Cited by 650Dermatology and Skin DiseasesT-cell and B-cell ImmunologyContact Dermatitis and Allergies

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The immunological anatomy of the skin

Kabashima, Kenji, Honda, Tetsuya, Ginhoux, Florent, Egawa, Gyohei·2019·Nature Reviews Immunology

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Abstract

The skin is the outermost organ of the body and is continuously exposed to external pathogens. Upon inflammation, various immune cells pass through, reside in or are recruited to the skin to orchestrate diverse cutaneous immune responses. To achieve this, immune cells interact with each other and even communicate with non-immune cells, including peripheral nerves and the microbiota. Immunologically important anatomical sites, such as skin appendages (for example, hair follicles and sweat glands) or postcapillary venules, act as special portal sites for immune cells and for establishing tertiary lymphoid structures, including inducible skin-associated lymphoid tissue. Here, we provide an overview of the key findings and concepts of cutaneous immunity in association with skin anatomy and discuss how cutaneous immune cells fine-tune physiological responses in the skin.

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Authors: Kabashima, K., Honda, T., Ginhoux, F., & Egawa, G.
Affiliations: Agency for Science, Technology and Research (SG)
Kyoto University (JP)
Corresponding author: Kabashima, Kenji
ORCID: Kabashima, Kenji
Honda, Tetsuya
Ginhoux, Florent
Egawa, Gyohei
Venue: Nature Reviews Immunology
Publisher: Springer Science and Business Media LLC
Published: 2018-11-14
Volume: 19
Issue: 1
Pages: 19-30
ISSN: 1474-1733 (ISSN-L)
1474-1741
DOI: 10.1038/s41577-018-0084-5
OpenAlex: W2901552928
Cited by: 650
References: 105
Citations by year: 2026: 73 · 2025: 103 · 2024: 104 · 2023: 103 · 2022: 68 · 2021: 105 · 2020: 66 · 2019: 28
FWCI: 8.08
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Immunology (publishedVersion)
PubMed (publishedVersion)
Funders: Japan Agency for Medical Research and Development
Japan Society for the Promotion of Science (17K19655)
Topics: Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Health Sciences › Medicine › Dermatology › Contact Dermatitis and Allergies
Keywords: skin immunity, skin anatomy, skin appendages, hair follicle, sweat glands, postcapillary venules, tertiary lymphoid structures, immune cell recruitment, peripheral nerves, skin microbiome, skin inflammation
MeSH terms: Animals, Humans, Immunity, Inflammation, Lymphocytes, Skin

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