The DOI matches its Crossref record; 235 of the 235 references it cites were found in a registry or an index.
Molecular mechanisms of antibiotic resistance revisited
Abstract
Antibiotic resistance is a global health emergency, with resistance detected to all antibiotics currently in clinical use and only a few novel drugs in the pipeline. Understanding the molecular mechanisms that bacteria use to resist the action of antimicrobials is critical to recognize global patterns of resistance and to improve the use of current drugs, as well as for the design of new drugs less susceptible to resistance development and novel strategies to combat resistance. In this Review, we explore recent advances in understanding how resistance genes contribute to the biology of the host, new structural details of relevant molecular events underpinning resistance, the identification of new resistance gene families and the interactions between different resistance mechanisms. Finally, we discuss how we can use this information to develop the next generation of antimicrobial therapies.
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“Efflux pumps, which facilitate multidrug resistance by expelling a broad range of antibiotics41, were also prevalent across multiple strains, particularly within Escherichia and Klebsiella, further complicating treatment options for infections by these pathogens in preterm infants.”
From Impact of early life antibiotic and probiotic treatment on gut microbiome and resistome of very-low-birth-weight preterm infants. (2025) · cites this paper as [41]
Citations
Cites
Liu, Y.-Y., Wang, Y., Walsh, T., Yi, L.-X., Zhang, R., Spencer, J., Doi, Y., Tian, G.-B., Dong, B.-L., Huang, X.-H., et al. (2016) · Lancet. Infectious Diseases (Print) · doi:10.1016/s1473-3099(15)00424-7 · Cited by 4,920
Molecular Basis of Bacterial Outer Membrane Permeability Revisited
Nikaido, H. (2003) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.67.4.593-656.2003 · Cited by 4,316
Molecular mechanisms of antibiotic resistance
Blair, J. M. A., Webber, M. A., Baylay, A. J., Ogbolu, D. O., & Piddock, L. J. V. (2015) · Nature Reviews Microbiology · doi:10.1038/nrmicro3380 · Cited by 4,092
Self-citationJ Antimicrob Chemother 1994; 33: 350–351
O’Shaughnessy, E. M., & DAS, S. S. (1994) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/33.2.350 · Cited by 3,758
Carbapenemases: the Versatile β-Lactamases
Queenan, A. M., & Bush, K. (2007) · Clinical Microbiology Reviews · doi:10.1128/cmr.00001-07 · Cited by 2,609
Yong, D., Toleman, M. A., Giske, C. G., Cho, H. S., Sundman, K., Lee, K., & Walsh, T. R. (2009) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00774-09 · Cited by 2,531
Updated Functional Classification of β-Lactamases
Bush, K., & Jacoby, G. A. (2010) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01009-09 · Cited by 2,367
Methicillin-resistant Staphylococcus aureus clinical strain with reduced vancomycin susceptibility
Hiramatsu, K. (1997) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/40.1.135 · Cited by 1,984
Ambler, R. P. (1980) · Philosophical transactions of the Royal Society of London. Series B, Biological sciences · doi:10.1098/rstb.1980.0049 · Cited by 1,839
Aminoglycoside modifying enzymes
Ramirez, M. S., & Tolmasky, M. E. (2010) · Drug Resistance Updates · doi:10.1016/j.drup.2010.08.003 · Cited by 1,504
Research works printed but not linked: 3
- Zhu, X.-Q. et al. Novel lnu(G) gene conferring resistance to lincomycin by nucleotidylation, located on Tn6260 from Enterococcus faecalis E531. J. Antimicrob. Chemother. 72, 993–997 (2016).
- Munita, J. M. & Arias, C. A. Mechanisms of antibiotic resistance. Microbiol. Spectr. 23, 464–472 (2016).
- Doi, Y., Wachino, J.-I. & Arakawa, Y. Aminoglycoside resistance: the emergence of acquired 16S ribosomal RNA methyltransferases. Infect. Dis. Clin. North Am. 30, 523–537 (2016). · DOI
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Tackling the outer membrane: facilitating compound entry into Gram-negative bacterial pathogens
Saxena, D., Maitra, R., Bormon, R., Czekanska, M., Meiers, J., Titz, A., Verma, S., & Chopra, S. (2023) · npj Antimicrobials and Resistance · doi:10.1038/s44259-023-00016-1 · Cited by 217
Nanozybiotics: advancing antimicrobial strategies through biomimetic mechanisms
Zhou, C., Wang, Q., Cao, H., Jiang, J., & Gao, L. (2024) · Advanced Materials · doi:10.1002/adma.202403362 · Cited by 114
Fu, Y., Dou, Q., Smalla, K., Wang, Y., Johnson, T. A., Brandt, K. K., Mei, Z., Liao, M., Hashsham, S. A., Schäffer, A., et al. (2023) · mLife · doi:10.1002/mlf2.12101 · Cited by 65
Kiu, R., Darby, E. M., Alcon-Giner, C., Acuna-Gonzalez, A., Camargo, A., Lamberte, L. E., Phillips, S., Sim, K., Shaw, A. G., Clarke, P., et al. (2025) · Nature communications · doi:10.1038/s41467-025-62584-2 · Cited by 36
“Ef fl ux pumps, which facilitate multidrug resistance by expelling a broad range of antibiotics 41 , were also prevalent across multiple strains, particularly within Escherichia and Klebsiella , further complicating treatment options for infections by these pathogens in preterm infants.”
Self-citationEl Meouche, I., Jain, P., Jolly, M. K., & Capp, J.-P. (2024) · Translational Oncology · doi:10.1016/j.tranon.2024.102069 · Cited by 22
Mahmud, Z., Manik, M. R. K., Rahman, A., Karim, M. M., & Islam, L. N. (2024) · Scientific Reports · doi:10.1038/s41598-024-71472-6 · Cited by 22
Grabeck, J., Mayer, J., Miltz, A., Casoria, M., Quagliata, M., Meinberger, D., Klatt, A. R., Wielert, I., Maier, B., Papini, A. M., et al. (2024) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.4c00078 · Cited by 7
Extensive natural variation in bacterial ribosomal drug-binding sites
Ekemezie, C. L., Chan, L. I., Brown, C. R., Helena-Bueno, K., Williams, T. A., & Melnikov, S. V. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115878 · Cited by 2
Metadata
- Authors
- Darby, E. M., Trampari, E., Siasat, P., Gaya, M. S., Alav, I., Webber, M. A., & Blair, J. M. A.
- Affiliations
- University of Birmingham (GB)
- Quadram Institute (GB)
- University of East Anglia (GB)
- Corresponding author
- Webber, Mark A.
- Blair, Jessica M. A.
- ORCID
- Venue
- Nature Reviews Microbiology
- Published
- 2022-11-21
- Volume
- 21
- Issue
- 5
- Pages
- 280-295
- ISSN
- 1740-1526 (ISSN-L)
- 1740-1534
- OpenAlex
- W4309666648
- Cited by
- 1,398
- References
- 235
- Citations by year
- 2026: 369 · 2025: 497 · 2024: 382 · 2023: 146 · 2022: 2
- FWCI
- 19.01
- Type
- journal article
- Language
- en
- Update notices
- correction (2024-02-02)
- Open access
- closed
- Licence
- Locations
- Nature Reviews Microbiology (publishedVersion)
- PubMed (publishedVersion)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
- UEA Digital Repository (University of East Anglia) (submittedVersion)
- Funders
- Medical Research Council (2438035)
- Biotechnology and Biological Sciences Research Council (BBS/E/F/00044426, BBS/E/F/000PR10349)
- Topics
- Health Sciences › Medicine › Microbiology (medical) › Antibiotic Resistance in Bacteria
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Health Sciences › Medicine › Infectious Diseases › Antimicrobial Resistance in Staphylococcus
- Keywords
- antibiotic resistance, molecular mechanisms of resistance, resistance genes, antibiotic efflux, drug modification
- MeSH terms
- Anti-Bacterial Agents, Bacteria, Drug Resistance, Microbial, Global Health
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