Cited by 96Autism Spectrum Disorder ResearchGastrointestinal motility and disordersChild Nutrition and Feeding Issues

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Autism spectrum disorders and the gastrointestinal tract: insights into mechanisms and clinical relevance

Hung, Lin Y., Margolis, Kara Gross·2024·Nature Reviews Gastroenterology & Hepatology

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Abstract

Autism spectrum disorders (ASDs) are recognized as central neurodevelopmental disorders diagnosed by impairments in social interactions, communication and repetitive behaviours. The recognition of ASD as a central nervous system (CNS)-mediated neurobehavioural disorder has led most of the research in ASD to be focused on the CNS. However, gastrointestinal function is also likely to be affected owing to the neural mechanistic nature of ASD and the nervous system in the gastrointestinal tract (enteric nervous system). Thus, it is unsurprising that gastrointestinal disorders, particularly constipation, diarrhoea and abdominal pain, are highly comorbid in individuals with ASD. Gastrointestinal problems have also been repeatedly associated with increased severity of the core symptoms diagnostic of ASD and other centrally mediated comorbid conditions, including psychiatric issues, irritability, rigid-compulsive behaviours and aggression. Despite the high prevalence of gastrointestinal dysfunction in ASD and its associated behavioural comorbidities, the specific links between these two conditions have not been clearly delineated, and current data linking ASD to gastrointestinal dysfunction have not been extensively reviewed. This Review outlines the established and emerging clinical and preclinical evidence that emphasizes the gut as a novel mechanistic and potential therapeutic target for individuals with ASD.

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Unraveling the Connections: Eating Issues, Microbiome, and Gastrointestinal Symptoms in Autism Spectrum Disorder
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Authors: Hung, L. Y., & Margolis, K. G.
Affiliations: New York University (US)
NYU Langone Health (US)
Corresponding author: Margolis, Kara Gross
ORCID: Hung, Lin Y.
Margolis, Kara Gross
Venue: Nature Reviews Gastroenterology & Hepatology
Publisher: Springer Science and Business Media LLC
Published: 2023-12-19
Volume: 21
Issue: 3
Pages: 142-163
ISSN: 1759-5045 (ISSN-L)
1759-5053
DOI: 10.1038/s41575-023-00857-1
OpenAlex: W4389937109
Semantic Scholar: ac9023f063ccd5025ccbc501f4fd67a5a4802d0f
Cited by: 96
References: 322
Citations by year: 2026: 42 · 2025: 40 · 2024: 14
FWCI: 3.60
Type: journal article
Language: en
Open access: closed
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Nature Reviews Gastroenterology & Hepatology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Health Sciences › Medicine › Psychiatry and Mental health › Child Nutrition and Feeding Issues
Keywords: autism spectrum disorder, gastrointestinal dysfunction, enteric nervous system, constipation, diarrhea, abdominal pain, gut-brain axis, neurodevelopmental disorders
MeSH terms: Autism Spectrum Disorder, Clinical Relevance, Constipation, Humans, Abdominal Pain, Gastrointestinal Tract

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Autism spectrum disorders and the gastrointestinal tract: insights into mechanisms and clinical relevance

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