A New Population of Myeloid-Derived Suppressor Cells in Hepatocellular Carcinoma Patients Induces CD4+CD25+Foxp3+ T Cells

Hoechst, Bastian; Ormandy, Lars A.; Ballmaier, Matthias; Lehner, Frank; Krüger, Christine; Manns, Michael P.; Greten, Tim F.; Korangy, Firouzeh

doi:10.1053/j.gastro.2008.03.020

Cited by 793Immune cells in cancerImmunotherapy and Immune ResponsesCancer Immunotherapy and Biomarkers

A New Population of Myeloid-Derived Suppressor Cells in Hepatocellular Carcinoma Patients Induces CD4+CD25+Foxp3+ T Cells

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Hoechst, Bastian, Ormandy, Lars A., Ballmaier, Matthias, Lehner, Frank, Krüger, Christine, Manns, Michael P., Greten, Tim F., Korangy, Firouzeh·2008·Gastroenterology

DOI 10.1053/j.gastro.2008.03.020

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Abstract

Background & aims Several studies have shown that development of hepatocellular carcinoma (HCC) generates a number of immune suppressive mechanisms in these patients. Myeloid-derived suppressor cells (MDSC) are a heterogeneous population of cells that have been shown to inhibit T-cell responses in tumor-bearing mice, but little is known about these cells in humans owing to a lack of specific markers. In this study, we have investigated the frequency and function of a new population of MDSC denoted here as CD14(+)HLA-DR(-/low) in HCC patients. We have also identified a novel, MDSC-mediated immune regulatory pathway in these patients.Methods We have directly isolated and characterized MDSCs for phenotype and function from peripheral blood (n = 111) and tumor (n = 12) of patients with HCC.Results The frequency of CD14(+)HLA-DR(-/low) cells in peripheral blood mononuclear cells (PBMC) from HCC patients was significantly increased in comparison with healthy controls. CD14(+) HLA-DR(-/low) cells were unable to stimulate an allogeneic T-cell response, suppressed autologous T-cell proliferation, and had high arginase activity, a hallmark characteristic of MDSC. Most important, CD14(+)HLA-DR(-/low) cells from HCC patients induced a CD4(+)CD25(+)Foxp3(+) regulatory T-cell population when cocultured with autologous T cells.Conclusion CD14(+)HLA-DR(-/low) cells are a new population of MDSC increased in blood and tumor of HCC patients. We propose a new mechanism by which MDSC exert their immunosuppressive function, through the induction of CD4(+)CD25(+)Foxp3(+) regulatory T cells in cocultured CD4(+) T cells. Understanding the mechanism of action of MDSC in HCC patients is important in the design of effective immunotherapeutic protocols.

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The liver contains abundant myeloid-derived suppressor cells that produce factors suppressing T cell activation.
“The liver also contains an abundance of MDSCs that produce factors suppressing T cell activation63.”
From Adjuvant and neoadjuvant immunotherapies in hepatocellular carcinoma (2024) · cites this paper as [63]
The Discussion (page not available in our copy) reports that MDSCs are increased in the tumors and peripheral blood of hepatocellular carcinoma patients and suppress T-cell responses through arginase activity. It does not establish that the liver generally contains abundant MDSCs; its finding is specific to patients with liver cancer. (LLM, conf=0.87)
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Zou, W. (2006) · Nature reviews. Immunology · doi:10.1038/nri1806 · Cited by 2,075 · see citing works
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Jonuleit, H., Schmitt, E., Schuler, G., Knop, J., & Enk, A. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.9.1213 · Cited by 1,538 · see citing works
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Swann, J. B., & Smyth, M. J. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31405 · Cited by 1,469 · see citing works
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Huang, B., Pan, P.-Y., Li, Q., Sato, A. I., Levy, D. E., Bromberg, J., Divino, C. M., & Chen, S.-H. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-1299 · Cited by 1,435 · see citing works
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Almand, B., Clark, J. I., Nikitina, E., van Beynen, J., English, N. R., Knight, S. C., Carbone, D. P., & Gabrilovich, D. I. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.1.678 · Cited by 1,340 · see citing works
Arginase I Production in the Tumor Microenvironment by Mature Myeloid Cells Inhibits T-Cell Receptor Expression and Antigen-Specific T-Cell Responses
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Greten TF, Manns MP, Korangy F. Immunotherapy of hepatocel- lular carcinoma. J Hepatol 2006;45:868 -878.

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Weber, R., Groth, C., Lasser, S., Arkhypov, I., Petrova, V., Altevogt, P., Utikal, J. S., & Umansky, V. (2020) · Cellular Immunology · doi:10.1016/j.cellimm.2020.104254 · Cited by 310 · see citing works
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Haile, L. A., von Wasielewski, R., Gamrekelashvili, J., Krüger, C., Bachmann, O. P., Westendorf, A. M., Buer, J., Liblau, R., Manns, M. P., Korangy, F., et al. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.06.032 · Cited by 308 · see citing works
Self-citation
IL4Rα+ Myeloid-Derived Suppressor Cell Expansion in Cancer Patients
Mandruzzato, S., Solito, S., Falisi, E., Francescato, S., Chiarion‐Sileni, V., D, S. M. M., Zanon, A., Rossi, C. R., Nitti, D., Bronte, V., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803831 · Cited by 302 · see citing works
Role of nonresolving inflammation in hepatocellular carcinoma development and progression
Yu, L., Yan, L., & Wang, H. (2018) · npj Precision Oncology · doi:10.1038/s41698-018-0048-z · Cited by 302 · see citing works
Direct and Differential Suppression of Myeloid-Derived Suppressor Cell Subsets by Sunitinib Is Compartmentally Constrained
Ko, J. S., Rayman, P. A., Ireland, J. L., Swaidani, S., Li, G., Bunting, K. D., Rini, B. I., Finke, J. H., & Cohen, P. A. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-3278 · Cited by 297 · see citing works
The functional crosstalk between myeloid-derived suppressor cells and regulatory T cells within the immunosuppressive tumor microenvironment
Haist, M., Stege, H., Grabbe, S., & Bros, M. (2021) · Cancers · doi:10.3390/cancers13020210 · Cited by 295 · see citing works
The yin and yang of evasion and immune activation in HCC
Makarova‐Rusher, O. V., Medina‐Echeverz, J., Duffy, A. G., & Greten, T. F. (2015) · Journal of Hepatology · doi:10.1016/j.jhep.2015.02.038 · Cited by 294 · see citing works
Self-citation
Myeloid-Derived Suppressor Cells in Tumors: From Mechanisms to Antigen Specificity and Microenvironmental Regulation
Yang, Y., Li, C., Liu, T., Dai, X., & Bazhin, A. V. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01371 · Cited by 294 · see citing works
Recent advances on the role of tumor exosomes in immunosuppression and disease progression
Filipazzi, P., Bürdek, M., Villa, A., Rivoltini, L., & Huber, V. (2012) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2012.02.005 · Cited by 281 · see citing works
Enhancement of tumor-associated antigen-specific T cell responses by radiofrequency ablation of hepatocellular carcinoma
Mizukoshi, E., Yamashita, T., Arai, K., Sunagozaka, H., Ueda, T., Arihara, F., Kagaya, T., Yamashita, T., Fushimi, K., & Kaneko, S. (2012) · Hepatology · doi:10.1002/hep.26153 · Cited by 278 · see citing works
Circulating and Tumor-Infiltrating Myeloid-Derived Suppressor Cells in Patients with Colorectal Carcinoma
Zhang, B., Wang, Z., Wu, L., Zhang, M., Li, W., Ding, J., Zhu, J., Wei, H., & Zhao, K. (2013) · PLoS ONE · doi:10.1371/journal.pone.0057114 · Cited by 273 · see citing works
Current knowledge on psoriasis and autoimmune diseases
McCormick, T. S., Ayala‐Fontanez, N., & Soler, D. C. (2016) · Psoriasis Targets and Therapy · doi:10.2147/ptt.s64950 · Cited by 270 · see citing works
Higher Frequencies of GARP+CTLA-4+Foxp3+ T Regulatory Cells and Myeloid-Derived Suppressor Cells in Hepatocellular Carcinoma Patients Are Associated with Impaired T-Cell Functionality
Kalathil, S. G., Lugade, A. A., Miller, A., Iyer, R. V., & Thanavala, Y. M. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-3381 · Cited by 269 · see citing works
Immunosuppressive CD14 + HLA‐DR low/− monocytes in prostate cancer
Vuk‐Pavlović, S., Bulur, P. A., Lin, Y., Qin, R., Szumlanski, C. L., Zhao, X., & Dietz, A. B. (2009) · The Prostate · doi:10.1002/pros.21078 · Cited by 265 · see citing works
Gut Microbiome Directs Hepatocytes to Recruit MDSCs and Promote Cholangiocarcinoma
Zhang, Q., Ma, C., Duan, Y., Heinrich, B., Rosato, U., Diggs, L. P., Ma, L., Roy, S., Fu, Q., Brown, Z. J., et al. (2020) · Cancer Discovery · doi:10.1158/2159-8290.cd-20-0304 · Cited by 263 · see citing works
Self-citation
Increased intratumoral regulatory T cells are related to intratumoral macrophages and poor prognosis in hepatocellular carcinoma patients
Zhou, J., Ding, T., Pan, W., Zhu, L., Li, L., & Zheng, L. (2009) · International Journal of Cancer · doi:10.1002/ijc.24556 · Cited by 255 · see citing works
Increase in CD14+HLA-DR−/low myeloid-derived suppressor cells in hepatocellular carcinoma patients and its impact on prognosis
Arihara, F., Mizukoshi, E., Kitahara, M., Takata, Y., Arai, K., Yamashita, T., Nakamoto, Y., & Kaneko, S. (2013) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-013-1447-1 · Cited by 254 · see citing works
Increased Myeloid-Derived Suppressor Cells in Gastric Cancer Correlate with Cancer Stage and Plasma S100A8/A9 Proinflammatory Proteins
Wang, L., Chang, E. W. Y., Wong, S. C., Ong, S., Chong, D. Q. Y., & Ling, K. L. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1202088 · Cited by 249 · see citing works
The significance of intertumor and intratumor heterogeneity in liver cancer
Liu, J., Dang, H. T., & Wang, X. W. (2018) · Experimental & Molecular Medicine · doi:10.1038/emm.2017.165 · Cited by 245 · see citing works
Immunosuppressive CD14+HLA-DRlow/− monocytes in B-cell non-Hodgkin lymphoma
Lin, Y., Gustafson, M. P., Bulur, P. A., Gastineau, D. A., Witzig, T. E., & Dietz, A. B. (2011) · Blood · doi:10.1182/blood-2010-05-283820 · Cited by 244 · see citing works
Phenotype, function and clinical implications of myeloid-derived suppressor cells in cancer patients
Filipazzi, P., Huber, V., & Rivoltini, L. (2011) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-011-1161-9 · Cited by 244 · see citing works
Emerging immunotherapy for HCC: A guide for hepatologists
Foerster, F., Gairing, S. J., Ilyas, S. I., & Galle, P. R. (2022) · Hepatology · doi:10.1002/hep.32447 · Cited by 244 · see citing works
Hypoxia induces myeloid-derived suppressor cell recruitment to hepatocellular carcinoma through chemokine (C-C motif) ligand 26
Chiu, D. K., Xu, I. M., Lai, R. K., Tse, A. P., Wei, L. L., Koh, H., Li, L. L., Lee, D., Lo, R. C., Wong, C., et al. (2016) · Hepatology · doi:10.1002/hep.28655 · Cited by 241 · see citing works
Immune checkpoint blockade in hepatocellular carcinoma: Current progress and future directions
Hato, T., Goyal, L., Greten, T. F., Duda, D. G., & Zhu, A. X. (2014) · Hepatology · doi:10.1002/hep.27246 · Cited by 241 · see citing works
Self-citation
Plasticity of human Th17 cells and iTregs is orchestrated by different subsets of myeloid cells
Hoechst, B., Gamrekelashvili, J., Manns, M. P., Greten, T. F., & Korangy, F. (2011) · Blood · doi:10.1182/blood-2010-11-317321 · Cited by 239 · see citing works
Self-citation
Trial watch
Senovilla, L., Vacchelli, E., Galon, J., Adjemian, S., Eggermont, A. M. M., Fridman, W. H., Sautès‐Fridman, C., Ma, Y., Tartour, É., Zitvogel, L., et al. (2012) · OncoImmunology · doi:10.4161/onci.22009 · Cited by 238 · see citing works
Systemic immune suppression in glioblastoma: the interplay between CD14+HLA-DRlo/neg monocytes, tumor factors, and dexamethasone
Gustafson, M. P., Lin, Y., New, K. C., Bulur, P. A., O’Neill, B. P., Gastineau, D. A., & Dietz, A. B. (2010) · Neuro-Oncology · doi:10.1093/neuonc/noq001 · Cited by 238 · see citing works
Tumour-derived PGD2 and NKp30-B7H6 engagement drives an immunosuppressive ILC2-MDSC axis
Trabanelli, S., Chevalier, M. F., Martínez-Usatorre, A., Gomez‐Cadena, A., Salomé, B., Lecciso, M., Salvestrini, V., Verdeil, G., Racle, J., Papayannidis, C., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-00678-2 · Cited by 231 · see citing works
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Self-citation
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Baumann, T., Dunkel, A., Schmid, C., Schmitt, S., Hiltensperger, M., Lohr, K., Laketa, V., Donakonda, S., Ahting, U., Lorenz‐Depiereux, B., et al. (2020) · Nature Immunology · doi:10.1038/s41590-020-0666-9 · Cited by 227 · see citing works
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Phenotype, development, and biological function of myeloid-derived suppressor cells
Zhao, Y., Wu, T., Shao, S., Shi, B., & Zhao, Y. X. (2015) · OncoImmunology · doi:10.1080/2162402x.2015.1004983 · Cited by 220 · see citing works
Immunotherapy in hepatocellular carcinoma: the complex interface between inflammation, fibrosis, and the immune response
Keenan, B. P., Fong, L. H., & Kelley, R. K. (2019) · Journal for ImmunoTherapy of Cancer · doi:10.1186/s40425-019-0749-z · Cited by 219 · see citing works
S100A9 a new marker for monocytic human myeloid‐derived suppressor cells
Zhao, F., Hoechst, B., Duffy, A. G., Gamrekelashvili, J., Fioravanti, S., Manns, M. P., Greten, T. F., & Korangy, F. (2012) · Immunology · doi:10.1111/j.1365-2567.2012.03566.x · Cited by 216 · see citing works
Self-citation
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Brimnes, M. K., Vangsted, A. J., Knudsen, L. M., Gimsing, P., Gang, A. O., Johnsen, H. E., & Svane, I. M. (2010) · Scandinavian Journal of Immunology · doi:10.1111/j.1365-3083.2010.02463.x · Cited by 214 · see citing works
Combined locoregional-immunotherapy for liver cancer
Greten, T. F., Mauda‐Havakuk, M., Heinrich, B., Korangy, F., & Wood, B. J. (2019) · Journal of Hepatology · doi:10.1016/j.jhep.2019.01.027 · Cited by 211 · see citing works
Self-citation
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Greten, T. F., Forner, A., Korangy, F., Nkontchou, G., Barget, N., Ayuso, C., Ormandy, L. A., Manns, M. P., Beaugrand, M., & Bruix, J. (2010) · BMC Cancer · doi:10.1186/1471-2407-10-209 · Cited by 210 · see citing works
Self-citation
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Panni, R. Z., Sanford, D. E., Belt, B. A., Mitchem, J. B., Worley, L. A., Goetz, B. D., Mukherjee, P., Wang‐Gillam, A., Link, D. C., DeNardo, D. G., et al. (2014) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-014-1527-x · Cited by 210 · see citing works
Increased CD14+HLA-DR-/low myeloid-derived suppressor cells correlate with extrathoracic metastasis and poor response to chemotherapy in non-small cell lung cancer patients
Huang, A., Zhang, B., Wang, B., Zhang, F., Fan, K., & Guo, Y. (2013) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-013-1450-6 · Cited by 209 · see citing works
Myeloid‐derived suppressor cells in cancer: recent progress and prospects
Khaled, Y. S., Ammori, B. J., & Elkord, E. (2013) · Immunology and Cell Biology · doi:10.1038/icb.2013.29 · Cited by 208 · see citing works
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Lechner, M. G., Megiel, C., Russell, S. M., Bingham, B., Arger, N., Woo, T. T., & Epstein, A. L. (2011) · Journal of Translational Medicine · doi:10.1186/1479-5876-9-90 · Cited by 208 · see citing works
Human Tumor-Infiltrating Myeloid Cells: Phenotypic and Functional Diversity
Elliott, L., Doherty, G. A., Sheahan, K. D., & Ryan, E. J. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00086 · Cited by 208 · see citing works
Complexity and challenges in defining myeloid-derived suppressor cells
Damuzzo, V., Pinton, L., Desantis, G., Solito, S., Marigo, I., Bronte, V., & Mandruzzato, S. (2014) · Cytometry Part B Clinical Cytometry · doi:10.1002/cyto.b.21206 · Cited by 205 · see citing works
Neutrophils in cancer
Treffers, L. W., Hiemstra, I. H., Kuijpers, T. W., van den Berg, T. K., & Matlung, H. L. (2016) · Immunological Reviews · doi:10.1111/imr.12444 · Cited by 204 · see citing works
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Zhou, J., Liu, M., Sun, H., Feng, Y., Xu, L., Chan, A. W. H., TONG, J. H. M., Wong, J., Chong, C. C. N., Lai, P. B. S., et al. (2017) · Gut · doi:10.1136/gutjnl-2017-314032 · Cited by 203 · see citing works
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Montero, A. J., Diaz-Montero, C. M., Kyriakopoulos, C. E., Bronte, V., & Mandruzzato, S. (2012) · Journal of Immunotherapy · doi:10.1097/cji.0b013e318242169f · Cited by 201 · see citing works
Signaling pathways involved in MDSC regulation
Trikha, P., & Carson, W. E. (2014) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2014.04.003 · Cited by 201 · see citing works
Immune-based therapies for hepatocellular carcinoma
Pinato, D. J., Guerra, N., Fessas, P., Murphy, R., Mineo, T., Mauri, F. A., Mukherjee, S. K., Thursz, M. R., Wong, C. N., Sharma, R., et al. (2020) · Oncogene · doi:10.1038/s41388-020-1249-9 · Cited by 200 · see citing works
Myeloid-derived suppressor cell measurements in fresh and cryopreserved blood samples
Kotsakis, A. P., Harasymczuk, M., Schilling, B., Georgoulias, V., Argiris, A. E., & Whiteside, T. L. (2012) · Journal of Immunological Methods · doi:10.1016/j.jim.2012.04.004 · Cited by 199 · see citing works
Immunotherapy for hepatocellular carcinoma: Current and future
Johnston, M. P., & Khakoo, S. I. (2019) · World Journal of Gastroenterology · doi:10.3748/wjg.v25.i24.2977 · Cited by 196 · see citing works
The immunobiology of hepatocellular carcinoma in humans and mice: Basic concepts and therapeutic implications
Hou, J., Zhang, H., Sun, B., & Karin, M. (2019) · Journal of Hepatology · doi:10.1016/j.jhep.2019.08.014 · Cited by 191 · see citing works
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Matsuda, M., & Seki, E. (2020) · Seminars in Liver Disease · doi:10.1055/s-0040-1708876 · Cited by 189 · see citing works
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Hepatic carcinoma-associated fibroblasts enhance immune suppression by facilitating the generation of myeloid-derived suppressor cells
Deng, Y., Cheng, J., Fu, B., Liu, W., Chen, G., Zhang, Q., & Yang, Y. (2016) · Oncogene · doi:10.1038/onc.2016.273 · Cited by 188 · see citing works
The Liver Is a Site for Tumor-Induced Myeloid-Derived Suppressor Cell Accumulation and Immunosuppression
Ilkovitch, D., & Lopez, D. M. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-4625 · Cited by 187 · see citing works
Direct and Indirect Modulation of T Cells by VEGF-A Counteracted by Anti-Angiogenic Treatment
Bourhis, M., Palle, J., Galy–Fauroux, I., & Terme, M. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.616837 · Cited by 186 · see citing works
Regulation of accumulation and function of myeloid derived suppressor cells in different murine models of hepatocellular carcinoma
Kapanadze, T. G., Gamrekelashvili, J., Ma, C., Chan, C., Zhao, F., Hewitt, S. M., Zender, L., Kapoor, V., Felsher, D. W., Manns, M. P., et al. (2013) · Journal of Hepatology · doi:10.1016/j.jhep.2013.06.010 · Cited by 184 · see citing works
Self-citation
Correlation between frequencies of blood monocytic myeloid-derived suppressor cells, regulatory T cells and negative prognostic markers in patients with castration-resistant metastatic prostate cancer
Idorn, M., Køllgaard, T., Kongsted, P., Sengeløv, L., & Straten, P. T. (2014) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-014-1591-2 · Cited by 182 · see citing works
Myeloid-derived suppressor cells in cancer: therapeutic targets to overcome tumor immune evasion
Lu, J., Luo, Y., Rao, D., Wang, T., Lei, Z., Chen, X., Zhang, B., Li, Y., Liu, B., Xia, L., et al. (2024) · Experimental Hematology and Oncology · doi:10.1186/s40164-024-00505-7 · Cited by 180 · see citing works
Reciprocal Relationship between Myeloid-Derived Suppressor Cells and T Cells
Nagaraj, S., Youn, J., & Gabrilovich, D. I. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1300654 · Cited by 179 · see citing works
Adaptive immunity suppresses formation and progression of diethylnitrosamine-induced liver cancer
Schneider, C., Teufel, A., Yevsa, T., Staib, F., Hohmeyer, A., Walenda, G., Zimmermann, H. W., Vucur, M., Huss, S., Gaßler, N., et al. (2012) · Gut · doi:10.1136/gutjnl-2011-301116 · Cited by 179 · see citing works

Increased circulating L in−/low CD 33+ HLA‐DR − myeloid‐derived suppressor cells in hepatocellular carcinoma patients
Shen, P., Wang, A., He, M., Wang, Q., & Zheng, S. (2013) · Hepatology Research · doi:10.1111/hepr.12167 · Cited by 67 · see citing works
Delineation of monocytic and early‐stage myeloid‐derived suppressor cells in the peripheral blood of patients with hepatocarcinoma
Chivite‐Lacaba, M., Justo, I., Utrero‐Rico, A., Caso, Ó., González‐Cuadrado, C., Rey, M. J. D., Laguna‐Goya, R., Arroyo‐Ródenas, J., Alfocea‐Molina, Á., Ruigómez‐Martín, C. C., et al. (2025) · International Journal of Cancer · doi:10.1002/ijc.35390 · Cited by 10 · see citing works
Up-regulated myeloid-derived suppressor cell contributes to hepatocellular carcinoma development by impairing dendritic cell function
Hu, C., Gan, J., Zhang, R., Cheng, Y., & Huang, G. (2010) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365521.2010.516450 · Cited by 161 · see citing works
Therapeutic Values of Myeloid-Derived Suppressor Cells in Hepatocellular Carcinoma: Facts and Hopes
Wang, Y., Zhang, T., Sun, M., Ji, X., Xie, M., Huang, W., & Xia, L. (2021) · Cancers · doi:10.3390/cancers13205127 · Cited by 32 · see citing works
Increased Populations of Regulatory T Cells in Peripheral Blood of Patients with Hepatocellular Carcinoma
Ormandy, L. A., Hillemann, T., Wedemeyer, H. H., Manns, M. P., Greten, T. F., & Korangy, F. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-3232 · Cited by 643 · see citing works
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Authors: Hoechst, B., Ormandy, L. A., Ballmaier, M., Lehner, F., Krüger, C., Manns, M. P., Greten, T. F., & Korangy, F.
Affiliations: Medizinische Hochschule Hannover (DE)
Corresponding author: Korangy, Firouzeh
ORCID: Ballmaier, Matthias
Lehner, Frank
Manns, Michael P.
Greten, Tim F.
Korangy, Firouzeh
Venue: Gastroenterology
Publisher: Elsevier BV
Published: 2008-07
Volume: 135
Issue: 1
Pages: 234-243
ISSN: 0016-5085 (ISSN-L)
DOI: 10.1053/j.gastro.2008.03.020
OpenAlex: W2059688175
Cited by: 793
References: 31
Citations by year: 2026: 18 · 2025: 20 · 2024: 25 · 2023: 34 · 2022: 50 · 2021: 46 · 2020: 53 · 2019: 40 · 2018: 39 · 2017: 60 · 2016: 54 · 2015: 65 · 2014: 55 · 2013: 65 · 2012: 59
FWCI: 15.02
Type: journal article
Language: en
Update notices: erratum (2011-08-01)
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Gastroenterology (publishedVersion)
PubMed (publishedVersion)
Funders: Deutsche Forschungsgemeinschaft (SFB-738)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
Keywords: myeloid-derived suppressor cells, hepatocellular carcinoma, regulatory T cells, immunosuppression, arginase activity, CD4+CD25+Foxp3+ T cells, tumor immune microenvironment, T cell proliferation inhibition, cancer immunotherapy
MeSH terms: Aged, Arginase, Cell Communication, Cell Division, Cells, Cultured, Female, Flow Cytometry, Carcinoma, Hepatocellular, HLA-DR Antigens, Humans, Immune Tolerance, Liver Neoplasms, Male, Middle Aged, Biomarkers, CD4-Positive T-Lymphocytes, CD4 Antigens, Immunophenotyping, Interleukin-10, Lipopolysaccharide Receptors, Myeloid Cells, Forkhead Transcription Factors, Interleukin-2 Receptor alpha Subunit

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A New Population of Myeloid-Derived Suppressor Cells in Hepatocellular Carcinoma Patients Induces CD4+CD25+Foxp3+ T Cells

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