Cited by 96Autism Spectrum Disorder ResearchGastrointestinal motility and disordersChild Nutrition and Feeding Issues

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Autism spectrum disorders and the gastrointestinal tract: insights into mechanisms and clinical relevance

Hung, Lin Y., Margolis, Kara Gross·2024·Nature Reviews Gastroenterology & Hepatology

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Abstract

Autism spectrum disorders (ASDs) are recognized as central neurodevelopmental disorders diagnosed by impairments in social interactions, communication and repetitive behaviours. The recognition of ASD as a central nervous system (CNS)-mediated neurobehavioural disorder has led most of the research in ASD to be focused on the CNS. However, gastrointestinal function is also likely to be affected owing to the neural mechanistic nature of ASD and the nervous system in the gastrointestinal tract (enteric nervous system). Thus, it is unsurprising that gastrointestinal disorders, particularly constipation, diarrhoea and abdominal pain, are highly comorbid in individuals with ASD. Gastrointestinal problems have also been repeatedly associated with increased severity of the core symptoms diagnostic of ASD and other centrally mediated comorbid conditions, including psychiatric issues, irritability, rigid-compulsive behaviours and aggression. Despite the high prevalence of gastrointestinal dysfunction in ASD and its associated behavioural comorbidities, the specific links between these two conditions have not been clearly delineated, and current data linking ASD to gastrointestinal dysfunction have not been extensively reviewed. This Review outlines the established and emerging clinical and preclinical evidence that emphasizes the gut as a novel mechanistic and potential therapeutic target for individuals with ASD.

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Diet rapidly and reproducibly alters the human gut microbiome
David, L. A., Maurice, C. F., Carmody, R. N., Gootenberg, D. B., Button, J. E., Wolfe, B. E., Ling, A. V., Devlin, A. S., Varma, Y., Fischbach, M. A., et al. (2014) · Nature · doi:10.1038/nature12820 · Cited by 10,100
Epigenetic Regulations of GABAergic Neurotransmission: Relevance for Neurological Disorders and Epigenetic Therapy
Shrestha, S., & Offer, S. M. (2016) · Medical Epigenetics · doi:10.1159/000444713 · Cited by 8,951
Gut microbiota regulate motor deficits and neuroinflammation in a model of Parkinson's disease
Sampson, T. R., Debelius, J. W., Thron, T., Janssen, S., Shastri, G. G., Ilhan, Z. E., Challis, C., Schretter, C. E., Rocha, S., Gradinaru, V., et al. (2016) · Cell · doi:10.1016/j.cell.2016.11.018 · Cited by 3,622
Microbiota Modulate Behavioral and Physiological Abnormalities Associated with Neurodevelopmental Disorders
Hsiao, E. Y., McBride, S. W., Hsien, S., Sharon, G., Hyde, E. R., McCue, T., Codelli, J. A., Chow, J., Reisman, S. E., Petrosino, J. F., et al. (2013) · Cell · doi:10.1016/j.cell.2013.11.024 · Cited by 3,283
Normal gut microbiota modulates brain development and behavior
Heijtz, R. D., Wang, S., Anuar, F., Qian, Y., Björkholm, B., Samuelsson, A., Hibberd, M. L., Forssberg, H., & Pettersson, S. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1010529108 · Cited by 3,228
Postnatal microbial colonization programs the hypothalamic–pituitary–adrenal system for stress response in mice
Sudo, N., Chida, Y., Aiba, Y., Sonoda, J., Oyama, N., Yu, X., Kubo, C., & Koga, Y. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2004.063388 · Cited by 2,735
Prevalence and Characteristics of Autism Spectrum Disorder Among Children Aged 8 Years — Autism and Developmental Disabilities Monitoring Network, 11 Sites, United States, 2020
Maenner, M. J., Warren, Z., Williams, A. R., Amoakohene, E., Bakian, A. V., Bilder, D. A., Durkin, M. S., Fitzgerald, R. T., Furnier, S. M., Hughes, M. M., et al. (2023) · MMWR. Surveillance Summaries · doi:10.15585/mmwr.ss7202a1 · Cited by 2,706
The gut microbiota influences blood-brain barrier permeability in mice
Braniste, V., Al-Asmakh, M., Kowal, C., Anuar, F., Abbaspour, A., Tóth, M., Korecka, A., Bakocevic, N., Ng, L. G., Kundu, P., et al. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3009759 · Cited by 2,530
A microbial symbiosis factor prevents intestinal inflammatory disease
Mazmanian, S. K., Round, J. L., & Kasper, D. L. (2008) · Nature · doi:10.1038/nature07008 · Cited by 2,340
The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner
Clarke, G., Grenham, S., Scully, P., Fitzgerald, P., Moloney, R. D., Shanahan, F., Dinan, T. G., & Cryan, J. F. (2013) · Molecular Psychiatry · doi:10.1038/mp.2012.77 · Cited by 1,893
Prevalence and characteristics of autism spectrum disorder among children aged 8 years—Autism and Developmental Disabilities Monitoring Network, 11 sites, United States, 2018.
Maenner, M. J., Shaw, K. A., Bakian, A. V., Bilder, D. A., Durkin, M. S., Esler, A., Furnier, S. M., Hallas, L., Hall-Lande, J., Hudson, A., et al. (2021) · MMWR. Surveillance Summaries · doi:10.15585/mmwr.ss7011a1 · Cited by 1,818
Oxytocin and vasopressin in the human brain: social neuropeptides for translational medicine
Meyer-Lindenberg, A., Domes, G., Kirsch, P., & Heinrichs, M. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3044 · Cited by 1,688
Microbial Exposure During Early Life Has Persistent Effects on Natural Killer T Cell Function
Olszak, T., An, D., Zeissig, S., Vera, M. P., Richter, J., Franke, A., Glickman, J. N., Siebert, R., Baron, R. M., Kasper, D. L., et al. (2012) · Science · doi:10.1126/science.1219328 · Cited by 1,661
Reduced anxiety-like behavior and central neurochemical change in germ-free mice: Behavior in germ-free mice
Neufeld, K. M., Kang, N., Bienenstock, J., & Foster, J. A. (2011) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2010.01620.x · Cited by 1,392
Microbiota Transfer Therapy Alters Gut Ecosystem and Improves Gastrointestinal and Autism Symptoms: An Open-Label Study
Kang, D.-W., Adams, J. B., Gregory, A. C., Borody, T., Chittick, L., Fasano, A., Khoruts, A., Geis, E., Maldonado, J., McDonough-Means, S., et al. (2017) · Microbiome · doi:10.1186/s40168-016-0225-7 · Cited by 1,391
Prenatal Valproate Exposure and Risk of Autism Spectrum Disorders and Childhood Autism
Christensen, J., Grønborg, T. K., Sørensen, M. J., Schendel, D., Parner, E. T., Pedersen, L. H., & Vestergaard, M. (2013) · JAMA · doi:10.1001/jama.2013.2270 · Cited by 1,357
The ketogenic diet for the treatment of childhood epilepsy: a randomised controlled trial
Neal, E. G., Chaffe, H., Schwartz, R. H., Lawson, M. S., Edwards, N., Fitzsimmons, G., Whitney, A., & Cross, J. H. (2008) · The Lancet Neurology · doi:10.1016/s1474-4422(08)70092-9 · Cited by 1,227
The maternal interleukin-17a pathway in mice promotes autism-like phenotypes in offspring
Choi, G. B., Yim, Y. S., Wong, H., Kim, S., Kim, H., Kim, S. V., Hoeffer, C. A., Littman, D. R., & Huh, J. R. (2016) · Science · doi:10.1126/science.aad0314 · Cited by 1,214 · cited 1×
“In a mouse model of MIA, an IL-17-mediated pro-inflammatory response is generated that is linked to the development of placental inflammation as well as neuropathology and behaviours consistent with ASD in offspring 197 .”
Maternal immune activation: Implications for neuropsychiatric disorders
Estes, M. L., & McAllister, A. K. (2016) · Science · doi:10.1126/science.aag3194 · Cited by 1,206 · cited 5×
“One of the most well-studied preclinical models of maternal inflammation is one in which pregnant mice or primates are treated with poly(I:C), a validated viral mimetic 44,45,126,185,186 .”
Influential
Human Gut Microbiota from Autism Spectrum Disorder Promote Behavioral Symptoms in Mice
Sharon, G., Cruz, N. J., Kang, D.-W., Gandal, M. J., Wang, B., Kim, Y.-M., Zink, E. M., Casey, C. P., Taylor, B. C., Lane, C. J., et al. (2019) · Cell · doi:10.1016/j.cell.2019.05.004 · Cited by 1,182
Linking the Human Gut Microbiome to Inflammatory Cytokine Production Capacity
Schirmer, M., Smeekens, S. P., Vlamakis, H. C., Jaeger, M., Oosting, M., Franzosa, E. A., ter Horst, R., Jansen, T., Jacobs, L., Bonder, M. J., et al. (2016) · Cell · doi:10.1016/j.cell.2016.10.020 · Cited by 1,173
Microbial reconstitution reverses maternal diet-induced social and synaptic deficits in offspring
Buffington, S. A., Di Prisco, G. V., Auchtung, T. A., Ajami, N. J., Petrosino, J. F., & Costa-Mattioli, M. (2016) · Cell · doi:10.1016/j.cell.2016.06.001 · Cited by 1,163
A critical assessment of the “sterile womb” and “in utero colonization” hypotheses: implications for research on the pioneer infant microbiome
Perez-Muñoz, M. E., Arrieta, M.-C., Ramer-Tait, A. E., & Walter, J. (2017) · Microbiome · doi:10.1186/s40168-017-0268-4 · Cited by 1,096
Gastrointestinal flora and gastrointestinal status in children with autism – comparisons to typical children and correlation with autism severity
Adams, J. B., Johansen, L. J., Powell, L. D., Quig, D., & Rubin, R. A. (2011) · BMC Gastroenterology · doi:10.1186/1471-230x-11-22 · Cited by 1,076
Maturation of the infant microbiome community structure and function across multiple body sites and in relation to mode of delivery
Chu, D. M., Ma, J., Prince, A. L., Antony, K. M., Seferovic, M. D., & Aagaard, K. M. (2017) · Nature Medicine · doi:10.1038/nm.4272 · Cited by 1,063
The Gut Microbiota Mediates the Anti-Seizure Effects of the Ketogenic Diet
Olson, C. A., Vuong, H. E., Yano, J. M., Liang, Q. Y., Nusbaum, D. J., & Hsiao, E. Y. (2018) · Cell · doi:10.1016/j.cell.2018.04.027 · Cited by 1,057
New evidences on the altered gut microbiota in autism spectrum disorders
Strati, F., Cavalieri, D., Albanese, D., De Felice, C., Donati, C., Hayek, J., Jousson, O., Leoncini, S., Renzi, D., Calabrò, A., et al. (2017) · Microbiome · doi:10.1186/s40168-017-0242-1 · Cited by 1,040
A Neuroligin-3 Mutation Implicated in Autism Increases Inhibitory Synaptic Transmission in Mice
Tabuchi, K., Blundell, J., Etherton, M. R., Hammer, R. E., Liu, X., Powell, C. M., & Südhof, T. C. (2007) · Science · doi:10.1126/science.1146221 · Cited by 997
Pyrosequencing study of fecal microflora of autistic and control children
Finegold, S. M., Dowd, S. E., Gontcharova, V., Liu, C., Henley, K. E., Wolcott, R. D., Youn, E., Summanen, P. H., Granpeesheh, D., Dixon, D., et al. (2010) · Anaerobe · doi:10.1016/j.anaerobe.2010.06.008 · Cited by 977
Reduced incidence of Prevotella and other fermenters in intestinal microflora of autistic children
Kang, D.-W., Park, J. G., Ilhan, Z. E., Wallstrom, G., LaBaer, J., Adams, J. B., & Krajmalnik-Brown, R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0068322 · Cited by 976
Autism From 2 to 9 Years of Age
Lord, C., Risi, S., DiLavore, P. S., Shulman, C., Thurm, A., & Pickles, A. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.6.694 · Cited by 973
The Lancet Commission on the future of care and clinical research in autism
Lord, C., Charman, T., Havdahl, A., Carbone, P., Anagnostou, E., Boyd, B., Carr, T., de Vries, P. J., Dissanayake, C., Divan, G., et al. (2022) · The Lancet · doi:10.1016/s0140-6736(21)01541-5 · Cited by 924 · cited 2×
“The compound SB-121, which contains a combination of L. reuteri , formulated with dextran microparticles, and maltose, was demonstrated to be safe and well-tolerated and also associated with improvements in adaptive behaviour measured by Vineland-3 and social preference 234 .”
Evaluation, Diagnosis, and Treatment of Gastrointestinal Disorders in Individuals With ASDs: A Consensus Report
Buie, T., Campbell, D. B., Fuchs, G. J., Furuta, G. T., Levy, J., VandeWater, J., Whitaker, A. H., Atkins, D., Bauman, M. L., Beaudet, A. L., et al. (2010) · Pediatrics · doi:10.1542/peds.2009-1878c · Cited by 872
Microbiota is essential for social development in the mouse
Desbonnet, L., Clarke, G., Shanahan, F., Dinan, T. G., & Cryan, J. F. (2014) · Molecular Psychiatry · doi:10.1038/mp.2013.65 · Cited by 866
Mechanisms underlying microbial-mediated changes in social behavior in mouse models of autism spectrum disorder
Sgritta, M., Dooling, S. W., Buffington, S. A., Momin, E. N., Francis, M. B., Britton, R. A., & Costa-Mattioli, M. (2019) · Neuron · doi:10.1016/j.neuron.2018.11.018 · Cited by 865
Gastrointestinal Symptoms in Autism Spectrum Disorder: A Meta-analysis
McElhanon, B. O., McCracken, C., Karpen, S., & Sharp, W. G. (2014) · Pediatrics · doi:10.1542/peds.2013-3995 · Cited by 831 · cited 1×
“However, the most commonly reported diagnoses are abdominal pain, functional diarrhoea, functional constipation, gastroesophageal reflux disease, and selective feeding of particular foods or textures 23–25 .”
Disruptive CHD8 Mutations Define a Subtype of Autism Early in Development
Bernier, R., Golzio, C., Xiong, B., Stessman, H. A., Coe, B. P., Penn, O., Witherspoon, K., Gerdts, J., Baker, C., Vulto-van Silfhout, A. T., et al. (2014) · Cell · doi:10.1016/j.cell.2014.06.017 · Cited by 798
Differences between the gut microflora of children with autistic spectrum disorders and that of healthy children
Parracho, H. M., Bingham, M. O., Gibson, G. R., & McCartney, A. L. (2005) · Journal of Medical Microbiology · doi:10.1099/jmm.0.46101-0 · Cited by 784
Perturbations in Gut Microbiota Composition in Psychiatric Disorders
Nikolova, V. L., Smith, M. R. B., Hall, L. J., Cleare, A. J., Stone, J. M., & Young, A. H. (2021) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2021.2573 · Cited by 777
Gut microbiota depletion from early adolescence in mice: implications for brain and behaviour
Desbonnet, L., Clarke, G., Traplin, A., O’Sullivan, O., Crispie, F., Moloney, R. D., Cotter, P. D., Dinan, T. G., & Cryan, J. F. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.04.004 · Cited by 760
Long-term benefit of microbiota transfer therapy on autism symptoms and gut microbiota
Kang, D.-W., Adams, J. B., Coleman, D. M., Pollard, E. L., Maldonado, J., McDonough-Means, S., Caporaso, J. G., & Krajmalnik-Brown, R. (2019) · Scientific Reports · doi:10.1038/s41598-019-42183-0 · Cited by 749
Gastrointestinal Microflora Studies in Late‐Onset Autism
Finegold, S. M., Molitoris, D., Song, Y., Liu, C., Vaisanen, M., Bolte, E., McTeague, M., Sandler, R., Wexler, H., Marlowe, E. M., et al. (2002) · Clinical Infectious Diseases · doi:10.1086/341914 · Cited by 742
Maternal gut bacteria promote neurodevelopmental abnormalities in mouse offspring
Kim, S., Kim, H., Yim, Y. S., Ha, S., Atarashi, K., Tan, T. G., Longman, R. S., Honda, K., Littman, D. R., Choi, G. B., et al. (2017) · Nature · doi:10.1038/nature23910 · Cited by 678
Maternal metabolic conditions and risk for autism and other neurodevelopmental disorders
Krakowiak, P., Walker, C. K., Bremer, A. A., Baker, A. S., Ozonoff, S., Hansen, R. L., & Hertz-Picciotto, I. (2012) · PEDIATRICS · doi:10.1542/peds.2011-2583 · Cited by 675
Maternal immune activation yields offspring displaying mouse versions of the three core symptoms of autism
Malkova, N. V., Yu, C. Z., Hsiao, E. Y., Moore, M. J., & Patterson, P. H. (2012) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2012.01.011 · Cited by 662
Regulation of prefrontal cortex myelination by the microbiota
Hoban, A. E., Stilling, R. M., Ryan, F. J., Shanahan, F., Dinan, T. G., Claesson, M. J., Clarke, G., & Cryan, J. F. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.42 · Cited by 635
Gastrointestinal microbiota in children with autism in Slovakia
Tomova, A., Husarova, V., Lakatosova, S., Bakos, J., Vlkova, B., Babinska, K., & Ostatnikova, D. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2014.10.033 · Cited by 632
Growing up in a bubble: using germ-free animals to assess the influence of the gut microbiota on brain and behavior
Luczynski, P., McVey Neufeld, K.-A., Oriach, C. S., Clarke, G., Dinan, T. G., & Cryan, J. F. (2016) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyw020 · Cited by 632 · cited 1×
“Germ-free mice exhibit abnormalities in the development of the immune system, ENS and CNS, limiting their relevance for human translation 68,73,113–115 .”
Meta-analysis of SHANK Mutations in Autism Spectrum Disorders: A Gradient of Severity in Cognitive Impairments
Leblond, C. S., Nava, C., Polge, A., Gauthier, J., Huguet, G., Lumbroso, S., Giuliano, F., Stordeur, C., Depienne, C., Mouzat, K., et al. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004580 · Cited by 630
Short-Term Benefit From Oral Vancomycin Treatment of Regressive-Onset Autism
Sandler, R. H., Finegold, S. M., Bolte, E. R., Buchanan, C. P., Maxwell, A. P., Väisänen, M.-L., Nelson, M. N., & Wexler, H. M. (2000) · Journal of Child Neurology · doi:10.1177/088307380001500701 · Cited by 614
Mouse Microbiota Models: Comparing Germ-Free Mice and Antibiotics Treatment as Tools for Modifying Gut Bacteria
Kennedy, E. A., King, K. Y., & Baldridge, M. T. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01534 · Cited by 602
Establishing or Exaggerating Causality for the Gut Microbiome: Lessons from Human Microbiota-Associated Rodents
Walter, J., Armet, A. M., Finlay, B. B., & Shanahan, F. (2020) · Cell · doi:10.1016/j.cell.2019.12.025 · Cited by 596
Emerging Roles for the Gut Microbiome in Autism Spectrum Disorder
Vuong, H. E., & Hsiao, E. Y. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.08.024 · Cited by 595
Gut microbiota regulates maturation of the adult enteric nervous system via enteric serotonin networks
De Vadder, F., Grasset, E., Mannerås Holm, L., Karsenty, G., Macpherson, A. J., Olofsson, L. E., & Bäckhed, F. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1720017115 · Cited by 566
The maternal microbiome modulates fetal neurodevelopment in mice
Vuong, H. E., Pronovost, G. N., Williams, D. W., Coley, E. J. L., Siegler, E. L., Qiu, A., Kazantsev, M., Wilson, C. J., Rendon, T., & Hsiao, E. Y. (2020) · Nature · doi:10.1038/s41586-020-2745-3 · Cited by 564
The Co-Morbidity Burden of Children and Young Adults with Autism Spectrum Disorders
Kohane, I. S., McMurry, A., Weber, G., MacFadden, D., Rappaport, L., Kunkel, L., Bickel, J., Wattanasin, N., Spence, S., Murphy, S., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033224 · Cited by 562
Alterations of the Intestinal Barrier in Patients With Autism Spectrum Disorders and in Their First‐degree Relatives
de Magistris, L., Familiari, V., Pascotto, A., Sapone, A., Frolli, A., Iardino, P., Carteni, M., De Rosa, M., Francavilla, R., Riegler, G., et al. (2010) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e3181dcc4a5 · Cited by 546
Gastrointestinal Problems in Children with Autism, Developmental Delays or Typical Development
Chaidez, V., Hansen, R. L., & Hertz-Picciotto, I. (2014) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-013-1973-x · Cited by 528
Transplantation of fecal microbiota from patients with irritable bowel syndrome alters gut function and behavior in recipient mice
De Palma, G., Lynch, M. D. J., Lu, J., Dang, V. T., Deng, Y., Jury, J., Umeh, G., Miranda, P. M., Pigrau Pastor, M., Sidani, S., et al. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aaf6397 · Cited by 505
Impaired Carbohydrate Digestion and Transport and Mucosal Dysbiosis in the Intestines of Children with Autism and Gastrointestinal Disturbances
Williams, B. L., Hornig, M., Buie, T., Bauman, M. L., Cho Paik, M., Wick, I., Bennett, A., Jabado, O., Hirschberg, D. L., & Lipkin, W. I. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024585 · Cited by 492
Adult hippocampal neurogenesis is regulated by the microbiome
Ogbonnaya, E. S., Clarke, G., Shanahan, F., Dinan, T. G., Cryan, J. F., & O’Leary, O. F. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.12.023 · Cited by 491
A gut-derived metabolite alters brain activity and anxiety behaviour in mice
Needham, B. D., Funabashi, M., Adame, M. D., Wang, Z., Boktor, J. C., Haney, J., Wu, W.-L., Rabut, C., Ladinsky, M. S., Hwang, S.-J., et al. (2022) · Nature · doi:10.1038/s41586-022-04396-8 · Cited by 489
Microbiota and the social brain
Sherwin, E., Bordenstein, S. R., Quinn, J. L., Dinan, T. G., & Cryan, J. F. (2019) · Science · doi:10.1126/science.aar2016 · Cited by 462
The 22q13.3 Deletion Syndrome (Phelan-McDermid Syndrome)
Phelan, K., & McDermid, H. E. (2011) · Molecular Syndromology · doi:10.1159/000334260 · Cited by 460
Complex interactions among diet, gastrointestinal transit, and gut microbiota in humanized mice
Kashyap, P. C., Marcobal, A., Ursell, L. K., Larauche, M., Duboc, H., Earle, K. A., Sonnenburg, E. D., Ferreyra, J. A., Higginbottom, S. K., Million, M., et al. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.01.047 · Cited by 451
Specific probiotic therapy attenuates antibiotic induced visceral hypersensitivity in mice
Verdú, E. F., Bercik, P., Verma-Gandhu, M., Huang, X.-X., Blennerhassett, P., Jackson, W., Mao, Y., Wang, L., Rochat, F., & Collins, S. M. (2006) · Gut · doi:10.1136/gut.2005.066100 · Cited by 448
Low-Dose Penicillin in Early Life Induces Long-Term Changes in Murine Gut Microbiota, Brain Cytokines and Behavior
Leclercq, S., Mian, F. M., Stanisz, A. M., Bindels, L. B., Cambier, E., Ben-Amram, H., Koren, O., Forsythe, P., & Bienenstock, J. (2017) · Nature Communications · doi:10.1038/ncomms15062 · Cited by 434
Altered gut microbiota and activity in a murine model of autism spectrum disorders
de Theije, C. G. M., Wopereis, H., Ramadan, M., van Eijndthoven, T., Lambert, J., Knol, J., Garssen, J., Kraneveld, A. D., & Oozeer, R. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2013.12.005 · Cited by 433
Low Relative Abundances of the Mucolytic Bacterium Akkermansia muciniphila and Bifidobacterium spp. in Feces of Children with Autism
Wang, L., Christophersen, C. T., Sorich, M. J., Gerber, J. P., Angley, M. T., & Conlon, M. A. (2011) · Applied and Environmental Microbiology · doi:10.1128/aem.05212-11 · Cited by 432
The microbiota regulate neuronal function and fear extinction learning
Chu, C., Murdock, M. H., Jing, D., Won, T. H., Chung, H., Kressel, A. M., Tsaava, T., Addorisio, M. E., Putzel, G. G., Zhou, L., et al. (2019) · Nature · doi:10.1038/s41586-019-1644-y · Cited by 421
Glial cells in the mouse enteric nervous system can undergo neurogenesis in response to injury
Laranjeira, C., Sandgren, K., Kessaris, N., Richardson, W. D., Potocnik, A. J., Berghe, P. V., & Pachnis, V. (2011) · Journal of Clinical Investigation · doi:10.1172/jci58200 · Cited by 418
Ketogenic diet for human diseases: the underlying mechanisms and potential for clinical implementations
Zhu, H., Bi, D., Zhang, Y., Kong, C., Du, J., Wu, X., Wei, Q., & Qin, H. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00831-w · Cited by 412
Essential roles of enteric neuronal serotonin in gastrointestinal motility and the development/survival of enteric dopaminergic neurons
Li, Z., Chalazonitis, A., Huang, Y.-Y., Mann, J. J., Margolis, K. G., Yang, Q. M., Kim, D. O., Cote, F., Mallet, J., & Gershon, M. D. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.6684-10.2011 · Cited by 403
Self-citation
Gut microbial products regulate murine gastrointestinal motility via Toll-like receptor 4 signaling
Anitha, M., Vijay–Kumar, M., Sitaraman, S. V., Gewirtz, A. T., & Srinivasan, S. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.06.034 · Cited by 397
Allelic heterogeneity at the serotonin transporter locus (SLC6A4) confers susceptibility to autism and rigid-compulsive behaviors
Sutcliffe, J. S., Delahanty, R. J., Prasad, H. C., McCauley, J. L., Han, Q., Jiang, L., Li, C., Folstein, S. E., & Blakely, R. D. (2005) · The American Journal of Human Genetics · doi:10.1086/432648 · Cited by 392
Maternal infection during pregnancy and risk of autism spectrum disorders: a systematic review and meta-analysis
Jiang, H.-Y., Xu, L.-L., Shao, L., Xia, R.-M., Yu, Z.-H., Ling, Z.-X., Yang, F., Deng, M., & Ruan, B. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.06.005 · Cited by 391
The early infant gut microbiome varies in association with a maternal high-fat diet
Chu, D. M., Antony, K. M., Ma, J., Prince, A., Showalter, L., Moller, M., & Aagaard, K. M. (2016) · Genome Medicine · doi:10.1186/s13073-016-0330-z · Cited by 382
Differences in fecal microbial metabolites and microbiota of children with autism spectrum disorders
Kang, D.-W., Ilhan, Z. E., Isern, N. G., Hoyt, D. W., Howsmon, D. P., Shaffer, M., Lozupone, C. A., Hahn, J., Adams, J. B., & Krajmalnik-Brown, R. (2018) · Anaerobe · doi:10.1016/j.anaerobe.2017.12.007 · Cited by 381
Application of Novel PCR-Based Methods for Detection, Quantitation, and Phylogenetic Characterization of Sutterella Species in Intestinal Biopsy Samples from Children with Autism and Gastrointestinal Disturbances
Williams, B. L., Hornig, M., Parekh, T., & Lipkin, W. I. (2012) · mBio · doi:10.1128/mbio.00261-11 · Cited by 378
The role of probiotics in children with autism spectrum disorder: A prospective, open-label study
Shaaban, S. Y., El Gendy, Y. G., Mehanna, N. S., El-Senousy, W. M., El-Feki, H. S. A., Saad, K., & El-Asheer, O. M. (2018) · Nutritional Neuroscience · doi:10.1080/1028415x.2017.1347746 · Cited by 374
Autism-related dietary preferences mediate autism-gut microbiome associations
Yap, C. X., Henders, A. K., Alvares, G. A., Wood, D., Krause, L., Tyson, G. W., Restuadi, R., Wallace, L. M., McLaren, T., Hansell, N. K., et al. (2021) · Cell · doi:10.1016/j.cell.2021.10.015 · Cited by 371
Autism After Infection, Febrile Episodes, and Antibiotic Use During Pregnancy: An Exploratory Study
Atladóttir, H. Ó., Henriksen, T. B., Schendel, D. E., & Parner, E. T. (2012) · Pediatrics · doi:10.1542/peds.2012-1107 · Cited by 369
A prebiotic intervention study in children with autism spectrum disorders (ASDs)
Grimaldi, R., Gibson, G. R., Vulevic, J., Giallourou, N., Castro-Mejía, J. L., Hansen, L. H., Leigh Gibson, E., Nielsen, D. S., & Costabile, A. (2018) · Microbiome · doi:10.1186/s40168-018-0523-3 · Cited by 369
Ketogenic Diet and Epilepsy: What We Know So Far
Meira, I. D., Romão, T. T., do Prado, H. J. P., Krüger, L. T., Pires, M. E. P., & da Conceição, P. O. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00005 · Cited by 369
The prevalence of neurodevelopmental disorders in children prenatally exposed to antiepileptic drugs
Bromley, R. L., Mawer, G. E., Briggs, M., Cheyne, C., Clayton-Smith, J., Garcia-Finana, M., Kneen, R., Lucas, S. B., Shallcross, R., Baker, G. A., et al. (2013) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp-2012-304270 · Cited by 367
An overview of links between obesity and mental health
Avila, C., Holloway, A. C., Hahn, M. K., Morrison, K. M., Restivo, M., Anglin, R., & Taylor, V. H. (2015) · Current Obesity Reports · doi:10.1007/s13679-015-0164-9 · Cited by 366
Neuronal programming by microbiota regulates intestinal physiology
Obata, Y., Castaño, Á., Boeing, S., Bon‐Frauches, A. C., Fung, C., Fallesen, T. L., de Agüero, M. G., Yılmaz, B., Lopes, R., Huseynova, A., et al. (2020) · Nature · doi:10.1038/s41586-020-1975-8 · Cited by 365
Microbiota-related Changes in Bile Acid & Tryptophan Metabolism are Associated with Gastrointestinal Dysfunction in a Mouse Model of Autism
Golubeva, A. V., Joyce, S. A., Moloney, G., Burokas, A., Sherwin, E., Arboleya, S., Flynn, I., Khochanskiy, D., Moya-Pérez, A., Peterson, V., et al. (2017) · EBioMedicine · doi:10.1016/j.ebiom.2017.09.020 · Cited by 364
Adult microbiota‐deficient mice have distinct dendritic morphological changes: differential effects in the amygdala and hippocampus
Luczynski, P., Whelan, S. O., O'SULLIVAN, C. T. D., Clarke, G. A., Shanahan, F., Dinan, T. G., & Cryan, J. F. (2016) · European Journal of Neuroscience · doi:10.1111/ejn.13291 · Cited by 360
Microbiota controls the homeostasis of glial cells in the gut lamina propria
Kabouridis, P. S., Lasrado, R., McCallum, S., Chng, S. H., Snippert, H. J., Clevers, H., Pettersson, S., & Pachnis, V. (2015) · Neuron · doi:10.1016/j.neuron.2014.12.037 · Cited by 358
Autism-linked neuroligin-3 R451C mutation differentially alters hippocampal and cortical synaptic function
Etherton, M. R., Földy, C., Sharma, M., Tabuchi, K., Liu, X., Shamloo, M., Malenka, R. C., & Südhof, T. C. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1111093108 · Cited by 354
Altered gut microbial profile is associated with abnormal metabolism activity of Autism Spectrum Disorder
Dan, Z., Mao, X., Liu, Q., Guo, M., Zhuang, Y., Liu, Z., Chen, K., Chen, J., Xu, R., Tang, J., et al. (2020) · Gut Microbes · doi:10.1080/19490976.2020.1747329 · Cited by 350
Blood serotonin levels in autism spectrum disorder: A systematic review and meta-analysis
Gabriele, S., Sacco, R., & Persico, A. M. (2014) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2014.02.004 · Cited by 346
Prospective investigation of autism and genotype-phenotype correlations in 22q13 deletion syndrome and SHANK3 deficiency
Soorya, L. V., Kolevzon, A. L., Zweifach, J., Lim, T., Dobry, Y., Schwartz, L., Frank, Y., Wang, A. T., Cai, G., Parkhomenko, E., et al. (2013) · Molecular Autism · doi:10.1186/2040-2392-4-18 · Cited by 345
Elevated maternal C-reactive protein and autism in a national birth cohort
Brown, A. S., Sourander, A., Hinkka-Yli-Salomäki, S., McKeague, I. W., Sundvall, J., & Surcel, H.-M. (2014) · Molecular Psychiatry · doi:10.1038/mp.2012.197 · Cited by 343
Modeling an autism risk factor in mice leads to permanent immune dysregulation
Hsiao, E. Y., McBride, S. W., Chow, J., Mazmanian, S. K., & Patterson, P. H. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1202556109 · Cited by 340
Effect of gut microbiota on depressive-like behaviors in mice is mediated by the endocannabinoid system
Chevalier, G., Siopi, E., Guenin‐Macé, L., Pascal, M., Laval, T., Rifflet, A., Boneca, I. G., Demangel, C., Colsch, B., Pruvost, A., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-19931-2 · Cited by 337
Altered composition and function of intestinal microbiota in autism spectrum disorders: A systematic review
Liu, F., Li, J., Wu, F., Zheng, H., Peng, Q., & Zhou, H. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0389-6 · Cited by 336
Autism gene variant causes hyperserotonemia, serotonin receptor hypersensitivity, social impairment and repetitive behavior
Veenstra-VanderWeele, J., Muller, C. L., Iwamoto, H., Sauer, J. E., Owens, W. A., Shah, C. R., Cohen, J., Mannangatti, P., Jessen, T., Thompson, B. J., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1112345109 · Cited by 333
Gastrointestinal dysfunction in autism: parental report, clinical evaluation, and associated factors
Gorrindo, P., Williams, K. C., Lee, E. B., Walker, L. S., McGrew, S. G., & Levitt, P. (2012) · Autism Research · doi:10.1002/aur.237 · Cited by 325
Probiotics and fructo-oligosaccharide intervention modulate the microbiota-gut brain axis to improve autism spectrum reducing also the hyper-serotonergic state and the dopamine metabolism disorder
Wang, Y., Li, N., Yang, J.-J., Zhao, D.-M., Chen, B., Zhang, G.-Q., Chen, S., Cao, R.-F., Yu, H., Zhao, C.-Y., et al. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.104784 · Cited by 324
Association Between Gut Microbiota and Autism Spectrum Disorder: A Systematic Review and Meta-Analysis
Xu, M., Xu, X., Li, J., & Li, F. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00473 · Cited by 309
Reversing behavioural abnormalities in mice exposed to maternal inflammation
Shin Yim, Y., Park, A., Berrios, J., Lafourcade, M., Pascual, L. M., Soares, N., Yeon Kim, J., Kim, S., Kim, H., Waisman, A., et al. (2017) · Nature · doi:10.1038/nature23909 · Cited by 303
The microbiome is essential for normal gut intrinsic primary afferent neuron excitability in the mouse
McVey Neufeld, K. A., Mao, Y. K., Bienenstock, J., Foster, J. A., & Kunze, W. A. (2013) · Neurogastroenterology & Motility · doi:10.1111/nmo.12049 · Cited by 299
Gastrointestinal symptoms in autism spectrum disorder: A review of the literature on ascertainment and prevalence
Holingue, C., Newill, C., Lee, L., Pasricha, P. J., & Daniele Fallin, M. (2018) · Autism Research · doi:10.1002/aur.1854 · Cited by 296
Distinct Microbiome-Neuroimmune Signatures Correlate With Functional Abdominal Pain in Children With Autism Spectrum Disorder
Luna, R. A., Oezguen, N., Balderas, M., Venkatachalam, A., Runge, J. K., Versalovic, J., Veenstra-VanderWeele, J., Anderson, G. M., Savidge, T., & Williams, K. C. (2017) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2016.11.008 · Cited by 295
Irritable bowel syndrome: a gut microbiota-related disorder?
Bhattarai, Y., Muniz Pedrogo, D. A., & Kashyap, P. C. (2017) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00338.2016 · Cited by 294
The Effect of Microbiota and the Immune System on the Development and Organization of the Enteric Nervous System
Obata, Y., & Pachnis, V. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.07.044 · Cited by 286
Prosocial effects of oxytocin and clinical evidence for its therapeutic potential
Striepens, N., Kendrick, K. M., Maier, W., & Hurlemann, R. (2011) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2011.07.001 · Cited by 283
The hypersensitivity to colonic distension of IBS patients can be transferred to rats through their fecal microbiota
Crouzet, L., Gaultier, E., Del'Homme, C., Cartier, C., Delmas, E., Dapoigny, M., Fioramonti, J., & Bernalier‐Donadille, A. (2013) · Neurogastroenterology & Motility · doi:10.1111/nmo.12103 · Cited by 280 · cited 1×
“conditions associated with gut–brain axis dysfunction 43,80,81 , including visceral pain 82 , comorbid gastrointestinal dysmotility and anxiety in individuals with irritable bowel syndrome (IBS) 83,84 , and Parkinson disease 85 .”
Application of a ketogenic diet in children with autistic behavior: Pilot study
Evangeliou, A., Vlachonikolis, I., Mihailidou, H., Spilioti, M., Skarpalezou, A., Makaronas, N., Prokopiou, A., Christodoulou, P., Liapi-Adamidou, G., Helidonis, E., et al. (2003) · Journal of Child Neurology · doi:10.1177/08830738030180020501 · Cited by 279
Adult enteric nervous system in health is maintained by a dynamic balance between neuronal apoptosis and neurogenesis
Kulkarni, S., Micci, M., Leser, J. M., Shin, C., Tang, S., Fu, Y., Liu, L., Li, Q., Saha, M., Li, C., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1619406114 · Cited by 278
The placental interleukin-6 signaling controls fetal brain development and behavior
Wu, W.-L., Hsiao, E. Y., Yan, Z., Mazmanian, S. K., & Patterson, P. H. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.11.007 · Cited by 275
Ketogenic diet modifies the gut microbiota in a murine model of autism spectrum disorder
Newell, C., Bomhof, M. R., Reimer, R. A., Hittel, D. S., Rho, J. M., & Shearer, J. (2016) · Molecular Autism · doi:10.1186/s13229-016-0099-3 · Cited by 272
Behavioural and neurochemical consequences of chronic gut microbiota depletion during adulthood in the rat
Hoban, A. E., Moloney, R. D., Golubeva, A. V., McVey Neufeld, K. A., O’Sullivan, O., Patterson, E., Stanton, C., Dinan, T. G., Clarke, G., & Cryan, J. F. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.10.003 · Cited by 270
Obesity and Autism
Hill, A. P., Zuckerman, K. E., & Fombonne, E. J. (2015) · PEDIATRICS · doi:10.1542/peds.2015-1437 · Cited by 256
Pilot study of probiotic/colostrum supplementation on gut function in children with autism and gastrointestinal symptoms
Sanctuary, M. R., Kain, J. N., Chen, S. Y., Kalanetra, K., Lemay, D. G., Rose, D. R., Yang, H. T., Tancredi, D. J., German, J. B., Slupsky, C. M., et al. (2019) · PLOS ONE · doi:10.1371/journal.pone.0210064 · Cited by 255
Plasma and Fecal Metabolite Profiles in Autism Spectrum Disorder
Needham, B. D., Adame, M. D., Serena, G., Rose, D. R., Preston, G. M., Conrad, M. C., Campbell, A. S., Donabedian, D. H., Fasano, A., Ashwood, P., et al. (2020) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.09.025 · Cited by 254
Systematic review: the global incidence of faecal microbiota transplantation-related adverse events from 2000 to 2020
Marcella, C., Cui, B., Kelly, C. R., Ianiro, G., Cammarota, G., & Zhang, F. (2021) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.16148 · Cited by 250
Multi-level analysis of the gut–brain axis shows autism spectrum disorder-associated molecular and microbial profiles
Morton, J. T., Jin, D.-M., Mills, R. H., Shao, Y., Rahman, G., McDonald, D. T., Zhu, Q., Balaban, M., Jiang, Y., Cantrell, K., et al. (2023) · Nature Neuroscience · doi:10.1038/s41593-023-01361-0 · Cited by 246
Gastrointestinal symptoms in a sample of children with pervasive developmental disorders
Nikolov, R. N., Bearss, K. E., Lettinga, J., Erickson, C., Rodowski, M., Aman, M. G., McCracken, J. T., McDougle, C. J., Tierney, E., Vitiello, B., et al. (2009) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-008-0637-8 · Cited by 240
Comparison of Fecal Microbiota in Children with Autism Spectrum Disorders and Neurotypical Siblings in the Simons Simplex Collection
Son, J. S., Zheng, L. J., Rowehl, L. M., Tian, X., Zhang, Y., Zhu, W., Litcher-Kelly, L., Gadow, K. D., Gathungu, G., Robertson, C. E., et al. (2015) · PLOS ONE · doi:10.1371/journal.pone.0137725 · Cited by 229
Fecal Microbiota Transplantation Is Highly Effective in Real-World Practice: Initial Results From the FMT National Registry
Kelly, C. R., Yen, E. F., Grinspan, A. M., Kahn, S. A., Atreja, A., Lewis, J. D., Moore, T. A., Rubin, D. T., Kim, A. M., Serra, S. M., et al. (2020) · Gastroenterology · doi:10.1053/j.gastro.2020.09.038 · Cited by 227
The Gut Microbiota Mediates the Anti-Seizure Effects of the Ketogenic Diet
Olson, C. A., Vuong, H. E., Yano, J. M., Liang, Q. Y., Nusbaum, D. J., & Hsiao, E. Y. (2018) · Cell · doi:10.1016/j.cell.2018.06.051 · Cited by 224
Early Identification of Autism Spectrum Disorder Among Children Aged 4 Years — Autism and Developmental Disabilities Monitoring Network, 11 Sites, United States, 2020
Shaw, K. A., Bilder, D. A., McArthur, D., Williams, A. R., Amoakohene, E., Bakian, A. V., Durkin, M. S., Fitzgerald, R. T., Furnier, S. M., Hughes, M. M., et al. (2023) · MMWR. Surveillance Summaries · doi:10.15585/mmwr.ss7201a1 · Cited by 223
Enhanced Cortisol Response to Stress in Children in Autism
Spratt, E. G., Nicholas, J. S., Brady, K. T., Carpenter, L. A., Hatcher, C. R., Meekins, K. A., Furlanetto, R. W., & Charles, J. M. (2012) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-011-1214-0 · Cited by 222
Lack of Benefit of a Single Dose of Synthetic Human Secretin in the Treatment of Autism and Pervasive Developmental Disorder
SANDLER, A. D., Sutton, K. A., DeWeese, J., Girardi, M. A., Sheppard, V., & Bodfish, J. W. (1999) · New England Journal of Medicine · doi:10.1056/nejm199912093412404 · Cited by 217
Dysbiosis of microbiome and probiotic treatment in a genetic model of autism spectrum disorders
Tabouy, L., Getselter, D., Ziv, O., Karpuj, M., Tabouy, T., Lukic, I., Maayouf, R., Werbner, N., Ben-Amram, H., Nuriel-Ohayon, M., et al. (2018) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2018.05.015 · Cited by 214
Autism and Clostridium tetani
Bolte, E. R. (1998) · Medical Hypotheses · doi:10.1016/s0306-9877(98)90107-4 · Cited by 213
Pathways underlying the gut-to-brain connection in autism spectrum disorders as future targets for disease management
de Theije, C. G. M., Wu, J., da Silva, S. L., Kamphuis, P. J. G. H., Garssen, J., Korte, S. M., & Kraneveld, A. D. (2011) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2011.07.013 · Cited by 212
Disorders of the enteric nervous system — a holistic view
Niesler, B., Küerten, S., Demir, İ. E., & Schäfer, K. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-020-00385-2 · Cited by 209
Molecular Characterisation of Gastrointestinal Microbiota of Children With Autism (With and Without Gastrointestinal Dysfunction) and Their Neurotypical Siblings
Gondalia, S. V., Palombo, E. A., Knowles, S. R., Cox, S. B., Meyer, D., & Austin, D. W. (2012) · Autism Research · doi:10.1002/aur.1253 · Cited by 208
Drosophila Histone Demethylase KDM5 Regulates Social Behavior through Immune Control and Gut Microbiota Maintenance
Chen, K., Luan, X., Liu, Q., Wang, J., Chang, X., Snijders, A. M., Mao, J.-H., Secombe, J., Dan, Z., Chen, J.-H., et al. (2019) · Cell Host & Microbe · doi:10.1016/j.chom.2019.02.003 · Cited by 208
Microbe-host interactions: influence of the gut microbiota on the enteric nervous system
Hyland, N. P., & Cryan, J. F. (2016) · Developmental Biology · doi:10.1016/j.ydbio.2016.06.027 · Cited by 207
Effects of Serotonin and Slow-Release 5-Hydroxytryptophan on Gastrointestinal Motility in a Mouse Model of Depression
Israelyan, N., Colle, A. D., Li, Z., Park, Y., Xing, A., Jacobsen, J. P. R., Luna, R. A., Jensen, D. D., Madra, M., Saurman, V. E., et al. (2019) · Gastroenterology · doi:10.1053/j.gastro.2019.04.022 · Cited by 206
Self-citation
Fecal Microbiota Transplantation Relieves Gastrointestinal and Autism Symptoms by Improving the Gut Microbiota in an Open-Label Study
Li, N., Chen, H., Cheng, Y., Xu, F., Ruan, G., Ying, S., Tang, W., Chen, L., Chen, M., Lv, L., et al. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.759435 · Cited by 206
Effects of Probiotic Supplementation on Gastrointestinal, Sensory and Core Symptoms in Autism Spectrum Disorders: A Randomized Controlled Trial
Santocchi, E., Guiducci, L., Prosperi, M., Calderoni, S., Gaggini, M., Apicella, F., Tancredi, R., Billeci, L., Mastromarino, P., Grossi, E., et al. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.550593 · Cited by 198
Clinical and genomic evaluation of 201 patients with Phelan–McDermid syndrome
Sarasua, S. M., Boccuto, L., Sharp, J. L., Dwivedi, A., Chen, C.-F., Rollins, J. D., Rogers, R. C., Phelan, K., & DuPont, B. R. (2014) · Human Genetics · doi:10.1007/s00439-014-1423-7 · Cited by 197
Desulfovibrio species are potentially important in regressive autism
Finegold, S. M. (2011) · Medical Hypotheses · doi:10.1016/j.mehy.2011.04.032 · Cited by 197
Pharmacological reduction of mucosal but not neuronal serotonin opposes inflammation in mouse intestine
Margolis, K. G., Stevanovic, K. D., Li, Z., Yang, Q., Oravecz, T., Zambrowicz, B., Jhaver, K. G., Diacou, A., & Gershon, M. D. (2013) · Gut · doi:10.1136/gutjnl-2013-304901 · Cited by 192
Self-citation
Gastrointestinal symptoms and behavioral problems in preschoolers with Autism Spectrum Disorder
Fulceri, F., Morelli, M., Santocchi, E., Cena, H., Del Bianco, T., Narzisi, A., Calderoni, S., & Muratori, F. (2016) · Digestive and Liver Disease · doi:10.1016/j.dld.2015.11.026 · Cited by 191
The maternal vaginal microbiome partially mediates the effects of prenatal stress on offspring gut and hypothalamus
Jašarević, E., Howard, C. D., Morrison, K., Misic, A., Weinkopff, T., Scott, P., Hunter, C., Beiting, D., & Bale, T. L. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0182-5 · Cited by 189
Gastrointestinal Symptoms in Autism Spectrum Disorder: A Systematic Review
Leader, G., Abberton, C., Cunningham, S., Gilmartin, K., Grudzien, M., Higgins, E., Joshi, L., Whelan, S., & Mannion, A. (2022) · Nutrients · doi:10.3390/nu14071471 · Cited by 185
Probiotics for gastrointestinal symptoms and quality of life in autism: a placebo-controlled pilot trial
Arnold, L. E., Luna, R. A., Williams, K., Chan, J., Parker, R. A., Wu, Q., Hollway, J. A., Jeffs, A., Lu, F., Coury, D. L., et al. (2019) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2018.0156 · Cited by 183
Blockade of interleukin-6 receptor in the periphery promotes rapid and sustained antidepressant actions: a possible role of gut–microbiota–brain axis
Zhang, J.-C., Yao, W., Dong, C., Yang, C., Ren, Q., Ma, M., & Hashimoto, K. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.112 · Cited by 182
Pre‐pregnancy and pregnancy obesity and neurodevelopmental outcomes in offspring: a systematic review
Lieshout, R. J. V., Taylor, V. H., & Boyle, M. H. (2011) · Obesity Reviews · doi:10.1111/j.1467-789x.2010.00850.x · Cited by 178
Human serotonin transporter variants display altered sensitivity to protein kinase G and p38 mitogen-activated protein kinase
Prasad, H. C., Zhu, C.-B., McCauley, J. L., Samuvel, D. J., Ramamoorthy, S., Shelton, R. C., Hewlett, W. A., Sutcliffe, J. S., & Blakely, R. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501432102 · Cited by 178
SHANK3 as an autism spectrum disorder-associated gene
Uchino, S., & Waga, C. (2013) · Brain and Development · doi:10.1016/j.braindev.2012.05.013 · Cited by 176
Sex-related alterations of gut microbiota composition in the BTBR mouse model of autism spectrum disorder
Coretti, L., Cristiano, C., Florio, E., Scala, G., Lama, A., Keller, S., Cuomo, M., Russo, R., Pero, R., Paciello, O., et al. (2017) · Scientific Reports · doi:10.1038/srep45356 · Cited by 175
Microbiota regulates visceral pain in the mouse
Luczynski, P., Tramullas, M., Viola, M. F., Shanahan, F., Clarke, G. A., O’Mahony, S. M., Dinan, T. G., & Cryan, J. F. (2017) · eLife · doi:10.7554/elife.25887 · Cited by 174
Alterations of oral microbiota distinguish children with autism spectrum disorders from healthy controls
Qiao, Y., Wu, M., Feng, Y., Zhou, Z., Chen, L., & Chen, F. (2018) · Scientific Reports · doi:10.1038/s41598-018-19982-y · Cited by 174
Ketogenic Diet Improves Core Symptoms of Autism in BTBR Mice
Ruskin, D. N., Svedova, J., Cote, J. L., Sandau, U., Rho, J. M., Kawamura, M., Boison, D., & Masino, S. A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0065021 · Cited by 173
Neuronal Serotonin Regulates Growth of the Intestinal Mucosa in Mice
Gross, E. R., Gershon, M. D., Margolis, K. G., Gertsberg, Z. V., & Cowles, R. A. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.05.007 · Cited by 172
Self-citation
Gluten-free and casein-free diets in the treatment of autism spectrum disorders: A systematic review
Mulloy, A. M., Lang, R. B., O’Reilly, M. F., Sigafoos, J., Lancioni, G. E., & Rispoli, M. J. (2009) · Research in Autism · doi:10.1016/j.rasd.2009.10.008 · Cited by 172
A modified ketogenic gluten-free diet with MCT improves behavior in children with autism spectrum disorder
Lee, R. W. Y., Corley, M. J., Pang, A. P. S., Arakaki, G., Abbott, L., Nishimoto, M., Miyamoto, R. H., Lee, E., Yamamoto, S., Maunakea, A. K., et al. (2018) · Physiology & Behavior · doi:10.1016/j.physbeh.2018.02.006 · Cited by 171
Role of interleukin-6-mediated inflammation in the pathogenesis of inflammatory bowel disease: focus on the available therapeutic approaches and gut microbiome
Shahini, A., & Shahini, A. (2022) · Journal of Cell Communication and Signaling · doi:10.1007/s12079-022-00695-x · Cited by 171
Probiotics in Irritable Bowel Syndrome: An Up-to-Date Systematic Review
Dale, H. F., Rasmussen, S. H., Asiller, Ö. Ö., & Lied, G. A. (2019) · Nutrients · doi:10.3390/nu11092048 · Cited by 169
Gut microbiota changes in patients with autism spectrum disorders
Ding, X., Xu, Y., Zhang, X., Zhang, L., Duan, G., Song, C., Li, Z., Yang, Y., Wang, Y., Wang, X., et al. (2020) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2020.06.032 · Cited by 166
A review of rhythm and responsiveness of cortisol in individuals with autism spectrum disorders
Taylor, J. L., & Corbett, B. A. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.07.015 · Cited by 165
Early Identification of Autism Spectrum Disorder Among Children Aged 4 Years — Autism and Developmental Disabilities Monitoring Network, 11 Sites, United States, 2018
Shaw, K. A., Maenner, M. J., Bakian, A. V., Bilder, D. A., Durkin, M. S., Furnier, S. M., Hughes, M. M., Patrick, M., Pierce, K., Salinas, A., et al. (2021) · MMWR. Surveillance Summaries · doi:10.15585/mmwr.ss7010a1 · Cited by 165
A double-blind, placebo-controlled, crossover-designed probiotic feeding study in children diagnosed with autistic spectrum disorders.
Parracho, H. M. R. T., Gibson, G. R., Knott, F., Bosscher, D., Kleerebezem, M., & McCartney, A. L. (2010) · International Journal of Probiotics and Prebiotics · Cited by 162
New and Preliminary Evidence on Altered Oral and Gut Microbiota in Individuals with Autism Spectrum Disorder (ASD): Implications for ASD Diagnosis and Subtyping Based on Microbial Biomarkers
Kong, X., Liu, J., Çetinbaş, M., Sadreyev, R. I., Koh, M., Huang, H. Y., Adeseye, A., He, P., Zhu, J., Russell, H., et al. (2019) · Nutrients · doi:10.3390/nu11092128 · Cited by 155
Distinct Fecal and Plasma Metabolites in Children with Autism Spectrum Disorders and Their Modulation after Microbiota Transfer Therapy
Kang, D., Adams, J. B., Vargason, T., Santiago, M., Hahn, J., & Krajmalnik‐Brown, R. (2020) · mSphere · doi:10.1128/msphere.00314-20 · Cited by 154
Underdevelopment of the gut microbiota and bacteria species as non-invasive markers of prediction in children with autism spectrum disorder
Wan, Y., Zuo, T., Xu, Z., Zhang, F., Zhan, H., Dorothy, C. H. A. N., Leung, T.-F., Yeoh, Y. K., Chan, F. K. L., Chan, R., et al. (2021) · Gut · doi:10.1136/gutjnl-2020-324015 · Cited by 154
Eating behaviors, diet quality, and gastrointestinal symptoms in children with autism spectrum disorders: a brief review
Kral, T. V. E., Eriksen, W. T., Souders, M. C., & Pinto-Martin, J. A. (2013) · Journal of Pediatric Nursing · doi:10.1016/j.pedn.2013.01.008 · Cited by 153
Maternal gut bacteria drive intestinal inflammation in offspring with neurodevelopmental disorders by altering the chromatin landscape of CD4+ T cells
Kim, E., Paik, D., Ramírez, R. N., Biggs, D. G., Park, Y., Kwon, H., Choi, G. B., & Huh, J. R. (2021) · Immunity · doi:10.1016/j.immuni.2021.11.005 · Cited by 153
Effect of gluten free diet on gastrointestinal and behavioral indices for children with autism spectrum disorders: a randomized clinical trial
Ghalichi, F., Ghaemmaghami, J., Malek, A., & Ostadrahimi, A. (2016) · World Journal of Pediatrics · doi:10.1007/s12519-016-0040-z · Cited by 150
Altered gut microbiota in Rett syndrome
Strati, F., Cavalieri, D., Albanese, D., Felice, C. D., Donati, C., Hayek, J., Jousson, O., Leoncini, S., Pindo, M., Renzi, D., et al. (2016) · Microbiome · doi:10.1186/s40168-016-0185-y · Cited by 149
Gut microbiota changes in children with autism spectrum disorder: a systematic review
Ho, L. K. H., Tong, V. J. W., Syn, N., Nagarajan, N., Tham, E. H., Tay, S. K., Shorey, S., Tambyah, P. A., & Law, E. C. N. (2020) · Gut Pathogens · doi:10.1186/s13099-020-0346-1 · Cited by 149
Mitochondrial Dysfunction in Autism Spectrum Disorders
SIDDIQUI, M., Elwell, C. E., & Johnson, M. H. (2016) · Autism - Open Access · doi:10.4172/2165-7890.1000190 · Cited by 145
Important role of mucosal serotonin in colonic propulsion and peristaltic reflexes: in vitro analyses in mice lacking tryptophan hydroxylase 1
Heredia, D. J., Gershon, M. D., Koh, S. D., Corrigan, R. D., Okamoto, T., & Smith, T. K. (2013) · The Journal of Physiology · doi:10.1113/jphysiol.2013.256230 · Cited by 144
Diet can impact microbiota composition in children with autism spectrum disorder
Berding, K., & Donovan, S. M. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00515 · Cited by 144
Functioning Among Typically Developing Siblings of Individuals with Autism Spectrum Disorder: A Meta-Analysis
Shivers, C. M., Jackson, J. B., & McGregor, C. M. (2018) · Clinical Child and Family Psychology Review · doi:10.1007/s10567-018-0269-2 · Cited by 144
Correlation of Gut Microbiome Between ASD Children and Mothers and Potential Biomarkers for Risk Assessment
Li, N., Yang, J., Zhang, J., Liang, C., Wang, Y., Chen, B., Zhao, C., Wang, J., Zhang, G., Zhao, D., et al. (2019) · Genomics Proteomics & Bioinformatics · doi:10.1016/j.gpb.2019.01.002 · Cited by 141
Fecal Microbiome Transplantation from Children with Autism Spectrum Disorder Modulates Tryptophan and Serotonergic Synapse Metabolism and Induces Altered Behaviors in Germ-Free Mice
Xiao, L., Yan, J., Yang, T., Zhu, J., Li, T., Wei, H., & Chen, J. (2021) · mSystems · doi:10.1128/msystems.01343-20 · Cited by 141
Ketogenic diet versus gluten free casein free diet in autistic children: a case-control study
El-Rashidy, O. F., El-Baz, F. M., Gendy, Y. G. E., Khalaf, R. I., Reda, D., & Saad, K. (2017) · Metabolic Brain Disease · doi:10.1007/s11011-017-0088-z · Cited by 140
Serotonin transporter variant drives preventable gastrointestinal abnormalities in development and function
Margolis, K. G., Li, Z., Stevanovic, K., Saurman, V., Israelyan, N., Anderson, G. M., Snyder, I., Veenstra-VanderWeele, J., Blakely, R. D., & Gershon, M. D. (2016) · Journal of Clinical Investigation · doi:10.1172/jci84877 · Cited by 139
Self-citation
Intestinal bacteria maintain adult enteric nervous system and nitrergic neurons via Toll-like receptor 2-induced neurogenesis in mice
Yarandi, S. S., Kulkarni, S., Saha, M., Sylvia, K. E., Sears, C. L., & Pasricha, P. J. (2020) · Gastroenterology · doi:10.1053/j.gastro.2020.03.050 · Cited by 138
Myelin as a regulator of development of the microbiota-gut-brain axis
Keogh, C. E., Kim, D. H. J., Pusceddu, M. M., Knotts, T. A., Rabasa, G., Sladek, J. A., Hsieh, M. T., Honeycutt, M., Brust-Mascher, I., Barboza, M., et al. (2021) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2020.11.001 · Cited by 137
The Therapeutic Role of Ketogenic Diet in Neurological Disorders
Pietrzak, D., Kasperek, K., Rękawek, P., & Piątkowska‐Chmiel, I. (2022) · Nutrients · doi:10.3390/nu14091952 · Cited by 136
Developmental–behavioral profiles in children with autism spectrum disorder and co‐occurring gastrointestinal symptoms
Restrepo, B., Angkustsiri, K., Taylor, S. L., Rogers, S. J., Cabral, J., Heath, B. E., Hechtman, A., Solomon, M., Ashwood, P., Amaral, D. G., et al. (2020) · Autism Research · doi:10.1002/aur.2354 · Cited by 129
Development of colonic motility in the neonatal mouse-studies using spatiotemporal maps
Roberts, R. R., Murphy, J. F., Young, H. M., & Bornstein, J. C. (2006) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00444.2006 · Cited by 128
Enhanced activity of human serotonin transporter variants associated with autism
Prasad, H. C., Steiner, J. A., Sutcliffe, J. S., & Blakely, R. (2008) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2008.0143 · Cited by 126
The Prevalence and Characteristics of Children With Profound Autism, 15 Sites, United States, 2000-2016
Hughes, M. M., Shaw, K. A., DiRienzo, M., Durkin, M. S., Esler, A., Hall‐Lande, J., Wiggins, L. D., Zahorodny, W. M., Singer, A., & Maenner, M. J. (2023) · Public Health Reports · doi:10.1177/00333549231163551 · Cited by 126
Autism spectrum disorder in Phelan-McDermid syndrome: initial characterization and genotype-phenotype correlations
Oberman, L. M., Boccuto, L., Cascio, L., Sarasua, S. M., & Kaufmann, W. E. (2015) · Orphanet Journal of Rare Diseases · doi:10.1186/s13023-015-0323-9 · Cited by 125
Maternal metabolic risk factors for autism spectrum disorder: an analysis of electronic medical records and linked birth data
Connolly, N., Anixt, J., Manning, P., Ping‐I Lin, D., Marsolo, K. A., & Bowers, K. (2016) · Autism Research · doi:10.1002/aur.1586 · Cited by 125
Markers of celiac disease and gluten sensitivity in children with autism
Lau, N. M., Green, P. H. R., Taylor, A. K., Hellberg, D., Ajamian, M., Tan, C. Z., Kosofsky, B. E., Higgins, J. J., Rajadhyaksha, A. M., & Alaedini, A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0066155 · Cited by 124
Antibiotic-induced dysbiosis of the microbiota impairs gut neuromuscular function in juvenile mice
Caputi, V., Marsilio, I., Filpa, V., Cerantola, S., Orso, G., Bistoletti, M., Paccagnella, N., De Martin, S., Montopoli, M., Dall'Acqua, S., et al. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13965 · Cited by 124
The impact of maternal high-fat diet on offspring neurodevelopment
Urbonaite, G., Knyzeliene, A., Bunn, F. S., Smalskys, A., & Neniškytė, U. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.909762 · Cited by 124
The association between emotional and behavioral problems and gastrointestinal symptoms among children with high-functioning autism
Mazefsky, C. A., Schreiber, D. R., Olino, T. M., & Minshew, N. J. (2013) · Autism · doi:10.1177/1362361313485164 · Cited by 122
A descriptive review on the prevalence of gastrointestinal disturbances and their multiple associations in autism spectrum disorder
Lefter, R., Ciobica, A., Timofte, D., Stanciu, C., & Trifan, A. (2019) · Medicina · doi:10.3390/medicina56010011 · Cited by 120
Prevalence of overweight and obesity among US youth with autism spectrum disorder
Healy, S., Aigner, C. J., & Haegele, J. A. (2018) · Autism · doi:10.1177/1362361318791817 · Cited by 119
Effect of vitamin A supplementation on gut microbiota in children with autism spectrum disorders - a pilot study
Liu, J., Liu, X., Xiong, X.-Q., Yang, T., Cui, T., Hou, N.-L., Lai, X., Liu, S., Guo, M., Liang, X.-H., et al. (2017) · BMC Microbiology · doi:10.1186/s12866-017-1096-1 · Cited by 115
Association of Hospitalization for Infection in Childhood With Diagnosis of Autism Spectrum Disorders: A Danish Cohort Study
Atladóttir, H. Ó., Thorsen, P., Schendel, D. E., Østergaard, L., Lemcke, S., & Parner, E. T. (2010) · Archives of Pediatrics & Adolescent Medicine · doi:10.1001/archpediatrics.2010.9 · Cited by 114 · cited 1×
“Maternal inflammation caused by a confirmed viral or bacterial infection, or a fever lasting longer than 7 days, has been associated with an up to threefold increased risk of ASD development in exposed progeny 187,188 .”
Environmental exposures associated with elevated risk for autism spectrum disorder may augment the burden of deleterious de novo mutations among probands
Pugsley, K., Scherer, S. W., Bellgrove, M. A., & Hawi, Z. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01142-w · Cited by 114
Diet: the keystone of autism spectrum disorder?
Peretti, S., Mariano, M. R. G., Mazzocchetti, C., Mazza, M., Pino, M. C., di Pianella, A. V., & Valenti, M. (2018) · Nutritional Neuroscience · doi:10.1080/1028415x.2018.1464819 · Cited by 112
Safety and target engagement of an oral small-molecule sequestrant in adolescents with autism spectrum disorder: an open-label phase 1b/2a trial
Campbell, A. S., Needham, B. D., Meyer, C. R., Tan, J. H. J., Conrad, M. C., Preston, G. M., Bolognani, F., Rao, S. G., Heussler, H., Griffith, R., et al. (2022) · Nature Medicine · doi:10.1038/s41591-022-01683-9 · Cited by 112
The Gut Microbiota and Associated Metabolites Are Altered in Sleep Disorder of Children With Autism Spectrum Disorders
Hua, X., Zhu, J., Yang, T., Guo, M., Li, Q., Chen, J., & Li, T. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00855 · Cited by 110
Biologically active peptide-containing fractions in schizophrenia and childhood autism.
Reichelt, K. L., Hole, K., Hamberger, A., Sælid, G. A., Edminson, P. D., Bræstrup, C., Lingjærde, O., Ledaal, P., & Ørbeck, H. (1981) · PubMed · Cited by 109
Oral probiotic administration during pregnancy prevents autism‐related behaviors in offspring induced by maternal immune activation via anti‐inflammation in mice
Wang, X., Yang, J., Zhang, H., Yu, J., & Yao, Z. (2019) · Autism Research · doi:10.1002/aur.2079 · Cited by 109

Research works printed but not linked: 3

Kanner, L. Autistic disturbances of affective contact. Nerv. Child 2, 217–250 (1943).
Achenbach, T. M. & Rescorla, L. A. Manual for the ASEBA preschool forms and profiles Vol. 30 (ASEBA, 2000).
Hales, C. M., Carroll, M. D., Fryar, C. D. & Ogden, C. L. Prevalence of obesity and severe obesity among adults: United States, 2017–2018. NCHS Data Brief 360, 1–8 (2020).

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Unraveling the Connections: Eating Issues, Microbiome, and Gastrointestinal Symptoms in Autism Spectrum Disorder
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Authors: Hung, L. Y., & Margolis, K. G.
Affiliations: New York University (US)
NYU Langone Health (US)
Corresponding author: Margolis, Kara Gross
ORCID: Hung, Lin Y.
Margolis, Kara Gross
Venue: Nature Reviews Gastroenterology & Hepatology
Publisher: Springer Science and Business Media LLC
Published: 2023-12-19
Volume: 21
Issue: 3
Pages: 142-163
ISSN: 1759-5045 (ISSN-L)
1759-5053
DOI: 10.1038/s41575-023-00857-1
OpenAlex: W4389937109
Semantic Scholar: ac9023f063ccd5025ccbc501f4fd67a5a4802d0f
Cited by: 96
References: 322
Citations by year: 2026: 42 · 2025: 40 · 2024: 14
FWCI: 3.60
Type: journal article
Language: en
Open access: closed
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Nature Reviews Gastroenterology & Hepatology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Health Sciences › Medicine › Psychiatry and Mental health › Child Nutrition and Feeding Issues
Keywords: autism spectrum disorder, gastrointestinal dysfunction, enteric nervous system, constipation, diarrhea, abdominal pain, gut-brain axis, neurodevelopmental disorders
MeSH terms: Autism Spectrum Disorder, Clinical Relevance, Constipation, Humans, Abdominal Pain, Gastrointestinal Tract

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Autism spectrum disorders and the gastrointestinal tract: insights into mechanisms and clinical relevance

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