The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Multifunctional biomolecule nanostructures for cancer therapy
Open accessAbstract
Biomolecule-based nanostructures are inherently multifunctional and harbour diverse biological activities, which can be explored for cancer nanomedicine. The supramolecular properties of biomolecules can be precisely programmed for the design of smart drug delivery vehicles, enabling efficient transport in vivo, targeted drug delivery and combinatorial therapy within a single design. In this Review, we discuss biomolecule-based nanostructures, including polysaccharides, nucleic acids, peptides and proteins, and highlight their enormous design space for multifunctional nanomedicines. We identify key challenges in cancer nanomedicine that can be addressed by biomolecule-based nanostructures and survey the distinct biological activities, programmability and in vivo behaviour of biomolecule-based nanostructures. Finally, we discuss challenges in the rational design, characterization and fabrication of biomolecule-based nanostructures, and identify obstacles that need to be overcome to enable clinical translation. Multifunctional nanostructures are explored for smart cancer nanomedicine. This Review discusses nanostructures made of biomolecules, including polysaccharides, nucleic acids, peptides and proteins, which are inherently multifunctional and allow the targeting and delivery of cancer drugs to tumour tissue.
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Cites
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Cited by
Li, Y., Ma, X., Yue, Y., Zhang, K., Cheng, K., Feng, Q., Ma, N., Liang, J., Zhang, T., Zhang, L., et al. (2022) · Advanced Materials · doi:10.1002/adma.202109984 · Cited by 247
Self-citationWang, J., Zhu, M., & Nie, G. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.113974 · Cited by 153
Self-citationNano-ROS-generating approaches to cancer dynamic therapy: Lessons from nanoparticles
Zhang, Q., Luo, Q., Liu, Z., Sun, M., & Dong, X. (2023) · Chemical Engineering Journal · doi:10.1016/j.cej.2022.141225 · Cited by 94
Ye, L., Zhao, G., Ma, J., Gan, Q., Luo, N., Pan, D., Chen, C., Chen, X., & Ning, S. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-026-02769-3 · Cited by 10
Drug-Loaded Biomimetic Carriers for Non-Hodgkin’s Lymphoma Therapy: Advances and Perspective
Li, X., Zhang, Y., Wang, C., Wang, L., Ye, Y., Xue, R., Shi, Y., Su, Q., Zhu, Y., & Wang, L. (2024) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.3c01480 · Cited by 4
Metadata
- Authors
- Wang, J., Li, Y., & Nie, G.
- Venue
- Nature Reviews Materials
- Published
- 2021-05-19
- Volume
- 6
- Issue
- 9
- Pages
- 766-783
- ISSN
- 2058-8437 (ISSN-L)
- OpenAlex
- W3162871690
- Cited by
- 488
- References
- 26
- FWCI
- 5.90
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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