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Drugging the efferocytosis process: concepts and opportunities
Open accessAbstract
The daily removal of billions of apoptotic cells in the human body via the process of efferocytosis is essential for homeostasis. To allow for this continuous efferocytosis, rapid phenotypic changes occur in the phagocytes enabling them to engulf and digest the apoptotic cargo. In addition, efferocytosis is actively anti-inflammatory and promotes resolution. Owing to its ubiquitous nature and the sheer volume of cell turnover, efferocytosis is a point of vulnerability. Aberrations in efferocytosis are associated with numerous inflammatory pathologies, including atherosclerosis, cancer and infections. The recent exciting discoveries defining the molecular machinery involved in efferocytosis have opened many avenues for therapeutic intervention, with several agents now in clinical trials.
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“efferocytosis in other settings can promote fibrosis as part of the tissue resolution process, for example, by secreting TGF-β1 (12, 13).”
From Impaired TIM4-mediated efferocytosis by liver macrophages contributes to fibrosis in metabolic dysfunction–associated steatohepatitis (2025) · cites this paper as [13]
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“While some progress has been made with respect to the Fractalkine receptor (CX3C motif chemokine receptor 1), Axl, MerTK, CD47 and Tim4/3, no approaches have thus far been clinically approved (64).”
From Cholesterol efflux protein, ABCA1, supports anticancer functions of myeloid immune cells (2026) · cites this paper as [64]
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“The accumulation of dead cells in disease settings indicates impaired clearance of dead cells by macrophages (“efferocytosis”) (12, 13).”
From Impaired TIM4-mediated efferocytosis by liver macrophages contributes to fibrosis in metabolic dysfunction–associated steatohepatitis (2025) · cites this paper as [13]
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“Efferocytosis not only prevents dead cell accumulation but also reprograms macrophages to execute tissue resolution functions, and impaired efferocytosis contributes to many human chronic inflammatory diseases (12, 13).”
From Impaired TIM4-mediated efferocytosis by liver macrophages contributes to fibrosis in metabolic dysfunction–associated steatohepatitis (2025) · cites this paper as [13]
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“It is seen as a major hurdle to using antigen presenting cells in cell-based therapies (61–64).”
From Cholesterol efflux protein, ABCA1, supports anticancer functions of myeloid immune cells (2026) · cites this paper as [64]
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Cites
1 retracted
Tan, X., Zhang, Z., Yao, H., & Shen, L. (2018) · Cancer Letters · doi:10.1016/j.canlet.2018.08.012 · Cited by 76
RetractedHallmarks of Cancer: The Next Generation
Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590
Hanahan, D., & Weinberg, R. A. (2000) · Cell · doi:10.1016/s0092-8674(00)81683-9 · Cited by 29,219
Ultrastructural Characterization of the Lower Motor System in a Mouse Model of Krabbe Disease
Cappello, V., Marchetti, L., Parlanti, P., Landi, S., Tonazzini, I., Cecchini, M., Piazza, V., & Gemmi, M. (2016) · Scientific Reports · doi:10.1038/s41598-016-0001-8 · Cited by 13,097
The trinity of COVID-19: immunity, inflammation and intervention
Tay, M. Z., Poh, C. M., Rénia, L., MacAry, P. A., & Ng, L. F. P. (2020) · Nature Reviews Immunology · doi:10.1038/s41577-020-0311-8 · Cited by 4,360
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
Baker, D. J., Wijshake, T., Tchkonia, T., LeBrasseur, N. K., Childs, B. G., van de Sluis, B., Kirkland, J. L., & van Deursen, J. M. (2011) · Nature · doi:10.1038/nature10600 · Cited by 3,670
Tumour-educated macrophages promote tumour progression and metastasis
Pollard, J. W. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1256 · Cited by 3,414
Fadok, V. A., Voelker, D. R., Campbell, P. A., Cohen, J., Bratton, D. L., & Henson, P. M. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.148.7.2207 · Cited by 3,321
Immunogenic Cell Death in Cancer Therapy
Kroemer, G., Galluzzi, L., Kepp, O., & Zitvogel, L. (2013) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032712-100008 · Cited by 3,303
Immunogenic cell death in cancer and infectious disease
Galluzzi, L., Buqué, A., Kepp, O., Zitvogel, L., & Kroemer, G. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2016.107 · Cited by 3,119
Research works printed but not linked: 4
- Urbani, L. et al. in Transplantation Proceedings 1175–1178 (Elsevier, 2004).
- Dalli, J., Colas, R., Shinohara, M. & Serhan, C. N. Aging delays resolution of acute inflammation in mice: reprogramming the host response with novel nano-proresolving. Medicines 193, 4235–4244 (2014).
- Noelia, A. et al. Apoptotic cells promote their own clearance and immune tolerance through activation of the nuclear receptor LXR. Immunity 31, 245–258 (2009). This important study highlights the role of nuclear receptors in anti-inflammatory effects of efferocytosis and plausible therapeutic advantages of targeting the pathway. · DOI
- Bohan, D. et al. Targeting the receptor AXL by bemcentinib prevents SARS-CoV-2 infection. Top. Antivir. Med. 29, 137–138 (2021).
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Lenk, L., Baccelli, I., Laqua, A., Heymann, J., Reimer, C., Dietterle, A., Winterberg, D., Mary, C., Corallo, F., Taurelle, J., et al. (2024) · Blood · doi:10.1182/blood.2023021088 · Cited by 19
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Deng, H., Xu, Y., Wu, K., Li, Y.-C., Zhang, Y.-J., Yu, H.-F., Li, C., Xu, D., & Wang, F. (2025) · Theranostics · doi:10.7150/thno.103701 · Cited by 9
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Bendre, S. V., Wang, Y., Hajyousif, B., K C, R., Bhogale, S. G., Pradeep, D., Krawczynska, N., Schane, C. P., Weisser, E., Singh, A., et al. (2026) · Science Advances · doi:10.1126/sciadv.adx5490 · Cited by 8
“It is seen as a major hurdle to using antigen-presenting cells in cell-based therapies ( 73 – 76 ).”
Synthesis of F127-GA@ZnO nanogel as a cisplatin drug delivery pH-sensitive system
Sơn, N. N., Thanh, V. M., & Huong, N. T. (2024) · RSC Advances · doi:10.1039/d4ra06514j · Cited by 8
Wang, Z., Sheng, J., Lu, G., & Zhang, L. J. (2024) · EngMedicine · doi:10.1016/j.engmed.2024.100043 · Cited by 8
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Jha, A., & Kumar, H. (2025) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2025.177808 · Cited by 8
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Wang, J., Xia, W.-Y., Liao, Y.-S., & Yuan, J. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1597528 · Cited by 8
Anti-Inflammatory Therapies for Atherosclerotic Stroke Prevention
Georgakis, M. K., Melton, P. W., Živković, L., Kopczak, A., & Katsanos, A. H. (2025) · Neurology · doi:10.1212/wnl.0000000000214214 · Cited by 8
Popa, A. E., Popa, E., Dramba, T., Coman, A. E., Poroch, M., Ungureanu, M. I., Bacușcă, A. I., Slănină, A. M., Bacoanu, G., & Poroch, V. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262311383 · Cited by 7
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Pandey, V. K., Acharya, T. K., Willcox, K. F., Dembla, S., Ramanujan, A., Grieco, A. R., Zuberi, Y. A., Mahalingam, R., Shepherd, A. J., Heijnen, C. J., et al. (2026) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2511401122 · Cited by 8
Ye, X., Xu, Z., Shen, D., Jin, Y.-J., Li, J., Xu, X., Tong, L., & Gao, F. (2024) · Experimental Neurology · doi:10.1016/j.expneurol.2024.114964 · Cited by 8
Bandyadka, S., Lebo, D. P. V., Mondragon, A. A., Serizier, S. B., Kwan, J., Peterson, J. S., Chasse, A. Y., Jenkins, V., Calikyan, A., Ortega, A., et al. (2025) · PLoS Genetics · doi:10.1371/journal.pgen.1011220 · Cited by 8
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Yim, J., Hope, C., Huelse, J. M., & Graham, D. K. (2025) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2025.2511178 · Cited by 8
Xu, K., Liu, Y. S., Luo, H., & Wang, T. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1218244 · Cited by 8
Chen, L., Kadoya, K., Endo, T., Iwasaki, N., & Terkawi, M. A. (2025) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2025.05.002 · Cited by 7
Liu, P., Wang, Q., Wang, S., Liu, Y., Chen, Q., Qin, W., Liu, X., Ye, X., Jiao, Y., Yuan, H., et al. (2025) · Aging Cell · doi:10.1111/acel.70097 · Cited by 7
Zhang, S., Li, L., Li, J., Ruan, S., Zuo, A., Lei, S., & Guo, Y. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.115056 · Cited by 7
Zhao, X. R., Li, M., Li, J., Han, Y., Gong, Y., Zhang, Z., Shi, J., Jin, C., Liu, J., & Si, P. (2025) · Advanced Science · doi:10.1002/advs.202502876 · Cited by 7
He, Z., Chen, N., Zhang, Y., Du, H., & Jie, L. (2026) · Journal of Inflammation Research · doi:10.2147/jir.s582297 · Cited by 7
Liang, Z., Long, X., Xiong, Z., Wong, P. P.-C., HUANG, S., Chen, S., Zhang, Y., Zhang, L., Leung, C., Cao, J., et al. (2026) · Cancer Cell · doi:10.1016/j.ccell.2026.05.005 · Cited by 7
Wang, Z., Xie, G., Xie, Y., Hu, M., Hu, Q., Yang, M., Zhang, L., Zhu, J., & Zhang, C. (2024) · Chemical Engineering Journal · doi:10.1016/j.cej.2024.154207 · Cited by 7
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Metadata
- Authors
- Mehrotra, P., & Ravichandran, K. S.
- Affiliations
- VIB-UGent Center for Inflammation Research (BE)
- Washington University in St. Louis (US)
- Corresponding author
- Ravichandran, Kodi S.
- Venue
- Nature Reviews Drug Discovery
- Published
- 2022-06-01
- Volume
- 21
- Issue
- 8
- Pages
- 601-620
- ISSN
- 1474-1776 (ISSN-L)
- 1474-1784
- PMC
- PMC9157040
- OpenAlex
- W4281737563
- Cited by
- 459
- References
- 231
- Citations by year
- 2026: 130 · 2025: 153 · 2024: 104 · 2023: 66 · 2022: 6
- FWCI
- 8.88
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Nature Reviews Drug Discovery (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion)
- Funders
- National Heart, Lung, and Blood Institute (P01HL120840)
- National Institute of General Medical Sciences (R35GM122542)
- National Institute of Allergy and Infectious Diseases (R01AI159551)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Keywords
- efferocytosis, phagocytes, anti-inflammatory mechanism, inflammation resolution, therapeutic target, atherosclerosis, cancer, infection
- MeSH terms
- Homeostasis, Humans, Phagocytes, Phagocytosis, Apoptosis, Atherosclerosis
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