The DOI matches its Crossref record; 212 of the 213 references it cites were found in a registry or an index.
Targeting IL-6 trans-signalling: past, present and future prospects
Open accessAbstract
Interleukin-6 (IL-6) is a key immunomodulatory cytokine that affects the pathogenesis of diverse diseases, including autoimmune diseases, chronic inflammatory conditions and cancer. Classical IL-6 signalling involves the binding of IL-6 to the membrane-bound IL-6 receptor α-subunit (hereafter termed ‘mIL-6R’) and glycoprotein 130 (gp130) signal-transducing subunit. By contrast, in IL-6 trans-signalling, complexes of IL-6 and the soluble form of IL-6 receptor (sIL-6R) signal via membrane-bound gp130. A third mode of IL-6 signalling — known as cluster signalling — involves preformed complexes of membrane-bound IL-6–mIL-6R on one cell activating gp130 subunits on target cells. Antibodies and small molecules have been developed that block all three forms of IL-6 signalling, but in the past decade, IL-6 trans-signalling has emerged as the predominant pathway by which IL-6 promotes disease pathogenesis. The first selective inhibitor of IL-6 trans-signalling, sgp130, has shown therapeutic potential in various preclinical models of disease and olamkicept, a sgp130Fc variant, had promising results in phase II clinical studies for inflammatory bowel disease. Technological developments have already led to next-generation sgp130 variants with increased affinity and selectivity towards IL-6 trans-signalling, along with indirect strategies to block IL-6 trans-signalling. Here, we summarize our current understanding of the biological outcomes of IL-6-mediated signalling and the potential for targeting this pathway in the clinic. This Review details the discovery of the interleukin-6 (IL-6) trans-signalling pathway and the subsequent development of biologics that specifically inhibit this pathway. Emerging evidence suggests that specifically targeting IL-6 trans-signalling can reduce pathological disease-promoting activities of IL-6 without blocking the protective actions of IL-6 in infection and tissue repair.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“In MM cells, the JAK/STAT3 pathway is triggered by cytokines from the gp130 receptor family, such as IL-6, leukemia inhibitory factor (LIF), and oncostatin-M (OSM).”
From Multiple myeloma: signaling pathways and targeted therapy (2024) · cites this paper as [108]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Additionally, the binding of IL-6 to its receptor (IL-6R) leads to the activation of JAK1, which phosphorylates STAT3, thereby activating the JAK/STAT pathway [108].”
From Multiple myeloma: signaling pathways and targeted therapy (2024) · cites this paper as [108]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Soluble gp130Fc, named olamkicept or TJ301, is consists of two soluble human gp130 proteins fused with the Fc of human IgG, and selectively targets the IL-6-sIL-6R complex [79].”
From The double-edged effects of IL-6 in liver regeneration, aging, inflammation, and diseases (2024) · cites this paper as [79]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“As IL-6 classic signaling plays crucial roles in the initiation of inflammation and the host defense against pathogen infection, global blockade of IL-6 signaling may reduce the induction of hepatic acute-phase proteins upon infection, such as Listeria monocytogenes [79].”
From The double-edged effects of IL-6 in liver regeneration, aging, inflammation, and diseases (2024) · cites this paper as [79]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Tissue-based map of the human proteome
Uhlén, M., Fagerberg, L., Hallström, B. M., Lindskog, C., Oksvold, P., Mardinoglu, A., Sivertsson, Å., Kampf, C., Sjöstedt, E., Asplund, A., et al. (2015) · Science · doi:10.1126/science.1260419 · Cited by 15,286
Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients
Hadjadj, J., Yatim, N., Barnabei, L., Corneau, A., Boussier, J., Smith, N., Péré, H., Charbit, B., Bondet, V., Chenevier-Gobeaux, C., et al. (2020) · Science · doi:10.1126/science.abc6027 · Cited by 2,984
The global burden of IBD: from 2015 to 2025
Kaplan, G. G. (2015) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2015.150 · Cited by 2,639
Grivennikov, S., Karin, E., Terzic, J., Mucida, D., Yu, G.-Y., Vallabhapurapu, S., Scheller, J., Rose-John, S., Cheroutre, H., Eckmann, L., et al. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.01.001 · Cited by 2,155
Self-citationHirano, T., Yasukawa, K., Harada, H., Taga, T., Watanabe, Y., Matsuda, T., Kashiwamura, S.-I., Nakajima, K., Koyama, K., Iwamatsu, A., et al. (1986) · Nature · doi:10.1038/324073a0 · Cited by 2,139
Complex Immune Dysregulation in COVID-19 Patients with Severe Respiratory Failure
Giamarellos-Bourboulis, E. J., Netea, M. G., Rovina, N., Akinosoglou, K., Antoniadou, A., Antonakos, N., Damoraki, G., Gkavogianni, T., Adami, M.-E., Katsaounou, P., et al. (2020) · Cell Host & Microbe · doi:10.1016/j.chom.2020.04.009 · Cited by 2,045 · cited 1×
“Dysregulated IL-6 signalling is a hallmark of infections, including SARS-CoV-2, that are characterized by hyperinflammation 137–145 , with high IL-6 levels in patients with COVID-19 being implicated in the depletion of CD4 + T cells, CD8 + T cells and natural killer cells 146 .”
Abani, O., Abbas, A., Abbas, F., Abbas, M., Abbasi, S., Abbass, H., Abbott, A., Abdallah, N., Abdelaziz, A., Abdelfattah, M., et al. (2021) · The Lancet · doi:10.1016/s0140-6736(21)00676-0 · Cited by 1,983
Interleukin-6 receptor antagonists in critically ill patients with Covid-19.
The REMAP-CAP Investigators (2021) · New England Journal of Medicine · doi:10.1056/nejmoa2100433 · Cited by 1,962
Impaired immune and acute-phase responses in interleukin-6-deficient mice
Kopf, M., Baumann, H., Freer, G., Freudenberg, M., Lamers, M., Kishimoto, T., Zinkernagel, R., Bluethmann, H., & Köhler, G. (1994) · Nature · doi:10.1038/368339a0 · Cited by 1,768 · cited 2×
“Studies in IL-6-deficient mice showed that IL-6 contributes to the pathogenesis of many inflammatory diseases, including bacterial and viral infections 66 , arthritis 67,68 , experimental colitis 69 and multiple sclerosis 70 .”
Gauldie, J., Richards, C. D., Harnish, D. C., Lansdorp, P. M., & Baumann, H. J. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.20.7251 · Cited by 1,635
Research works printed but not linked: 1
- Kang, S., Narazaki, M., Metwally, H. & Kishimoto, T. Historical overview of the interleukin-6 family cytokine. J. Exp. Med. 2020, 5 (2020).
Cited by
Sorted by citations
Items 101–200 of 555
Dai, X., Li, L., Yan, X., Fan, Q., Wang, R., Zhang, W., Chen, W., Liu, Y., Meng, J., & Wang, J. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1239592 · Cited by 18
Interleukins in Platelet Biology: Unraveling the Complex Regulatory Network
Huang, M., Wang, L., Zhang, Q., Zhou, L., Liao, R., Wu, A., Wang, X., Luo, J., Huang, F., Zou, W., et al. (2024) · Pharmaceuticals · doi:10.3390/ph17010109 · Cited by 19
Pramanik, S., Harini Devi, M., Chakrabarty, S., Paylar, B., Pradhan, A., Thaker, M., Ayyadhury, S., Manavalan, A., Olsson, P., Pramanik, G., et al. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105834 · Cited by 18
Luka, S., Golea, A. C., Tat, R. M., Lupan-Mureșan, E.-M., Voicescu, G. T., Vesa, Ș. C., & Ionescu, D. C. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13195678 · Cited by 18
Eslami, M., Monemi, M., Nazari, M. A., Azami, M. H., Rad, P. S., Oksenych, V., & Naderian, R. (2025) · Pharmaceuticals · doi:10.3390/ph18020197 · Cited by 18
Maleki, K. T., Niemetz, L., Christ, W., Byström, J. W., Thunberg, T., Ahlm, C., & Klingström, J. (2025) · PLoS Pathogens · doi:10.1371/journal.ppat.1013042 · Cited by 17
Bullock, E., Rozyczko, A., Shabbir, S., Tsoupi, I., Young, A. I. J., Trávníčková, J., Gómez-Cuadrado, L., Mabruk, Z., Carrasco, G., Morrow, E. S., et al. (2025) · Breast Cancer Research · doi:10.1186/s13058-025-02074-x · Cited by 17
Inflammatory biomarkers for predicting postoperative atrial fibrillation in cardiac surgery
Cozlac, A.-R., Staicu, R. E., Sintean, M., Negru, A. G., Gorun, F. I., Ciurescu, S., Vernic, C., Lascu, A., Deutsch, P., Horhat, F. G., et al. (2025) · Journal of Medicine and Life · doi:10.25122/jml-2025-0085 · Cited by 17
Job, J. T., Visakh, N. U., Pathrose, B., Alfarhan, A., Rajagopal, R., Thayyullathil, J., Thejass, P., Ramesh, V., & Narayanankutty, A. (2023) · Chemistry & Biodiversity · doi:10.1002/cbdv.202301223 · Cited by 17
Targeting inerleukin-6 for renoprotection
Gubernatorova, E. O., MIu, S., Drutskaya, M. S., Lebedeva, S. A., Bukhanova, D., Materenchuk, M. Y., & Mutig, K. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1502299 · Cited by 17
Colleluori, G., Viola, V., Bathina, S., Armamento‐Villareal, R., Qualls, C., Giordano, A., & Villareal, D. T. (2025) · Clinical Nutrition · doi:10.1016/j.clnu.2025.05.016 · Cited by 16
Role of astrocytes in the pathogenesis of perinatal brain injury
Li, L., Cui, X., Zhu, B., Zhou, L., Guo, Y., Liu, T., & Shi, Y. (2025) · Molecular Medicine · doi:10.1186/s10020-025-01328-w · Cited by 16
Tang, Q., Wang, X., Yang, F., Liang, L., Li, Y., Liu, W., Zhou, R., & Ma, B. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1681190 · Cited by 17
Wang, Y., Wu, J., Yao, J., Chen, J., Cheng, K. K. Y., Ho, M. Y.-M., Lee, C., Lam, K. S. L., Tse, M. A., Panagiotou, G., et al. (2025) · Cell Metabolism · doi:10.1016/j.cmet.2025.10.013 · Cited by 16
Feng, X., Peng, D., Qiu, Y., Guo, Q., Zhang, X., Li, Z., & Pan, C. (2024) · Inflammation · doi:10.1007/s10753-024-02124-0 · Cited by 16
Qiao, J., Xu, X., Zhou, X., Wu, Y., Wang, J., Xi, H., Liu, C., Wang, Y., Zhou, L., Zhou, X. M., et al. (2025) · ACS Nano · doi:10.1021/acsnano.4c17325 · Cited by 17
Sidhic, J., George, S., Alfarhan, A., Rajagopal, R., Olatunji, O. J., & Narayanankutty, A. (2023) · Molecules · doi:10.3390/molecules28196875 · Cited by 16
Zhao, Q., Dai, H., Jiang, H., Zhang, N., Hou, F., Yang, Z., Gao, Y., Liu, W., Feng, Z., Hu, Y., et al. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116583 · Cited by 15
Wagner, F., Schreiber, S., Bagger, Y. Z., Bruzelius, K., Falahati, A., Sternebring, O., Ravi, A., & Pinton, P. (2024) · Clinical and Translational Science · doi:10.1111/cts.13832 · Cited by 15
A Snapshot of Cytokine Dynamics: A Fine Balance Between Health and Disease
Mallick, S., Duttaroy, A. K., & Bose, B. (2024) · Journal of Cellular Biochemistry · doi:10.1002/jcb.30680 · Cited by 15
Yadav, M. K., Singh, S. P., & Egwuagu, C. E. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1514080 · Cited by 15
Orioli, L., & Thissen, J. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1554617 · Cited by 17
Efficient count-based models improve power and robustness for large-scale single-cell eQTL mappingPreprint
Zhang, Z., Kim, A., Suboc, N., Mancuso, N., & Gazal, S. (2025) · medRxiv · doi:10.1101/2025.01.18.25320755 · Cited by 15
Targeting the NLRP3 Inflammasome-Gasdermin D Axis to Combat Cardiovascular Diseases
Choi, J. S. Y., Pervin, M., Vince, J. E., Sharma, A., & de Haan, J. B. (2025) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2025.09.006 · Cited by 15
Napoleon, M. A., Yang, X., Zhang, Y., Morrissey, A., Krinsky, S., Lazowski, A., Bouchouari, H., Malloum, A. B., Sellinger, I. E., Edwards, T., et al. (2025) · Science Translational Medicine · doi:10.1126/scitranslmed.adn5772 · Cited by 14
Self-citationDynamic neuro-immune regulation of psychiatric risk loci in human neurons
Townsley, K. G., Lee, S. H., Williams, S., Cartwright, S., Cohen, S., Sen, A., Jia, M., Young, H. E., Dobbyn, L., Deans, M., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-77114-x · Cited by 14
Role of Interleukin-6 in Atherothrombosis and Myocardial Infarction
Huse, C., Gregersen, I., Holme, F. A., Ueland, T., Skjelland, M., Aamodt, A. H., Dahl, T. B., Aukrust, P., & Halvorsen, B. L. (2026) · Current Atherosclerosis Reports · doi:10.1007/s11883-025-01387-8 · Cited by 13
Wang, T., Yang, S., Long, Y., Li, Y., Wang, T., & Hou, Z. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1293826 · Cited by 13
Li, H., Xin, G., Zhou, Q., Yu, X., Wan, C., Wang, Y., Wen, A., Zhang, K., Zhang, B., Cao, Y. Q., et al. (2024) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2024.107286 · Cited by 13
Hansen, S. S. K., Krautz, R., Rago, D., Havelund, J. F., Stigliani, A., Færgeman, N. J., Prézelin, A., Rivière, J., Couturier‐Tarrade, A., Akimov, V., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-48492-x · Cited by 13
Yu, L., Zhang, D., Yin, Y., Li, X., Bai, C., Zhou, Q., Liu, X., Tian, X., Xu, D., Yu, X., et al. (2024) · International Journal of Surgery · doi:10.1097/js9.0000000000001897 · Cited by 13
Recent approaches of antibody therapeutics in androgenetic alopecia
Jin, S., Kim, J., & Sung, J. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1434961 · Cited by 13
Zhang, J., Yu, M., Zhang, T., Song, X., Ying, S., Shen, Z., & Yu, C. (2024) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjae134 · Cited by 13
Targeting interleukin-6 pathways in giant cell arteritis management: A narrative review of evidence
Samson, M., Dasgupta, B., Sammel, A. M., Salvarani, C., Pagnoux, C., Hajj‐Ali, R. A., Schmidt, W., & Cid, M. C. (2024) · Autoimmunity Reviews · doi:10.1016/j.autrev.2024.103716 · Cited by 13
Zorc, R., Redmond, C., Sylvester, M., Maclean, M. J., Almeida, L. Y., Quinn, K. A., Tomelleri, A., Campochiaro, C., Dagna, L., Gutierrez‐Rodrigues, F., et al. (2025) · Annals of the Rheumatic Diseases · doi:10.1016/j.ard.2025.01.049 · Cited by 13
The biology of interleukin-6 family cytokines is regulated by glycosylation
Kohrs, L., Buettner, F. F. R., Lokau, J., & Garbers, C. (2025) · Biochemical Journal · doi:10.1042/bcj20240769 · Cited by 14
Self-citationHou, D., Cai, D., Dai, W., Liao, X., Tan, M., Zheng, X., Wang, L., Liu, J., Wang, J., Wang, X., et al. (2025) · Blood Advances · doi:10.1182/bloodadvances.2024015496 · Cited by 13
deGoma, E. M., Walsh, J., & Georgakis, M. K. (2025) · Circulation Genomic and Precision Medicine · doi:10.1161/circgen.125.005103 · Cited by 13
Immune responses in COVID-19 patients: Insights into cytokine storms and adaptive immunity kinetics
Zhang, J. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e34577 · Cited by 13
Cytokines of the interleukin-6 family as emerging targets in inflammatory bowel disease
Garbers, C., & Lokau, J. (2024) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2024.2306341 · Cited by 12
Self-citationTaming the cytokine storm: small molecule inhibitors targeting IL-6/IL-6α receptor
Zia, K., Nur‐e‐Alam, M., Ahmad, A., & Ul‐Haq, Z. (2024) · Molecular Diversity · doi:10.1007/s11030-023-10805-5 · Cited by 12
The role and impact of the IL-6 mediated JAK2-STAT1/3 signaling pathway in the pathogenesis of gout
Zhang, Z., Wang, P., Lei, T., Guo, J., Jiang, Y., Li, Y., Zheng, J., Wang, S., Xu, H., Jian, G., et al. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1480844 · Cited by 12
Xu, J., Li, Y., Li, X., Tan, X. N. S., Liu, L., Cao, L., & Xu, H. (2025) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.66.4.67 · Cited by 12
The immunology of exercise: Mechanisms, mediators, and therapeutic opportunities
Phelps, C. M., & Meisel, M. (2026) · Immunity · doi:10.1016/j.immuni.2026.04.016 · Cited by 12
Exploring the landscape of synthetic IL ‐6‐type cytokines
Scheller, J., Ettich, J., Wittich, C., Pudewell, S., Floss, D. M., & Rafii, P. (2023) · FEBS Journal · doi:10.1111/febs.16909 · Cited by 13
Self-citationKuroyanagi, G., Kamiya, N., Yamaguchi, R., & Kim, H. K. W. (2023) · Osteoarthritis and Cartilage Open · doi:10.1016/j.ocarto.2023.100386 · Cited by 12
Reich, O., Regauer, S., Gutiérrez, A. L., & Kashofer, K. (2024) · Laboratory Investigation · doi:10.1016/j.labinv.2024.102108 · Cited by 11
Interleukin-6: Molecular Mechanisms and Therapeutic Perspectives in Atrial Fibrillation
Yu, J.-F., Dong, Q., & Du, Y. (2025) · Current Medical Science · doi:10.1007/s11596-025-00021-7 · Cited by 11
Pan, Y., Zhao, X., Chen, Q., Zhao, T., Ma, Y., Hai, W., Xiang, Y., Jiang, P. Z., Li, W., Yan, Q., et al. (2025) · Microbiological Research · doi:10.1016/j.micres.2025.128217 · Cited by 11
Risby-Jones, G., Marallag, J., Jagaraj, C. J., Atkin, J. D., Walker, A. K., Woodruff, T. M., Lee, J. D., & Fung, J. N. (2025) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2025.06.021 · Cited by 11
Self-adaptive biomaterials for tissue repair: from design to application
Zheng, W., Jin, Z., Chen, X., Wang, Q., Kang, Y., Chang, J., Peng, P., Wang, B., & Gao, C. (2025) · Progress in Materials Science · doi:10.1016/j.pmatsci.2025.101593 · Cited by 12
Molecular Mechanisms Underlying Atherosclerosis and Current Advances in Targeted Therapeutics
Zhu, B. J. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27020634 · Cited by 11
Rafii, P., Cruz, P. R., Ettich, J., Seibel, C., Padrini, G., Wittich, C., Lang, A., Petzsch, P., Köhrer, K., Moll, J. M., et al. (2024) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2024.107251 · Cited by 11
Self-citationWeitz, H. T., Ettich, J., Rafii, P., Wittich, C., Schultz, L., Frank, N. C., Heise, D., Krusche, M., Lokau, J., Garbers, C., et al. (2024) · FEBS Journal · doi:10.1111/febs.17309 · Cited by 11
Self-citationNonspecific Inhibition of IL6 Family Cytokine Signalling by Soluble gp130
Widjaja, A. A., & Cook, S. A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25031363 · Cited by 10
IL-6 signaling pathway differentiation for endometriosis and inflammatory diseases
Castle, R. (2024) · Exploration of Immunology · doi:10.37349/ei.2024.00153 · Cited by 10
Curren, B. F., Ahmed, T., Rashid, R. B., Sebina, I., Sikder, M. A. A., Howard, D. R., Alorro, M., Ullah, M. A., Bissell, A., Rahman, M. M., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114974 · Cited by 10
Self-citationItorralba, J., Brand‐Arzamendi, K., Saab, G., Muccilli, A. D., & Schneider, R. (2025) · BMC Neurology · doi:10.1186/s12883-025-04145-0 · Cited by 11
The Roles of IL-6, IL-8, and TNF-α in Pediatric Immune Defense and Infection Severity
Obaji, M. U., Oli, A. N., & Ugwu, M. C. (2025) · OBM Genetics · doi:10.21926/obm.genet.2502293 · Cited by 10
RING1 dictates GSDMD-mediated inflammatory response and host susceptibility to pathogen infection
Li, Y., Gao, W., Qiu, Y., Pan, J., Guo, Q., Liu, X., Geng, L., Shen, Y., Deng, Y., Hu, Z., et al. (2025) · Cell Death and Differentiation · doi:10.1038/s41418-025-01527-2 · Cited by 10
Lundin, J. I., Peters, U., Hu, Y., Ammous, F., Benjamin, E. J., Bis, J. C., Brody, J. A., Cushman, M., Fuller, H., Gignoux, C. R., et al. (2025) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2025.120219 · Cited by 10
Interleukin family in vascular calcification: molecular mechanisms and therapeutic perspectives
Zhao, Y., Li, H., & Guo, Y. (2025) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2025.1619018 · Cited by 10
Nie, D., Zhang, H., Wang, H., Song, W., Yuan, D., Zhu, D., Mao, G., Guo, T., & Lin, M. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.157269 · Cited by 10
Proteolytic profiling of human plasma reveals an immunoactive complement C3 fragment
Demir, F., Kovalenko, E., Lassé, M., Svenningsen, E. B., Jensen, J. M. B., Billing, A. M., Groeneveld, K., Hutzfeldt, A. D., Nilges, L., Guerra, J. P. L., et al. (2025) · The EMBO Journal · doi:10.1038/s44318-025-00598-8 · Cited by 10
Jung, Y. Y., Kim, C., Shanmugam, M. K., Deivasigamani, A., Chinnathambi, A., Alharbi, S. A., Rangappa, K. S., Hui, K. M., Sethi, G., Mohan, C. D., et al. (2023) · Cellular Signalling · doi:10.1016/j.cellsig.2023.111003 · Cited by 10
Cheng, Y., Zhao, R., Qiao, M., Ma, Y., Li, T., Li, N., Shen, Y., Huang, X., & Song, L. (2024) · Foods · doi:10.3390/foods13040626 · Cited by 10
Ectodomain shedding of PLA2R1 is mediated by the metalloproteases ADAM10 and ADAM17
Dolla, G., Nicolas, S., dos Santos, L. R., Bourgeois, A., Pardossi‐Piquard, R., Bihl, F., Zaghrini, C., Justino, J., Payré, C., Mansuelle, P., et al. (2024) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2024.107480 · Cited by 10
Self-citationMorató, X., Puerta, R., Cano, A. C., Orellana, A., de Rojas, I., Capdevila, M., Montrreal, L., Rosende‐Roca, M., García‐González, P., Olivé, C., et al. (2024) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2024.100899 · Cited by 10
Çekin, N., Akın, Ş., Pınarbaşı, E., & Doğan, H. O. (2024) · Mammalian Genome · doi:10.1007/s00335-024-10085-w · Cited by 10
Chiu, Y.-S., Wu, K.-J., Yu, S.-J., Wu, K.-L., Hsieh, C.-Y., Chou, Y.-S., Chen, K.-Y., Wang, Y.-S., Bae, E.-K., Hung, T.-W., et al. (2024) · Cell Transplantation · doi:10.1177/09636897241296366 · Cited by 10
Giollabhui, N. M., Lowry, C. A., Nyer, M., Foster, S. L., Liu, R. T., Smith, D. G., Cole, S. P., Mason, A. E., Mischoulon, D., & Raison, C. L. (2024) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2024.04.040 · Cited by 9
Crosstalk between lipocalin-2 and IL-6 in traumatic brain injury: Closely related biomarkers
Kim, J., Jeong, H., Hyeon, S. J., Park, U., Oh, W., Hwang, J., Lim, H., Ko, P., Lee, H., Lee, W., et al. (2024) · Experimental Neurology · doi:10.1016/j.expneurol.2024.115092 · Cited by 9
Yu, X., Li, G., Zhou, S., Liu, X., Yin, F., Li, D., & Zhou, D.-Y. (2024) · Food & Function · doi:10.1039/d4fo04200j · Cited by 9
Targeting RNA adenosine editing and modification enzymes for RNA therapeutics
Vlachogiannis, N. I., Polycarpou‐Schwarz, M., Avdi, A.-P., Tual‐Chalot, S., & Stellos, K. (2025) · Molecular Therapy · doi:10.1016/j.ymthe.2025.05.021 · Cited by 9
The Dual Role of Myokines in Fatigue Associated with Inflammatory Joint Diseases
Chmielewski, G., Kuna, J., Jaśkiewicz, Ł., Knapik, M., Mikiewicz, M., Majewski, M. S., & Krajewska–Włodarczyk, M. (2025) · Journal of Inflammation Research · doi:10.2147/jir.s545914 · Cited by 9
Huse, C., Murphy, S. L., Yang, K., Balzer, N. R., Stokke, M. K., Anstensrud, A. K., Bjerkeli, V., Rentz, T., Jha, P. K., Ugland, H. K., et al. (2025) · EBioMedicine · doi:10.1016/j.ebiom.2025.105960 · Cited by 9
Interleukin‑6 and ischemic stroke: From mechanisms to clinical prospects (Review)
Wang, X., Zhang, X., Lin, J., & Lin, P. (2026) · Molecular Medicine Reports · doi:10.3892/mmr.2026.13790 · Cited by 9
Obesity Arrhythmias: Role of IL-6 Trans-Signaling
Aromolaran, K. A., Corbin, A. C., & Aromolaran, A. S. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25158407 · Cited by 9
Groza, Y., Lacina, L., Kuchař, M., Kafkova, L. R., Zachová, K., Janoušková, O., Osička, R., Černý, J., Petroková, H., Mierzwicka, J. M., et al. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-024-01630-w · Cited by 9
Zhang, Y., Ning, D., Nie, J., Hou, X., Li, W., Gan, Z., & Lu, Y. (2025) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2025.110183 · Cited by 8
Defining optimal electrospun membranes to enhance biological activities of human endometrial MSCs
An, J., Ma, T., Wang, Q., Zhang, J., Santerre, J. P., Wang, W., Ma, P., & Zhang, X. (2025) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2025.1551791 · Cited by 8
Hsieh, M.-H., Lai, P.-F., Chen, P., Liu, X., Chen, W.-L., Kuo, W., Wang, S.-D., Kao, H.-F., Lin, L., Wu, L. S.-H., et al. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26188800 · Cited by 8
Harnessing the Estradienone Scaffold to Develop Dual GPBAR1 and LIFR Modulators for Liver Fibrosis
Gregorio, R. D., Moraca, F., Rapacciuolo, P., Fiorillo, B., Morretta, E., Giorgio, C. D., Marchianò, S., Lachi, G., Massa, C., Sensini, B., et al. (2025) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5c00705 · Cited by 8
Interleukin 6 Signalling in Heart Failure With Preserved and Reduced Ejection Fraction
Самойлова, Е. В., Korotaeva, A. A., Жиров, И. В., Aksenova, Y. O., Николаевна, Н. С., & Тereschenko, S. N. (2024) · Kardiologiia · doi:10.18087/cardio.2024.3.n2534 · Cited by 8
Quan, W., Xu, C., Ma, C., Chen, X., Yu, D., Li, Z., Wang, D., Tang, F. R., Wan, G.-P., Wan, J., et al. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.112707 · Cited by 8
Simon‐Szabó, L., Lizák, B., Sturm, G., Somogyi, A., Takács, I., & Németh, Z. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25169113 · Cited by 8
Shi, W., Sun, H., Yao, Q., Liu, H., Zhang, L., & Han, W. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.114403 · Cited by 8
Sun, L., Wu, Y., Akinyemi, L. I., Cao, Z., Fan, Z., Liu, H., Yang, Z., Zhang, L., & Zhang, F. (2025) · Cancer Medicine · doi:10.1002/cam4.70777 · Cited by 8
Probiotics as technological innovations in psychiatric disorders: patents and research reviews
de Lima, A. A., Santos, S. S., de Araújo, M. A., Vinderola, G., Villarreal, C. F., & Viana, M. D. M. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1567097 · Cited by 8
STAT4 Mediates IL-6 Trans-Signaling Arrhythmias in High Fat Diet Guinea Pig Heart
Corbin, A. C., Aromolaran, K. A., & Aromolaran, A. S. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25147813 · Cited by 8
Wu, O., Wu, Y., Zhang, X., Liu, W. Y., Zhang, H., Khederzadeh, S., Lu, X., & Zhu, X.-W. (2024) · Immunogenetics · doi:10.1007/s00251-024-01332-0 · Cited by 7
Structural basis of signaling complex inhibition by IL-6 domain-swapped dimers
Yudenko, A., Bukhdruker, S. S., Shishkin, P., Rodin, S., Burtseva, A., Petrov, A., Pigareva, N. V., Av, S., Zinovev, E. V., Eliseev, I. E., et al. (2024) · Structure · doi:10.1016/j.str.2024.10.028 · Cited by 7
Zhou, J.-R., Liao, Y., Cao, L., Ma, R., He, Y., Li, N., Zhu, D., Zhao, X., Huang, X., & Sun, Y. (2025) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiaf041 · Cited by 7
The RNA-binding protein RRP1 brakes macrophage one-carbon metabolism to suppress autoinflammation
Zhou, Y.-M., Li, M., Jin, K., Wen, M., Qin, H., Xu, Y., Wang, C., Zhang, X., & Cao, X. (2025) · Nature Communications · doi:10.1038/s41467-025-62173-3 · Cited by 8
Filannino, F. M., Soleti, R., Ruggiero, M., de Stefano, M. I., Panaro, M. A., Lofrumento, D. D., Trotta, T., Maffione, A. B., Benameur, T., Cianciulli, A., et al. (2025) · Molecules · doi:10.3390/molecules30153131 · Cited by 7
Plasma proteomic profiles identify biomarkers predicting Crohn’s disease up to 16 years before onset
Feng, J. Q., Chen, S., Li, Q., Long, Y., Ma, Y., Zhang, L., Zeng, R., Luo, D., Meng, M., Yu, S., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-66483-4 · Cited by 7
The Heterogeneity and Function of Stromal Cells in the Tumor Microenvironment
Wang, X., Li, S., Xue, Y., Liang, X., Ma, X., Zhang, K., & Wang, Y. (2026) · Research · doi:10.34133/research.1183 · Cited by 7
Exercise-induced myokines in metabolic regulation: mechanisms, mimetics, and translational potential
Aslam, M. A., Lee, J., Bowen, T. S., & Huh, J. Y. (2026) · Archives of Pharmacal Research · doi:10.1007/s12272-026-01624-x · Cited by 7
Cioce, M., Gatti, V., Napolitano, F., Giorgiano, N. M., Marra, A., Portella, G., Fiorelli, A., Pentimalli, F., & Fazio, V. M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25105355 · Cited by 7
Li, K., Cai, J., Jiang, Z., Meng, Q., Zhao, M., Xiao, H. M., Chen, G., Qiao, C., Luo, L., Yu, J., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-69429-w · Cited by 7
Metadata
- Authors
- Rose-John, S., Jenkins, B. J., Garbers, C., Moll, J. M., & Scheller, J.
- Affiliations
- Hudson Institute of Medical Research (AU)
- Otto-von-Guericke-Universität Magdeburg (DE)
- Heinrich Heine University Düsseldorf (DE)
- Corresponding author
- Scheller, Jürgen
- Venue
- Nature Reviews Immunology
- Published
- 2023-04-17
- Volume
- 23
- Issue
- 10
- Pages
- 666-681
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- PMC
- PMC10108826
- OpenAlex
- W4366085911
- Semantic Scholar
- 5ffbde604bb1ef36987e5c29a105b9a8541a3137
- Cited by
- 524
- References
- 213
- Citations by year
- 2026: 146 · 2025: 184 · 2024: 151 · 2023: 43
- FWCI
- 16.99
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Defense (LC170062)
- Deutsche Forschungsgemeinschaft (CRC877, SFB 877, CRC 841, 125440785)
- Deutsche Krebshilfe
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
- Keywords
- interleukin-6, IL-6 trans-signalling, soluble IL-6 receptor, gp130, sgp130, IL-6 receptor alpha, inflammatory bowel disease, autoimmune disease, chronic inflammation, cancer, cytokine therapy
- MeSH terms
- Humans, Neoplasms, Interleukin-6, Cytokines, Receptors, Interleukin-6, Cytokine Receptor gp130
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
