Cited by 167Coagulation, Bradykinin, Polyphosphates, and AngioedemaRenin-Angiotensin System StudiesComplement system in diseases

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Crosstalk between the renin–angiotensin, complement and kallikrein–kinin systems in inflammation

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Bekassy, Zivile, Lopatko Fagerström, Ingrid, Bader, Michael, Karpman, Diana·2022·Nature reviews. Immunology

DOI 10.1038/s41577-021-00634-8PMC PMC8579187

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Abstract

During severe inflammatory and infectious diseases, various mediators modulate the equilibrium of vascular tone, inflammation, coagulation and thrombosis. This Review describes the interactive roles of the renin-angiotensin system, the complement system, and the closely linked kallikrein-kinin and contact systems in cell biological functions such as vascular tone and leakage, inflammation, chemotaxis, thrombosis and cell proliferation. Specific attention is given to the role of these systems in systemic inflammation in the vasculature and tissues during hereditary angioedema, cardiovascular and renal glomerular disease, vasculitides and COVID-19. Moreover, we discuss the therapeutic implications of these complex interactions, given that modulation of one system may affect the other systems, with beneficial or deleterious consequences.

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Authors: Bekassy, Z., Lopatko Fagerström, I., Bader, M., & Karpman, D.
Affiliations: Lund University (SE)
Corresponding author: Karpman, Diana
ORCID: Bekassy, Zivile
Karpman, Diana
Venue: Nature reviews. Immunology
Publisher: Springer Science and Business Media LLC
Published: 2021-11-10
Volume: 22
Issue: 7
Pages: 411-428
ISSN: 1474-1733 (ISSN-L)
1474-1741
DOI: 10.1038/s41577-021-00634-8
PMC: PMC8579187
OpenAlex: W3211940634
Cited by: 167
References: 290
Citations by year: 2026: 25 · 2025: 34 · 2024: 46 · 2023: 42 · 2022: 20
FWCI: 3.85
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature reviews. Immunology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
MDC Repository (Max-Delbrueck-Center for Molecular Medicine) (submittedVersion)
Lund University Publications (Lund University) (submittedVersion)
Funders: Deutsche Forschungsgemeinschaft (SFB1365)
Crafoordska Stiftelsen
Knut och Alice Wallenbergs Stiftelse (Wallenberg Clinical Scholar 2015.0320, 2015.0320)
Vetenskapsrådet (2017-01920)
Topics: Health Sciences › Medicine › Hematology › Coagulation, Bradykinin, Polyphosphates, and Angioedema
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
Life Sciences › Immunology and Microbiology › Immunology › Complement system in diseases
Keywords: renin-angiotensin system, complement system, kallikrein-kinin system, contact system, inflammation, hereditary angioedema, vasculitis, glomerular disease, COVID-19 pandemic, vascular tone, vascular leakage, thrombosis, chemotaxis, cell proliferation, cardiovascular disease, kidney disease, therapeutic target
MeSH terms: COVID-19, Complement System Proteins, Humans, Inflammation, Renin-Angiotensin System, Thrombosis, Kallikrein-Kinin System

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Crosstalk between the renin–angiotensin, complement and kallikrein–kinin systems in inflammation

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