Cited by 729Cholesterol and Lipid MetabolismLipid Membrane Structure and BehaviorCancer, Lipids, and Metabolism

The DOI matches its Crossref record; 146 of the 150 references it cites were found in a registry or an index.

Liver X receptors in lipid signalling and membrane homeostasis

Open access

Wang, Bo, Tontonoz, Peter·2018·Nature Reviews Endocrinology

DOI 10.1038/s41574-018-0037-xPMC PMC6433546

Open this paper in CoChat — free account

Abstract

Liver X receptors α and β (LXRα and LXRβ) are nuclear receptors with pivotal roles in the transcriptional control of lipid metabolism. Transcriptional activity of LXRs is induced in response to elevated cellular levels of cholesterol. LXRs bind to and regulate the expression of genes that encode proteins involved in cholesterol absorption, transport, efflux, excretion and conversion to bile acids. The coordinated, tissue-specific actions of the LXR pathway maintain systemic cholesterol homeostasis and regulate immune and inflammatory responses. LXRs also regulate fatty acid metabolism by controlling the lipogenic transcription factor sterol regulatory element-binding protein 1c and regulate genes that encode proteins involved in fatty acid elongation and desaturation. LXRs exert important effects on the metabolism of phospholipids, which, along with cholesterol, are major constituents of cellular membranes. LXR activation preferentially drives the incorporation of polyunsaturated fatty acids into phospholipids by inducing transcription of the remodelling enzyme lysophosphatidylcholine acyltransferase 3. The ability of the LXR pathway to couple cellular sterol levels with the saturation of fatty acids in membrane phospholipids has implications for several physiological processes, including lipoprotein production, dietary lipid absorption and intestinal stem cell proliferation. Understanding how LXRs regulate membrane composition and function might provide new therapeutic insight into diseases associated with dysregulated lipid metabolism, including atherosclerosis, diabetes mellitus and cancer.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/s41574-018-0037-x

Cites

146 of 146 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Inflammation, Atherosclerosis, and Coronary Artery Disease
Hansson, G. K. (2005) · New England Journal of Medicine · doi:10.1056/nejmra043430 · Cited by 8,773
A Receptor-Mediated Pathway for Cholesterol Homeostasis
Brown, M. S., & Goldstein, J. L. (1986) · Science · doi:10.1126/science.3513311 · Cited by 5,703
Atherosclerosis
Lusis, A. J. (2000) · Nature · doi:10.1038/35025203 · Cited by 4,880
NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
Duewell, P., Kono, H., Rayner, K. J., Sirois, C. M., Vladimer, G., Bauernfeind, F. G., Abela, G. S., Franchi, L., Nuñez, G., Schnurr, M., et al. (2010) · Nature · doi:10.1038/nature08938 · Cited by 4,026
Progress and challenges in translating the biology of atherosclerosis
Libby, P., Ridker, P. M., & Hansson, G. K. (2011) · Nature · doi:10.1038/nature10146 · Cited by 4,010
Macrophages in atherosclerosis: a dynamic balance
Moore, K. J., Sheedy, F. J., & Fisher, E. A. (2013) · Nature reviews. Immunology · doi:10.1038/nri3520 · Cited by 2,559
The coregulator exchange in transcriptional functions of nuclear receptors
Glass, C. K., & Rosenfeld, M. G. (2000) · Genes & Development · doi:10.1101/gad.14.2.121 · Cited by 2,233
Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor
Hörlein, A., Näär, A. M., Heinzel, T., Torchia, J., Gloss, B. R., Kurokawa, R., Ryan, A. K., Kamei, Y., Söderström, M., Glass, C. K., et al. (1995) · Nature · doi:10.1038/377397a0 · Cited by 2,072
Niemann-Pick C1 Like 1 Protein Is Critical for Intestinal Cholesterol Absorption
Altmann, S. W., Davis, H. R., Zhu, L.-J., Yao, X., Hoos, L. M., Tetzloff, G. G., Iyer, S. P. N., Maguire, M., Golovko, A., Zeng, M., et al. (2004) · Science · doi:10.1126/science.1093131 · Cited by 1,818
A transcriptional co-repressor that interacts with nuclear hormone receptors
Chen, J. D., & Evans, R. M. (1995) · Nature · doi:10.1038/377454a0 · Cited by 1,794

Show all 150 references

Sorted by citations

Items 401–500 of 729

Role of Nuclear Receptors on the Progression of Multiple Sclerosis: A Review
Babaalizadeh, B., Kalaki-Jouybari, F., Kahaki, F. A., Afkhami, H., & Razavi, Z.-S. (2025) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-025-01563-z · Cited by 7
Identification of a hormone response element that mediates suppression of APOF by LXR and PPARα agonists
Liu, Y., Izem, L., & Morton, R. E. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2019.158583 · Cited by 7
Non-coding RNA-Associated Therapeutic Strategies in Atherosclerosis
Tang, Y., Li, H., & Chen, C. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.889743 · Cited by 8
Differential Effects of Bariatric Surgery on Plasma Levels of ANGPTL3 and ANGPTL4.
Bini, S., D’Erasmo, L., Astiarraga, B., Minicocci, I., Palumbo, M., Pecce, V., Polito, L., Costanzo, A. D., Haeusler, R. A., Arca, M., et al. (2021) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2022.08.019 · Cited by 7
Vertical Sleeve Gastrectomy Attenuates the Progression of Non-Alcoholic Steatohepatitis in Mice on a High-Fat High-Cholesterol Diet
Whang, E. C., Liu, Y., Kageyama, S., Woo, S., Yang, J., Lee, R., Li, Z., Ji, H., Chen, Y., & Kupiec‐Weglinski, J. W. (2019) · Obesity Surgery · doi:10.1007/s11695-019-03860-1 · Cited by 7
Setosphapyrone C and D accelerate macrophages cholesterol efflux by promoting LXRα/ABCA1 pathway
Li, T., Yin, J., Yu-bin, J., Lin, P. C., Li, Y., Yang, Z., Hu, S., Wang, J., Zhang, B., Koshti, S., et al. (2020) · Archives of Pharmacal Research · doi:10.1007/s12272-020-01255-w · Cited by 7
Nuclear Receptor Atlases of Choroidal Tissues Reveal Candidate Receptors Associated with Age-Related Macular Degeneration
Peavey, J. J., Parmar, V. M., & Malek, G. (2022) · Cells · doi:10.3390/cells11152386 · Cited by 7
Peroxisomal integrity in demyelination-associated microglia enables cellular debris clearance and myelin renewal in mice
Barnes-Vélez, J. A., Zhang, X., Peña Señeriz, Y. L., Scott, K. A., Guan, Y., & Hu, J. (2026) · Journal of Clinical Investigation · doi:10.1172/jci179985 · Cited by 6
“Sterol export pathway gene products, including APOE, are transcriptionally regulated in part by liver X receptor (LXR), a nuclear receptor activated by oxysterols and sterol intermediates (37).”
Alterations in cardiac function correlate with a disruption in fatty acid metabolism in a mouse model of SMA
Nair, N., Kline, R., Boyd, I., Anikumar, M., Thomson, A. J. W., Lamont, D. J., Gray, G. A., Wishart, T. M., & Murray, L. M. (2025) · Human Molecular Genetics · doi:10.1093/hmg/ddaf006 · Cited by 6
Role of Protein Regulators of Cholesterol Homeostasis in Immune Modulation and Cancer Pathophysiology
Wang, Y., Bendre, S. V., Krauklis, S. A., Steelman, A. J., & Nelson, E. R. (2025) · Endocrinology · doi:10.1210/endocr/bqaf031 · Cited by 6
A translational approach to improve therapeutics in atopic dermatitis and beyond
Liu, D., Patel, D., Lau, M., Largen, J., Hu, B., He, H., & Guttman‐Yassky, E. (2025) · The Journal of Immunology · doi:10.1093/jimmun/vkaf049 · Cited by 7
Liver X receptor agonists in central nervous system disorders: From neuroprotection to clinical challenges
Zhang, Q., Mao, J.-D., Wang, M., Chen, H., Wang, Q.-F., Zhang, K., Yang, L., Ma, X., Wang, C., & Wu, Y. (2025) · Neuroscience · doi:10.1016/j.neuroscience.2025.07.050 · Cited by 6
Association between in vitro nuclear receptor-activating profiles of chemical compounds and their in vivo hepatotoxicity in rats
Kodama, S., Yoshii, N., OTA, A., Takeshita, J., Yoshinari, K., & Ono, A. (2021) · The Journal of Toxicological Sciences · doi:10.2131/jts.46.569 · Cited by 6
Excessive exogenous cholesterol activating intestinal LXRα-ABCA1/G5/G8 signaling pathway can not reverse atherosclerosis in ApoE−/− mice
Yu, X., Ding, X., Feng, H., Bi, Y., Yu, H., Shan, J., & Bian, H. (2023) · Lipids in Health and Disease · doi:10.1186/s12944-023-01810-6 · Cited by 6
Integrative analysis of hepatic transcriptional profiles reveals genetic regulation of atherosclerosis in hyperlipidemic Diversity Outbred-F1 mice
Kim, M., Huda, M. N., Evans, L. W., Que, E. S., Gertz, E., Maeda-Smithies, N., & Bennett, B. J. (2023) · Scientific Reports · doi:10.1038/s41598-023-35917-8 · Cited by 7
Liver X receptors induce antiproliferative effects in basal‐like breast cancer
Haugen, M. H., Gythfeldt, H. V. D. L., Egeland, E. V., Normann, L. S., Pandya, A. D., Vedin, L., Juell, S., Tenstad, E. M., Øy, G. F., Kristian, A., et al. (2023) · Molecular Oncology · doi:10.1002/1878-0261.13476 · Cited by 6
Enzymatically Formed Oxysterols and Cell Death
Urano, Y., & Noguchi, N. (2023) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-43883-7_10 · Cited by 7
Role of chaperones and endoplasmic reticulum stress in protein complexity associated with dyslipidemia: A future perspective to novel therapeutics (Review)
Huq, M. S. A., & Rajamani, K. (2023) · World Academy of Sciences Journal · doi:10.3892/wasj.2023.218 · Cited by 6
PKMYT1 knockdown inhibits cholesterol biosynthesis and promotes the drug sensitivity of triple-negative breast cancer cells to atorvastatin
Gao, W., Guo, X., Sun, L., Gai, J., Cao, Y., & Zhang, S. (2024) · PeerJ · doi:10.7717/peerj.17749 · Cited by 6
Role of post-translational modifications of Sp1 in cardiovascular diseases
Sun, X., Zhou, Q., Xiao, C., Mao, C., Liu, Y., Chen, G., & Song, Y. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1453901 · Cited by 6
CYP7B1 deficiency impairs myeloid cell activation in autoimmune disease of the central nervous system
Song, H., Lv, A., Zhu, Z., Li, R., Zhao, Q., Yu, X., Jiang, J., Lin, X., Zhang, C., Li, R., et al. (2024) · PNAS Nexus · doi:10.1093/pnasnexus/pgae334 · Cited by 6
The Liver X Receptor Promotes Immune Homeostasis via Controlled Activation of the Innate Immune System in the Liver
Nakashima, H., Kearney, B. M., & Kinoshita, M. (2024) · Biomolecules · doi:10.3390/biom15010025 · Cited by 6
Roles of ABCA1 in Chronic Obstructive Pulmonary Disease
Gu, Y., Bi, X., Liu, X., Qian, Q., Wen, Y., Hua, S., Fu, Q., Zheng, Y., & Sun, S. (2025) · COPD Journal of Chronic Obstructive Pulmonary Disease · doi:10.1080/15412555.2025.2493701 · Cited by 8
Differential effects of and mechanisms underlying the protection of cardiomyocytes by liver-X-receptor subtypes against high glucose stress-induced injury.
He, Q., Wang, F.-D., Fan, Y., Wang, C., & Zhang, J. (2018) · Biochemical and Biophysical Research Communications - BBRC · doi:10.1016/j.bbrc.2018.07.050 · Cited by 5
Regulation of calcific vascular and valvular disease by nuclear receptors
Sallam, T., Tintut, Y., & Demer, L. L. (2019) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000632 · Cited by 6
Exogenous Addition of 25‐Hydroxycholesterol Reduces Level of Very Long‐Chain Fatty Acids in X‐Linked Adrenoleukodystrophy
Jang, J., Lee, J. W., Song, J., Kim, D., & Min, K. H. (2019) · ChemistryOpen · doi:10.1002/open.201800281 · Cited by 6
27-Hydroxycholesterol exacerbates hepatic insulin resistance via plasma membrane cholesterol remodeling
Yang, J., Yang, X., Zheng, Y., Wang, A., Kong, Z., Xiao, Q., Tian, Y., Dong, H., Zhang, Z., Wang, M., et al. (2025) · Metabolism · doi:10.1016/j.metabol.2025.156392 · Cited by 5
Dysregulated bile acid metabolism drives lipid peroxidation and ferroptosis in NAFLD: therapeutic potential for traditional Chinese medicine
Liu, J., Li, F., Zeng, Q., Hu, W., Yang, L., Luo, S., Li, D., & Deng, Y. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1669805 · Cited by 8
The pathogenesis of metabolic dysfunction-associated steatotic liver disease and nucleoside reverse transcriptase inhibitors (NRTIs) -based HIV-antiretroviral regimens: A comprehensive narrative review
Horn, M., Gumede, N. M., & Gamede, M. W. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.118633 · Cited by 5
Carrier free oral Co-delivery of atorvastatin via baicalein-copper-network for atherosclerosis therapy through senescence reversal and multi-mechanistic synergy
Liu, K., Li, G., Liang, X., Wang, C., Zhu, N., Fu, X., Zhang, Y., Liu, C., & Yang, J. (2026) · Bioactive Materials · doi:10.1016/j.bioactmat.2025.12.036 · Cited by 5
Cellular Mechanisms and Therapeutic Targeting of Long Noncoding RNAs in Atherosclerotic Disease
Abu‐Khudir, R., Doghish, A. S., Abd‐Elmawla, M. A., Ghaiad, H. R., Aborehab, N. M., Zaki, M. B., Mohamed, H. H., Mohammed, O. A., Hamad, R. S., & Elimam, H. (2026) · IUBMB Life · doi:10.1002/iub.70090 · Cited by 6
Proteomics as a tool to study the osteoimmunomodulatory role of metallic ions in a sol–gel coating
García‐Arnáez, I., Romero‐Gavilán, F., Cerqueira, A., Azkargorta, M., Elortza, F., Suay, J., Goñi, I., & Gurruchaga, M. (2023) · Journal of Materials Chemistry B · doi:10.1039/d3tb01204b · Cited by 5
Reprogramming of the LXRα Transcriptome Sustains Macrophage Secondary Inflammatory Responses
de la Rosa, J. V., Tabraue, C., Huang, Z., Orizaola, M. C., Martin‐Rodríguez, P., Steffensen, K. R., Zapata, J. M., Boscá, L., Tontonoz, P., Alemany, S., et al. (2024) · Advanced Science · doi:10.1002/advs.202307201 · Cited by 4
Self-citation
Investigation of Liver X Receptor Gene Variants and Oxysterol Dysregulation in Autism Spectrum Disorder
Babayiğit, T. M., Akay, G. G., Uytun, M. Ç., Doğan, Ö., Serdar, M. A., Efendi, G. Y., Erman, A. G., Yürümez, E., & Öztop, D. B. (2024) · Children · doi:10.3390/children11050551 · Cited by 5
The Contribution of Cholesterol and Squalene Synthase in Cancer: Molecular Mechanisms, Lipid Rafts and Therapeutic Approaches
Mavridi, D., Katavati, T., & Kourounakis, A. P. (2025) · Medicinal Research Reviews · doi:10.1002/med.70012 · Cited by 7
Ethyl Acetate Extract of Dracocephalum heterophyllum Benth Ameliorates Nonalcoholic Steatohepatitis and Fibrosis via Regulating Bile Acid Metabolism, Oxidative Stress and Inhibiting Inflammation
Fang, Y., Sun, D., Li, G., Lv, Y. M., Li, J., Wang, Q., & Dang, J. (2022) · Separations · doi:10.3390/separations9100273 · Cited by 5
Combined with UPLC-Triple-TOF/MS-based plasma lipidomics and molecular pharmacology reveals the mechanisms of schisandrin against Alzheimer’s disease
Zhao, T., Zhang, Y., Zhang, C., Chang, Y.-F., Cui, M., Sun, Y., Hao, W., Yan, Y., Gu, S., Xie, Y., et al. (2023) · Chinese Medicine · doi:10.1186/s13020-023-00714-y · Cited by 5
Lipid Metabolic Regulatory Crosstalk Between Cancer Cells and Tumor-Associated Macrophages
Liu, S., Shen, Y., Yin, L., Liu, J., & Zu, X. (2023) · DNA and Cell Biology · doi:10.1089/dna.2023.0071 · Cited by 5
Hepatic Huwe1 loss protects mice from non-alcoholic fatty liver disease through lipid metabolic rewiring
Feng, W. W., Bang, S., Takacs, E. M., Day, C., Crawford, K. J., Al-Sheyab, R. F., Almufarrej, D. B., Wells, W. A., Ilchenko, S., Kasumov, T., et al. (2023) · iScience · doi:10.1016/j.isci.2023.108405 · Cited by 5
IRX4204 Induces Senescence and Cell Death in HER2-positive Breast Cancer and Synergizes with Anti-HER2 Therapy
Moyer, C. L., Lanier, A. L., Qian, J., Coleman, D., Hill, J. L., Vuligonda, V., Sanders, M. E., Mazumdar, A., & Brown, P. H. (2024) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-23-3839 · Cited by 5
LXR-dependent enhancer activation regulates the temporal organization of the liver’s response to refeeding leading to lipogenic gene overshoot
Korenfeld, N., Gorbonos, T., Florian, M. C. R., Rotaro, D., Goldberg, D. T., Radushkevitz-Frishman, T., Charni‐Natan, M., Bar‐Shimon, M., Cummins, C. L., & Goldstein, I. (2024) · PLoS Biology · doi:10.1371/journal.pbio.3002735 · Cited by 4
Hyocholic acid: A novel therapeutic strategy for metabolic syndrome
Rong, B., Zhang, Q., Zhang, X., Zhang, N., Shen, Z., Pang, Y., Lin, X. K., Liu, D., & Yang, X. (2024) · The Innovation Life · doi:10.59717/j.xinn-life.2024.100093 · Cited by 5
Effect of activation of liver X receptor alpha on cardiac & hepatic ABCC10 and SLC17A5 drug transporters in hypercholesterolemic rat model
El‐Ashmawy, N. E., Khedr, N. F., Sallam, M., & Nossier, A. I. (2022) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2022.04.046 · Cited by 5
Molecular features and predictive models identify the most lethal subtype and a therapeutic target for osteosarcoma
Zheng, K., Hou, Y., Zhang, Y., Wang, F., Sun, A., & Dong, Y. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1111570 · Cited by 5
An untargeted serum and urine lipidomics research based on UPLC–MS revealed the lipid alterations on adjuvant‐induced arthritis rats
Shi, W., & Han, Y. (2023) · Biomedical Chromatography · doi:10.1002/bmc.5736 · Cited by 5
Cholestenoic acid analogues as inverse agonists of the liver X receptors
Álvarez, L. D., Dansey, M. V., Ogara, M. F., Peña, C. I., Houtman, R., Veleiro, A. S., Pecci, A., & Burton, G. (2020) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2020.105585 · Cited by 5
Ludwigia adscendens (L.) Hara extract inhibits sebum overproduction and improves sebaceous gland function via the PPARγ/LXRα/SREBP1 pathway
Liu, Y., Liu, J., Xu, R., Yuan, Y., Sun, Q., Ding, S., Wang, F., & Qu, L. (2025) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2025.120416 · Cited by 4
Development and validation of a novel sodium-overload related genes signature for prognostic prediction in breast cancer: integrating bioinformatics and experimental approaches
Feng, Q., Yang, W., Su, G., Wu, F., & Xing, C. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1653903 · Cited by 4
Cholesterol metabolism on stem cell fate determination: a frontier horizon
Xu, B., Li, L., Wei, Q., Wang, Y., Huang, H., Pang, T., Wei, Z., Zheng, G., & Li, Y. (2025) · Stem Cell Research & Therapy · doi:10.1186/s13287-025-04687-7 · Cited by 4
Ergosterol and β-sitosterol exert cholesterol-lowering effects by enhancing gut microbiota-mediated cholesterol sulfonation and total bile acid excretion in mice
Zhang, S., Huang, Z., Wang, X., Lu, X., Xie, Q., Su, Z., Xie, J., Chen, J.-N., & Chen, L. (2026) · Food & Function · doi:10.1039/d5fo03052h · Cited by 4
Advances in understanding lipid metabolism in oligodendrocyte development and neurodegenerative diseases
Sun, Q.-Q., Bao, M., Gao, R., Wang, S.-K., Zhang, Y., Wang, L.-B., Zhang, Y., & Li, X. (2026) · Clinical Science · doi:10.1042/cs20258150 · Cited by 4
Stereoselective effects and its potential mechanism of ofloxacin on the growth and development of Rana nigromaculata: mainly liver lipid metabolism
Zhang, W., Teng, M., & Yan, J. (2025) · Frontiers of Environmental Science & Engineering · doi:10.1007/s11783-025-1970-2 · Cited by 4
Adropin expression reflects circadian, lipoprotein, and mitochondrial processes in human tissues
Stevens, J. R., Clemence, G., Zhou, M., Gamie, F., Aggarwal, G., McMillan, R. P., Hulver, M. W., Martinez, L. O., van der Brug, M., Vellas, B. J., et al. (2025) · Molecular Metabolism · doi:10.1016/j.molmet.2025.102196 · Cited by 8
Multi-omics analysis revealed the addiction to glutamine and susceptibility to de novo lipogenesis of endometrial neoplasm
Zhu, Y., Zheng, Y., Zhang, Q., Chen, L., Ouyang, Y., Song, Z., Zhao, B., Gu, C., Kong, B., Huang, H., et al. (2025) · Science China Life Sciences · doi:10.1007/s11427-024-2761-y · Cited by 4
Radioresistance via lipid metabolism: intrinsic, acquired, and tumor microenvironment
Su, Y., & Li, T. (2024) · Precision Nutrition · doi:10.1097/pn9.0000000000000068 · Cited by 6
A novel dammarane triterpenoid alleviates atherosclerosis by activating the LXRα pathway
Huang, Y. H., Ran, X., Liu, H., Luo, M., Qin, Y., Yan, J., Li, X., & Jia, Y. (2023) · Chinese Medicine · doi:10.1186/s13020-023-00758-0 · Cited by 4
Extract of Gualou-Xiebai Herb Pair Improves Lipid Metabolism Disorders by Enhancing the Reverse Cholesterol Transport in Atherosclerosis Mice
Liu, Y., Wang, T., Ding, L., Li, Z., Zhang, Y., Dai, M., & Wu, H. (2024) · Current Neurovascular Research · doi:10.2174/0115672026308438240405055719 · Cited by 4
Exserolide J ameliorates lipid accumulation in vitro by regulating liver X receptor alpha and peroxisome proliferator-activated receptor alpha proteins
Zhang, Y., Wang, X., Liu, T., Zhang, Z., Song, W.-G., & Guo, S. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e31861 · Cited by 4
Complex dichotomous links of nonalcoholic fatty liver disease and inflammatory bowel disease: exploring risks, mechanisms, and management modalities
Aggarwal, K., Singh, B. P., Goel, A., Agrawal, D., Bansal, S., Kanagala, S. G., Anamika, F., Gupta, A., & Jain, R. (2024) · Intestinal Research · doi:10.5217/ir.2024.00001 · Cited by 4
Intestinal retinol saturase is implicated in the development of obesity and epithelial homeostasis upon injury
Kiefer, M. F., Meng, Y., Yang, N. Y., Vahrenbrink, M., Wulff, S., Li, C., Wowro, S. J., Petricek, K. M., Sommerfeld, M., Flores, R. E., et al. (2024) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00035.2024 · Cited by 4
Baolier Capsule’s Secret Weapon: Piperine Boosts Cholesterol Excretion to Combat Atherosclerosis
Wei, M., LYu, P., Li, P., Hu, J., Wu, R., Ouyang, Q., & Guo, K. (2024) · Drug Design Development and Therapy · doi:10.2147/dddt.s499598 · Cited by 4
Recent Highlights of ATVB
Dron, J. S., Lazarte, J., & Hegele, R. A. (2018) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.118.311581 · Cited by 4
Aldehyde Dehydrogenase 1-related Genes in Triple-negative Breast Cancer Investigated Using Network Analysis
Yamada, A., SUZUKI, C., Shima, H., Kida, K., Adachi, S., Yamamoto, S., Narui, K., Tanabe, M., Shimizu, D., Taniguchi, R., et al. (2020) · Anticancer Research · doi:10.21873/anticanres.14696 · Cited by 4
Comparative proteomics analysis for identifying the lipid metabolism related pathways in patients with Klippel-Feil syndrome
Li, Z., Zhang, C., Qiu, B., Niu, Y., Leng, L., Cai, S., Tian, Y., Zhang, J., Qiu, G., Wu, N., et al. (2021) · Annals of Translational Medicine · doi:10.21037/atm-20-5155 · Cited by 4
The effect of hydroxychloroquine on cholesterol metabolism in statin treated patients after myocardial infarction
Ulander, L., Simonen, P. P., Tolppanen, H., Hartman, O., Rissanen, T. T., Eklund, K. K., Kalaoja, M., Kurkela, M. J., Neuvonen, M., Niemi, M., et al. (2023) · Atherosclerosis Plus · doi:10.1016/j.athplu.2023.06.003 · Cited by 4
Flindissone, a Limonoid Isolated from Trichilia prieuriana, Is an LXR Agonist
Rešetar, M., Tietcheu, B. R. G., Tsamo, A. T., Chen, Y., Schachner, D., Stolzlechner, S., Pagna, J. I. M., Beniddir, M. A., Kirchmair, J., & Dirsch, V. M. (2023) · Journal of Natural Products · doi:10.1021/acs.jnatprod.3c00059 · Cited by 4
Aster: A New Star in Cholesterol Trafficking
Kutyavin, V. I., & Chawla, A. (2018) · Cell · doi:10.1016/j.cell.2018.09.025 · Cited by 5
Integration and comparison of multi-omics profiles of NGLY1 deficiency plasma and cellular models to identify clinically relevant molecular phenotypesPreprint
Chen, S., Wang, G., Shen, X., Hornburg, D., Rego, S. M., Hoffman, R., Nevins, S. A., Cheng, X., & Snyder, M. P. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.05.28.446235 · Cited by 4
Upregulation of LXRβ/ABCA1 pathway alleviates cochlear hair cell senescence of C57BL/6 J mice via reducing lipid droplet accumulation
Guo, D., Wu, J., Shen, C., Zhang, A., Zou, T., Chen, K., Huang, W., Pan, Y., Shen, Y., Ji, P., et al. (2025) · Biogerontology · doi:10.1007/s10522-025-10192-4 · Cited by 3
Lactobacillus fermentum 166, Derived from Yak Yogurt from Tibetan Areas of Sichuan, Improves High-Fat-Diet-Induced Hyperlipidemia by Modulating Gut Microbiota and Liver- and Gut-Related Pathways
Zhang, S., Xu, L., Zhu, C., Li, J., Fu, Y., Shuang, W., & Chen, L. (2025) · Foods · doi:10.3390/foods14050867 · Cited by 3
MicroRNAs in metabolic syndrome: Mechanisms, diagnosis, and therapy
Rahman, M. A., Islam, M. M., Islam, M. M., Ripon, M. A. R., & Hossain, M. S. (2025) · Advances in clinical chemistry · doi:10.1016/bs.acc.2025.06.003 · Cited by 4
Liver X Receptor Activation Alleviates Hepatic Ischemia‐Reperfusion Injury in Diabetes by Inhibiting NF‐κB–NLRP3 Activation
Jiang, C., Ding, W., Hu, Y., & Yang, C. (2025) · Immunity Inflammation and Disease · doi:10.1002/iid3.70243 · Cited by 3
Bmal1 is involved in the regulation of macrophage cholesterol homeostasis
Pan, X., O’Hare, J., Mowdawalla, C., Mota, S., Wang, N., & Hussain, M. M. (2025) · JCI Insight · doi:10.1172/jci.insight.194304 · Cited by 4
Exploring a genetic basis for the metabolic perturbations in ME/CFS using UK biobank
Huang, K., Muneeb, M., Thomas, N., Schneider‐Futschik, E. K., Gooley, P. R., Ascher, D. B., & Armstrong, C. W. (2025) · iScience · doi:10.1016/j.isci.2025.114316 · Cited by 3
Macrophage METTL3 synergizes with YTHDF2 to promote atherosclerosis by inhibiting the LXR-α/ABCA1 pathway
Tu, Y.-F., Li, Y., Qin, J.-F., Chen, W., Zhu, X., Sammad, A., & Yin, K. (2026) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2026.104568 · Cited by 3
Gut microbiota-dependent 24-hydroxycholesterol metabolism contributes to capsaicin-induced amelioration of Alzheimer’s disease-like pathology in mice
Li, Y., Wang, H., Zhang, D., Wang, S., Li, Z., Li, J., Tai, S., Tong, D., Wang, B., Lu, D., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-68937-9 · Cited by 5
Self-citation
The deficiency of ALKBH5 promotes lenvatinib resistance and CD8+ T cell exhaustion via accumulation of the cholesterol metabolite 27HC in hepatocellular carcinoma
Wang, J., Jia, W., Zhou, Y., Zhao, W., Feng, Y., Lv, Q., Liang, L., Deming, Z., Xu, C., Ling, X., et al. (2026) · Cancer Letters · doi:10.1016/j.canlet.2026.218316 · Cited by 3
A Computational Framework to Evaluate Interactions of BPA and Its Analogs with Human Liver X Receptor-Beta for Health Risk Assessment
Pathak, R. K., Kumar, S., & Kumar, V. (2026) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.5c00460 · Cited by 3
Fatty acid metabolism—an emerging regulatory node in T‐cell immunometabolism
Arenberg, B. C., Sack, M. N., & Wu, J. (2026) · Clinical & Translational Immunology · doi:10.1002/cti2.70091 · Cited by 3
Activation of the Reverse Cholesterol Transport Pathway: A Strategy to Ameliorate Lipid Metabolic Dyshomeostasis in the Microenvironment Following Spinal Cord Injury
Wang, X., Tan, G., Feng, R., Ni, M., gao, F., & Li, J. (2026) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-026-01754-2 · Cited by 3
Cav3.1 T-type calcium channel blocker NNC 55-0396 reduces atherosclerosis by increasing cholesterol efflux
Tsai, M., Cho, R., Lin, C., Jheng, Y., Lien, C., Chen, C., & Tzeng, B. (2024) · Biochemical Pharmacology · doi:10.1016/j.bcp.2024.116096 · Cited by 3
Therapeutic potential of oleic acid supplementation in myotonic dystrophy muscle cell models
Moreno, N., Sabater-Arcis, M., Sevilla, T., Alonso, M. P., Ohana, J., Bargiela, A., & Artero, R. D. (2024) · Biological Research · doi:10.1186/s40659-024-00496-z · Cited by 3
Effects of dietary supplementation with butyrate glycerides on lipid metabolism, intestinal morphology, and microbiota population in laying hens
Zhou, M., Luo, Y., Qiu, J., Wang, H., Li, X., Zhang, K., Li, X., Yaqoob, M. U., & Wang, M. (2025) · Poultry Science · doi:10.1016/j.psj.2024.104755 · Cited by 3
Intermittent Fasting
Bernabé, B. P., Oliveira, M. L., Wolf, P. G., McLeod, A., Gabel, K., Cares, K., Robinson, N., DiPiazza, B., Varady, K. A., & Tussing-Humphreys, L. M. (2025) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2024.10.007 · Cited by 4
Laminar shear stress promotes accumulation of polyunsaturated fatty acid in aortic endothelial cells through upregulation of LPCAT3 enzyme activity
Bousquet, D., & Guillot, N. (2025) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2025.159638 · Cited by 3
Exploring the anticancer potential of ergosterol and ergosta-5,22,25-triene-3-ol against colorectal cancer: Insights from experimental models and molecular mechanisms
Taank, Y., & Agnihotri, N. (2025) · Biochemical Pharmacology · doi:10.1016/j.bcp.2025.117061 · Cited by 3
Functional interaction between immune checkpoints and lipid metabolism in the development of arteriosclerosis obliterans
Zhang, J., Cui, L., Meng, X., Luo, Y., Ou, J., Wang, S., & Qiu, M. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1665454 · Cited by 3
Liver X receptor β is required for the survival of single-positive thymocytes by regulating IL-7Rα expression
Huang, H., Wu, X., Meng, D., Feng, Y., Zhou, L., Liu, Z., Tang, S., Li, X., Cao, Y., He, H., et al. (2020) · Cellular and Molecular Immunology · doi:10.1038/s41423-020-00546-y · Cited by 3
Liver X Receptor Expression and Pentraxin 3 Production in Chronic Rhinosinusitis and Sinonasal Mucosal Fibroblast Cells
Tsai, Y., Shen, P., Luo, S., & Wu, W. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10030452 · Cited by 3
ABCG1 is Expressed in an LXR-Independent Manner in Patients with Type 2 Diabetes Mellitus
Wang, H., Wang, J., Xu, X.-N., Zhao, X., & Liu, W. X. (2022) · Current Molecular Medicine · doi:10.2174/1566524023666220822150820 · Cited by 3
Precision pharmacological reversal of strain-specific diet-induced metabolic syndrome in mice informed by epigenetic and transcriptional regulation
Wulfridge, P., Davidovich, A., Salvador, A. C., Manno, G. C., Tryggvadóttir, R., Idrizi, A., Huda, M. N., Bennett, B. J., Adams, L. G., Hansen, K. D., et al. (2023) · PLoS Genetics · doi:10.1371/journal.pgen.1010997 · Cited by 4
Future therapeutic perspectives in nonalcoholic fatty liver disease: a focus on nuclear receptors, a promising therapeutic target
Stan, S. I., Biciuşcă, V., Clenciu, D., Mitrea, A., Boldeanu, M. V., Durand, P., & Dănoiu, S. (2023) · Medicine and Pharmacy Reports · doi:10.15386/mpr-2628 · Cited by 4
Autoimmune Pulmonary Alveolar Proteinosis: A Review of Pathogenesis and Emerging Therapies
Mathavan, A., Mathavan, A., Sathyanarayanan, S. P., McCarthy, C., & Ataya, A. (2024) · Current Pulmonology Reports · doi:10.1007/s13665-024-00356-x · Cited by 3
Prenatal bisphenol analogs exposure and placental DNA hypomethylation of genes in the PPAR signaling pathway: Insights for bisphenol analogs’ effects on infant anthropometry
Ji, H., Zhu, H., Wang, Z., Liang, H., Chen, Y., Liu, X., Yuan, W., Wu, Q., Yuan, Z., & Miao, M. (2024) · Environmental Research · doi:10.1016/j.envres.2024.120476 · Cited by 3
Cholesterol metabolism and tumor radiotherapy
Kuang, H., Lyu, J.-H., & Li, T. (2023) · journal of nutritional oncology · doi:10.1097/jn9.0000000000000019 · Cited by 3
Alcohol aggravates metabolic fatty liver in high-fat diet mice via gut microbiota and metabolite-mediated TLR4/NF-κB and MCT1/GPR pathways
Wang, N., Wang, C., Cao, X., Chang, J., & Zhang, Z. (2024) · Food Bioscience · doi:10.1016/j.fbio.2024.105816 · Cited by 3
Mechanism and therapeutic potential of liver injury induced by cholesterol-associated proteins
Zhou, Y., Cao, Y., Yin, Y., Xu, Z., Yang, X., Yang, B., Luo, P., Yan, H., & He, Q.-J. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1572592 · Cited by 3
Protective effect of Allium hookeri water extract and its main compound, Cycloalliin, on foam cell formation in THP-1-derived macrophages
Moon, H.-R., & Yun, J. (2025) · Food & Nutrition Research · doi:10.29219/fnr.v69.10763 · Cited by 3
LXR alters CD4 + T cell function through direct regulation of glycosphingolipid synthesisPreprint
Waddington, K. E., Robinson, G., Rubio-Cuesta, B., Chrifi-Alaoui, E., Andreone, S., Poon, K., Ivanova, I., Martin‐Gutierrez, L., Owen, D. M., Jury, E. C., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/721050 · Cited by 3
Substrate-Specific Function of PNPLA3 Facilitates Hepatic VLDL-Triglyceride Secretion During Stimulated LipogenesisPreprint
Johnson, S., Bao, H., McMahon, C., Chen, Y., Burr, S. D., Anderson, A. M., Madeyski-Bengtson, K., Lindén, D., Han, X., & Liu, J. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.08.30.553213 · Cited by 3

Authors: Wang, B., & Tontonoz, P.
Affiliations: University of California, Los Angeles (US)
Corresponding author: Tontonoz, Peter
ORCID: Wang, Bo
Tontonoz, Peter
Venue: Nature Reviews Endocrinology
Publisher: Springer Science and Business Media LLC
Published: 2018-06-14
Volume: 14
Issue: 8
Pages: 452-463
ISSN: 1759-5029 (ISSN-L)
1759-5037
DOI: 10.1038/s41574-018-0037-x
PMC: PMC6433546
OpenAlex: W2808548053
Cited by: 722
References: 150
Citations by year: 2026: 89 · 2025: 111 · 2024: 110 · 2023: 117 · 2022: 81 · 2021: 94 · 2020: 64 · 2019: 48 · 2018: 8
FWCI: 11.87
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature Reviews Endocrinology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
eScholarship (California Digital Library) (submittedVersion)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (K01DK114373)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Lipid Membrane Structure and Behavior
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
Keywords: liver X receptor, liver X receptor alpha, LXRβ, nuclear receptors, cholesterol homeostasis, lipid metabolism, SREBP-1c, fatty acid metabolism, membrane homeostasis, polyunsaturated fatty acids, bile acid synthesis, lipoprotein production, intestinal stem cell proliferation, atherosclerosis, diabetes mellitus, cancer
MeSH terms: Liver X Receptors, Animals, Cholesterol, Gene Expression Regulation, Homeostasis, Humans, Signal Transduction, Needs Assessment, Lipid Metabolism, Translational Research, Biomedical

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Liver X receptors in lipid signalling and membrane homeostasis

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks