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Drug-induced liver injury
Open accessAbstract
Drug-induced liver injury (DILI) is an adverse reaction to drugs or other xenobiotics that occurs either as a predictable event when an individual is exposed to toxic doses of some compounds or as an unpredictable event with many drugs in common use. Drugs can be harmful to the liver in susceptible individuals owing to genetic and environmental risk factors. These risk factors modify hepatic metabolism and excretion of the DILI-causative agent leading to cellular stress, cell death, activation of an adaptive immune response and a failure to adapt, with progression to overt liver injury. Idiosyncratic DILI is a relative rare hepatic disorder but can be severe and, in some cases, fatal, presenting with a variety of phenotypes, which mimic other hepatic diseases. The diagnosis of DILI relies on the exclusion of other aetiologies of liver disease as specific biomarkers are still lacking. Clinical scales such as CIOMS/RUCAM can support the diagnostic process but need refinement. A number of clinical variables, validated in prospective cohorts, can be used to predict a more severe DILI outcome. Although no pharmacological therapy has been adequately tested in randomized clinical trials, corticosteroids can be useful, particularly in the emergent form of DILI related to immune-checkpoint inhibitors in patients with cancer.
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“The vast majority of cases of DILI occur at therapeutic doses in a small proportion of individuals exposed to the drug, representing an idiosyncratic reaction, and therefore unpredictable based on the drug's mechanism of action and related to the uniqueness of the individual [1,2].”
From DILI Differences and Similarities between the US and Europe (2026) · cites this paper as [1]
In the citing paper
“Drug-induced liver injury (DILI) is an uncommon adverse reaction to drugs, and other chemicals, including herbal and dietary supplements (HDS).”
From DILI Differences and Similarities between the US and Europe (2026) · cites this paper as [1]
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Cited work 10.1128/aac.04976-14 · retracted 2015-12-28 · notice 10.1128/aac.04976-14 · this paper published 2019-08-22
Rated major: it would touch a result — a value a result rests on, reported and recomputed p-values on opposite sides of the significance level, two passages that conflict with no sign which is right, or a cited work retracted before this paper was published.
In the paper
“Francis, B. et al. Temporary removal: reference intervals for putative biomarkers of drug-induced liver injury and liver regeneration in healthy human volunteers. J. Hepatol. https://doi.org/10.1016/j.jhep.2018.04.024 (2018).”
Cited work 10.1016/j.jhep.2018.04.024 · retracted 2018-05-03 · notice 10.1016/j.jhep.2018.04.024 · this paper published 2019-08-22
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Francis, B., Clarke, J. I., Walker, L. E., Brillant, N., Jorgensen, A., Park, B. K., Pirmohamed, M., & Antoine, D. J. (2018) · Journal of Hepatology · doi:10.1016/j.jhep.2018.04.024 · Cited by 4
RetractedAhrens, J. H., & Sastic, C. (2015) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.04976-14 · Cited by 3
Retracted(1992) · PubMed · Cited by 33,716
The MOS 36-ltem Short-Form Health Survey (SF-36): I. Conceptual Framework and Item Selection
Ware, J. E., & Sherbourne, C. D. (1992) · Medical Care · doi:10.1097/00005650-199206000-00002 · Cited by 30,033
Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics
Kerr, J. F. R., Wyllie, A. H., & Currie, A. R. (1972) · British Journal of Cancer · doi:10.1038/bjc.1972.33 · Cited by 15,673
Improved Survival with Ipilimumab in Patients with Metastatic Melanoma
Hodi, F. S., O'Day, S. J., McDermott, D. F., Weber, R. W., Sosman, J. A., Haanen, J. B., Gonzalez, R., Robert, C., Schadendorf, D., Hassel, J. C., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa1003466 · Cited by 15,155
Li, P., Nijhawan, D., Budihardjo, I., Srinivasula, S. M., Ahmad, M., Alnemri, E. S., & Wang, X. (1997) · Cell · doi:10.1016/s0092-8674(00)80434-1 · Cited by 7,289
Beckman, J. S., Beckman, T. W., Chen, J., Marshall, P. A., & Freeman, B. A. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.4.1620 · Cited by 7,029
Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes
Esterbauer, H., Schaur, R. J., & Zollner, H. (1991) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(91)90192-6 · Cited by 6,672
Manns, M. P., McHutchison, J. G., Gordon, S. C., Rustgi, V. K., Shiffman, M. L., Reindollar, R., Goodman, Z. D., Koury, K. J., Ling, M.-H., & Albrecht, J. K. (2001) · The Lancet · doi:10.1016/s0140-6736(01)06102-5 · Cited by 6,027
Research works printed but not linked: 3
- Institute of Medicine. Exploring the Biological Contributions to Human Health: Does Sex Matter? (National Academies Press, 2001).
- Sanjuan-Jimenez, R. et al. Prevalence of hepatitis E markers in Spanish patients with suspected drug-induced liver injury [abstract]. Hepatology 66, 423A (2017).
- Abu-Sbeih, H., Styskel, B., Blechazz, B., Chalasani, N. & Miller, E. Clinically significant hepatotoxicity due to immune checkpoint inhibitors is rare but leads to treatment discontinuations in high proportion. Hepatology 68, 25A (2018).
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Items 501–600 of 922
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Zhang, B., Zhao, Z., Chen, X., Wang, F., Luo, Z., Gu, L., Tong, Q., & Zhang, Y. (2025) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2025.108840 · Cited by 4
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Ma, X., Xiong, S., Xiang, F., Li, Y., Lin, Y., Liu, Y., Lin, L., & Xie, J. (2025) · Antioxidants · doi:10.3390/antiox14101247 · Cited by 4
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Wang, Y., Sun, Y., Li, B., Xu, J., Wang, S., Xu, H., Jiang, Z., & Wu, X. (2025) · Journal of Future Foods · doi:10.1016/j.jfutfo.2025.07.024 · Cited by 4
He, Y., Chen, X.-D., Wu, S., Zhou, C.-B., Wang, P., Tang, S., Sun, Y.-S., Zhang, C., Wang, B.-Z., Gao, C.-H., et al. (2025) · Scientific Reports · doi:10.1038/s41598-025-24262-7 · Cited by 4
Guo, Z., Qiu, Y., Wang, Y., Zhang, J., Jiang, X., Wang, D., Yi, H., Huang, M., Chen, P., Zhang, F., et al. (2025) · Nano Today · doi:10.1016/j.nantod.2025.102934 · Cited by 4
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Ma, Y., Suo, J., Wang, Q., Wang, Z., Zhang, S., & Chen, S. (2025) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2025.118276 · Cited by 4
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Onaciu, A., Grama, A., Agoston, S., Mititelu, A., Maris, B. R., Ştefănescu, H., & Pop, T. L. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27010482 · Cited by 4
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Chung, H. A., Fralish, Z., Tu, T., & Reker, D. (2026) · iScience · doi:10.1016/j.isci.2026.115282 · Cited by 4
Tang, J., Chen, C., Guan, Z.-Y., Zhu, Z.-H., Pan, Y., Fu, Z.-Y., Zhu, J.-W., Cao, D., Wang, H.-Y., & Yu, L. (2026) · Cancer Letters · doi:10.1016/j.canlet.2026.218450 · Cited by 4
Zeng, K., Li, W., Li, C. C., Liu, S., Li, R., Kuang, S., Lei, C., Huang, Y., & Nie, Z. (2026) · Journal of the American Chemical Society · doi:10.1021/jacs.5c17253 · Cited by 4
da Costa, L. C., de Castro, C. L., Freitas-Alves, D. R., Vianna‐Jorge, R., & Santos, P. C. J. L. (2020) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-020-02934-9 · Cited by 4
Advanced human liver models for the assessment of drug-induced liver injury
Mun, S. J., Lee, J., Shin, Y., & Son, M. J. (2022) · Organoid · doi:10.51335/organoid.2022.2.e17 · Cited by 4
Feng, C., Ye, W., & Shan, Q.-W. (2024) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-024-03701-w · Cited by 4
Delaporte, F., Roger, E., Bejaud, J., Loyer, P., Lagarce, F., & Savary, C. C. (2024) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2024.124815 · Cited by 4
Saleh, R. O., Hamad, H. A., Najim, M. A., Menon, S. V., Kaur, M., Sivaprasad, G. V., Abohassan, M., Juan, W., Husseen, B., & Mustafa, Y. F. (2024) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-024-01617-x · Cited by 4
RetractedShi, Z., Huang, L., & Wang, H. (2025) · Digital Health · doi:10.1177/20552076251330078 · Cited by 4
Nanozymes: new strategy for the management drug-induced acute liver injury
Kan, M., Wang, Y., Cheng, N., Huang, K., & He, X. (2025) · Journal of Materials Chemistry B · doi:10.1039/d5tb00448a · Cited by 4
Mathematical modelling reveals compound-specific stress pathway activity
Burgers, E. J., Danilyuk, T. Y., Sharma, R. P., Renner, N., Verlohner, A., Rocker, N., Ternes, P., Wijaya, L. S., Leist, M., Bouwman, P., et al. (2025) · Toxicology · doi:10.1016/j.tox.2025.154234 · Cited by 4
Alharbi, N. S., Hamdy, N. A., Aboubakr, E. M., Alharbi, M., Ali, M. A. S., Alharbi, G., & El‐Mallah, A. (2025) · Pharmaceuticals · doi:10.3390/ph18091314 · Cited by 4
Shi, A., Cornwell, C., Yang, K., & Beringer, P. M. (2025) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.70073 · Cited by 4
Ye, L., Guo, G., Zhou, H., Chen, M., Fan, Z., & Zhang, J. (2025) · Scientific Reports · doi:10.1038/s41598-025-24217-y · Cited by 4
RIPK1 in Liver Parenchymal Cells Limits Murine Hepatitis during Acute CCl4-Induced Liver Injury
Hameed, H., Farooq, M., Vuillier, C., Piquet‐Pellorce, C., Hamon, A., Dimanche‐Boitrel, M., Samson, M., & Seyec, J. L. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23137367 · Cited by 4
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Niazi, B., Ahmed, K., Ahmed, M., Ali, S., Song, K., & Elias, S. (2022) · Case Reports in Gastroenterology · doi:10.1159/000526311 · Cited by 4
Gu, Y., Wang, Y., Wu, Z., Li, W., Liu, G., & Tang, Y. (2023) · Molecular Informatics · doi:10.1002/minf.202200284 · Cited by 4
Кошурба, І. В., Chyzh, M., Hladkykh, F. V., Komorovsky, R., & Marchenko, M. M. (2023) · Scripta Medica · doi:10.5937/scriptamed54-44663 · Cited by 4
Huang, X., Zhu, H., Lu, W., Cao, L., Fang, Z., Che, L., Lin, Y., Xu, S., Zhuo, Y., Hua, L., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242115561 · Cited by 4
Wang, Q.-L., Meng, L.-C., Zhao, Z. Z., Du, J., Li, P., Jiang, Y., & Li, H. (2024) · Talanta · doi:10.1016/j.talanta.2024.126108 · Cited by 4
Bajaj, P., Brennan, R., Laurent, S., Sauzeat, S., Dufault, M. R., Richards, B., & Adkins, K. (2025) · Toxicological Sciences · doi:10.1093/toxsci/kfaf012 · Cited by 4
Downregulation of DDIT4 levels with borneol attenuates hepatotoxicity induced by gilteritinib
Yin, Y., Cao, Y., Zhou, Y., Xu, Z., Luo, P., Yang, B., He, Q., Yan, H., & Yang, X. (2025) · Biochemical Pharmacology · doi:10.1016/j.bcp.2025.116869 · Cited by 4
Zhan, Y., Liao, J., Ye, L., Zhang, L., Zhang, Z., & Yin, J. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1564124 · Cited by 4
Multiple endogenous aldehydes amplify acetaminophen-induced liver injury
Pan, H., Luo, Q., Jing, Q., Chen, L., Li, N., Fang, C., & Shi, F. (2025) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2025.111619 · Cited by 4
Triaptosis and Cancer: Next Hope?
Li, Z., Zhou, K., Wu, J., Cao, L., Wang, G.-R., Luo, H.-Y., Liu, B., & Bu, L. (2025) · Research · doi:10.34133/research.0880 · Cited by 4
Les AINS et les inhibiteurs de la COX-2: principaux effets indésirables
Wirth, H., Hurlimann, R., & Flückiger, T. (2006) · Forum Médical Suisse ‒ Swiss Medical Forum · doi:10.4414/fms.2006.05816 · Cited by 4
Liang, D., Guan, Y., Zhu, J., Wu, J., Yu, X., Qiu, K., He, Z., & He, Q. (2021) · Annals of Palliative Medicine · doi:10.21037/apm-21-981 · Cited by 4
Ding, W., Wang, H., & Zhang, Y. (2022) · Liver Research · doi:10.1016/j.livres.2022.01.002 · Cited by 4
Alkot, A. M. F., Naeem, S. A., Sayed, S. E., Algendy, A., & Hablas, M. (2022) · International Journal of Medical Arts · doi:10.21608/ijma.2022.172037.1539 · Cited by 4
Hepatic Injury due to Drugs, Dietary and Herbal Supplements, Chemicals and Toxins
Kleiner, D. E. (2023) · Elsevier eBooks · doi:10.1016/b978-0-7020-8228-3.00012-0 · Cited by 4
Mazzolari, A., Sommaruga, L., Pedretti, A., & Vistoli, G. (2021) · Molecules · doi:10.3390/molecules26072098 · Cited by 4
Deng, J., Fu, Z., Wang, L., Liu, J., Chen, C., Fang, F., & Wang, X. (2022) · Epilepsy & Behavior Reports · doi:10.1016/j.ebr.2022.100568 · Cited by 4
The use of GV-971 induces liver injury in an Alzheimer's disease patientPreprint
Cheng, H. R., Wen, C. Y., Zhang, C., Kwapong, W. R., & Wang, Z. (2020) · doi:10.22541/au.159407155.51059312 · Cited by 4
Pinazo-Bandera, J. M., García‐Cortés, M., & Andrade, R. J. (2023) · HepatoBiliary Surgery and Nutrition · doi:10.21037/hbsn-23-319 · Cited by 4
Self-citationChen, L., Li, Z., Wei, W., An, B., Tian, Y., Liu, W., Niu, S., Wang, Y., Wang, L., Li, W., et al. (2023) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2023.04.051 · Cited by 3
Zimmermann, A., Scheffschick, A., Hänsel, R., Borchardt, H., Liu, J. L., Ehnert, S., Schicht, G., Seidemann, L., Aigner, A. M., Schiffmann, S., et al. (2024) · Archives of Toxicology · doi:10.1007/s00204-024-03943-8 · Cited by 3
Liver protection of CACA technical guidelines for holistic integrative management of cancer
Zhang, N., Lu, L., Cao, B., Gao, Y., Han, F., Li, L., Li, Q., Li, S., Li, X., Liu, J., et al. (2025) · Holistic Integrative Oncology · doi:10.1007/s44178-025-00157-5 · Cited by 3
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Choi, S.-G., Kim, S., Kim, J., Choi, M.-K., Han, J., Koo, D.-J., Lee, S., Kim, A., Gu, J., Kim, K. H., et al. (2025) · Science Advances · doi:10.1126/sciadv.ads9269 · Cited by 3
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Nagesh, V. K., Martinez, E., Badam, S., Harrison, J. L., Basta, M., Varughese, V. J., Anwar, G. R., Deshpande, V., Francis, D. T., Islek, D., et al. (2025) · World Journal of Critical Care Medicine · doi:10.5492/wjccm.v14.i4.108840 · Cited by 3
Xiong, Y., Wang, D., Shi, X., Song, X., Liu, Z., Yang, Y., Gao, Y., Gong, Y., Lu, J., Ding, Y., et al. (2025) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2025.121079 · Cited by 3
Functional roles and regulatory mechanisms of paeonol in the treatment of liver disease
Shu, M. Z., Fang, M., Xu, T., & Yan, Q. (2026) · Natural Products and Bioprospecting · doi:10.1007/s13659-025-00554-3 · Cited by 3
Cao, Q., chen, S., Zhang, Y., Yang, J., & Wang, Z. (2026) · Clinics and Research in Hepatology and Gastroenterology · doi:10.1016/j.clinre.2026.102763 · Cited by 3
Zhang, Y., Miao, J., Zhou, D., Xu, D., Fu, P., Ou, Y., Pan, D., Li, C., Zheng, D., & Qiu, J. (2026) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2026.121331 · Cited by 3
Bejarano, I., Jiménez‐Jorge, S., Lobo-Acosta, M. Á., López, A. I. Á., Rosso-Fernández, C. M., Ruiz, R. L., Eichau, S., Ruíz-Peña, J. L., Geniz, M. A., Ampuero, J., et al. (2026) · CNS Drugs · doi:10.1007/s40263-025-01261-w · Cited by 3
Ruiz‐Malagón, A. J., Herraiz-Vilela, M., Pinazo-Bandera, J. M., Toro-Ortiz, J. P., Gomez, C. L., Ho‐Plagaro, A., Garrido‐Sánchez, L., Robles‐Díaz, M., Taminiau, B., Daube, G., et al. (2026) · Journal of Extracellular Vesicles · doi:10.1002/jev2.70240 · Cited by 3
Self-citationLi, X., Dai, C., Chen, X., Lv, X., Wang, X., Li, L., Xu, J., Jia, G., Zhang, J., Su, D., et al. (2026) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2026.139951 · Cited by 3
Li, Y., Sheng, H., Zhou, T., Xing, C., Kukasch, M., Shao, S., Youhanna, S. C., Vorrink, S. U., Liang, Y., Nies, A. T., et al. (2026) · Drug Metabolism and Disposition · doi:10.1016/j.dmd.2026.100346 · Cited by 3
Pineda-Salgado, L., Gupta, R., Jan, M., Turkoglu, O., Estilo, A., George, V., & Rahman, M. I. (2021) · Advances in Therapy · doi:10.1007/s12325-021-01856-x · Cited by 3
He, Z., Zeng, Y., Li, S., Lin, L., Zhou, R., Wang, F., Wenjiao, Y., Wu, Y., Yang, J., Chen, A., et al. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.944416 · Cited by 3
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Han, Y., Ma, Z., Zhou, M., Niu, M., Zhao, X., Guo, Y.-M., Song, X., Lu, Y., Bai, Z., Li, Z., et al. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.109084 · Cited by 3
Yang, T., Yang, Y., Chen, Y., Yang, Y., Shi, M., Tian, Y., Yuan, X., Yang, Z., & Chen, L. (2023) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2023.115168 · Cited by 3
Qian, W., Li, L., Zeng, X., Yin, J., & Guo, J. (2023) · Exploration of Digestive Diseases · doi:10.37349/edd.2023.00021 · Cited by 3
Wang, Y., Li, Y., Du, Y., Liao, H.-M., Li, J., Yao, W., Yuan, X.-Q., Guo, Q.-C., Deng, T., Deng, T., et al. (2024) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2024.104463 · Cited by 3
Proteolytic shedding of CD46 from human hepatocytes indicates liver stress
Kupke, P., Zhou, J. Y., Glehr, G., Riquelme, P., Scheibert, L., Adenugba, A., Schlitt, H. J., Geissler, E. K., Werner, J. M., & Hutchinson, J. A. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e40841 · Cited by 3
Bromelain and liver health: A comprehensive systematic review of preclinical studies
Pereira, I. C., Pedrosa-Santos, Á. M. C., Martins, J. A., de Sousa, A. A., Nobre, T. A., Torres, L. R. D. O., da Silva, F. C. C., Severo, J. S., Sousa, J. M. D. C. E., & Torres‐Leal, F. L. (2025) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2025.02.001 · Cited by 3
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Кошурба, І. В., Hladkykh, F. V., Liadova, T. I., & Chyzh, M. (2025) · doi:10.46879/2025.1 · Cited by 3
Chamay, S., Alter, A., Parikh, R., Khatri, S., Budh, D. P., & Spinnell, M. K. (2025) · JGH Open · doi:10.1002/jgh3.13042 · Cited by 3
Schuermans, S., Quanico, J. P., Kestens, C., Vandendriessche, S., Slowikowski, E., Crijns, M. L., Pörtner, N., Berghmans, N., Baggerman, G., Mattos, M. S., et al. (2025) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-025-05720-x · Cited by 3
Engineering a macromolecular JAK inhibitor for treating acute inflammation and endotoxaemia
Zhou, M., Wang, Y., Yang, B., Zhang, Y., Zhong, L., Hu, K., Pu, W., Luo, G., & Zhang, J. (2025) · Nature Biomedical Engineering · doi:10.1038/s41551-025-01521-6 · Cited by 3
Facile Engineering of Anti‐Inflammatory Nanotherapies by Host‐Guest Self‐Assembly
Yang, G., Wu, P., Yu, C., Zhang, J., & Song, J. (2020) · ChemistrySelect · doi:10.1002/slct.202001590 · Cited by 3
[A review on cell-based models of human liver disease in vitro].
Liu, T., Ge, Y., Yuan, M., Xiong, Q., & Zhao, J. (2021) · PubMed Central · doi:10.7507/1001-5515.202004027 · Cited by 3
Roman, A., Moldovan, S. A., Santini, A., Stoian, M., & Dobru, D. E. (2021) · The Journal of Critical Care Medicine · doi:10.2478/jccm-2021-0021 · Cited by 3
Paz, M. V., Niu, H., Segovia‐Zafra, A., Medina‐Cáliz, I., Sanabria‐Cabrera, J., Lucena, M. I., Andrade, R. J., & Álvarez‐Álvarez, I. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10225317 · Cited by 3
Self-citationRana, P., Khan, S., Arat, S., Potter, D., & Khan, N. (2022) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.2c00243 · Cited by 3
Li, J., Qian, H., & Pi, F. (2023) · Food Bioscience · doi:10.1016/j.fbio.2023.102388 · Cited by 3
Ordóñez-Zarama, Y. A., Delgado, E. R. M., Ruiz, J. A. R., & Blanco, J. A. R. (2023) · Revista Colombiana de Gastroenterología · doi:10.22516/25007440.866 · Cited by 3
Predicting drug-induced liver injury with artificial intelligence—a minireview
Li, T., Kusko, R. L., Thakkar, S., Liu, Z., & Tong, W. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-99136-0.00012-x · Cited by 3
Gunduz, M., Argikar, U. A., Cirello, A. L., Brown, A. P., Bonazzi, S., & Walles, M. (2023) · Drug Metabolism and Bioanalysis Letters · doi:10.2174/0118723128260455231104180653 · Cited by 3
Li, K., Zheng, X., Zhang, J., Yan, Z., Ji, Y., Ge, F., & Zhu, F. (2024) · Pharmaceutical Biology · doi:10.1080/13880209.2024.2309864 · Cited by 3
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Zhai, X., He, X., Huang, A., Liu, Z., Chen, S., Chang, B., Zhu, Y., Xie, H., Bai, Z., Xiao, X., et al. (2025) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.16876 · Cited by 3
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Gugsa, E., Ferede, W. T., Dejenie, T. A., Gebremedhin, M. T., Dessie, G., Alemu, B. A., Teferi, B., & Shibabaw, T. (2025) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2025.05.028 · Cited by 2
Xu, T., Ooka, M., Zhao, J., Sakamuru, S., Ngan, D. K., Zhang, L., Yang, S., Travers, J., Xia, M., Zhao, T., et al. (2025) · Environmental Health Perspectives · doi:10.1021/ehp.6c00052 · Cited by 2
Gu, W., Bai, R., Wang, J., Wang, J., Fang, C., Shi, Y., Wang, P., Wang, Q., Bing, W., Xie, T., et al. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.102169 · Cited by 2
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Xu, Z., Wang, S., Chen, H., Lv, T., Zhang, Z., Pu, F., Xie, Z., Feng, L., & Wang, P. (2025) · Fitoterapia · doi:10.1016/j.fitote.2025.107050 · Cited by 2
Feng, D., Ma, Y., Liu, X., Tang, S., Xiang, S., Wang, J., & Li, S. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1688711 · Cited by 2
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Daghar, H., Pyman, B., Maios, C., Doyle, J. J., Perlstein, E. O., Samarut, É., & Parker, J. A. (2026) · Communications Biology · doi:10.1038/s42003-026-09535-9 · Cited by 2
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Metadata
- Authors
- Andrade, R. J., Chalasani, N., Björnsson, E. S., Suzuki, A., Kullak-Ublick, G. A., Watkins, P. B., Devarbhavi, H., Merz, M., Lucena, M. I., Kaplowitz, N., & Aithal, G. P.
- Affiliations
- Indiana University School of Medicine (US)
- Duke University (US)
- Novartis (Switzerland) (CH)
- University of North Carolina at Chapel Hill (US)
- St.John's Medical College Hospital (IN)
- University of Zurich (CH)
- Spanish Clinical Research Network (ES)
- Nottingham University Hospitals NHS Trust (GB)
- Corresponding author
- Lucena, M. Isabel
- ORCID
- Venue
- Nature Reviews Disease Primers
- Published
- 2019-08-22
- Volume
- 5
- Issue
- 1
- Pages
- 58-58
- ISSN
- 2056-676X (ISSN-L)
- OpenAlex
- W1565605888
- Cited by
- 924
- References
- 982
- Citations by year
- 2026: 152 · 2025: 197 · 2024: 161 · 2023: 127 · 2022: 145 · 2021: 97 · 2020: 38
- FWCI
- 9.11
- Type
- journal article
- Language
- en
- Open access
- green
- www.zora.uzh.ch
- Licence
- Locations
- Nature Reviews Disease Primers (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, other-oa)
- RISalud Institutional Health Repository of Andalucía (submittedVersion, cc-by-nc-nd)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion, other-oa)
- Zurich Open Repository and Archive (University of Zurich)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Pharmacovigilance and Adverse Drug Reactions
- Health Sciences › Medicine › Pharmacology (medical) › Drug-Induced Adverse Reactions
- Keywords
- drug-induced liver injury, idiosyncratic drug reactions, xenobiotic toxicity, genetic susceptibility, hepatic metabolism, immune response, corticosteroids, immune checkpoint inhibitors, hepatotoxicity
- MeSH terms
- Biopsy, Humans, Risk Factors, Biomarkers, Chemical and Drug Induced Liver Injury
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