Dysregulation of type I interferon responses in COVID-19
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A main evasion strategy seems to be blocking type I interferon responses at several steps, such as viral RNA recognition, nuclear translocation of inflammatory transcription factors, and STAT1/STAT2 phosphorylation.
“A predominant strategy appears to be the inhibition of the type I interferon response58–60 at multiple points, including impaired recognition of viral RNA61,62, decreased nuclear translocation of pro-inflammatory transcription factors (such as IRF3, IRF7 and STAT1)61,63 and suppression of STAT1 and STAT2 phosphorylation64,65.”
From Immunological mechanisms of vaccine-induced protection against COVID-19 in humans (2021) · cites this paper as [58]
SARS-CoV-2 uses a multipronged strategy to antagonize the IFN system, with the clinical consequence of an insufficient type I IFN response in early COVID-19.
“As an immune evasion strategy, SARS-CoV-2 uses a multipronged strategy to antagonize the IFN system with the clinical consequence of an insufficient type I IFN response having been recognized in early COVID-19 studies (Acharya et al., 2020; Blanco-Melo et al., 2020; Sa Ribero et al., 2020).”
From COVID-19 and the human innate immune system (2021) · cites this paper as Acharya et al., 2020
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- Authors
- Acharya, D., Liu, G., & Gack, M. U.
- Affiliations
- University of Chicago (US)
- Corresponding author
- Gack, Michaela U.
- Venue
- Nature Reviews Immunology
- Published
- 2020-05-26
- Volume
- 20
- Issue
- 7
- Pages
- 397-398
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- PMC
- PMC7249038
- OpenAlex
- W3032859583
- Cited by
- 454
- References
- 10
- Citations by year
- 2026: 15 · 2025: 22 · 2024: 36 · 2023: 51 · 2022: 121 · 2021: 153 · 2020: 55 · 2013: 1
- FWCI
- 33.28
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Keywords
- type I interferon, COVID-19 pandemic, SARS-CoV-2, inflammatory cytokines, antiviral immunity, cytokine storm, viral pathogenesis
- MeSH terms
- Betacoronavirus, COVID-19, SARS-CoV-2, Animals, Humans, Interferon Type I, Pneumonia, Viral, Interferon-alpha, Coronavirus Infections, Pandemics
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