202001549 · Cited by 236
Ferroptosis-driven nanotherapeutics for cancer treatment
Shan, X., Li, S., Sun, B., Chen, Q., Sun, J., He, Z., & Luo, C. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.01.008 · Cited by 209
Nanoscale CaH2 materials for synergistic hydrogen-immune cancer therapy
Gong, F., Xu, J., Liu, B., Yang, N., Cheng, L., Huang, P., Wang, C., Chen, Q., Ni, C., & Liu, Z. (2021) · Chem · doi:10.1016/j.chempr.2021.11.020 · Cited by 205
Supramolecular Nanofibrils Formed by Coassembly of Clinically Approved Drugs for Tumor Photothermal Immunotherapy
Li, S., Zhang, W., Xing, R., Yuan, C., Xue, H., & Yan, X. (2021) · Advanced Materials · doi:10.1002/adma.202100595 · Cited by 200
Sheddable Prodrug Vesicles Combating Adaptive Immune Resistance for Improved Photodynamic Immunotherapy of Cancer
Gao, A., Chen, B., Gao, J., Zhou, F., Saeed, M., Hou, B., Li, Y., & Yu, H. (2019) · Nano Letters · doi:10.1021/acs.nanolett.9b04012 · Cited by 198
Precision-engineered metal and metal-oxide nanoparticles for biomedical imaging and healthcare applications
Truong, T. T., Mondal, S. A., Doan, V. H. M., Tak, S., Choi, J., Oh, H., Nguyen, T. D., Misra, M., Lee, B., & Oh, J. (2024) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2024.103263 · Cited by 193
Bioengineered nanogels for cancer immunotherapy
Ma, X., Li, S., Liu, Y., Zhang, T., Xue, P., Kang, Y., Sun, Z., & Xu, Z. (2022) · Chemical Society Reviews · doi:10.1039/d2cs00247g · Cited by 186
Precision cancer sono-immunotherapy using deep-tissue activatable semiconducting polymer immunomodulatory nanoparticles
Li, J., Luo, Y., Zeng, Z., Cui, D. M., Huang, J., Xu, C., Li, L., Pu, K., & Zhang, R. (2022) · Nature Communications · doi:10.1038/s41467-022-31551-6 · Cited by 184
Advances in synthetic lethality for cancer therapy: cellular mechanism and clinical translation
Topatana, W., Juengpanich, S., Li, S., Cao, J., Hu, J., Lee, J., Suliyanto, K., Ma, D., Zhang, B., Chen, M., et al. (2020) · Journal of Hematology & Oncology · doi:10.1186/s13045-020-00956-5 · Cited by 193
A Biomimetic Aggregation‐Induced Emission Photosensitizer with Antigen‐Presenting and Hitchhiking Function for Lipid Droplet Targeted Photodynamic Immunotherapy
Xu, X., Deng, G., Sun, Z., Luo, Y., Liu, J., Yu, X., Zhao, Y., Gong, P., Liu, G., Zhang, P., et al. (2021) · Advanced Materials · doi:10.1002/adma.202102322 · Cited by 171
ExoSTING, an extracellular vesicle loaded with STING agonists, promotes tumor immune surveillance
Jang, S. C., Economides, K. D., Moniz, R. J., Sia, C. L., Lewis, N. D., McCoy, C., Zi, T., Zhang, K. X., Harrison, R. A., Lim, J. Y. H., et al. (2021) · Communications Biology · doi:10.1038/s42003-021-02004-5 · Cited by 173
Extracellular Vesicles from Akkermansia muciniphila Elicit Antitumor Immunity Against Prostate Cancer via Modulation of CD8+ T Cells and Macrophages
Luo, Z., Xia, K., Liu, Y.-W., Liu, J., Rao, S., Hu, X., Chen, C., Xu, R., Wang, Z., & Xie, H. (2021) · International Journal of Nanomedicine · doi:10.2147/ijn.s304515 · Cited by 167
Extracellular vesicles in ovarian cancer chemoresistance, metastasis, and immune evasion
Tian, W., Lei, N., Zhou, J., Chen, M., Guo, R., Qin, B., Li, Y., & Chang, L. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-04510-8 · Cited by 162
MRI-traceable theranostic nanoparticles for targeted cancer treatment
Anani, T., Rahmati, S., Nayer, S., & David, A. E. (2020) · Theranostics · doi:10.7150/thno.48811 · Cited by 159
Rethinking Antigen Source: Cancer Vaccines Based on Whole Tumor Cell/tissue Lysate or Whole Tumor Cell
Diao, L., & Liu, M. (2023) · Advanced Science · doi:10.1002/advs.202300121 · Cited by 161
The progress and perspective of nanoparticle-enabled tumor metastasis treatment
Zhang, W., Wang, F., Hu, C., Zhou, Y., Gao, H., & Hu, J. (2020) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2020.07.013 · Cited by 152
An Up‐to‐Date Review on Alginate Nanoparticles and Nanofibers for Biomedical and Pharmaceutical Applications
Dodero, A., Alberti, S., Gaggero, G., Ferretti, M., Botter, R., Vicini, S., & Castellano, M. (2021) · Advanced Materials Interfaces · doi:10.1002/admi.202100809 · Cited by 154
Charge‐Reversal Polymer Nano‐modulators for Photodynamic Immunotherapy of Cancer
He, S., Li, J., Cheng, P., Zeng, Z., Zhang, C., Duan, H., & Pu, K. (2021) · Angewandte Chemie International Edition · doi:10.1002/anie.202106392 · Cited by 148
Target Reprogramming Lysosomes of CD8+ T Cells by a Mineralized Metal–Organic Framework for Cancer Immunotherapy
Zhao, Q. P., Gong, Z., Li, Z., Wang, J., Zhang, J., Zhao, Z., Zhang, P., Zheng, S., Miron, R. J., Yuan, Q., et al. (2021) · Advanced Materials · doi:10.1002/adma.202100616 · Cited by 146
Engineering of Living Cells with Polyphenol‐Functionalized Biologically Active Nanocomplexes
Zhao, Z., Pan, D. C., Qi, Q. M., Kim, J., Kapate, N., Sun, T., Shields, C. W., Wang, L., Wu, D., Kwon, C. J., et al. (2020) · Advanced Materials · doi:10.1002/adma.202003492 · Cited by 145
Reactive oxygen species-powered cancer immunotherapy: Current status and challenges
He, M., Wang, M., Xu, T., Zhang, M., Dai, H., Wang, C., Ding, D., & Zhong, Z. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.02.040 · Cited by 147
Fucoidan-based, tumor-activated nanoplatform for overcoming hypoxia and enhancing photodynamic therapy and antitumor immunity
Chung, C., Lu, K.-Y., Lee, W.-C., Hsu, W., Lee, W.-F., Dai, J.-Z., Shueng, P., Lin, C., & Mi, F. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.120227 · Cited by 142
Microfluidic synthesis of lipid-based nanoparticles for drug delivery: recent advances and opportunities
Mehraji, S., & DeVoe, D. L. (2024) · Lab on a Chip · doi:10.1039/d3lc00821e · Cited by 144
Biomimetic and bioinspired nano‐platforms for cancer vaccine development
Feng, C., Tan, P., Nie, G., & Zhu, M. (2023) · Exploration · doi:10.1002/exp.20210263 · Cited by 139
Recent Advances in Cell Membrane‐Derived Biomimetic Nanotechnology for Cancer Immunotherapy
Raza, F., Zafar, H., Zhang, S., Kamal, Z., Su, J., Yuan, W., & Mingfeng, Q. (2021) · Advanced Healthcare Materials · doi:10.1002/adhm.202002081 · Cited by 135
Context-dependent functions of pattern recognition receptors in cancer
Man, S. M., & Jenkins, B. J. (2022) · Nature reviews. Cancer · doi:10.1038/s41568-022-00462-5 · Cited by 143
Toll-like receptor 9 agonists and combination therapies: strategies to modulate the tumour immune microenvironment for systemic anti-tumour immunity
Dongye, Z., Li, J., & Wu, Y. (2022) · British Journal of Cancer · doi:10.1038/s41416-022-01876-6 · Cited by 138
Nanoparticles-encapsulated polymeric microneedles for transdermal drug delivery
Chen, M., Quan, G., Sun, Y. H., Yang, D., Pan, X., & Wu, C. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.06.039 · Cited by 136
Checkpoint Nano‐PROTACs for Activatable Cancer Photo‐Immunotherapy
Zhang, C., Xu, M., He, S., Huang, J., Xu, C., & Pu, K. (2022) · Advanced Materials · doi:10.1002/adma.202208553 · Cited by 132
Nano-enhanced immunotherapy: Targeting the immunosuppressive tumor microenvironment
Jin, Y., Huang, Y., Ren, H., Huang, H., Lai, C., Wang, W., Tong, Z., Zhang, H., Wu, W., Liu, C., et al. (2024) · Biomaterials · doi:10.1016/j.biomaterials.2023.122463 · Cited by 130
Modulation of tumor microenvironment for immunotherapy: focus on nanomaterial-based strategies
Liu, Y., Guo, J., & Huang, L. (2020) · Theranostics · doi:10.7150/thno.42998 · Cited by 129
Recent Advances in Molecular Mechanisms of Cancer Immunotherapy
Kciuk, M., Yahya, E. B., Mohamed, M. M. I., Rashid, S., Iqbal, M. O., Kontek, R., Abdulsamad, M. A., & Allaq, A. A. (2023) · Cancers · doi:10.3390/cancers15102721 · Cited by 135
Tumor cell membrane enveloped aluminum phosphate nanoparticles for enhanced cancer vaccination
Gan, J., Du, G., He, C., Jiang, M., Mou, X., Xue, J., & Sun, X. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.07.008 · Cited by 125
Nanovaccines with cell-derived components for cancer immunotherapy
Meng, Z., Zhang, Y., Zhou, X., Ji, J., & Liu, Z. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.114107 · Cited by 126
Theranostic nanoparticles with disease-specific administration strategies
Zhang, P., Li, Y., Tang, W., Zhao, J., Jing, L., & McHugh, K. J. (2021) · Nano Today · doi:10.1016/j.nantod.2021.101335 · Cited by 120
Targeting regulated cell death in tumor nanomedicines
Zeng, Q., Ma, X., Song, Y., Chen, Q., Jiao, Q., & Zhou, L. (2021) · Theranostics · doi:10.7150/thno.67932 · Cited by 120
Engineering Prodrug Nanomedicine for Cancer Immunotherapy
Yang, B., Gao, J., Pei, Q., Xu, H., & Yu, H. (2020) · Advanced Science · doi:10.1002/advs.202002365 · Cited by 116
Engineering Strategies for Immunomodulatory Cytokine Therapies: Challenges and Clinical Progress
Pires, I. S., Hammond, P. T., & Irvine, D. J. (2021) · Advanced Therapeutics · doi:10.1002/adtp.202100035 · Cited by 116
Leveraging self-assembled nanobiomaterials for improved cancer immunotherapy
Vincent, M. P., Navidzadeh, J. O., Bobbala, S. K. R., & Scott, E. A. (2022) · Cancer Cell · doi:10.1016/j.ccell.2022.01.006 · Cited by 117
Regulating trained immunity with nanomedicine
van Leent, M. M. T., Priem, B., Schrijver, D. P., de Dreu, A., Hofstraat, S. R. J., Zwolsman, R. C., Beldman, T. J., Netea, M. G., & Mulder, W. J. M. (2022) · Nature Reviews Materials · doi:10.1038/s41578-021-00413-w · Cited by 117
Immunogenic PANoptosis‐Initiated Cancer Sono‐Immune Reediting Nanotherapy by Iteratively Boosting Cancer Immunity Cycle
Zhou, L., Lyu, J., Liu, F., Su, Y., Feng, L., & Zhang, X. (2023) · Advanced Materials · doi:10.1002/adma.202305361 · Cited by 115
One‐Step Symbiosis of Bimetallic Peroxides Nanoparticles to Induce Ferroptosis/Cuproptosis and Activate cGAS‐STING Pathway for Enhanced Tumor Immunotherapy
Liu, B., Chen, X., Zhu, Y., Chen, H. H., Tan, J., Yang, Z., Li, J., Zheng, P., Feng, L., Wang, Q., et al. (2025) · Advanced Materials · doi:10.1002/adma.202500337 · Cited by 112
Biomimetic nanoparticles deliver mRNAs encoding costimulatory receptors and enhance T cell mediated cancer immunotherapy
Li, W., Zhang, X., Zhang, C., Yan, J., Hou, X., Du, S., Zeng, C., Zhao, W., Deng, B., McComb, D. W., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-27434-x · Cited by 113
pH-Responsive Nanoparticles for Cancer Immunotherapy: A Brief Review
Yan, Y., & Ding, H. (2020) · Nanomaterials · doi:10.3390/nano10081613 · Cited by 113
Smart Nanosized Drug Delivery Systems Inducing Immunogenic Cell Death for Combination with Cancer Immunotherapy
Zhou, L., Zhang, P., Wang, H., Wang, D., & Li, Y. (2020) · Accounts of Chemical Research · doi:10.1021/acs.accounts.0c00254 · Cited by 108
Augmenting Immunogenic Cell Death and Alleviating Myeloid‐Derived Suppressor Cells by Sono‐Activatable Semiconducting Polymer Nanopartners for Immunotherapy
Ding, M., Zhang, Y., Yu, N., Zhou, J., Zhu, L., Wang, X., & Li, J. (2023) · Advanced Materials · doi:10.1002/adma.202302508 · Cited by 108
Nanotransferrin-Based Programmable Catalysis Mediates Three-Pronged Induction of Oxidative Stress to Enhance Cancer Immunotherapy
Bai, S., Lu, Z., Jiang, Y., Shi, X., Xu, D., Shi, Y., Lin, G., Liu, C., Zhang, Y., & Liu, G. (2021) · ACS Nano · doi:10.1021/acsnano.1c08619 · Cited by 104
Antibody-based drug delivery systems for cancer therapy: Mechanisms, challenges, and prospects
Chen, Z., Kankala, R. K., Yang, Z., Li, W., Xie, S., Li, H., Chen, A., & Zou, L. (2022) · Theranostics · doi:10.7150/thno.72594 · Cited by 108
Engineered Nanovaccine Targeting Clec9a+ Dendritic Cells Remarkably Enhances the Cancer Immunotherapy Effects of STING Agonist
Gou, S., Liu, W., Wang, S., Chen, G., Chen, Z., Qiu, L., Zhou, X., Wu, Y., Qi, Y., & Gao, Y. (2021) · Nano Letters · doi:10.1021/acs.nanolett.1c03243 · Cited by 107
Engineered extracellular vesicles as intelligent nanosystems for next-generation nanomedicine
Fan, Z., Jiang, C., Wang, Y., Wang, K., Marsh, J., Zhang, D., Chen, X., & Nie, L. (2022) · Nanoscale Horizons · doi:10.1039/d2nh00070a · Cited by 103
From Design to Clinic: Engineered Nanobiomaterials for Immune Normalization Therapy of Cancer
Saeed, M., Chen, F., Ye, J., Shi, Y., Lammers, T., Geest, B. G. D., Xu, Z. P., & Yu, H. (2021) · Advanced Materials · doi:10.1002/adma.202008094 · Cited by 102
Emerging nanomedicines of paclitaxel for cancer treatment
Chen, Q., Xu, S., Liu, S., Wang, Y., & Liu, G. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.01.010 · Cited by 100
3D Printing Scaffold Vaccine for Antitumor Immunity
Zhang, Y., Xu, J., Fei, Z., Dai, H., Fan, Q., Yang, Q., Chen, Y., Wang, B., & Wang, C. (2021) · Advanced Materials · doi:10.1002/adma.202106768 · Cited by 99
A prodrug hydrogel with tumor microenvironment and near-infrared light dual-responsive action for synergistic cancer immunotherapy
Ding, M., Fan, Y., Lv, Y., Liu, J., Yu, N., Kong, D., Sun, H., & Li, J. (2022) · Acta Biomaterialia · doi:10.1016/j.actbio.2022.06.041 · Cited by 99
Advances in Magnetic Nanoparticle‐Mediated Cancer Immune‐Theranostics
Cheng, H., Tsao, H., Chiang, C., & Chen, S. (2020) · Advanced Healthcare Materials · doi:10.1002/adhm.202001451 · Cited by 98
Boosting Checkpoint Immunotherapy with Biomaterials
Liu, L., Pan, Y., Zhao, C., Huang, P., Chen, X. S., & Rao, L. (2023) · ACS Nano · doi:10.1021/acsnano.2c11691 · Cited by 97
Black Phosphorus Nanosheet with High Thermal Conversion Efficiency for Photodynamic/Photothermal/Immunotherapy
Xu, D., Liu, J., Wang, Y., Jian, Y., Wu, W., & Lv, R. (2020) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.0c00984 · Cited by 94
Recent Advances in Nanotechnology for the Treatment of Melanoma
Cassano, R., Cuconato, M., Calviello, G., Serini, S., & Trombino, S. (2021) · Molecules · doi:10.3390/molecules26040785 · Cited by 94
Targeting the Tumor Microenvironment in Colorectal Peritoneal Metastases
Ceelen, W. P., Ramsay, R. G., Narasimhan, V., Heriot, A. G., & Wever, O. D. (2020) · Trends in cancer · doi:10.1016/j.trecan.2019.12.008 · Cited by 95
Biosynthesis of Self‐Assembled Proteinaceous Nanoparticles for Vaccination
Pan, C., Wu, J., Qing, S., Zhang, X., Zhang, L., Yue, H., Zeng, M., Wang, B., Yuan, Z., Qiu, Y., et al. (2020) · Advanced Materials · doi:10.1002/adma.202002940 · Cited by 93
Sex as an important factor in nanomedicine
Hajipour, M. J., Aghaverdi, H., Serpooshan, V., Vali, H., Sheibani, S., & Mahmoudi, M. (2021) · Nature Communications · doi:10.1038/s41467-021-23230-9 · Cited by 92
Nanocarriers Used in Drug Delivery to Enhance Immune System in Cancer Therapy
Lôbo, G. C. N. B., Paiva, K. L. R., Silva, A. L. G., Simões, M. M., Radicchi, M. A., & Báo, S. N. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13081167 · Cited by 93
Interventional hydrogel microsphere vaccine as an immune amplifier for activated antitumour immunity after ablation therapy
Liu, X., Zhuang, Y., Huang, W., Wu, Z., Chen, Y., Shan, Q., Zhang, Y., Wu, Z., Ding, X., Qiu, Z., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-39759-w · Cited by 91
Lipid-based nanosystems: the next generation of cancer immune therapy
Cheng, Z., Fobian, S., Gurrieri, E., Amin, M., D’Agostino, V., Falahati, M., Zalba, S., Debets, R., Garrido, M. J., Saeed, M., et al. (2024) · Journal of Hematology & Oncology · doi:10.1186/s13045-024-01574-1 · Cited by 95
Metal Oxide Nanoparticles in Therapeutic Regulation of Macrophage Functions
Dukhinova, M., Prilepskii, A. Y., Shtil, A. A., & Vinogradov, V. V. (2019) · Nanomaterials · doi:10.3390/nano9111631 · Cited by 89
Liposomal Cytarabine as Cancer Therapy: From Chemistry to Medicine
Salehi, B., Selamoğlu, Z., Mileski, K. S., Pezzani, R., Redaelli, M., Cho, W. C. S., Kobarfard, F., Rajabi, S., Martorell, M., Kumar, P., et al. (2019) · Biomolecules · doi:10.3390/biom9120773 · Cited by 90
Lymph node-targeting nanovaccines for cancer immunotherapy
Wang, Q., Wang, Z., Sun, X., Jiang, Q., Sun, B., He, Z., Zhang, S., Luo, C., & Sun, J. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.09.015 · Cited by 90
Nanomedicine Combats Drug Resistance in Lung Cancer
Zheng, X., Song, X.-H., Zhu, G., Pan, D., Li, H., Hu, J., Xiao, K., Gong, Q., Gu, Z., Luo, K., et al. (2023) · Advanced Materials · doi:10.1002/adma.202308977 · Cited by 94
Nanotechnology-enhanced immunotherapy for metastatic cancer
Zhang, P., Meng, J., Li, Y., Chen, Y., Hou, Y., Tang, W., McHugh, K. J., & Jing, L. (2021) · The Innovation · doi:10.1016/j.xinn.2021.100174 · Cited by 88
Emerging strategies in developing multifunctional nanomaterials for cancer nanotheranostics
Ang, M. J. Y., Chan, S. Y., Goh, Y. Y., Luo, Z., Lau, J. W., & Liu, X. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.113907 · Cited by 87
Emerging Technologies for Local Cancer Treatment
Chua, C. Y. X., Ho, J., Demaria, S., Mauro Ferrari, B., & Grattoni, A. (2020) · Advanced Therapeutics · doi:10.1002/adtp.202000027 · Cited by 88
Leveraging Semiconducting Polymer Nanoparticles for Combination Cancer Immunotherapy
Wu, J., & Pu, K. (2023) · Advanced Materials · doi:10.1002/adma.202308924 · Cited by 88
Nanomaterials in anticancer applications and their mechanism of action - A review
Das, C. G. A., Kumar, V. G., Dhas, T. S., Karthick, V., & Kumar, C. M. V. (2022) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2022.102613 · Cited by 84
Upregulation of exosome secretion from tumor-associated macrophages plays a key role in the suppression of anti-tumor immunity
Zhong, W., Lu, Y., Han, X., Yang, J., Qin, Z., Zhang, W., Yu, Z., Wu, B., Liu, S., Xu, W., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113224 · Cited by 85
Nano-immunotherapy: Overcoming tumour immune evasion
Guevara, M. L., Persano, F., & Persano, S. (2019) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2019.11.010 · Cited by 83

Authors: Goldberg, M. S.
Affiliations: Massachusetts Institute of Technology (US)
Corresponding author: Goldberg, Michael S.
ORCID: Goldberg, Michael S.
Venue: Nature reviews. Cancer
Publisher: Springer Science and Business Media LLC
Published: 2019-09-06
Volume: 19
Issue: 10
Pages: 587-602
ISSN: 1474-175X (ISSN-L)
1474-1768
DOI: 10.1038/s41568-019-0186-9
OpenAlex: W2972159813
Cited by: 628
References: 142
Citations by year: 2026: 44 · 2025: 67 · 2024: 81 · 2023: 98 · 2022: 114 · 2021: 122 · 2020: 92 · 2019: 10
FWCI: 8.06
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature reviews. Cancer (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Keywords: cancer immunotherapy, nanotechnology, nanoparticles, biomaterials, drug delivery, immune evasion, spatiotemporal control, pharmacokinetics, co-delivery, adoptive immunotherapy, tumor targeting, nanomedicine
MeSH terms: Animals, Biocompatible Materials, Humans, Immune System, Immunologic Factors, Immunotherapy, Leukocytes, Neoplasms, Nucleic Acids, T-Lymphocytes, Drug Delivery Systems, Adoptive Transfer, Nanomedicine, Nanoparticles

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Improving cancer immunotherapy through nanotechnology

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks