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Insulin–PI3K signalling: an evolutionarily insulated metabolic driver of cancer
Open accessAbstract
Cancer is driven by incremental changes that accumulate, eventually leading to oncogenic transformation. Although genetic alterations dominate the way cancer biologists think about oncogenesis, growing evidence suggests that systemic factors (for example, insulin, oestrogen and inflammatory cytokines) and their intracellular pathways activate oncogenic signals and contribute to targetable phenotypes. Systemic factors can have a critical role in both tumour initiation and therapeutic responses as increasingly targeted and personalized therapeutic regimens are used to treat patients with cancer. The endocrine system controls cell growth and metabolism by providing extracellular cues that integrate systemic nutrient status with cellular activities such as proliferation and survival via the production of metabolites and hormones such as insulin. When insulin binds to its receptor, it initiates a sequence of phosphorylation events that lead to activation of the catalytic activity of phosphoinositide 3-kinase (PI3K), a lipid kinase that coordinates the intake and utilization of glucose, and mTOR, a kinase downstream of PI3K that stimulates transcription and translation. When chronically activated, the PI3K pathway can drive malignant transformation. Here, we discuss the insulin-PI3K signalling cascade and emphasize its roles in normal cells (including coordinating cell metabolism and growth), highlighting the features of this network that make it ideal for co-option by cancer cells. Furthermore, we discuss how this signalling network can affect therapeutic responses and how novel metabolic-based strategies might enhance treatment efficacy for cancer.
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“Although not covered in this review, the importance of aberrant functions of different PLCs and PI3Ks in disease development is well established and continues to expand [11,62,67,72,134–138].”
From Phosphatidylinositol(4,5)bisphosphate: diverse functions at the plasma membrane (2020) · cites this paper as [67]
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“p110α heterodimers play a key role in glucose homeostasis and in insulin and growth factor signalling [65–67].”
From Phosphatidylinositol(4,5)bisphosphate: diverse functions at the plasma membrane (2020) · cites this paper as [67]
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Cites
Hanahan, D., & Weinberg, R. A. (2000) · Cell · doi:10.1016/s0092-8674(00)81683-9 · Cited by 29,219
Cerami, E., Gao, J., Dogrusoz, U., Gross, B. E., Sumer, S. O., Aksoy, B. A., Jacobsen, A., Byrne, C. J., Heuer, M. L., Larsson, E., et al. (2012) · Cancer Discovery · doi:10.1158/2159-8290.cd-12-0095 · Cited by 17,455
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
Vander Heiden, M. G., Cantley, L. C., & Thompson, C. B. (2009) · Science · doi:10.1126/science.1160809 · Cited by 16,197
Self-citationIntegrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal
Gao, J., Aksoy, B. A., Dogrusoz, U., Dresdner, G., Gross, B., Sumer, S. O., Sun, Y., Jacobsen, A., Sinha, R., Larsson, E., et al. (2013) · Science Signaling · doi:10.1126/scisignal.2004088 · Cited by 15,160
On Respiratory Impairment in Cancer Cells
Warburg, O. H. (1956) · Science · doi:10.1126/science.124.3215.269 · Cited by 3,472
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism
Engelman, J. A., Luo, J., & Cantley, L. C. (2006) · Nature Reviews Genetics · doi:10.1038/nrg1879 · Cited by 3,330
Self-citationThe PI3K Pathway in Human Disease
Fruman, D. A., Chiu, H., Hopkins, B. D., Bagrodia, S., Cantley, L. C., & Abraham, R. T. (2017) · Cell · doi:10.1016/j.cell.2017.07.029 · Cited by 2,749
Self-citationAlpelisib for PIK3CA -Mutated, Hormone Receptor–Positive Advanced Breast Cancer
André, F., Ciruelos, E., Rubovszky, G., Campone, M., Loibl, S., Rugo, H. S., Iwata, H., Conte, P., Mayer, I. A., Kaufman, B., et al. (2019) · New England Journal of Medicine · doi:10.1056/nejmoa1813904 · Cited by 2,622
Cancer cell metabolism: warburg and beyond
Hsu, P. P., & Sabatini, D. M. (2008) · Cell · doi:10.1016/j.cell.2008.08.021 · Cited by 2,452
Insulin and insulin-like growth factor signalling in neoplasia
Pollak, M. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2536 · Cited by 2,059
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Herms, A., & Jones, P. H. (2023) · Annual Review of Cancer Biology · doi:10.1146/annurev-cancerbio-061421-012447 · Cited by 18
Current mechanisms in obesity and tumor progression
Fosam, A. E., & Perry, R. J. (2020) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000690 · Cited by 18
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Jia, W., Luo, S., Guo, H. W., & Kong, D. (2022) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2022.2132293 · Cited by 20
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Karwen, T., Kolczyńska, K., Gross, C., Löffler, M. C., Friedrich, M., Loza‐Valdes, A., Schmitz, W., Wit, M., Dziaczkowski, F., Белых, А. Е., et al. (2023) · EMBO Molecular Medicine · doi:10.15252/emmm.202216858 · Cited by 18
Kumar, N., Ambriz, J. R., Tsai, K., Mim, M. S., Flores-Flores, M., Chen, W., Zartman, J. J., & Alber, M. (2024) · Nature Communications · doi:10.1038/s41467-024-46698-7 · Cited by 16
Ketogenic diet induces autophagy to alleviate bleomycin-induced pulmonary fibrosis in murine models
Mu, E., Wang, J., Chen, L., lin, S., Chen, J., & Huang, X. (2020) · Experimental Lung Research · doi:10.1080/01902148.2020.1840667 · Cited by 18
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Fazeli, P. K., & Steinhauser, M. L. (2025) · Endocrine Reviews · doi:10.1210/endrev/bnaf021 · Cited by 19
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Duggan, M. R., Weaver, M. W., & Khalili, K. (2021) · Aging · doi:10.18632/aging.202459 · Cited by 16
Wang, G., Chen, L., Qin, S., Zheng, Y., Xia, C., Yao, J., Wang, P., & Deng, L. (2022) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202200186 · Cited by 15
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Kľučková, K., D’Avola, A., & Riches, J. C. (2022) · Cancers · doi:10.3390/cancers14225552 · Cited by 16
Malik, N., Kim, Y., Yan, H., Tseng, Y., du Bois, W., Ayaz, G., Tran, A. D., Ramírez, L. V., Yang, H. H., Michalowski, A. M., et al. (2023) · Cancer Research · doi:10.1158/0008-5472.can-22-2525 · Cited by 16
Wei, N., Wu, T., Wu, C., Wang, S., Tao, Z., Wang, G., Zhao, X., Diao, K., Wang, J., Chen, J., et al. (2023) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjad023 · Cited by 15
Morishita, K., Nakahata, S., & Ichikawa, T. (2020) · Cancer Science · doi:10.1111/cas.14716 · Cited by 15
Mir, R., Elfaki, I., Abuduhier, F. M., Alotaibi, M. A., Alalawy, A. I., Barnawi, J., Babakr, A. T., Mir, R., Mirghani, H. O., Hamadi, A., et al. (2021) · Journal of Personalized Medicine · doi:10.3390/jpm11090861 · Cited by 15
Hua, J., Lin, H., Wang, X., Qian, Z., Vaughn, M. G., Tabet, M., Wang, C., & Lin, H. (2024) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2024.102968 · Cited by 16
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Wu, D., Yuan, X., Zhou, R., Chen, W., Li, W., Li, Z., Li, X., Zhu, R., Wang, H., & Yang, Y. (2023) · Food & Function · doi:10.1039/d2fo02887e · Cited by 13
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Dinesh, B. G. H., Bandral, S. K., Sadashivappa, N. M., Ganjipete, S., Ammunje, D. N., Kunjiappan, S., Theivendren, P., Jays, J., & Pavadai, P. (2025) · Current Pharmaceutical Design · doi:10.2174/0113816128357976250122042633 · Cited by 13
Gaunt, J. R., Zainolabidin, N., Yip, A. K. K., Tan, J. M., Low, A. Y. T., Chen, A. I., & Ch’ng, T. H. (2023) · Journal of Neuroinflammation · doi:10.1186/s12974-023-02913-8 · Cited by 12
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Deng, J., Lin, J., Liu, C., Li, J., Cai, J., Zhou, X., & Li, X. (2022) · Scientific Reports · doi:10.1038/s41598-022-25698-x · Cited by 11
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Yu, L., Qian, J., Li, X., Tian, M., Bai, X., Yang, J., Deng, R., Lu, C., He, X., Lü, A., et al. (2026) · Molecular Biomedicine · doi:10.1186/s43556-026-00408-5 · Cited by 12
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Shen, S., Guo, J., Lv, N., Chen, Q., & Tong, J. (2022) · International Journal of Oncology · doi:10.3892/ijo.2022.5445 · Cited by 9
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Liu, Q., Gu, L., Qiu, J., & Junbo, Q. (2023) · Journal of Gastrointestinal Oncology · doi:10.21037/jgo-22-1166 · Cited by 9
Xing, X., Cao, F.-M., Gao, L., & Song, M. (2023) · Molecular Biology Reports · doi:10.1007/s11033-023-08623-x · Cited by 8
Kuang, D.-D., Zhang, T., Guo, X.-Y., Pan, L., Li, Q.-M., Luo, J., Li, X., & Zha, X. (2025) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.4c11144 · Cited by 9
Dou, C.-X., Qu, H.-Z., Qin, Y., Wang, X., Yan, H., Li, R., Zhao, Y., Zhou, J., & Wang, X. (2025) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2025.138769 · Cited by 8
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Zhou, J., Wei, X., Xu, H. Y., Hu, H. B., Li, F. X., Zhou, W., Chen, Y., & Liu, Z. (2022) · Medicine · doi:10.1097/md.0000000000030494 · Cited by 8
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Ling, S., Dexter, A., Race, A. M., Sharma, S., Hamm, G. R., Polanska, U. M., Marshall, J. F., Takáts, Z., Brindle, K. M., Yuneva, M. O., et al. (2025) · Disease Models & Mechanisms · doi:10.1242/dmm.050804 · Cited by 8
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Wang, T., Li, X., Liu, N., Yang, Y. A., & Gong, Q. (2023) · Journal of Plant Physiology · doi:10.1016/j.jplph.2023.154100 · Cited by 7
Li, S., Liu, Z., Chen, Q., Chen, Y., & Ji, S. (2024) · Scientific Reports · doi:10.1038/s41598-024-62917-z · Cited by 7
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Barker, R. M., Chambers, A., Kehoe, P. G., Rowe, E., & Perks, C. M. (2024) · Clinical Science · doi:10.1042/cs20230317 · Cited by 9
Wißmiller, K., Bilekova, S., Frankó, A., Lutz, S. Z., Katsburg, M., Gulde, S., Pellegata, N. S., Stenzl, A., Heni, M., Berti, L., et al. (2023) · Molecular Metabolism · doi:10.1016/j.molmet.2023.101706 · Cited by 7
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Montrose, D. C., & Galluzzi, L. (2022) · Cancer Research · doi:10.1158/0008-5472.can-22-0686 · Cited by 6
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Meiling, S., Han, Z., Luo, Z., Ge, L., Zhang, X., Feng, K., Zhang, G., Xu, F., Zhou, H., Han, H., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-75889-x · Cited by 6
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Yan, X., Li, J., Zhang, Y., Liang, C., Liang, P., Li, T., Liu, Q., & Hui, X. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1292944 · Cited by 6
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Podmore, L., Poloz, Y., Iorio, C., Mouaaz, S., Nixon, K., Smirnov, P., McDonnell, B., Lam, S. H. L., Zhang, B., Tharmapalan, P., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113251 · Cited by 7
Moosavi, D., Mullens, D. A., Davidson, L. A., Fan, Y.-Y., Goldsby, J. S., Ivanov, I. V., Levy, L., Kahsai, O. J., Curtis, K. R., Raftery, D., et al. (2025) · American Journal of Clinical Nutrition · doi:10.1016/j.ajcnut.2025.04.031 · Cited by 5
Control of phosphatidylinositol‐3‐kinase signaling by nanoscale membrane compartmentalization
Cabral‐Dias, R., & Antonescu, C. N. (2022) · BioEssays · doi:10.1002/bies.202200196 · Cited by 5
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Cheng, W., Cai, C., Xu, Y., Xiao, X., Shi, T., Liao, Y., Wang, X., Chen, S., Zhou, M., & Liao, Z. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-06355-1 · Cited by 5
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Nair, N. U., Greninger, P., Friedman, A. A., Amzallag, A., Cortez, E., Sahu, A. D., Lee, J. S., Dastur, A., Egan, R. K., Murchie, E., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.06.03.447011 · Cited by 5
Ji, H., Yang, T., Li, C., Zhu, Y., Zheng, Z., Zhang, J., Liu, Y., Gao, Y., Wu, H., Jiang, J., et al. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115676 · Cited by 4
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Maya, A. V., Neuhaus, L., Nogay, L., Singh, A., Heckmann, L., Grass, I., Buescher, J. M., Kierdorf, K., & Classen, A.-K. (2025) · Nature Communications · doi:10.1038/s41467-025-66995-z · Cited by 5
Ishigami, J., Hu, X. F., Schlosser, P., Austin, T. R., Chen, J., Psaty, B. M., Dowdy, D. W., Ballantyne, C. M., Grams, M. E., Coresh, J., et al. (2025) · The Journal of Applied Laboratory Medicine · doi:10.1093/jalm/jfaf179 · Cited by 4
Abdullah, K. M., Sharma, G., Anjum, B., Alam, M. F., Yadav, S., Singh, Y., Sinha, R. A., Venkatesh, V., Siddiqui, J. A., & Chakravarti, B. (2026) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2026.101458 · Cited by 4
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Lin, T.-Y., Ramsamooj, S., Perrier, T., Liberatore, K. M., Lantier, L., Vasan, N., Karukurichi, K. R., Hwang, S., Kesicki, E. A., Kastenhuber, E. R., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113535 · Cited by 4
Self-citationOtegbeye, E. E., Fritz, C. D. L., Liao, J., Smith, R. K., & Cao, Y. (2021) · Current Colorectal Cancer Reports · doi:10.1007/s11888-021-00465-8 · Cited by 5
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Tan, W., Zhang, J., Deng, Z., Dai, F., Tang, L., Hu, W., & Liu, H. (2023) · Cancer Medicine · doi:10.1002/cam4.6073 · Cited by 3
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Agu, I., José, I. R., Ram, A. R., Oberbauer, D., Albeck, J. G., & Díaz‐Muñoz, S. L. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.07.03.601932 · Cited by 4
Shang, B., Liu, T., Hartwell, H. J., Douillet, C., Venkatratnam, A., Shi, Q., Miller, M. A., Zou, F., Krupenko, S. A., Ideraabdullah, F., et al. (2025) · Archives of Toxicology · doi:10.1007/s00204-025-04107-y · Cited by 3
Huu, T. N., Thanh, H. D., Kim, M.-K., Sah, D. K., Trinh, V. H., Yoon, H. J., Choi, J. M., Lee, G.-H., Kim, S., & Lee, S.-R. (2026) · npj Metabolic Health and Disease · doi:10.1038/s44324-025-00094-x · Cited by 3
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Sears, B., & Saha, A. K. (2022) · IntechOpen eBooks · doi:10.5772/intechopen.103787 · Cited by 5
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Wei, X., Du, P., Luo, Y., Zhao, Y., Zhou, X., Chen, G., & Zhang, B. (2025) · Foods · doi:10.3390/foods14172989 · Cited by 4
Pasula, M. B., Sapkota, S., Sylvester, P. W., & Briski, K. P. (2024) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2024.112341 · Cited by 3
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Self-citationBadawy, A. A., Ghamry, H. I., Mokhtar, N., Sulaiman, A. H. A., Ali, E. I., Ebrahim, H. A., Eldesoqui, M. B., & El‐Magd, M. A. (2025) · Journal of Radiation Research and Applied Sciences · doi:10.1016/j.jrras.2025.101590 · Cited by 3
Eriksson, J., Zheng, S., Popa, M. L., Bao, J., Dai, J., Wang, W., McCormack, E., Vähärautio, A., & Tang, J. P. (2025) · Cancer Research · doi:10.1158/0008-5472.can-24-3753 · Cited by 2
Udobi, M. E., Bella-Omunagbe, M., Afolabi, I. S., & Chinedu, S. N. (2026) · Frontiers in Physiology · doi:10.3389/fphys.2026.1766078 · Cited by 2
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Elliott, J. A., & Reynolds, J. V. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-91707-0.00013-9 · Cited by 2
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Rettig, A. R., & Ganesh, K. (2024) · Cancer Research · doi:10.1158/0008-5472.can-24-0835 · Cited by 2
Metadata
- Authors
- Hopkins, B. D., Goncalves, M. D., & Cantley, L. C.
- Affiliations
- Icahn School of Medicine at Mount Sinai (US)
- Weill Cornell Medicine (US)
- Corresponding author
- Hopkins, Benjamin D.
- Venue
- Nature Reviews Endocrinology
- Published
- 2020-03-03
- Volume
- 16
- Issue
- 5
- Pages
- 276-283
- ISSN
- 1759-5029 (ISSN-L)
- 1759-5037
- PMC
- PMC7286536
- OpenAlex
- W3009258273
- Cited by
- 288
- References
- 78
- Citations by year
- 2026: 34 · 2025: 50 · 2024: 46 · 2023: 52 · 2022: 45 · 2021: 41 · 2020: 20
- FWCI
- 3.81
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature Reviews Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (K08CA230318, R00CA230384, R35CA197588)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Keywords
- insulin signaling, PI3K signaling, mTOR, oncogenic transformation, cancer metabolism, insulin resistance, insulin receptor, cancer therapy resistance, metabolic targeting, tumor initiation
- MeSH terms
- Animals, Endocrine System, Biological Evolution, Humans, Insulin, Neoplasms, Signal Transduction, Phosphatidylinositol 3-Kinases
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