Molecular mechanisms of antibiotic resistance revisited

A Molecular Perspective on Colistin and Klebsiella pneumoniae: Mode of Action, Resistance Genetics, and Phenotypic Susceptibility

Elias, R., Duarte, A., & Perdigão, J. (2021) · Diagnostics · doi:10.3390/diagnostics11071165 · Cited by 42

N-acetylmuramic acid 6-phosphate lyases (MurNAc etherases): role in cell wall metabolism, distribution, structure, and mechanism

Jaeger, T., & Mayer, C. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-7399-x · Cited by 41

Characteristics and diversity of mutations in regulatory genes of resistance-nodulation-cell division efflux pumps in association with drug-resistant clinical isolates of Acinetobacter baumannii

Salehi, B., Ghalavand, Z., Yadegar, A., & Eslami, G. (2021) · Antimicrobial Resistance and Infection Control · doi:10.1186/s13756-021-00924-9 · Cited by 41

Efflux Impacts Intracellular Accumulation Only in Actively Growing Bacterial Cells

Whittle, E. E., McNeil, H. E., Trampari, E., Webber, M. A., Overton, T. W., & Blair, J. M. A. (2021) · mBio · doi:10.1128/mbio.02608-21 · Cited by 41

The streptogramin antibiotics: update on their mechanism of action

Beyer, D., & Pepper, K. (1998) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.7.4.591 · Cited by 40

Identification of Binding Sites for Efflux Pump Inhibitors of the AcrAB-TolC Component AcrA

Darżynkiewicz, Z. M., Green, A. T., Abdali, N., Hazel, A. J., Fulton, R. L., Kimball, J., Gryczynski, Z. K., Gumbart, J. C., Parks, J. M., Smith, J. C., et al. (2019) · Biophysical Journal · doi:10.1016/j.bpj.2019.01.010 · Cited by 35

Genetic Basis and Functional Consequences of Differential Expression of the CmeABC Efflux Pump in Campylobacter jejuni Isolates

Grinnage‐Pulley, T., & Zhang, Q. (2015) · PLoS ONE · doi:10.1371/journal.pone.0131534 · Cited by 34

Inhibition of Aminoglycoside‐Deactivating Enzymes APH(3′)‐IIIa and AAC(6′)‐Ii by Amphiphilic Paromomycin O2′′‐Ether Analogues

Szychowski, J., Kondo, J., Zahr, O., et al. (2011) · ChemMedChem · doi:10.1002/cmdc.201100346 · Cited by 33

Genome-wide analysis of horizontally acquired genes in the genus Mycobacterium

Panda, A., Drancourt, M., Tuller, T., & Pontarotti, P. (2018) · Scientific Reports · doi:10.1038/s41598-018-33261-w · Cited by 33

ApmA Is a Unique Aminoglycoside Antibiotic Acetyltransferase That Inactivates Apramycin

Bordeleau, E., Stogios, P. J., Evdokimova, E., et al. (2021) · mBio · doi:10.1128/mbio.02705-20 · Cited by 32

Dual Regulation of the Small RNA MicC and the Quiescent Porin OmpN in Response to Antibiotic Stress in Escherichia coli

Dam, S., Pagès, J., & Masi, M. (2017) · Antibiotics · doi:10.3390/antibiotics6040033 · Cited by 31

Deciphering Determinants in Ribosomal Methyltransferases That Confer Antimicrobial Resistance

Bhujbalrao, R., & Anand, R. (2019) · Journal of the American Chemical Society · doi:10.1021/jacs.8b10277 · Cited by 31

Diacylglycerol Kinase A Is Essential for Polymyxin Resistance Provided by EptA, MCR-1, and Other Lipid A Phosphoethanolamine Transferases

Purcell, A. B., Voss, B. J., & Trent, M. S. (2021) · Journal of Bacteriology · doi:10.1128/jb.00498-21 · Cited by 30

Fitness effects of plasmids shape the structure of bacteria–plasmid interaction networks

Newbury, A., Dawson, B. R., Klümper, U., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2118361119 · Cited by 29

Sal-type ABC-F proteins: intrinsic and common mediators of pleuromutilin resistance by target protection in staphylococci

Mohamad, M., Nicholson, D. E., Saha, C. K., et al. (2022) · Nucleic Acids Research · doi:10.1093/nar/gkac058 · Cited by 28

Could Dampening Expression of the Neisseria gonorrhoeae mtrCDE -Encoded Efflux Pump Be a Strategy To Preserve Currently or Resurrect Formerly Used Antibiotics To Treat Gonorrhea?

Chen, S.-C., Connolly, K. L., Rouquette-Loughlin, C. E., et al. (2019) · mBio · doi:10.1128/mbio.01576-19 · Cited by 27

Impact of mcr-1 on the Development of High Level Colistin Resistance in Klebsiella pneumoniae and Escherichia coli

Zhu, X., Liu, Y., Wu, R., et al. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.666782 · Cited by 23

Positive Selection Inhibits Plasmid Coexistence in Bacterial Genomes

Carrilero, L., Kottara, A., Guymer, D., Harrison, E., Hall, J. P. J., & Brockhurst, M. A. (2021) · mBio · doi:10.1128/mbio.00558-21 · Cited by 23

First report of NDM-1-producing Klebsiella pneumoniae imported from Africa to Italy: Evidence of the need for continuous surveillance

Principe, L., Mauri, C., Conte, V., et al. (2016) · Journal of Global Antimicrobial Resistance · doi:10.1016/j.jgar.2016.10.004 · Cited by 21

How Mycobacterium tuberculosis drug resistance has shaped anti-tubercular drug discovery

Bhagwat, A., Deshpande, A., & Parish, T. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.974101 · Cited by 20

Detection of NDM-19, a novel variant of the New Delhi metallo-β-lactamase with increased carbapenemase activity under zinc-limited conditions, in Switzerland

Mancini, S., Keller, P. M., Greiner, M., Bruderer, V. L., & Imkamp, F. (2019) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/j.diagmicrobio.2019.06.003 · Cited by 18

Genome-Wide Association Studies for the Detection of Genetic Variants Associated With Daptomycin and Ceftaroline Resistance in Staphylococcus aureus

Weber, R. E., Fuchs, S., Layer, F., Sommer, A. K., Bender, J. K., Thürmer, A., Werner, G., & Strommenger, B. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.639660 · Cited by 18

A tale of two plasmids: contributions of plasmid associated phenotypes to epidemiological success among Shigella

Silva, P. M. D., Stenhouse, G. E., Blackwell, G. A., Bengtsson, R. J., Jenkins, C., Hall, J. P. J., & Baker, K. S. (2022) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2022.0581 · Cited by 17

A genomic view of experimental intraspecies and interspecies transformation of a rifampicin-resistance allele into Neisseria meningitidis

Alfsnes, K., Frye, S. A., Eriksson, J., et al. (2018) · Microbial Genomics · doi:10.1099/mgen.0.000222 · Cited by 13

Cryo-EM as a tool to study bacterial efflux systems and the membrane proteome

Klenotic, P. A., Morgan, C. E., & Yu, E. W. (2021) · Faculty Reviews · doi:10.12703/r/10-24 · Cited by 13

Genomic and Phenotypic Analysis of Linezolid-Resistant Staphylococcus epidermidis in a Tertiary Hospital in Innsbruck, Austria

Huber, S., Knoll, M. A., Berktold, M., Würzner, R., Brindlmayer, A., Weber, V., Posch, A. E., Mrazek, K., Lepuschitz, S., Ante, M., et al. (2021) · Microorganisms · doi:10.3390/microorganisms9051023 · Cited by 13

Recent paradigm shift in the assembly of bacterial tripartite efflux pumps and the type I secretion system

Jo, I., Kim, J., Xu, Y., et al. (2019) · The Journal of Microbiology · doi:10.1007/s12275-019-8520-1 · Cited by 12

A Novel KPC Variant KPC-55 in Klebsiella pneumoniae ST307 of Reinforced Meropenem-Hydrolyzing Activity

Yoon, E.-J., Choi, Y. J., Park, S. H., Shin, J. H., Park, S. G., Choi, J. R., & Jeong, S. H. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.561317 · Cited by 12

Nde1 is a Rab9 effector for loading late endosomes to cytoplasmic dynein motor complex

Zhang, Y., Chen, Z., Wang, F., Sun, H., Zhu, X., Ding, J., & Zhang, T. (2021) · Structure · doi:10.1016/j.str.2021.10.013 · Cited by 12

Efflux Pumps in Neisseria gonorrhoeae: Contributions to Antimicrobial Resistance and Virulence

Shafer, W. M., Yu, E. W., Rouquette-Loughlin, C. E., et al. (2016) · Springer eBooks · doi:10.1007/978-3-319-39658-3_17 · Cited by 11

Identification of the novel class D β-lactamase OXA-679 involved in carbapenem resistance in Acinetobacter calcoaceticus

Tietgen, M., Kramer, J. S., Brunst, S., et al. (2019) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkz080 · Cited by 11

Outer membrane permeability: Antimicrobials and diverse nutrients bypass porins in Pseudomonas aeruginosa

Ude, J., Tripathi, V., Buyck, J. M., et al. (2021) · edoc (University of Basel) · doi:10.5451/unibas-ep86560 · Cited by 10

Interactions of a bacterial RND transporter with a transmembrane small protein in a lipid environmentPreprint

Du, D., Neuberger, A., Orr, M. W., Newman, C. E., Hsu, P., Samsudin, F., Harris, A., Ramos, L. M., Debela, M., Khalid, S., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/813394 · Cited by 3

Defining the link between efflux pumps and biofilm formation

Holden, E. R., & Webber, M. A. (2020) · Access Microbiology · doi:10.1099/acmi.mim2019.po0007 · Cited by 1

Editorial: Structural and Biochemical Aspects of the Interaction of β-Lactamases With State-of-the-Art Inhibitors

Papp‐Wallace, K. M., Docquier, J., Kerff, F., et al. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.849324 · Cited by 1

Tackling the outer membrane: facilitating compound entry into Gram-negative bacterial pathogens

Saxena, D., Maitra, R., Bormon, R., Czekanska, M., Meiers, J., Titz, A., Verma, S., & Chopra, S. (2023) · npj Antimicrobials and Resistance · doi:10.1038/s44259-023-00016-1 · Cited by 217

Nanozybiotics: advancing antimicrobial strategies through biomimetic mechanisms

Zhou, C., Wang, Q., Cao, H., Jiang, J., & Gao, L. (2024) · Advanced Materials · doi:10.1002/adma.202403362 · Cited by 114

Gut microbiota research nexus: One Health relationship between human, animal, and environmental resistomes

Fu, Y., Dou, Q., Smalla, K., Wang, Y., Johnson, T. A., Brandt, K. K., Mei, Z., Liao, M., Hashsham, S. A., Schäffer, A., et al. (2023) · mLife · doi:10.1002/mlf2.12101 · Cited by 65

Impact of early life antibiotic and probiotic treatment on gut microbiome and resistome of very-low-birth-weight preterm infants.

Kiu, R., Darby, E. M., Alcon-Giner, C., Acuna-Gonzalez, A., Camargo, A., Lamberte, L. E., Phillips, S., Sim, K., Shaw, A. G., Clarke, P., et al. (2025) · Nature communications · doi:10.1038/s41467-025-62584-2 · Cited by 36

Drug tolerance and persistence in bacteria, fungi and cancer cells: Role of non-genetic heterogeneity

El Meouche, I., Jain, P., Jolly, M. K., & Capp, J.-P. (2024) · Translational Oncology · doi:10.1016/j.tranon.2024.102069 · Cited by 22

A genetic platform to investigate the functions of bacterial drug efflux pumps

Teelucksingh, T., Thompson, L. K., Zhu, S., Kuehfuss, N. M., Goetz, J. A., Gilbert, S., MacNair, C. R., Geddes‐McAlister, J., Brown, E. D., & Cox, G. (2022) · Nature Chemical Biology · doi:10.1038/s41589-022-01119-y · Cited by 46

Synthesis and evaluation of fluoroquinolone derivatives as substrate-based inhibitors of bacterial efflux pumps

German, N., Wei, P., Kaatz, G. W., & Kerns, R. J. (2008) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2008.01.042 · Cited by 68

Efflux Pump Inhibitors: A Novel Approach to Combat Efflux-Mediated Drug Resistance in Bacteria

Wang, Y., Venter, H., & Ma, S. (2015) · Current Drug Targets · doi:10.2174/1389450116666151001103948 · Cited by 116

Target (MexB)- and Efflux-Based Mechanisms Decreasing the Effectiveness of the Efflux Pump Inhibitor D13-9001 in Pseudomonas aeruginosa PAO1: Uncovering a New Role for MexMN-OprM in Efflux of β-Lactams and a Novel Regulatory Circuit (MmnRS) Controlling MexMN Expression

Ranjitkar, S., Jones, A. K., Mostafavi, M., Zwirko, Z., Iartchouk, O., Barnes, S. W., Walker, J. R., Willis, T. W., Lee, P. S., & Dean, C. R. (2018) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01718-18 · Cited by 23

Screening of medicinal plants of Himachal Pradesh for efflux pump inhibitory activity against Escherichia coli

Kumar, R., Jandaik, S., & Patial., P. (2016) · Journal of Pharmacognosy and Phytochemistry · Cited by 1